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1. 发明授权

EP2049558B1 NAPHTHALENE 2-CARBOXYLATE DERIVATIVE USEFUL FOR SYNTHESIZING GEMCITABINE AND A METHOD FOR PREPARING THE SAME 有权
标题翻译：对于吉西他滨SUITABLE萘-2-羧酸酯衍生物和方法的合成及其
公开(公告)号：EP2049558B1
公开(公告)日：2012-03-21
申请号：EP07793303.4
申请日：2007-07-30
申请人： Yuil Pharm Tech Co., Ltd. , Chiro Genix Co., Ltd. , Kim, Kyu Wann , Kim, Kyoung Soo , Park, Young Won , Park, Young Jun , Lee, Won Kyoung
发明人： KIM, Kyu Wann , KIM, Kyoung Soo , PARK, Young Won , PARK, Young Jun , LEE, Won Kyoung
IPC分类号： C07H19/073
CPC分类号： C07H19/073 , Y02P20/55
摘要： Disclosed herein are novel naphthalene-2-carboxylate derivatives of Formula (I), which are useful for the synthesis of gemcitabine, as well as a preparation method. The novel derivatives have naphthalene-2-carboxlate as the hydroxy protecting group of 2-deoxy-2, 2-dif luoro- pentofuranose-1-ulose. (I) wherein Rl and R2 are each independently hydrogen, methyl, chloro, fluoro, bromo, iodo, methoxy, ethoxy or nitro.

2. 发明公开

EP2049558A1 NAPHTHALENE 2-CARBOXYLATE DERIVATIVE USEFUL FOR SYNTHESIZING GEMCITABINE AND A METHOD FOR PREPARING THE SAME 有权
标题翻译：对于吉西他滨SUITABLE萘-2-羧酸酯衍生物和方法的合成及其
公开(公告)号：EP2049558A1
公开(公告)日：2009-04-22
申请号：EP07793303.4
申请日：2007-07-30
申请人： Yuil Pharm Tech Co., Ltd. , Chiro Genix Co., Ltd. , Kim, Kyu Wann , Kim, Kyoung Soo , Park, Young Won , Park, Young Jun , Lee, Won Kyoung
发明人： KIM, Kyu Wann , KIM, Kyoung Soo , PARK, Young Won , PARK, Young Jun , LEE, Won Kyoung
IPC分类号： C07H19/073
CPC分类号： C07H19/073 , Y02P20/55
摘要： Disclosed herein are novel naphthalene-2-carboxylate derivatives of Formula (I), which are useful for the synthesis of gemcitabine, as well as a preparation method. The novel derivatives have naphthalene-2-carboxlate as the hydroxy protecting group of 2-deoxy-2, 2-dif luoro- pentofuranose-1-ulose. (I) wherein Rl and R2 are each independently hydrogen, methyl, chloro, fluoro, bromo, iodo, methoxy, ethoxy or nitro.

3. 发明申请

WO2008016244A1 NAPHTHALENE 2-CARBOXYLATE DERIVATIVE USEFUL FOR SYNTHESIZING GEMCITABINE AND A METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用于合成格列宾的萘甲酸2-羧酸酯衍生物及其制备方法
公开(公告)号：WO2008016244A1
公开(公告)日：2008-02-07
申请号：PCT/KR2007/003648
申请日：2007-07-30
申请人： YUIL PHARM TECH CO., LTD , CHIRO GENIX CO., LTD , KIM, Kyu Wann , KIM, Kyoung Soo , PARK, Young Won , PARK, Young Jun , LEE, Won Kyoung
发明人： KIM, Kyu Wann , KIM, Kyoung Soo , PARK, Young Won , PARK, Young Jun , LEE, Won Kyoung
IPC分类号： C07H19/073
CPC分类号： C07H19/073 , Y02P20/55
摘要： Disclosed herein are novel naphthalene-2-carboxylate derivatives of Formula (I), which are useful for the synthesis of gemcitabine, as well as a preparation method. The novel derivatives have naphthalene-2-carboxlate as the hydroxy protecting group of 2-deoxy-2, 2-dif luoro- pentofuranose-1-ulose. (I) wherein Rl and R2 are each independently hydrogen, methyl, chloro, fluoro, bromo, iodo, methoxy, ethoxy or nitro.
摘要翻译：本文公开了式（I）的新颖的萘-2-羧酸酯衍生物，其可用于吉西他滨的合成以及制备方法。该新型衍生物具有萘-2-甲酸酯作为2-脱氧-2,2-二氟 - 呋喃糖醛酸1-胡萝卜素的羟基保护基。（I）其中R1和R2各自独立地为氢，甲基，氯，氟，溴，碘，甲氧基，乙氧基或硝基。

