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1. 发明授权

US4721777A Process for the virus-inactivation of immunoglobulin 失效
标题翻译：免疫球蛋白病毒灭活的方法
公开(公告)号：US4721777A
公开(公告)日：1988-01-26
申请号：US778708
申请日：1985-09-23
申请人： Yahiro Uemura , Katuhiro Uriyu , Tsuyoshi Takahashi , Takashi Goto , Masahiro Funayama , Masayuki Nishida , Tadakazu Suyama
发明人： Yahiro Uemura , Katuhiro Uriyu , Tsuyoshi Takahashi , Takashi Goto , Masahiro Funayama , Masayuki Nishida , Tadakazu Suyama
IPC分类号： C07K16/00 , A61K39/395 , A61L2/00 , C07K14/435 , C12P21/00 , C12P21/08 , C07K3/12
CPC分类号： A61L2/0023 , A61K39/39591 , Y10S530/861 , Y10S530/863
摘要： Virus-contaminated immunoglobulin can be virus-inactivated by heating it in a substantially dry state at a temperature of 30.degree. to 100.degree. C. for a period of time sufficient for inactivating virus with maintaining original activity of the immunoglobulin. The addition of glycine, sodium chloride, sodium acetate, polyethylene glycol, albumin or mannitol enhances the effect and gives good solubility and good state to the solution of the virus-inactivated immunoglobulin.
摘要翻译：病毒污染的免疫球蛋白可以通过在30至100℃的温度下以基本上干燥的状态加热病毒灭活一段足以使病毒灭活并维持免疫球蛋白原始活性的时间。加入甘氨酸，氯化钠，乙酸钠，聚乙二醇，白蛋白或甘露醇可增强病毒灭活的免疫球蛋白的作用，并提供良好的溶解度和良好的状态。

2. 发明授权

US5132406A Method of producing immunoglobulin preparations for intravenous injection 失效
标题翻译：生产用于静脉注射的免疫抑制素制剂的方法
公开(公告)号：US5132406A
公开(公告)日：1992-07-21
申请号：US348139
申请日：1989-05-05
申请人： Yahiro Uemura , Katuhiro Uriyu , Kazuo Takechi , Yutaka Hirao , Tadakazu Suyama
发明人： Yahiro Uemura , Katuhiro Uriyu , Kazuo Takechi , Yutaka Hirao , Tadakazu Suyama
IPC分类号： A61K39/395 , A61K38/00 , A61L2/00 , C07K16/00
CPC分类号： C07K16/00 , A61L2/0023 , A61K38/00
摘要： A method of producing immunoglobulin preparations for intravenous injection which starts with an immunoblobulin-containing fraction and comprises the treatment steps of:(a) treating said fraction with 4-10 weight/volume percent of polyethylene glycol having a molecular weight of 1,000-10,000 under conditions of pH 4-6, ion strength 0.0001-0.1M and temperature 0.degree.-4.degree. C. and recovering the supernatant,(b) treating the supernatant obtained in step (a) with 10-15 weight/volume percent of polyethylene glycol having a molecular weight of 1,000-10,000 under conditions of pH 6-9, ion strength 0.0001-0.1M and temperature 0.degree.-4.degree. C. and recovering the resulting precipitate, and(c) heat-treating, in any desired step, said immunoglobulin in the presence of a stabilizer under conditions sufficient to inactivate contaminant viruses.The preparations obtained according to the invention retain immunoglobulins without substantial inactivation thereof, and are substantially free of such contaminants as anti-human blood group substance antibodies. With contaminant viruses inactivated as a result of the heat treatment, said preparations have good solubility and are sufficiently low in anticomplement activity.
摘要翻译：一种生产用于静脉注射的免疫球蛋白制剂的方法，其起始于含免疫球蛋白的级分，并且包括以下处理步骤：（a）用4-10重量/体积％的分子量为1,000-10,000的聚乙二醇处理所述级分，条件pH 4-6，离子强度0.0001-0.1M，温度0℃-4℃，回收上清液，（b）用10-15重量/体积％聚乙二醇处理步骤（a）中得到的上清液在pH 6-9，离子强度为0.0001-0.1M，温度为0〜-4℃的条件下分子量为1,000〜10,000，回收所得沉淀物，（c）在任何所需步骤中热处理，所述免疫球蛋白在足以灭活污染性病毒的条件下在稳定剂存在下进行。根据本发明获得的制剂保留免疫球蛋白而基本上不灭活，并且基本上不含抗人血型物质抗体等污染物。随着由于热处理而灭活的污染物病毒，所述制剂具有良好的溶解性并且抗补体活性足够低。

