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1. 发明申请

WO2007007327A2 IL-32 MODULATORS 审中-公开
标题翻译： IL-32调制器
公开(公告)号：WO2007007327A2
公开(公告)日：2007-01-18
申请号：PCT/IL2006/000798
申请日：2006-07-10
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , THE REGENTS OF THE UNIVERSITY OF COLORADO , NOVICK, Daniela , RUBINSTEIN, Menachem , DINARELLO, Charles, A. , KIM, Soo-Hyun
发明人： NOVICK, Daniela , RUBINSTEIN, Menachem , DINARELLO, Charles, A. , KIM, Soo-Hyun
IPC分类号： G01N33/68 , A61K38/00 , C07K14/00 , A61K31/00
CPC分类号： C07K14/54 , G01N33/6869
摘要： The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use.
摘要翻译：本发明涉及筛选白细胞介素32（IL-32）调节剂，IL-32调节剂及其用途的方法。

2. 发明申请

WO2002092008A3 USE OF IL-18 INHIBITORS FOR THE TREATEMENT OR PREVENTION OF SEPSIS 审中-公开
公开(公告)号：WO2002092008A3
公开(公告)日：2002-11-21
申请号：PCT/US2002/015556
申请日：2002-05-16
申请人： YEDA RESEARCH AND DEVELOPMENT CO., LTD. , DINARELLO, Charles, A. , FANTUZZI, Giamila , KIM, Soo-Hyun , REZNIKOV, Leonid , RUBINSTEIN, Menachem , NOVICK, Daniela , SCHWARTSBURD, Boris
发明人： DINARELLO, Charles, A. , FANTUZZI, Giamila , KIM, Soo-Hyun , REZNIKOV, Leonid , RUBINSTEIN, Menachem , NOVICK, Daniela , SCHWARTSBURD, Boris
IPC分类号： A61K38/00
摘要： The present invention relates to the use of an inhibitor of IL.18 in the manufacture of a medicament for the treatment and/or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrome (SIRS) selected from severe sepsis and septic shock, and also for sepsis related cardiac dysfunction.

3. 发明申请

WO2005047478A2 COMPOSITIONS AND METHODS FOR REGULATION OF TUMOR NECROSIS FACTOR-ALPHA 审中-公开
标题翻译：用于调节肿瘤坏死因子-ALPHA的组合物和方法
公开(公告)号：WO2005047478A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/037578
申请日：2004-11-12
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , KIM, Soo-Hyun , DINARELLO, Charles, A. , AZAM, Tania
发明人： KIM, Soo-Hyun , DINARELLO, Charles, A. , AZAM, Tania
IPC分类号： C12N
CPC分类号： C07K16/244 , A61K38/00 , A61K2039/505 , C07K14/54 , C07K2316/96 , C07K2317/55 , C07K2317/76
摘要： The present invention relates to compositions and methods relating to an interleukin18- inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In particular, the present invention provides compositions and methods for treating autoimmune diseases and cancer, in part by regulation of tumor necrosis factor-alpha expression.
摘要翻译：本发明涉及涉及被称为肿瘤坏死因子-α诱导因子（TAIF）或白细胞介素-32（IL-32）的白细胞介素18诱导型细胞因子的组合物和方法。特别地，本发明部分通过调节肿瘤坏死因子-α表达来提供治疗自身免疫性疾病和癌症的组合物和方法。

4. 发明公开

EP1913400A2 IL-32 MODULATORS 有权
标题翻译： IL-32调节剂
公开(公告)号：EP1913400A2
公开(公告)日：2008-04-23
申请号：EP06766125.6
申请日：2006-07-10
申请人： YEDA RESEARCH AND DEVELOPMENT CO., LTD. , The Regents of the University of Colorado
发明人： NOVICK, Daniela Weizmann Institute of Science , RUBINSTEIN, Menachem , DINARELLO, Charles, A. , KIM, Soo-Hyun
IPC分类号： G01N33/68 , A61K38/00 , C07K14/00 , A61K31/00
CPC分类号： C07K14/54 , G01N33/6869
摘要： The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use. Proteinase 3 has been identified as an IL-32 binding protein capable of deavege thereof. Inhibition of PR 3 activity to process IL-32 or neutralization of IL-32 by- inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases (e.g. inflammatory diseases).