4. 发明授权

EP2049558B8 NAPHTHALENE 2-CARBOXYLATE DERIVATIVE USEFUL FOR SYNTHESIZING GEMCITABINE AND A METHOD FOR PREPARING THE SAME 有权
标题翻译：用于合成吉西他滨的萘二羧酸衍生物及其制备方法
公开(公告)号：EP2049558B8
公开(公告)日：2012-08-01
申请号：EP07793303.4
申请日：2007-07-30
申请人： Yuil Pharm Tech Co., Ltd. , Chiro Genix Co., Ltd.
发明人： KIM, Kyu Wann , KIM, Kyoung Soo , PARK, Young Won , PARK, Young Jun , LEE, Won Kyoung
IPC分类号： C07H19/073
CPC分类号： C07H19/073 , Y02P20/55
摘要： Disclosed herein are novel naphthalene-2-carboxylate derivatives of Formula (I), which are useful for the synthesis of gemcitabine, as well as a preparation method. The novel derivatives have naphthalene-2-carboxlate as the hydroxy protecting group of 2-deoxy-2, 2-dif luoro- pentofuranose-1-ulose. (I) wherein Rl and R2 are each independently hydrogen, methyl, chloro, fluoro, bromo, iodo, methoxy, ethoxy or nitro.
摘要翻译：本文公开了可用于合成吉西他滨的式（I）的新型萘-2-羧酸酯衍生物，以及制备方法。该新衍生物具有萘-2-甲酸酯作为2-脱氧-2,2-二氟 - 呋喃戊糖-1-酮的羟基保护基。（I）其中R1和R2各自独立地为氢，甲基，氯，氟，溴，碘，甲氧基，乙氧基或硝基。

5. 发明申请

WO2011152658A2 PHARMACEUTICAL COMPOSITION COMPRISING PIPERAZINE DITHIOCTATE AND GLIMEPIRIDE 审中-公开
标题翻译：药物组合物，包括哌嗪脱氢和吡咯
公开(公告)号：WO2011152658A2
公开(公告)日：2011-12-08
申请号：PCT/KR2011/004004
申请日：2011-06-01
申请人： CELLTRION CHEMICAL RESEARCH INSTITUTE , CELLTRION PHARM, INC. , KIM, Kyoung Soo , SHIN, Dong Seong , KWON, Hyuk Jin , PARK, Young Jun , CHO, Kyoung-suk , YU, KeeWon , LEE, In Suk , NOH, Jin-hyoung , SONG, Hyun-Nam , KIM, Dong Youn , KIM, Joon Woo
发明人： KIM, Kyoung Soo , SHIN, Dong Seong , KWON, Hyuk Jin , PARK, Young Jun , CHO, Kyoung-suk , YU, KeeWon , LEE, In Suk , NOH, Jin-hyoung , SONG, Hyun-Nam , KIM, Dong Youn , KIM, Joon Woo
IPC分类号： C07D339/02 , C07D295/027 , A61P3/10
CPC分类号： C07D339/04 , C07D207/38
摘要： The present invention relates to a pharmaceutical composition for treating or preventing type II diabetes mellitus comprising piperazine dithioctate and glimepiride, which is a new combination drug. The pharmaceutical composition of the present invention has strong synergistic effects for treating type II diabetes mellitus by improving metabolic disorders and insulin resistance of diabetic patients as well as lowering blood glucose levels, and by increasing glucose uptake in cells, compared with single treatment of piperazine dithioctate or glimepiride, or combination treatment of thioctic acid and glimepiride.
摘要翻译：本发明涉及用于治疗或预防II型糖尿病的药物组合物，其包含哌嗪二硫代酸酯和作为新组合药物的格列美脲。本发明的药物组合物通过改善糖尿病患者的代谢紊乱和胰岛素抵抗以及降低血糖水平以及通过增加细胞中的葡萄糖摄取而与治疗II型糖尿病相比具有很强的协同效应，与单次治疗哌嗪二硫代辛酸或格列美脲，或硫辛酸和格列美脲的组合治疗。