3. 发明授权

US4959320A Monoclonal antibody, process for preparing same, reagent for detecting cancer antigen containing the monoclonal antibody and process for preparing same 失效
标题翻译：单克隆抗体，其制备方法，用于检测含有单克隆抗体的癌抗原的试剂及其制备方法
公开(公告)号：US4959320A
公开(公告)日：1990-09-25
申请号：US763587
申请日：1985-08-08
申请人： Yahiro Uemura , Kazumi Fukuyama , Takashi Kobayashi , Yoshiaki Kanou , Ryutaro Yamana , Eiji Kashiwagi , Tomokuni Taniguchi , Kazuaki Nakura , Masahiro Watanabe , Masayuki Nishida , Tadakazu Suyama
发明人： Yahiro Uemura , Kazumi Fukuyama , Takashi Kobayashi , Yoshiaki Kanou , Ryutaro Yamana , Eiji Kashiwagi , Tomokuni Taniguchi , Kazuaki Nakura , Masahiro Watanabe , Masayuki Nishida , Tadakazu Suyama
IPC分类号： G01N33/574 , A61K38/00 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/3046 , C07K16/303 , A61K38/00
摘要： A monoclonal antibody is described, having a specific reactivity with a cancer-associated antigen selected from pancreas cancer-associated antigen, intestinum crassum cancer-associated antigen and hepatoma-associated antigen and has the following characteristics:(1) it exists in a blood serum of pancreas cancer, intestinum crassum cancer and hepatoma patients;(2) it comprises glycoproteins;(3) it has a molecular weight of about 700,000 to 1,500,000, as measured by gel-filtration and determined by comparison with that of a known protein;(4) it has a maximum absorption of 2800 nm when dissolved in 0.1 M acetic acid buffer solution (pH 4.5); and(5) it is released at least in a cultured supernatant medium of establihed cell line of COLO-201, TE-1, TE-2, TE-3, NRC-12, MKN-45 and KATO III. The monoclonal antibody is utilized as a reagent for detecting pancreas cancer, intestinum crassum cancer and hepatoma. A process for preparing the monoclonal antibody and a process for preparing the reagent are also disclosed.
摘要翻译：描述了与选自胰腺癌相关抗原，肠um癌相关抗原和肝癌相关抗原的癌相关抗原具有特异性反应性的单克隆抗体，具有以下特征：（1）其存在于血清的胰腺癌，肠um癌和肝癌患者; （2）它包含糖蛋白; （3）通过凝胶过滤测定，其分子量约为700,000至1,500,000，并与已知蛋白质的比较确定; （4）当溶于0.1M乙酸缓冲溶液（pH 4.5）时，其最大吸收为2800nm; 至少在COLO-201，TE-1，TE-2，TE-3，NRC-12，MKN-45和KATO III的建立细胞系的培养上清培养基中释放。单克隆抗体用作检测胰腺癌，肠um癌和肝癌的试剂。还公开了制备单克隆抗体的方法和制备该试剂的方法。

