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1. 发明公开

EP1507764A4 NOVEL ENANTIOMERS OF TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： TETRAHYDROISOQUINOLINDERIVATEN及其药学上可接受的盐的对映体的新; 其制备方法和药物组合物
公开(公告)号：EP1507764A4
公开(公告)日：2005-06-22
申请号：EP02781911
申请日：2002-10-05
申请人： YUN-CHOI HYE-SOOK , CHANG KI-CHURL , LEE DUCK-HYUNG
发明人： YUN-CHOI HYE-SOOK , CHANG KI-CHURL , LEE DUCK-HYUNG
IPC分类号： C07D217/04 , A61K31/472 , A61P7/02 , A61P9/04 , A61P9/10 , A61P9/12 , C07D217/08 , C07D217/16 , C07D217/18 , C07D217/20 , C07D401/06 , C07D401/10 , C07D401/12 , C07D413/10 , A61K31/4725 , A61P9/00 , C07D207/18
CPC分类号： C07D401/06 , C07D217/18 , C07D217/20 , C07D401/10 , C07D401/12 , C07D413/10

2. 发明专利

DE69911633T2 未知
公开(公告)号：DE69911633T2
公开(公告)日：2004-06-17
申请号：DE69911633
申请日：1999-10-21
申请人： KOREA INST SCI & TECH , YUN CHOI HYE SOOK , CHANG KI CHURL , LEE DUCK HYUNG
发明人： YUN-CHOI HYE SOOK , CHANG KI-CHURL , LEE DUCK-HYUNG , RYU JAE-CHUN
IPC分类号： C07D217/02 , A61K31/47 , A61K31/472 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P19/02 , A61P29/00 , A61P31/04 , A61P43/00 , A61P31/02
摘要： Disclosed are pharmaceutical compositions for the treatment and prophylaxis of heart failure, thrombosis, iNOS-induced tissue injury, septicemia, and disseminated intravascular coagulation. The compositions comprise, as a pharmacologically active ingredient, the compounds represented by the following chemical formulas 1 and 2, each of them showing heart stimulating activity, hypotensive activity, inhibitory activity against platelet aggregation, and suppressive activity against iNOS expression in combination and at once.

3. 发明专利

DE69911633D1 未知
公开(公告)号：DE69911633D1
公开(公告)日：2003-10-30
申请号：DE69911633
申请日：1999-10-21
申请人： KOREA INST SCI & TECH , YUN CHOI HYE SOOK , CHANG KI CHURL , LEE DUCK HYUNG
发明人： YUN-CHOI HYE SOOK , CHANG KI-CHURL , LEE DUCK-HYUNG , RYU JAE-CHUN
IPC分类号： C07D217/02 , A61K31/47 , A61K31/472 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P19/02 , A61P29/00 , A61P31/04 , A61P43/00 , A61P31/02
摘要： Disclosed are pharmaceutical compositions for the treatment and prophylaxis of heart failure, thrombosis, iNOS-induced tissue injury, septicemia, and disseminated intravascular coagulation. The compositions comprise, as a pharmacologically active ingredient, the compounds represented by the following chemical formulas 1 and 2, each of them showing heart stimulating activity, hypotensive activity, inhibitory activity against platelet aggregation, and suppressive activity against iNOS expression in combination and at once.

4. 发明申请

WO2009096737A3 NOVEL ORGANIC GERMANIUM COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：新有机锗化合物及其组合物作为活性成分
公开(公告)号：WO2009096737A3
公开(公告)日：2009-09-24
申请号：PCT/KR2009000467
申请日：2009-01-30
申请人： UNIV CHUNG ANG IND , HAM SEUNG WOOK , LEE KWANG HO , LEE DUCK-HYUNG , PARK AE JA
发明人： HAM SEUNG WOOK , LEE KWANG HO , LEE DUCK-HYUNG , PARK AE JA
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： The present invention relates to a novel organic germanium compound represented by the following formula 1 and a composition comprising the same as an active ingredient for anti-cancer, antiviral, anti-inflammatory and immunomodulatory activities. Since water solubility of the disclosed novel organic germanium compound is remarkably improved, the compound shows high absorption when applied in vivo, and therefore an inherent efficacy of the germanium can be sufficiently exhibited. In formula 1, each R1, R2 and R3 may independently be a C1-C4 linear or branched alkyl, a C2-C6 alkenyl group, a C2-C4 alkynyl group, a C1-C4 alkylamino, hydrogen, nitrogen, oxygen, sulfur or halo; said R1, R2 and R3 may form a ring by being connected each other independently; R4 is a functional group which may increase solubility of the compound in water; X is a C1-C4 linear or branched alkyl, a C2-C6 alkenyl group, and a C2-C4 alkynyl group; X is C1-C4 alkylamino, nitrogen, oxygen or sulfur; each m, n and o may independently be an integer of 0-10; and Ge is germanium.
摘要翻译：本发明涉及由下式1表示的新型有机锗化合物和包含其的抗癌，抗病毒，抗炎和免疫调节活性的活性成分的组合物。由于所公开的新型有机锗化合物的水溶性显着提高，因此当在体内应用时，该化合物显示高吸收性，因此能够充分发挥锗的固有功效。在式1中，每个R 1，R 2和R 3可以独立地为C 1 -C 4直链或支链烷基，C 2 -C 6烯基，C 2 -C 4炔基，C 1 -C 4烷基氨基，氢，氮，氧，硫或光环; 所述R1，R2和R3可以独立地相互连接形成环; R4是可以增加化合物在水中的溶解度的官能团; X是C1-C4直链或支链烷基，C2-C6烯基和C2-C4炔基; X是C 1 -C 4烷基氨基，氮，氧或硫; 每个m，n和o可以独立地为0-10的整数; Ge是锗。

5. 发明申请

WO2006065480A3 TETRAHYDROCARBAZOLES AS ACTIVE AGENTS FOR INHIBITING VEGF PRODUCTION BY TRANSLATIONAL CONTROL 审中-公开
标题翻译：四氯化碳作为通过翻译控制抑制VEGF生产的活性剂
公开(公告)号：WO2006065480A3
公开(公告)日：2006-08-03
申请号：PCT/US2005042483
申请日：2005-11-23
申请人： PTC THERAPEUTICS INC , LENNOX WILLIAM JOSEPH , QI HONGYAN , LEE DUCK-HYUNG , CHOI SOONGYU , MOON YOUNG-CHOON
发明人： LENNOX WILLIAM JOSEPH , QI HONGYAN , LEE DUCK-HYUNG , CHOI SOONGYU , MOON YOUNG-CHOON
IPC分类号： A61K31/403 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/496 , A61K31/506 , A61P35/00 , C07D307/91 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/02 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D487/04 , C07D487/06 , C07D498/04 , C07D519/00
CPC分类号： A61K31/403 , A61K31/343 , A61K31/4035 , A61K31/407 , A61K31/4162 , A61K31/4184 , A61K31/4188 , A61K31/424 , A61K31/4245 , A61K31/506 , A61K31/5377 , C07D209/08 , C07D209/90 , C07D471/04
摘要： The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.
摘要翻译：本发明涉及抑制血管发生的方法，化合物和组合物。更具体地说，本发明涉及抑制VEGF产生的方法，化合物和组合物。

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