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1. 发明申请

US20120283184A1 INHIBITORS OF TYPE 2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS 有权
标题翻译： 2型血管内皮生长因子受体的抑制剂
公开(公告)号：US20120283184A1
公开(公告)日：2012-11-08
申请号：US13552398
申请日：2012-07-18
申请人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
发明人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC分类号： A61K38/17 , A61P27/02 , A61P29/00 , A61P35/00 , C12N5/071 , A61P9/00
CPC分类号： C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
摘要： The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
摘要翻译：本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。本公开还提供了与单结构域结合多肽相关的各种改进。

2. 发明授权

US07858739B2 Inhibitors of type 2 vascular endothelial growth factor receptors 有权
标题翻译： 2型血管内皮生长因子受体的抑制剂
公开(公告)号：US07858739B2
公开(公告)日：2010-12-28
申请号：US11448171
申请日：2006-06-05
申请人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
发明人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC分类号： C07K14/78 , A61K38/39
CPC分类号： C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
摘要： The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
摘要翻译：本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。本公开还提供了与单结构域结合多肽相关的各种改进。

3. 发明授权

US08609613B2 Methods of inhibiting type 2 vascular endothelial growth factor receptors using polypeptides 有权
标题翻译：使用多肽抑制2型血管内皮生长因子受体的方法
公开(公告)号：US08609613B2
公开(公告)日：2013-12-17
申请号：US13552398
申请日：2012-07-18
申请人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
发明人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC分类号： A61K38/39 , A61P29/00 , A61P35/00 , A61P19/02 , C07K14/78 , C07K14/475 , C07K14/705
CPC分类号： C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
摘要： The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
摘要翻译：本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。本公开还提供了与单结构域结合多肽相关的各种改进。

4. 发明授权

US08324362B2 Nucleic acid encoding 10FN3 polypeptide inhibitors of Type 2 vascular endothelial growth factor receptors 有权
标题翻译：编码2型血管内皮生长因子受体的10FN3多肽抑制剂的核酸
公开(公告)号：US08324362B2
公开(公告)日：2012-12-04
申请号：US12788240
申请日：2010-05-26
申请人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
发明人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC分类号： C07H21/04 , C12N15/63 , C12N15/09 , C12N1/21 , C12N1/15 , C12N5/10 , A61K38/39 , C07K14/78 , A61P35/00
CPC分类号： C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
摘要： The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
摘要翻译：本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。本公开还提供了与单结构域结合多肽相关的各种改进。

5. 发明授权

US07847062B2 Pharmacokinetic modulation and compositions for modified FN3 polypeptides 有权
标题翻译：药代动力学调节和修饰的FN3多肽的组合物
公开(公告)号：US07847062B2
公开(公告)日：2010-12-07
申请号：US11482641
申请日：2006-07-07
申请人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
发明人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC分类号： C07K14/78 , A61K38/39
CPC分类号： C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
摘要： The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
摘要翻译：本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。本公开还提供了与单结构域结合多肽相关的各种改进。

6. 发明申请

US20080220049A1 Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins 审中-公开
标题翻译：纤连蛋白支架结构域蛋白的眼内输送的组合物和方法
公开(公告)号：US20080220049A1
公开(公告)日：2008-09-11
申请号：US11894045
申请日：2007-08-17
申请人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
发明人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC分类号： A61F9/00 , A61K39/395 , A61K38/16 , A61P27/02 , A61P9/10
CPC分类号： C07K16/2863 , A61K2039/505 , C07K14/00 , C07K16/30 , C07K2317/31 , C07K2317/73 , C07K2317/92 , C07K2318/20
摘要： The present disclosure relates to novel sustained-release intraocular drug delivery systems and improvements in the treatment of retinopathies. In particular, fibronectin scaffold domain proteins that selectively inhibit VEGFR-2 are contemplated.
摘要翻译：本公开涉及新型持续释放眼内药物递送系统和治疗视网膜病变的改善。特别地，考虑了选择性抑制VEGFR-2的纤连蛋白支架结构域蛋白。

8. 发明授权

US4753279A Roller support attachment for work benches 失效
标题翻译：工作台上的滚筒支撑附件
公开(公告)号：US4753279A
公开(公告)日：1988-06-28
申请号：US83523
申请日：1987-08-07
申请人： Alan S. Harris
发明人： Alan S. Harris
IPC分类号： B23D47/02 , B23Q3/10 , B27B31/00 , B25H1/02
CPC分类号： B23Q3/105 , B23D47/025 , B27B31/003 , Y10S269/901 , Y10T83/7693
摘要： An adjustable roller support attachment is disclosed for mounting on a clamping type work bench, available for example, under the trademark WORKMATE, for facilitate the handling of long stock in stationary power tools, the roller support attachment including a support having a yoke portion for rotatably mounting a roller and a wide, elongated base for clamping engagement by vise jaws of the work bench, a stabilizing element or collar surrounding the support base with a stabilizing surface for resting on an upper surface of the vise jaws, and a screw element or the like for releasably securing the stabilizing element to the support base in order to both stabilize the support and roller on the work bench while also facilitating height adjustment of te support attachment on the work bench for aligning the roller with a portion of the stationary power tool.
摘要翻译：公开了一种用于安装在例如商标为WORKMATE的夹紧型工作台上的可调节辊支撑附件，用于便于处理固定动力工具中的长料，该滚子支撑附件包括具有用于可转动安装辊子和宽的细长基座，用于通过工作台的虎钳钳夹紧接合，围绕支撑基座的稳定元件或套环具有用于搁置在虎钳爪的上表面上的稳定表面，以及螺钉元件或类似于将稳定元件可释放地固定到支撑基座，以便使工作台上的支撑件和辊都稳定，同时还便于在工作台上的支撑件附件的高度调节，以使辊与固定动力工具的一部分对准。

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