4. 发明授权

US4335099A Employment of enteric coated IgA for hypoproteinemia in intestinal infectious diseases 失效
标题翻译：肠道包衣IgA用于肠道传染病中的低蛋白血症
公开(公告)号：US4335099A
公开(公告)日：1982-06-15
申请号：US185929
申请日：1980-09-10
申请人： Satoshi Funakoshi , Katuhiro Uriyu , Yahiro Uemura , Katashi Nakane , Akio Yamane
发明人： Satoshi Funakoshi , Katuhiro Uriyu , Yahiro Uemura , Katashi Nakane , Akio Yamane
IPC分类号： A61K39/395 , A61K9/32 , A61K9/48 , A61K9/50 , A61K9/52 , A61K38/00 , A61P37/04 , C07K16/12 , A61K9/34 , A61K9/36 , A61K9/40 , A61K31/74 , A61K31/78 , A61K31/79 , A61K39/00
CPC分类号： C07K16/12 , A61K9/4891 , A61K9/5073 , A61K38/00 , Y10S424/804
摘要： A method of treating hypoproteinemia is disclosed in which an enteric film coated IgA-rich gamma globulin is administered orally to a person suffering therefrom until total serum content and plasma content are restored. The film coating is soluble in neutral or alkaline media by insoluble in acid media.
摘要翻译：公开了一种治疗低蛋白血症的方法，其中将含有肠溶膜的含有IgA的γ球蛋白经口给予患有这种血小板的人，直至全部血清含量和血浆含量恢复。薄膜包衣在酸性介质中不溶于中性或碱性介质。

5. 发明授权

US4010074A Method for purification and recovery of urokinase 失效
标题翻译：尿激酶的纯化和回收方法
公开(公告)号：US4010074A
公开(公告)日：1977-03-01
申请号：US683239
申请日：1976-05-04
申请人： Yahiro Uemura , Katuhiro Uriyu , Satoshi Funakoshi
发明人： Yahiro Uemura , Katuhiro Uriyu , Satoshi Funakoshi
IPC分类号： C12N9/72 , C07G7/02
CPC分类号： C12N9/6462 , C12Y304/21073 , Y10S435/815
摘要： Highly purified urokinase is obtained in a high yield by adsorbing urokinase from an aqueous crude urokuinase solution including human urine at a pH of about 4.0 to about 7.0 on a water-insoluble polysaccharide containing agarose and agaropectin, for example, agar and Sepharose, and by eluting urokinase with an alkaline solution (pH of about 8 to 11) or concentrated salt solution.
摘要翻译：通过在含有约4.0至约7.0的pH值的人尿液水性粗尿素酶溶液中，在含有琼脂糖和琼脂糖的水不溶性多糖例如琼脂和琼脂糖上吸附尿激酶，并通过以下方式获得高纯度的尿激酶：用碱性溶液（约8至11的pH）或浓盐溶液洗脱尿激酶。

6. 发明授权

US4876088A Gamma-globulin injectable solutions containing sorbitol 失效
标题翻译：含有山梨醇的γ-球蛋白可注射溶液
公开(公告)号：US4876088A
公开(公告)日：1989-10-24
申请号：US152217
申请日：1988-02-05
申请人： Yutaka Hirao , Kazuo Takechi , Katuhiro Uriyu , Yahiro Uemura
发明人： Yutaka Hirao , Kazuo Takechi , Katuhiro Uriyu , Yahiro Uemura
IPC分类号： A61K9/00 , A61K39/395 , A61K47/26 , C08L89/00
CPC分类号： A61K9/0019 , A61K39/39591 , A61K47/26
摘要： An intravenously injectable solution of chemically unmodified .gamma.-globulin having a complete molecular structure is disclosed, said solution containing sorbitol as a stabilizer and having a low electrical conductivity and a pH of about 5.5.+-.0.2. The injectable solution does not cause an increase of .gamma.-globulin polymer, a rise of anticomplement titer, or impairment of the activities of the .gamma.-globulin, either during preservation or upon administration to a living body.

7. 发明授权

US4845199A Process for heat treating chemically unmodified gamma-globulin 失效
标题翻译：化学未改性的γ-球蛋白的热处理方法
公开(公告)号：US4845199A
公开(公告)日：1989-07-04
申请号：US71685
申请日：1987-07-09
申请人： Yutaka Hirao , Katuhiro Uriyu , Kazuo Takechi , Yahiro Uemura
发明人： Yutaka Hirao , Katuhiro Uriyu , Kazuo Takechi , Yahiro Uemura
IPC分类号： A61L2/00
CPC分类号： A61L2/0023 , Y10S530/83
摘要： A process for heat treating an aqueous solution containing chemically unmodified .gamma.-globulin, wherein said heat treating is carried out in the presence of sorbitol is disclosed. By the heat treatment, impurity viruses can be inactivated without causing impairment of activities of chemically unmodified .gamma.-globulin, increasing polymer contents or increasing an anticomplement titer.
摘要翻译：公开了一种用于热处理含有化学未改性的γ-球蛋白的水溶液的方法，其中所述热处理在山梨醇存在下进行。通过热处理，可以使杂质病毒灭活而不引起化学未改性的γ-球蛋白活性的损害，增加聚合物含量或增加抗补体滴度。

