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1. 发明申请

US20070173728A1 Cyclic variation of heart rate detection and treatment 审中-公开
标题翻译：心率检测和治疗的循环变化
公开(公告)号：US20070173728A1
公开(公告)日：2007-07-26
申请号：US11338997
申请日：2006-01-25
申请人： Yachuan Pu , Quan Ni , Yinghong Yu
发明人： Yachuan Pu , Quan Ni , Yinghong Yu
IPC分类号： A61M16/00 , A61B5/02 , A61B5/08 , A62B7/00
CPC分类号： A61B5/0809 , A61B5/02405 , A61B5/0402 , A61B5/0488 , A61B5/4818 , A61M16/0069 , A61M16/024 , A61M2016/0039 , A61N1/3601
摘要： Systems and methods provide for detection of repeated disordered breathing episodes and presence of cyclic variation of heart rate (CVHR) and/or associated presence of cyclic variations in hemodynamic changes resulting from such disordered breathing episodes. A therapy may be delivered to mitigate the CVHR. The therapy for CVHR mitigation or other therapy may be delivered or adjusted to mitigate the disordered breathing.
摘要翻译：系统和方法提供了检测重复的无序呼吸发作和心率（CVHR）的周期性变化的存在和/或由这种无序呼吸发作引起的血液动力学变化的循环变化的相关存在。可以进行治疗以减轻CVHR。 CVHR缓解或其他治疗方法的治疗可以进行或调整，以减轻无序呼吸。

2. 发明授权

US07440803B2 Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods 有权
标题翻译：基于闭环阻抗的心脏再同步治疗系统，装置和方法
公开(公告)号：US07440803B2
公开(公告)日：2008-10-21
申请号：US11264941
申请日：2005-11-02
申请人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas R. Daum , Julio C. Spinelli , Jeffrey E. Stahmann
发明人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas R. Daum , Julio C. Spinelli , Jeffrey E. Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

3. 发明申请

US20090048637A1 CLOSED LOOP IMPEDANCE-BASED CARDIAC RESYNCHRONIZATION THERAPY SYSTEMS, DEVICES, AND METHODS 有权
标题翻译：基于闭环阻塞的心脏再生治疗系统，装置和方法
公开(公告)号：US20090048637A1
公开(公告)日：2009-02-19
申请号：US12254631
申请日：2008-10-20
申请人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas R. Daum , Julio C. Spinelli , Jeffrey E. Stahmann
发明人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas R. Daum , Julio C. Spinelli , Jeffrey E. Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量峰 - 峰体积或最大心室容积变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

4. 发明申请

US20060271119A1 Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods 有权
标题翻译：基于闭环阻抗的心脏再同步治疗系统，装置和方法
公开(公告)号：US20060271119A1
公开(公告)日：2006-11-30
申请号：US11264941
申请日：2005-11-02
申请人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas Daum , Julio Spinelli , Jeffrey Stahmann
发明人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas Daum , Julio Spinelli , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

5. 发明授权

US09031647B2 Guidewire and signal analyzer for pacing site optimization 有权
标题翻译：导丝和信号分析仪进行起搏站点优化
公开(公告)号：US09031647B2
公开(公告)日：2015-05-12
申请号：US13293707
申请日：2011-11-10
申请人： Barun Maskara , Yinghong Yu , Bruce A. Tockman , Sunipa Saha , Martin McDaniel , Geng Zhang
发明人： Barun Maskara , Yinghong Yu , Bruce A. Tockman , Sunipa Saha , Martin McDaniel , Geng Zhang
IPC分类号： A61N1/05 , A61B5/0472 , A61B5/00 , A61N1/372 , A61B5/042
CPC分类号： A61N1/056 , A61B5/042 , A61B5/0422 , A61B5/0472 , A61B5/6851 , A61N1/37241 , A61N2001/0585
摘要： Cardiac lead implantation systems, devices, and methods for lead implantation are disclosed. An illustrative cardiac lead implantation system comprises a mapping guidewire including one or more electrodes configured for sensing cardiac electrical activity, a signal analyzer including an analysis module configured for analyzing an electrocardiogram signal sensed by the mapping guidewire, and a user interface configured for monitoring one or more hemodynamic parameters within the body. The sensed electrical activity signal can be used by the analysis module to compute a timing interval associated with ventricular depolarization.
摘要翻译：公开了用于引线植入的心脏引线植入系统，装置和方法。示例性心脏引线植入系统包括：映射导丝，其包括被配置为感测心脏电活动的一个或多个电极;信号分析器，包括被配置用于分析由所述映射导丝所感测的心电图信号的分析模块;以及用户界面，被配置为监视一个或更多血液动力学参数在体内。感测的电活动信号可以被分析模块用于计算与心室去极化相关的定时间隔。

