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1. 发明授权

US06177085B1 Generation of immune response using immunogenic conjugate of molecules 失效
标题翻译：使用分子的免疫原性缀合物产生免疫应答
公开(公告)号：US06177085B1
公开(公告)日：2001-01-23
申请号：US08467884
申请日：1995-06-06
申请人： Yan-ping Yang , Ali Kandil , Lucy Gisonni , Raafat Emil Fahmy Fahim , Michel Henri Klein
发明人： Yan-ping Yang , Ali Kandil , Lucy Gisonni , Raafat Emil Fahmy Fahim , Michel Henri Klein
IPC分类号： A61K3909
CPC分类号： C07K17/10 , A61K39/092 , A61K2039/55505 , A61K2039/6068 , C07K14/285 , Y10S424/831
摘要： Immunogenic conjugate molecules comprising at least a portion of a capsular polysaccharide of a Streptococcus strain linked to at least a portion of an outer membrane protein of a Haemophilus strain are provided in which the immunogenicity of the capsular polysaccharide is increased. Particularly capsular polysaccharide from Streptococcus pneumoniae are linked to an outer membrane protein of a Haemophilus influenzae strain, which protein may be the P1, P2 or particularly the P6 outer membrane protein. Conjugate molecules comprising the P6 protein linked to a capsular polysaccharide from an encapsulated pathogen other than Streptococcus also are described, in which the immunogenicity of the capsular polysaccharide is enhanced. Such conjugate molecules may be incorporated into immunogenic compositions for protecting a host against disease caused by the Streptococcus strain and preferably also the Haemophilus strain. The conjugate molecules and antibodies specific for the capsular polysaccharide or specific for the outer membrane protein may be employed in diagnostic procedures and kits. A process for individually isolating P1, P2 and P6 outer membrane proteins from a Haemophilus strain also is provided.
摘要翻译：提供包含与嗜血杆菌菌株的外膜蛋白的至少一部分连接的链球菌菌株的至少一部分荚膜多糖的免疫原性缀合物分子，其中荚膜多糖的免疫原性增加。特别是来自肺炎链球菌的荚膜多糖与流感嗜血杆菌菌株的外膜蛋白连接，该蛋白质可以是P1，P2或特别是P6外膜蛋白。还描述了包含与除链球菌以外的包囊病原体的荚膜多糖连接的P6蛋白的缀合物分子，其中荚膜多糖的免疫原性增强。这样的缀合物分子可以并入免疫原性组合物中，用于保护宿主免受由链球菌菌株引起的疾病，优选还有嗜血杆菌属菌株。对于荚膜多糖或对外膜蛋白特异的缀合物分子和抗体可用于诊断程序和试剂盒。还提供了从嗜血杆菌菌株单独分离P1，P2和P6外膜蛋白的方法。

2. 发明授权

US06329512B1 Immunogenic conjugate molecules 失效
标题翻译：免疫原性共轭分子
公开(公告)号：US06329512B1
公开(公告)日：2001-12-11
申请号：US08467883
申请日：1995-06-06
申请人： Yan-Ping Yang , Ali Kandil , Lucy Gisonni , Raafat Emil Fahmy Fahim , Michel Henri Klein
发明人： Yan-Ping Yang , Ali Kandil , Lucy Gisonni , Raafat Emil Fahmy Fahim , Michel Henri Klein
IPC分类号： A23J100
CPC分类号： C07K17/10 , A61K39/092 , A61K2039/55505 , A61K2039/6068 , C07K14/285 , Y10S424/831
摘要： Immunogenic conjugate molecules comprising at least a portion of a capsular polysaccharide of a Streptococcus strain linked to at least a portion of an outer membrane protein of a Haemophilus strain are provided in which the immunogenicity of the capsular polysaccharide is increased. Particularly capsular polysaccharide from Streptococcus pneumoniae are linked to an outer membrane protein of a Haemophilus influenzae strain, which protein may be the P1, P2 or particularly the P6 outer membrane protein. Conjugate molecules comprising the P6 protein linked to a capsular polysaccharide from an encapsulated pathogen other than Streptococcus also are described, in which the immunogenicity of the capsular polysaccharide is enhanced. Such conjugate molecules may be incorporated into immunogenic compositions for protecting a host against disease caused by the Streptococcus strain and preferably also the Haemophilus strain. The conjugate molecules and antibodies specific for the capsular polysaccharide or specific for the outer membrane protein may be employed in diagnostic procedures and kits. A process for individually isolating P1, P2 and P6 outer membrane proteins from a Haemophilus strain also is provided.
摘要翻译：提供包含与嗜血杆菌菌株的外膜蛋白的至少一部分连接的链球菌菌株的至少一部分荚膜多糖的免疫原性缀合物分子，其中荚膜多糖的免疫原性增加。特别是来自肺炎链球菌的荚膜多糖与流感嗜血杆菌菌株的外膜蛋白连接，该蛋白质可以是P1，P2或特别是P6外膜蛋白。还描述了包含与除链球菌以外的包囊病原体的荚膜多糖连接的P6蛋白的缀合物分子，其中荚膜多糖的免疫原性增强。这样的缀合物分子可以并入免疫原性组合物中，用于保护宿主免受由链球菌菌株引起的疾病，优选还有嗜血杆菌属菌株。对于荚膜多糖或对外膜蛋白特异的缀合物分子和抗体可用于诊断程序和试剂盒。还提供了从嗜血杆菌菌株单独分离P1，P2和P6外膜蛋白的方法。