8. 发明授权

US4361652A Method for stabilizing plasminogen 失效
标题翻译：纤溶酶原的稳定方法
公开(公告)号：US4361652A
公开(公告)日：1982-11-30
申请号：US225531
申请日：1981-01-16
申请人： Yahiro Uemura , Katuhiro Uriyu , Satoshi Funakoshi
发明人： Yahiro Uemura , Katuhiro Uriyu , Satoshi Funakoshi
IPC分类号： C12N9/96 , A61K38/48 , C12N9/68
CPC分类号： C12N9/6435 , C12Y304/21007
摘要： A method for stabilizing plasminogen which comprises adding a physiologically acceptable inorganic salt to a plaminogen-containing aqueous solution to give a final concentration of the salt of 0.002 to 0.4 M.
摘要翻译：一种用于稳定纤溶酶原的方法，其包括将生理上可接受的无机盐加入到含有plaminogen的水溶液中以得到0.002至0.4M的盐的最终浓度。

9. 发明授权

US4314935A Process for recovering interferon 失效
标题翻译：干扰素回收方法
公开(公告)号：US4314935A
公开(公告)日：1982-02-09
申请号：US175744
申请日：1980-08-06
申请人： Yahiro Uemura , Hirofumi Arimura , Hiroshi Morise , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yahiro Uemura , Hirofumi Arimura , Hiroshi Morise , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： C12P21/00 , A61K38/21 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/57 , A61K45/02 , C07G7/00
CPC分类号： C07K14/555 , Y10S435/811 , Y10S530/829 , Y10S530/837 , Y10S530/838 , Y10S530/848
摘要： A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolubilized sulfated polysaccharide and then selectively eluting the interferon with an aqueous solution of an inorganic salt.
摘要翻译：一种用于回收干扰素的方法，其包括将含有由人源诱导的细胞产生的干扰素的溶液与水不溶性硫酸化多糖接触以允许干扰素被吸附在水不溶性硫酸化多糖上，然后选择性地洗脱干扰素无机盐水溶液。

10. 发明授权

US4340589A Antithrombin preparation and process for the production thereof 失效
标题翻译：抗凝血酶制剂及其制备方法
公开(公告)号：US4340589A
公开(公告)日：1982-07-20
申请号：US237125
申请日：1981-02-18
申请人： Yahiro Uemura , Midori Nagatomo , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yahiro Uemura , Midori Nagatomo , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： A61K47/16 , A61K9/26 , A61K35/14 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/48 , A61K38/55 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26 , A61K47/42 , A61L2/00 , A61P7/02 , C07K14/81
CPC分类号： A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/42 , A61L2/0023 , C07K14/8128 , A61K38/00
摘要： An antithrombin preparation, secure and stable for a long period of time, can be obtained by freeze-drying an aqueous solution containing antithrombin-III as main component in the presence of an effective quantity of at least one member selected from the group consisting of proteins, sugars, amino acids, inorganic salts and salts of organic acids as stabilizer.
摘要翻译： PCT No.PCT / JP79 / 00154 Sec。 371日期1981年2月18日 102（e）日期1981年2月17日PCT申请日1979年6月18日PCT公布。公开号WO80 / 02798 日期为1980年12月24日。通过在有效量的至少一种成分的存在下，将含有抗凝血酶III作为主要成分的水溶液冷冻干燥，可以长期稳定稳定的抗凝血酶制剂选自蛋白质，糖，氨基酸，无机盐和有机酸的盐作为稳定剂。

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