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1. 发明申请

WO2004016643A2 TUMOR ASSOCIATED ANTIGEN, PEPTIDES THEREOF, AND USE OF SAME AS ANTI-TUMOR VACCINES 审中-公开
标题翻译：肿瘤相关抗原，其抗原及其作为抗肿瘤疫苗的用途
公开(公告)号：WO2004016643A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/023503
申请日：2003-07-28
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , MCINNIS, Patricia , EISENBACH, Lea , TIROSH, Boaz , CARMON, Lior , MACHLENKIN, Arthur , PAZ, Adrian , TZEHOVAL, Esther , FRIDKIN, Matityahu
发明人： EISENBACH, Lea , TIROSH, Boaz , CARMON, Lior , MACHLENKIN, Arthur , PAZ, Adrian , TZEHOVAL, Esther , FRIDKIN, Matityahu
IPC分类号： C07K
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K14/705 , C07K14/723
摘要： The invention relates to colon and prostate tumor associated antigen peptides obtainable from prostate specific G protein-coupled receptor (PSGR), six-transmembrane epithelial antigen of prostate (STEAP) and proteins encoded by genes found overexpressed in colon carcinoma cells, such as human 1-8D interferon induced transmembrane protein 2. The invention further relates to a polynucleotide encoding the tumor associated antigen peptides and to pharmaceutical compositions, which are preferably anti-tumor vaccine compositions, containing a tumor associated antigen, at least one tumor associated antigen peptide thereof, or encoding polynucleotide thereof as an active ingredient. The pharmaceutical compositions can be administered to a patient in need thereof to treat or inhibit the development of colon or prostate cancer.
摘要翻译：本发明涉及从前列腺特异性G蛋白偶联受体（PSGR）获得的结肠和前列腺肿瘤相关的抗原肽，前列腺的六跨膜上皮抗原（STEAP）和由在结肠癌细胞中过表达的基因编码的蛋白质，例如人1 -8D干扰素诱导的跨膜蛋白2.本发明还涉及编码肿瘤相关抗原肽和药物组合物的多核苷酸，其优选为抗肿瘤疫苗组合物，其含有肿瘤相关抗原，至少一种肿瘤相关抗原肽，或其编码多核苷酸作为活性成分。可将药物组合物施用于有需要的患者，以治疗或抑制结肠或前列腺癌的发生。

2. 发明申请

WO2006095330A2 METHODS AND IMMUNOGENIC CELL PREPARATIONS FOR TREATING ANTIGEN-ASSOCIATED DISEASES 审中-公开
标题翻译：用于治疗与抗原相关的疾病的方法和免疫细胞制备
公开(公告)号：WO2006095330A2
公开(公告)日：2006-09-14
申请号：PCT/IL2006/000218
申请日：2006-02-21
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , EISENBACH, Lea , MACHLENKIN, Arthur , PAZ, Adrian , TIROSH, Boaz , TZEHOVAL, Esther
发明人： EISENBACH, Lea , MACHLENKIN, Arthur , PAZ, Adrian , TIROSH, Boaz , TZEHOVAL, Esther
IPC分类号： A61K39/395
CPC分类号： C12N5/0639 , A61K35/15 , A61K39/0011 , A61K41/0009 , A61K41/0023 , A61K2039/5154
摘要： A method of inhibiting growth of, reducing or eliminating a cell population of a subject in need thereof is disclosed. The method comprises (a) thermally, mechanically and/or chemically damaging antigen-bearing cells which comprise at least one antigen characterizing cells of the cell population, with the proviso that the chemically damaging of the antigen-bearing cells is not predominantly effected using one or more antineoplastic agents, thereby generating immunogenic cells; and (b) introducing in the subject a cell aggregate which comprises the immunogenic cells and added antigen-presenting cells, thereby inducing an immune response for inhibiting growth of, reducing or eliminating the cell population of the subject.
摘要翻译：公开了抑制有需要的受试者生长，减少或消除细胞群体的方法。该方法包括（a）热，机械和/或化学损伤包含至少一种表征细胞群细胞的抗原的抗原携带细胞，附带条件是，抗原携带细胞的化学损伤不主要使用一种或更多的抗肿瘤剂，从而产生免疫原性细胞; 和（b）在受试者中引入包含免疫原性细胞和添加的抗原呈递细胞的细胞聚集体，由此诱导用于抑制或消除受试者细胞群的生长的免疫应答。