6. 发明申请

WO2011152657A3 ACETYL-L-CARNITINE MALATE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
公开(公告)号：WO2011152657A3
公开(公告)日：2011-12-08
申请号：PCT/KR2011/004002
申请日：2011-06-01
申请人： CELLTRION CHEMICAL RESEARCH INSTITUTE , CELLTRION PHARM, INC. , KIM, Kyoung Soo , PARK, Young Jun , SONG, Hyun-Nam , KIM, Dong Youn , KIM, Joon Woo , CHO, Kyoung-suk , YU, KeeWon , KWON, Hyuk Jin
发明人： KIM, Kyoung Soo , PARK, Young Jun , SONG, Hyun-Nam , KIM, Dong Youn , KIM, Joon Woo , CHO, Kyoung-suk , YU, KeeWon , KWON, Hyuk Jin
IPC分类号： C07C229/22 , C07C227/16 , A61K31/197 , A61P25/28
摘要： The present invention relates to acetyl-L-carnitine malate, a process for preparing the same, and a pharmaceutical composition comprising the same. The acetyl-L-carnitine malate of the present invention has good stability, solubility, and non-hygroscopicity to be effectively used for preparing a pharmaceutical composition.

7. 发明申请

WO2010151008A9 PIPERAZINE DITHIOCTATE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
公开(公告)号：WO2010151008A9
公开(公告)日：2010-12-29
申请号：PCT/KR2010/003954
申请日：2010-06-18
申请人： CELLTRION CHEMICAL RESEARCH INSTITUTE , CELLTRION PHARM, INC. , KIM, Kyoung Soo , PARK, Young Jun , SONG, Hyun-Nam , LEE, In Suk , KIM, Joon Woo
发明人： KIM, Kyoung Soo , PARK, Young Jun , SONG, Hyun-Nam , LEE, In Suk , KIM, Joon Woo
IPC分类号： C07D339/02 , C07D339/00
摘要： The present invention relates to piperazine dithioctate, a novel addition salt of thioctic acid with a base and a pharmaceutical composition comprising the same. The piperazine dithioctate according to the present invention has good thermal and moisture stability and high water-solubility as well as dosage increase lower than other addition salts, thereby being effectively used for preparing a pharmaceutical composition for antioxidation or for preventing or treating diabetic polyneuropathy, etc.

8. 发明申请

WO2012008711A2 ERLOTINIB DICHLOROACETATE AND ANTI-CANCER AGENT COMPRISING THE SAME 审中-公开
标题翻译： ERLOTINIB二氯乙酸酯和包含其的抗癌剂
公开(公告)号：WO2012008711A2
公开(公告)日：2012-01-19
申请号：PCT/KR2011/004985
申请日：2011-07-07
申请人： CELLTRION CHEMICAL RESEARCH INSTITUTE , CELLTRION PHARM, INC. , KIM, Kyoung Soo , PARK, Young Jun , SONG, Hyun-Nam , KIM, Dong Youn , KIM, Joon Woo , CHO, Kyoung-suk , YU, KeeWon , KWON, Hyuk Jin
发明人： KIM, Kyoung Soo , PARK, Young Jun , SONG, Hyun-Nam , KIM, Dong Youn , KIM, Joon Woo , CHO, Kyoung-suk , YU, KeeWon , KWON, Hyuk Jin
IPC分类号： C07D239/94 , A61K31/505 , A61P35/00
CPC分类号： A61K31/505
摘要： The present invention relates to erlotinib dichloroacetate and an anti-cancer agent comprising the same. The erlotinib dichloroacetate of the present invention can inhibit epidermal growth factor receptor as well as induce cancer cells to kill themselves via apoptosis, thereby inhibit growth of cancer cells and lead to their destruction, and show significantly enhanced anti-cancer effects by synergy between erlotinib and dichloroacetic acid.
摘要翻译：本发明涉及厄洛替尼二氯乙酸盐和包含其的抗癌剂。本发明的二氯乙酸厄洛替尼可以抑制表皮生长因子受体，并诱导癌细胞通过凋亡杀死自身，从而抑制癌细胞的生长并导致它们的破坏，并且通过厄洛替尼和二氯乙酸。