5. 发明授权

EP1913400B1 IL-32 MODULATORS 有权
标题翻译： IL-32调节剂
公开(公告)号：EP1913400B1
公开(公告)日：2010-11-24
申请号：EP06766125.6
申请日：2006-07-10
申请人： YEDA RESEARCH AND DEVELOPMENT CO., LTD. , The Regents of the University of Colorado
发明人： NOVICK, Daniela Weizmann Institute of Science , RUBINSTEIN, Menachem , DINARELLO, Charles, A. , KIM, Soo-Hyun
IPC分类号： G01N33/68 , A61K38/00 , C07K14/00 , A61K31/00
CPC分类号： C07K14/54 , G01N33/6869
摘要： The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use. Proteinase 3 has been identified as an IL-32 binding protein capable of deavege thereof. Inhibition of PR 3 activity to process IL-32 or neutralization of IL-32 by- inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases (e.g. inflammatory diseases).

6. 发明申请

WO2004032837A2 THE USE OF CYTOKINE ABLE TO BIND IL-18BP AND OF INHIBITING THE ACTIVITY OF A SECOND CYTOKINE 审中-公开
标题翻译：使用细胞因子结合IL-18BP并抑制第二细胞因子的活性
公开(公告)号：WO2004032837A2
公开(公告)日：2004-04-22
申请号：PCT/US2003/031378
申请日：2003-10-03
申请人： ARES TRADING S.A. , DINARELLO, Charles, A. , KIM, Soo-Hyun , BUFLER, Philip
发明人： DINARELLO, Charles, A. , KIM, Soo-Hyun , BUFLER, Philip
IPC分类号： A61K
CPC分类号： A61K38/2006 , A61K38/1793 , C07K16/245 , C12N15/1136 , C12N2310/11 , C12N2310/14
摘要： The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof, capable of binding to IL-18 BP or a mutein, fused protein, functional derivative or fragment thereof and capable of inhibiting a receptor of a cytokine-2, cytokine-2 being a member of the IL-1 family, preferably IL-18, in the manufacture of a medicament for the treatment or prevention of a disease which is caused or aggravated by inducing said receptor of cytokine-2.
摘要翻译：本发明涉及细胞因子-1，优选来自IL-1家族，更优选IL-1F7b或同种型，突变蛋白，融合蛋白，功能衍生物或其片段，能够结合IL-18BP或一种突变蛋白，融合蛋白，功能性衍生物或其片段，并能够抑制细胞因子-2的受体，细胞因子-2是IL-1家族的成员，优选IL-18，用于制备用于治疗的药物或预防通过诱导所述细胞因子-2受体引起或加重的疾病。

7. 发明公开

EP1692175A2 COMPOSITIONS AND METHODS FOR REGULATION OF TUMOR NECROSIS FACTOR-ALPHA 审中-公开
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR REGULIERUNG VON TUMORNEKROSEFAKTOR-ALPHA
公开(公告)号：EP1692175A2
公开(公告)日：2006-08-23
申请号：EP04810713.0
申请日：2004-11-12
申请人： The Regents of the University of Colorado, A Body Corporate
发明人： KIM, Soo-Hyun , DINARELLO, Charles, A. , AZAM, Tania
IPC分类号： C07K16/00 , A61K39/00 , C07K19/00 , C07H21/00
CPC分类号： C07K16/244 , A61K38/00 , A61K2039/505 , C07K14/54 , C07K2316/96 , C07K2317/55 , C07K2317/76
摘要： The present invention relates to compositions and methods relating to an interleukin18- inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In particular, the present invention provides compositions and methods for treating autoimmune diseases and cancer, in part by regulation of tumor necrosis factor-alpha expression.
摘要翻译：本公开涉及涉及称为肿瘤坏死因子-α诱导因子（TAIF）或白细胞介素-32（IL-32）的白细胞介素-18诱导型细胞因子的组合物和方法。特别地，本公开提供了部分通过调节肿瘤坏死因子-α表达来治疗自身免疫性疾病和癌症的组合物和方法。