3. 发明公开

EP1569514A2 TUMOR ASSOCIATED ANTIGEN, PEPTIDES THEREOF, AND USE OF SAME AS ANTI-TUMOR VACCINES 审中-公开
标题翻译：肿瘤相关抗原，多肽，以及它们用作抗肿瘤疫苗
公开(公告)号：EP1569514A2
公开(公告)日：2005-09-07
申请号：EP03788282.6
申请日：2003-07-28
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： EISENBACH, Lea , TIROSH, Boaz , CARMON, Lior , MACHLENKIN, Arthur , PAZ, Adrian , TZEHOVAL, Esther , FRIDKIN, Matityahu
IPC分类号： A01N37/18 , A61K35/00 , A61K39/00 , A61K48/00 , C07H21/04 , C07K7/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K14/705 , C07K14/723
摘要： The invention relates to colon and prostate tumor associated antigen peptides obtainable from prostate specific G protein-coupled receptor (PSGR), six-transmembrane epithelial antigen of prostate (STEAP) and proteins encoded by genes found overexpressed in colon carcinoma cells, such as human 1-8D interferon induced transmembrane protein 2. The invention further relates to a polynucleotide encoding the tumor associated antigen peptides and to pharmaceutical compositions, which are preferably anti-tumor vaccine compositions, containing a tumor associated antigen, at least one tumor associated antigen peptide thereof, or encoding polynucleotide thereof as an active ingredient. The pharmaceutical compositions can be administered to a patient in need thereof to treat or inhibit the development of colon or prostate cancer.

4. 发明申请

WO2008004234A2 MINIMALLY INVASIVE ELECTRO-STIMULATION SYSTEM 审中-公开
标题翻译：最小的入侵电刺激系统
公开(公告)号：WO2008004234A2
公开(公告)日：2008-01-10
申请号：PCT/IL2007/000840
申请日：2007-07-05
申请人： STIMPULSE LTD. , ARAD, Michael , SHILKRUT, Mark , PAZ, Adrian
发明人： ARAD, Michael , SHILKRUT, Mark , PAZ, Adrian
IPC分类号： A61N1/18
CPC分类号： A61N1/05 , A61N2/006
摘要： A system for electro-stimulation of an internal organ or a mezothelial cavity wall covering. The system is installed within a cavity wall adjacent the organ or tissue to be stimulated, and in electrical communication therewith, but without necessarily being in physical contact with it. The system can be deployed using a minimally invasive surgical procedure. The system comprises one or more stimulation electrodes, one or more sensors outputting a signal in accordance with a physiological characteristic of the subject, and a controller for applying the stimulation in accordance with the sensor output. The electrodes or sensors are deployed using a thin delivery tube inserted into the desired region. The electrodes are carried to the deployment site attached to an inflatable balloon, passed uninflated down the delivery tube, and inflated after passage therethrough, thus deploying the electrode in the intended region. The inflated balloon holds the electrode(s) in place.
摘要翻译：一种用于电刺激内脏器官或微创腔壁的系统。该系统安装在邻近要刺激的器官或组织的空腔壁内，并与之电气通信，但不一定与其物理接触。可以使用微创外科手术来部署系统。该系统包括一个或多个刺激电极，根据对象的生理特征输出信号的一个或多个传感器，以及根据传感器输出施加刺激的控制器。电极或传感器使用插入所需区域的薄输送管来展开。电极被携带到附接到可膨胀气囊的展开部位，通过未放置在输送管下方，并在通过之后膨胀，从而将电极展开在预期区域中。充气气囊将电极保持在适当的位置。