9. 发明申请

WO2011081408A2 IMATINIB DICHLOROACETATE AND ANTI-CANCER AGENT COMPRISING THE SAME 审中-公开
标题翻译： IMATINIB DICHLOROACETATE和包含它的抗癌药物
公开(公告)号：WO2011081408A2
公开(公告)日：2011-07-07
申请号：PCT/KR2010/009423
申请日：2010-12-28
申请人： CELLTRION CHEMICAL RESEARCH INSTITUTE , CELLTRION PHARM, INC. , KIM, Kyoung Soo , PARK, Young Jun , SONG, Hyun-Nam , KIM, Joon Woo
发明人： KIM, Kyoung Soo , PARK, Young Jun , SONG, Hyun-Nam , KIM, Joon Woo
IPC分类号： C07D403/14 , C07D403/02 , A61K31/496 , A61P35/00
CPC分类号： A61K31/496 , C07D401/04
摘要： The present invention relates to imatinib dichloroacetate and an anti-cancer agent comprising the same. The imatinib dichloroacetate of the present invention can inhibit tyrosine kinase as well as induce cancer cells to kill themselves via apoptosis, thereby inhibit growth of cancer cells and lead to their destruction, and show significantly enhanced anti-cancer effects by synergy between imatinib and dichloroacetic acid.
摘要翻译：本发明涉及二氯乙酸伊马替尼和包含其的抗癌剂。本发明的二氯乙酸伊马替尼可抑制酪氨酸激酶以及诱导癌细胞通过细胞凋亡杀死自身，从而抑制癌细胞的生长并导致它们的破坏，并且通过伊马替尼和二氯乙酸之间的协同作用显示显着增强的抗癌作用

10. 发明申请

WO2008066315A1 SHEET ATTACHING APPARATUS 审中-公开
标题翻译：表格附件
公开(公告)号：WO2008066315A1
公开(公告)日：2008-06-05
申请号：PCT/KR2007/006040
申请日：2007-11-27
申请人： SAMSUNG HEAVY IND. CO., LTD. , HAN, Seong-jong , PARK, Young Jun , LEE, Dong Bae
发明人： HAN, Seong-jong , PARK, Young Jun , LEE, Dong Bae
IPC分类号： B63B9/06 , B65H59/00
CPC分类号： B63B3/68
摘要： A sheet attaching apparatus having a first winding unit 610 for supplying a sheet 690, a driving part 400 for movement, and a frame 100 on which the first winding unit 610 and the driving port 400 installed, and a controller 10 includes a nozzle unit 200 detachably attached at the frame 100 and dispersing a glue supplied from an external glue supply line; a guide part 700 detachably attached at the frame 100 and guiding an attachment surface covered with the glue to be covered with the sheet 690; a second winding unit 620 supplying a protection film 691 covering and attaching both side portions of the sheet 690 covering the attachment surface; a roller 600 installed at the frame 100 and pressing the sheet 690 covering the attachment surface and the protection film 691 and spreading the glue uniformly on the attachment surface; and a video camera device 190 electrically connected to the controller 10 to capture a state of a sheet attaching process and send an image information generated therefrom.
摘要翻译：具有用于供应片材690的第一卷绕单元610，用于移动的驱动部件400和安装有第一卷绕单元610和驱动端口400的框架100的片材附接装置，并且控制器10包括喷嘴单元200 可拆卸地安装在框架100处，并分散从外部胶水供应线供应的胶水; 引导部件700可拆卸地安装在框架100处并且引导被被片材690覆盖的胶水覆盖的附接表面; 第二卷绕单元620提供覆盖并附着在覆盖安装面的片材690的两侧部分的保护膜691; 安装在框架100处并压紧覆盖安装表面的片材690和保护膜691并将胶水均匀地铺展在安装表面上的辊子600; 以及电连接到控制器10以捕获片材附着过程的状态并发送由其生成的图像信息的摄像机装置190。

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