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1. 发明专利

AU2001282436B2 Osteogenic growth oligopeptides as stimulants of hematopoiesis 未知
公开(公告)号：AU2001282436B2
公开(公告)日：2008-03-06
申请号：AU2001282436
申请日：2001-07-29
申请人： YISSUM RES DEV CO
发明人： BAB ITAI , MANSUR NURA , GREENBERG ZVI , MUHLRAD NURA , PETRINI MARIO , TRASCIATTI SILVIA , CHOREV MICHAEL , ROSINI SERGIO , GUREVITCH OLGA , SHTEYER ARYE
IPC分类号： A61K38/07 , A61K35/12 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/08 , A61K38/22 , A61P7/00 , A61P7/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P41/00 , A61P43/00 , C12N5/0789
摘要： The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analogous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.

2. 发明专利

NO20040378A 未知
公开(公告)号：NO20040378A
公开(公告)日：2004-03-26
申请号：NO20040378
申请日：2004-01-28
申请人： YISSUM RES DEV CO
发明人： BAB ITAI , TRASCIATTI SILVIA , CHOREV MICHAEL , SHTEYER ARYE , MUHLRAD NURA , MANSUR NURA , GUREVITCH OLGA , GREENBERG ZVI , ROSINI SERGIO , PETRINI MARIO
IPC分类号： A61K35/12 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/07 , A61K38/08 , A61K38/22 , A61P7/00 , A61P7/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P41/00 , A61P43/00 , C12N5/0789
CPC分类号： A61K38/08 , A61K38/07 , A61K2035/124 , C12N5/0647 , C12N2501/998

3. 发明专利

YU8104A OLIGOPEPTIDI OSTEOGENOG RASTA KAO STIMULATORI HEMATOPOEZE 未知
公开(公告)号：YU8104A
公开(公告)日：2006-08-17
申请号：YUP8104
申请日：2001-07-29
申请人： YISSUM RES DEV CO
发明人： BAB ITAI , CHOREV MICHAEL , SHTEYER ARYE , MUHLRAD NURA , MANSUR NURA , GUREVITCH OLGA , GREENBERG ZVI , ROSINI SERGIO , TRASCIATTI SILVIA , PETRINI MARIO
摘要： Ovaj pronalazak se odnosi na farmaceutsku mešavinu koja uključuje kao delotvoran sastojak jedan oligopeptid koji je identičan ili analogan C terminalnom delu OGP, koji ima stimulativne efekte na produkciju hematopoetičkih ćelija. Najpoželjniji oligopeptidi koji su korišćeni su Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly ili Met-Tyr-GlyPhe-Gly-Gly. Preciznije, ovi oligopeptidi pojačavaju primanje grafta transplantirane kostne srži, hemopoetičku rekonstrukciju, re-populaciju kostne srži i mobilizaciju perifernih matičnih ćelija, najbolje posle hemioterapije ili zračenja. Ovaj pronalazak dalje obezbeđuje metode tretmana i upotrebe ovih oligopeptida za pripremu farmaceutskih mešavina.[The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analagous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.

4. 发明专利

CZ2004300A3 Osteogenic growth oligopeptides as stimulants of hematopoiesis 未知
公开(公告)号：CZ2004300A3
公开(公告)日：2005-03-16
申请号：CZ2004300
申请日：2001-07-29
申请人： YISSUM RES DEV CO
发明人： BAB ITAI , CHOREV MICHAEL , SHTEYER ARYE , MUHLRAD NURA , MANSUR NURA , GUREVITCH OLGA , GREENBERG ZVI , ROSINI SERGIO , TRASCIATTI SILVIA , PETRINI MARIO
IPC分类号： A61K35/12 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/07 , A61K38/08 , A61K38/22 , A61P7/00 , A61P7/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P41/00 , A61P43/00 , C12N5/0789 , C12N5/00 , C12N5/08
摘要： The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analogous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.

5. 发明专利

CZ20040300A3 Osteogenic growth oligopeptides as stimulants of hematopoiesis 未知
公开(公告)号：CZ20040300A3
公开(公告)日：2005-03-16
申请号：CZ20040300
申请日：2001-07-29
申请人： YISSUM RES DEV CO
发明人： BAB ITAI , CHOREV MICHAEL , SHTEYER ARYE , MUHLRAD NURA , MANSUR NURA , GUREVITCH OLGA , GREENBERG ZVI , ROSINI SERGIO , TRASCIATTI SILVIA , PETRINI MARIO
IPC分类号： A61K35/12 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/07 , A61K38/08 , A61K38/22 , A61P7/00 , A61P7/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P41/00 , A61P43/00 , C12N5/0789 , C12N5/00 , C12N5/08
CPC分类号： A61K38/08 , A61K38/07 , A61K2035/124 , C12N5/0647 , C12N2501/998

6. 发明专利

NO20040378L 未知
公开(公告)号：NO20040378L
公开(公告)日：2004-03-26
申请号：NO20040378
申请日：2004-01-28
申请人： YISSUM RES DEV CO
发明人： BAB ITAI , TRASCIATTI SILVIA , CHOREV MICHAEL , SHTEYER ARYE , MUHLRAD NURA , MANSUR NURA , GUREVITCH OLGA , GREENBERG ZVI , ROSINI SERGIO , PETRINI MARIO
IPC分类号： A61K35/12 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/07 , A61K38/08 , A61K38/22 , A61P7/00 , A61P7/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P41/00 , A61P43/00 , C12N5/0789
摘要： The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analogous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.

7. 发明专利

CA2456092A1 OSTEOGENIC GROWTH OLIGOPEPTIDES AS STIMULANTS OF HEMATOPOIESIS 未知
公开(公告)号：CA2456092A1
公开(公告)日：2003-02-13
申请号：CA2456092
申请日：2001-07-29
申请人： YISSUM RES DEV CO
发明人： GREENBERG ZVI , BAB ITAI , ROSINI SERGIO , CHOREV MICHAEL , MANSUR NURA , SHTEYER ARYE , MUHLRAD NURA , GUREVITCH OLGA , TRASCIATTI SILVIA , PETRINI MARIO
IPC分类号： A61K35/12 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/07 , A61K38/08 , A61K38/22 , A61P7/00 , A61P7/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P41/00 , A61P43/00 , C12N5/0789 , C12N5/00 , C12N5/08
摘要： The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analagous to the C-termina l portion of OGP, having stimulatory activity on the production of hematopoiet ic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gl y- Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem ce ll mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in t he preparation of pharmaceutical compositions.

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