6. 发明授权

US08731667B2 Pacing output configuration selection for cardiac resynchronization therapy patients 有权
标题翻译：心脏再同步治疗患者的起搏输出配置选择
公开(公告)号：US08731667B2
公开(公告)日：2014-05-20
申请号：US13017475
申请日：2011-01-31
申请人： Barun Maskara , Yinghong Yu
发明人： Barun Maskara , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Cardiac therapy systems include multiple electrodes respectively positionable at multiple left ventricular electrode sites. A pulse generator is coupled to the electrodes and configured to deliver a cardiac resynchronization therapy (CRT). A processor is configured to measure, for each left ventricular electrode site, a timing interval between first and second cardiac signal features associated with left ventricular depolarization. The timing interval is associated with a degree of responsiveness of each left ventricular electrode site to CRT. The processor is configured to determine a pacing output configuration that provides improved patient responsiveness to CRT based on the timing interval measurements and to select at least one left ventricular electrode site from the plurality of left ventricular electrode sites based on the timing interval measurements. The processor may be configured to monitor for a change in hemodynamic status of the patient based on a change in the timing interval.
摘要翻译：心脏治疗系统包括分别位于多个左心室电极部位的多个电极。脉冲发生器耦合到电极并且被配置为递送心脏再同步治疗（CRT）。处理器被配置为针对每个左心室电极部位测量与左心室去极化相关联的第一和第二心脏信号特征之间的定时间隔。时间间隔与每个左心室电极部位对CRT的响应程度相关。处理器被配置为确定起搏输出配置，其基于时间间隔测量提供对CRT的改善的患者响应性，并且基于时间间隔测量从多个左心室电极位置中选择至少一个左心室电极部位。处理器可以被配置为基于时间间隔的变化来监视患者的血液动力学状态的变化。

7. 发明授权

US08620430B2 Selection of pacing sites to enhance cardiac performance 有权
公开(公告)号：US08620430B2
公开(公告)日：2013-12-31
申请号：US11479877
申请日：2006-06-30
申请人： Shantha Arcot-Krishnamurthy , Michael John Stucky , Yinghong Yu , Jiang Ding
发明人： Shantha Arcot-Krishnamurthy , Michael John Stucky , Yinghong Yu , Jiang Ding
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/36514 , A61N1/36535 , A61N1/36542 , A61N1/36557 , A61N1/36578 , A61N1/36592
摘要： Systems and methods for selection of electrodes and related pacing configuration parameters used to pace a heart chamber are described. A change in the hemodynamic state of a patient is detected. Responsive to the detected change, a distribution of an electrical, mechanical, or electromechanical parameter related to contractile function of a heart chamber with respect to locations of multiple electrodes disposed within the heart chamber is determined. A pacing output configuration, including one or more electrodes of the multiple electrodes, is selected and the heart chamber is paced using the selected pacing output configuration.

8. 发明授权

US08380293B2 Cardiac activation sequence monitoring and tracking 有权
标题翻译：心脏激活序列监测和跟踪
公开(公告)号：US08380293B2
公开(公告)日：2013-02-19
申请号：US13027612
申请日：2011-02-15
申请人： Yi Zhang , Scott Meyer , Aaron McCabe , Jeffrey E. Stahmann , Yinghong Yu , Carlos A Ricci
发明人： Yi Zhang , Scott Meyer , Aaron McCabe , Jeffrey E. Stahmann , Yinghong Yu , Carlos A Ricci
IPC分类号： A61B5/0428 , A61B5/0452
CPC分类号： A61B5/04011 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，诊断和除颤和/或起搏疗法。信号处理器接收与多个源相关联的多个复合信号，执行源分离，并且基于源分离产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号矢量。信号分离的方法包括检测心脏信号矢量相对于基线的特征的变化。可以选择一个或多个载体和/或激活序列，并且可以存储和跟踪与载体和/或激活序列相关联的信息。

9. 发明授权

US08295927B2 Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods 有权
标题翻译：基于闭环阻抗的心脏再同步治疗系统，装置和方法
公开(公告)号：US08295927B2
公开(公告)日：2012-10-23
申请号：US12254631
申请日：2008-10-20
申请人： Jiang Ding , Yinghong Yu , Julio C. Spinelli , Jeffrey E. Stahmann
发明人： Jiang Ding , Yinghong Yu , Julio C. Spinelli , Jeffrey E. Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量峰 - 峰体积或最大心室容积变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

10. 发明授权

US08214026B2 Method and apparatus for determining the coronary sinus vein branch accessed by a coronary sinus lead 有权
标题翻译：用于确定冠状静脉窦导管接近的冠状静脉窦静脉分支的方法和装置
公开(公告)号：US08214026B2
公开(公告)日：2012-07-03
申请号：US12976397
申请日：2010-12-22
申请人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio C. Spinelli
发明人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio C. Spinelli
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0456 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/3682
摘要： Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
摘要翻译：公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。电极位置的确定可用于自动调整VRT器件的工作参数。此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

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