3. 发明授权

US5681570A Immunogenic conjugate molecules 失效
标题翻译：免疫原性共轭分子
公开(公告)号：US5681570A
公开(公告)日：1997-10-28
申请号：US371965
申请日：1995-01-12
申请人： Yan-ping Yang , Ali Kandil , Lucy Gisonni , Raafat Emil Fahmy Fahim , Michel Henri Klein
发明人： Yan-ping Yang , Ali Kandil , Lucy Gisonni , Raafat Emil Fahmy Fahim , Michel Henri Klein
IPC分类号： A61P31/04 , C07K14/285 , C07K17/10 , A61K39/385 , A61K39/02 , A61K39/09 , A61K39/116
CPC分类号： C07K17/10 , A61K39/092 , C07K14/285 , A61K2039/55505 , A61K2039/6068 , Y10S424/831
摘要： Immunogenic conjugate molecules comprising at least a portion of a capsular polysaccharide of a Streptococcus strain linked to at least a portion of an outer membrane protein of a Haemophilus strain are provided in which the immunogenicity of the capsular polysaccharide is increased. Particularly capsular polysaccharide from Streptococcus pneumoniae are linked to an outer membrane protein of a Haemophilus influenzae strain, which protein may be the P1, P2 or particularly the P6 outer membrane protein. Conjugate molecules comprising the P6 protein linked to a capsular polysaccharide from an encapsulated pathogen other than Streptococcus also are described, in which the immunogenicity of the capsular polysaccharide is enhanced. Such conjugate molecules may be incorporated into immunogenic compositions for protecting a host against disease caused by the Streptococcus strain and preferably also the Haemophilus strain. The conjugate molecules and antibodies specific for the capsular polysaccharide or specific for the outer membrane protein may be employed in diagnostic procedures and kits. A process for individually isolating P1, P2 and P6 outer membrane proteins from a Haemophilus strain also is provided.
摘要翻译：提供包含与嗜血杆菌菌株的外膜蛋白的至少一部分连接的链球菌菌株的至少一部分荚膜多糖的免疫原性缀合物分子，其中荚膜多糖的免疫原性增加。特别是来自肺炎链球菌的荚膜多糖与流感嗜血杆菌菌株的外膜蛋白连接，该蛋白质可以是P1，P2或特别是P6外膜蛋白。还描述了包含与除链球菌以外的包囊病原体的荚膜多糖连接的P6蛋白的缀合物分子，其中荚膜多糖的免疫原性增强。这样的缀合物分子可以并入免疫原性组合物中，用于保护宿主免受由链球菌菌株引起的疾病，优选还有嗜血杆菌属菌株。对于荚膜多糖或对外膜蛋白特异的缀合物分子和抗体可用于诊断程序和试剂盒。还提供了从嗜血杆菌菌株单独分离P1，P2和P6外膜蛋白的方法。

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