5. 发明申请

WO2003096871A2 MULTIPURPOSE FLUID JET SURGICAL DEVICE 审中-公开
标题翻译：多用途流体喷枪手术装置
公开(公告)号：WO2003096871A2
公开(公告)日：2003-11-27
申请号：PCT/IL2003/000387
申请日：2003-05-14
申请人： PATENT MAX Q (P.M.Q) LTD. , PAZ, Adrian
发明人： PAZ, Adrian
IPC分类号： A61B
CPC分类号： A61B17/3203 , A61B2017/003 , A61B2018/046 , A61B2090/08021
摘要： A multipurpose fluid jet device for cutting, dissecting, abrading and/or hemostasis, comprising: (a) fluid jet forming means for generating a high pressure fluid jet used for performing the cutting, dissecting or abrading interventions; (b) one or more irrigation channels for directing said generated fluid from a nozzle located in a distal part of the apparatus; (c) a jet neutralizing or weakening means situated at the nozzle; (d9 a shaft for housing the fluid jet forming means and channel, or channels. A surgical method for cutting, dissecting or abrading, comprising; (a) forming one or more cutting jets using a high pressure liquid, being emitted from the distal end of a hand-held device; (b) forming additional jet or jets for neutralizing or weakening the cutting jets.
摘要翻译：一种用于切割，解剖，研磨和/或止血的多用途流体喷射装置，包括：（a）用于产生用于进行切割，解剖或研磨干预的高压流体射流的流体射流形成装置; （b）一个或多个冲洗通道，用于从位于所述设备的远端部分的喷嘴引导所述产生的流体; （c）位于喷嘴处的喷气中和或弱化装置; （d9）用于容纳流体射流形成装置和通道或通道的轴，用于切割，解剖或研磨的手术方法，包括：（a）使用高压液体形成一个或多个切割射流，从远端的手持装置;（b）形成用于中和或削弱切割射流的附加射流或射流。

6. 发明申请

WO2021048846A1 IMPOTENCE TREATMENT 审中-公开
公开(公告)号：WO2021048846A1
公开(公告)日：2021-03-18
申请号：PCT/IL2020/050985
申请日：2020-09-09
申请人： PAZ, Adrian
发明人： PAZ, Adrian
IPC分类号： A61F5/41 , A61N7/00
摘要： The current disclosure relates to a system for treating impotence. In some embodiments, the device includes a mount for holding a transducer in intimate contact to a penile tissue. For example, an ultrasound transducer and/or a vibration transducer may be held in vibrational communication with a corpora, a crura, a root of the penis and/or a glans. For example, the mount may include a sheath and/or a tubular body that may be rigid, partially flexible and/or flexible. The sheath may be open on one or both ends and/or may fully surround the penis and/or include a slit on one side. Optionally, the tubular body includes one or more extensions that reach the root of the penis and/or the crura. For example, the extensions may extend proximally from a proximal end of the sheath and/or the extensions may include transducers that face and/or inward (towards one another).

7. 发明申请

WO2007017880A3 IMPLANTABLE DEVICE FOR OBESITY PREVENTION 审中-公开
公开(公告)号：WO2007017880A3
公开(公告)日：2007-02-15
申请号：PCT/IL2006/000934
申请日：2006-08-13
申请人： STIMPLANT LTD. , PAZ, Adrian
发明人： PAZ, Adrian
IPC分类号： A61M29/00 , A61F2/04 , A61F2/02 , A61B5/103 , A61B5/117
摘要： A device for controlling the expansion of a hollow internal organ, comprising an inflatable balloon, which is inserted in an uninflated state into the desired position close to the organ using minimally invasive procedures. After insertion, the balloon is inflated to its required size and shape. The invention is useful for restricting the expansion of the stomach during meals, thus inducing a feeling of satiety and preventing over-eating. Inflation may be performed through a catheter connected to a readily accessible inflation port. In the case of the gastric embodiment, the balloon may be positioned pro-peritoneally, such that the procedure is surgically simple. One or more sensors located close to the organ to be controlled, may monitor a physiological effect relating to the organ, and the output of the sensor used to control the level of inflation of the balloon in order to correct the condition being monitored.