8. 发明授权

EP1425028B1 USE OF IL-18 INHIBITORS FOR THE TREATEMENT OR PREVENTION OF SEPSIS 有权
标题翻译： IL-18抑制剂在败血症的治疗或预防
公开(公告)号：EP1425028B1
公开(公告)日：2009-12-16
申请号：EP02736912.3
申请日：2002-05-16
申请人： Yeda Research And Development Co. Ltd.
发明人： DINARELLO, Charles, A. , FANTUZZI, Giamila , KIM, Soo-Hyun , REZNIKOV, Leonid , RUBINSTEIN, Menachem , NOVICK, Daniela , SCHWARTSBURD, Boris
IPC分类号： A61K38/17 , A61K39/395 , A61K48/00 , A61P31/00
CPC分类号： C07K16/244 , A61K38/1793 , A61K38/20 , A61K38/212 , A61K38/215 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K16/2866 , A61K2300/00
摘要： The present invention relates to the use of an inhibitor of IL.18 in the manufacture of a medicament for the treatment and/or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrome (SIRS) selected from severe sepsis and septic shock, and also for sepsis related cardiac dysfunction.

9. 发明授权

EP1257292B1 USE OF IL-18 INHIBITORS 有权
标题翻译： USE IL-18抑制剂的
公开(公告)号：EP1257292B1
公开(公告)日：2011-04-27
申请号：EP01911662.3
申请日：2001-02-20
申请人： Merck Serono SA , YEDA RESEARCH AND DEVELOPMENT CO., LTD.
发明人： CHVATCHKO, Yolande , DINARELLO, Charles , PLATER-ZYBERK, Christine , VAN DEVENTER, Santer , RUBINSTEIN, Menachem , NOVICK, Daniela , KIM, Soo-Hyun
IPC分类号： A61K38/17
CPC分类号： C07K16/244 , A61K38/00 , A61K39/395 , A61K48/00 , A61K2039/505 , A61K2300/00
摘要： The invention relates to the use of inhibitors of IL-18 in the preparation of a medicament for treatment and/or prevention of liver injury. The invention further relates to the use of IL-18 inhibitors in the preparation of a medicament for treatment and/or prevention of arthritis, in particular rheumatoid arthritis. In addition to this, the invention relates to the use of inhibitors of IL-18 in the preparation of a medicament for treatment and/or prevention of inflammatory bowel diseases, in particular of Crohn's disease and ulcerative colitis.

10. 发明申请

WO2004104853A1 AUTOMATICALLY WEBSITE CONNECTING SYSTEM KEYWORD AND CONTROL METHOD THEREOF 审中-公开
标题翻译：自动网站连接系统关键字及其控制方法
公开(公告)号：WO2004104853A1
公开(公告)日：2004-12-02
申请号：PCT/KR2004/001015
申请日：2004-04-30
申请人： UBIZ COMMUNICATION CO., LTD. , KIM, Soo-Hyun
发明人： KIM, Soo-Hyun
IPC分类号： G06F17/00
CPC分类号： G06F17/30887
摘要： Disclosed is an automatic website connection system using a keyword and a control method thereof, wherein an intername program installed in a user computer provides the user with a normal, speedy access to a corresponding website the user wants to access, not using a server but using common and personal databases install in the user computer, the program including a keyword search tool, a keyword setup tool, a DB conversion tool, an upgrade tool, an address window monitor tool, and common and personal databases. Connection speed to a desired website is increased by using a keyword input value for specific automatic conversion, so the user's time for ineffective web surfing is saved. Also, since system is easily embodied in the computer, an extra server for conversion is not needed. Lastly, the right on the program administration mode is given to the administrator as well as the user. Thus, anyone can easily use the system and create his own keyword environment in his personal computer for administering and controlling the program administration.
摘要翻译：公开了一种使用关键字及其控制方法的自动网站连接系统，其中安装在用户计算机中的国际游戏程序为用户提供正常，快速地访问用户希望访问的相应网站，而不使用服务器，但使用通用和个人数据库安装在用户计算机中，该程序包括关键词搜索工具，关键字设置工具，数据库转换工具，升级工具，地址窗口监视工具以及普通和个人数据库。通过使用特定自动转换的关键字输入值来增加对所需网站的连接速度，从而节省用户无效网页冲浪的时间。此外，由于系统容易体现在计算机中，因此不需要额外的转换服务器。最后，向管理员和用户提供程序管理模式的权限。因此，任何人都可以轻松地使用系统并在他的个人计算机中创建他自己的关键字环境，以管理和控制程序管理。

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