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    • 8. 发明专利
    • Antibodies and immunoconjugates and uses therefor
    • 抗体和免疫球蛋白及其用途
    • JP2013056896A
    • 2013-03-28
    • JP2012230391
    • 2012-10-18
    • Genentech Incジェネンテック, インコーポレイテッド
    • EBENS ALLEN J JRGRAY ALANE MLIANG WEI-CHINGWU YANYU SHANG-FAN
    • C07K16/28C12N15/09
    • C07K16/3061A61K39/39558A61K45/06A61K47/6803A61K47/6849A61K47/6855C07K16/2803C07K16/2896C07K2317/24C07K2317/56C07K2317/77C07K2317/92
    • PROBLEM TO BE SOLVED: To provide anti-CD22 antibodies and immunoconjugates thereof, and to provide methods of using anti-CD22 antibodies and immunoconjugates thereof.SOLUTION: The anti-CD22 antibodies are provided. A polynucleotide encoding the antibodies is provided. A vector comprising the polynucleotide is provided. A host cell comprising the vector is provided. A method of making an anti-CD22 antibody is provided, wherein the method comprises culturing the host cell under conditions suitable for expression of the polynucleotide encoding the antibody, and isolating the antibody. A B-cell proliferative disorder includes lymphoma, non-Hogkins lymphoma (NHL), aggressive NHL, relapsed aggressive NHL, relapsed indolent NHL, refractory NHL, refractory indolent NHL, chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma, leukemia, hairy cell leukemia (HCL), acute lymphocytic leukemia (ALL), and mantle cell lymphoma.
    • 待解决的问题:提供抗CD22抗体及其免疫缀合物,并提供使用抗CD22抗体及其免疫偶联物的方法。 解决方案:提供抗CD22抗体。 提供编码抗体的多核苷酸。 提供了包含该多核苷酸的载体。 提供了包含载体的宿主细胞。 提供制备抗CD22抗体的方法,其中所述方法包括在适于表达编码抗体的多核苷酸的条件下培养宿主细胞,并分离抗体。 B细胞增殖性疾病包括淋巴瘤,非霍金斯淋巴瘤(NHL),侵袭性NHL,复发性侵袭性NHL,复发性无痛NHL,难治性NHL,难治性惰性NHL,慢性淋巴细胞白血病(CLL),小淋巴细胞淋巴瘤,白血病,毛细胞 白血病(HCL),急性淋巴细胞白血病(ALL)和外套细胞淋巴瘤。 版权所有(C)2013,JPO&INPIT