8. 发明申请

WO2005004727A1 SURGICAL FASTENERS AND DEVICES FOR SURGICAL FASTENING 审中-公开
标题翻译：手术紧固件和外科手术器械
公开(公告)号：WO2005004727A1
公开(公告)日：2005-01-20
申请号：PCT/IL2004/000624
申请日：2004-07-11
申请人： ENDOGUN MEDICAL SYSTEMS LTD. , PAZ, Adrian , ROTENBERG, Dan , HOD, Eitan , KONIK, Anatoli , SHAHAR, Mark , SHABAT, Roni
发明人： PAZ, Adrian , ROTENBERG, Dan , HOD, Eitan , KONIK, Anatoli , SHAHAR, Mark , SHABAT, Roni
IPC分类号： A61B17/064
CPC分类号： A61B17/0401 , A61B17/06166 , A61B17/068 , A61B17/1222 , A61B2017/00805 , A61B2017/0409 , A61B2017/0417 , A61B2017/0441 , A61B2017/0649 , A61F2/0045
摘要： A surgical fastening device (100) for pinning a surgical filament to a body tissue. The device includes a grasping handle (107) and a slender shaft (102) extending from the grasping handle. A compartment (63) contains one or more surgical fasteners. An ejecting mechanism is used to eject a surgical fastener from a compartment containing one or more surgical fasteners. The device also includes a filament dispensing system (108) that dispenses surgical filament (109) along the shaft so that a fastener grasps the filament when being ejected from the shaft. The invention also provides surgical fasteners and surgical filaments for use in the device.
摘要翻译：一种用于将手术细丝钉入身体组织的手术紧固装置（100）。该装置包括把持手柄（107）和从把持手柄延伸的细长轴（102）。隔室（63）包含一个或多个手术紧固件。弹出机构用于从包含一个或多个手术紧固件的隔室中弹出手术紧固件。该装置还包括长丝分配系统（108），其沿着轴分配外科细丝（109），使得紧固件在从轴排出时抓住细丝。本发明还提供了用于该装置中的外科紧固件和手术细丝。

9. 发明申请

WO2007052276A1 EXTRACTING DEVICE FOR SURGICAL FASTENERS 审中-公开
标题翻译：用于外科紧固件的提取装置
公开(公告)号：WO2007052276A1
公开(公告)日：2007-05-10
申请号：PCT/IL2006/001273
申请日：2006-11-02
申请人： ENDOGUN MEDICAL SYSTEMS LTD. , PAZ, Adrian , HEFTMAN, Gilad , HOD, Eitan
发明人： PAZ, Adrian , HEFTMAN, Gilad , HOD, Eitan
IPC分类号： A61B17/00
CPC分类号： A61B17/076
摘要： The application provides a device (2) for extracting from a body tissue surgical fasteners (20) having a crown, a baseplate and prongs extending from the crown to the baseplate. The device includes a shaft having a lumen with a cross-sectional shape and dimensions to allow the crown to enter the lumen while preventing the baseplate from entering the lumen.
摘要翻译：本申请提供了一种用于从身体组织提取外科紧固件（20）的装置（2），所述手术紧固件具有冠部，底板和从冠部延伸到基板的尖头。该装置包括具有内腔的轴，该内腔具有横截面形状和尺寸，以允许牙冠进入内腔，同时防止基板进入内腔。

10. 发明申请

WO2006001009A3 DEVICE SYSTEM AND METHOD FOR TISSUE DISPLACEMENT OR SEPARATION 审中-公开
公开(公告)号：WO2006001009A3
公开(公告)日：2006-01-05
申请号：PCT/IL2005/000672
申请日：2005-06-23
申请人： BIOPROTECT LTD. , PAZ, Adrian , DOMB, Abraham, J.
发明人： PAZ, Adrian , DOMB, Abraham, J.
IPC分类号： A61B17/02
摘要： A tissue displacement/separation device is provided. The device includes a bladder which is expandable between a first tissue and a second tissue of a body. The bladder has an expanded shape which is selected capable of displacing or separating the first tissue from the second tissue in a manner suitable for protecting the first tissue from an effect of a treatment applied to the second tissue.

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