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1. 发明申请

WO2007034490A3 DIASTEREOMERIC PEPTIDES FOR MODULATING T CELL IMMUNITY 审中-公开
标题翻译：用于调节细胞免疫的二酯类抗生素
公开(公告)号：WO2007034490A3
公开(公告)日：2011-05-19
申请号：PCT/IL2006001113
申请日：2006-09-21
申请人： YEDA RES & DEV , SHAI YECHIEL , COHEN IRUN R , QUINTANA FRANCISCO , GERBER DORON
发明人： SHAI YECHIEL , COHEN IRUN R , QUINTANA FRANCISCO , GERBER DORON
IPC分类号： C07K7/06
CPC分类号： A61K38/1774
摘要： The present invention provides diastereomeric peptides derived from the T Cell Receptor alpha Transmembrane Domain, and lipophilic conjugates thereof, which peptides and conjugates are effective in preventing or treating T cell mediated inflammatory diseases. The invention provides pharmaceutical compositions comprising these diastereomeric peptides and conjugates, and uses thereof for therapy of inflammatory diseases, autoimmunity and graft rejection.
摘要翻译：本发明提供了衍生自T细胞受体α跨膜结构域的非对映异构肽及其亲脂性缀合物，该肽和缀合物可有效预防或治疗T细胞介导的炎性疾病。本发明提供包含这些非对映体肽和缀合物的药物组合物及其用于治疗炎性疾病，自身免疫和移植物排斥反应的用途。

2. 发明申请

WO2006077601A2 HIV-1 gp41 FUSION PEPTIDES FOR IMMUNOMODULATION 审中-公开
标题翻译： HIV-1 gp41用于免疫调节的融合蛋白
公开(公告)号：WO2006077601A2
公开(公告)日：2006-07-27
申请号：PCT/IL2006000096
申请日：2006-01-24
申请人： YEDA RES & DEV , SHAI YECHIEL , COHEN IRUN R , QUINTANA FRANCISCO J , GERBER DORON
发明人： SHAI YECHIEL , COHEN IRUN R , QUINTANA FRANCISCO J , GERBER DORON
IPC分类号： A61M5/315
CPC分类号： C07K14/005 , A61K38/162 , C07K2319/00 , C12N2740/16122
摘要： The present invention provides pharmaceutical compositions and methods for prevention or treatment of autoimmune diseases and other T cell mediated inflammatory diseases and conditions, which comprise as an active ingredient an effective quantity of a peptide derived from HIV gp41 fusion peptide domain or fragments, analogs, homologs and derivatives thereof. The invention further provides novel peptides derived from HIV gp41 fusion peptide domain, useful in the treatment of T cell mediated pathologies.
摘要翻译：本发明提供了用于预防或治疗自身免疫性疾病和其它T细胞介导的炎性疾病和病症的药物组合物和方法，其包含有效量的源自HIV gp41融合肽结构域或片段，类似物，同系物的有效成分及其衍生物。本发明还提供了衍生自HIV gp41融合肽结构域的新型肽，其可用于治疗T细胞介导的病理学。

3. 发明专利

IL190052A DIASTEREOMERIC PEPTIDES FOR MODULATING T CELL IMMUNITY 未知
公开(公告)号：IL190052A
公开(公告)日：2012-03-29
申请号：IL19005208
申请日：2008-03-10
申请人： YEDA RES & DEV , COHEN IRUN R , GERBER DORON , SHAI YECHIEL , QUINTANA FRANCISCO J
发明人： COHEN IRUN R , GERBER DORON , SHAI YECHIEL , QUINTANA FRANCISCO J

4. 发明申请

WO2011064779A3 PEPTIDES DERIVED FROM HIV-1 GP41 TRANSMEMBRANE FOR T - IMMUNOMODULATION 审中-公开
标题翻译：从HIV-1 GP41转运蛋白获得的免疫调节蛋白
公开(公告)号：WO2011064779A3
公开(公告)日：2011-10-13
申请号：PCT/IL2010000995
申请日：2010-11-29
申请人： YEDA RES & DEV , SHAI YECHIEL , COHEN IRUN R , COHEN TOMER
发明人： SHAI YECHIEL , COHEN IRUN R , COHEN TOMER
IPC分类号： C07K14/16 , C07K7/06
CPC分类号： C07K14/005 , C12N2740/16122
摘要： The present invention relates to peptides, derivatives and analogs comprising an amino acid sequence derived from the transmembrane domain of HIV gp41 protein, pharmaceutical compositions comprising same, and uses thereof for therapy of inflammatory diseases and disorders, such as T-cell and/or monocyte mediated diseases.
摘要翻译：本发明涉及包含衍生自HIV gp41蛋白的跨膜结构域的氨基酸序列的肽，衍生物和类似物，包含其的药物组合物及其用于治疗炎性疾病和病症如T细胞和/或单核细胞的用途介导的疾病。

5. 发明申请

WO0240529A3 DIASTEREOMERIC PEPTIDES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开
标题翻译：二甲酯类和包含它们的药物组合物
公开(公告)号：WO0240529A3
公开(公告)日：2003-03-20
申请号：PCT/IL0101036
申请日：2001-11-07
申请人： YEDA RES & DEV , SHAI YECHIEL , OREN ZIV , SHAHAR MICHAL , EYAL NURIT
发明人： SHAI YECHIEL , OREN ZIV , SHAHAR MICHAL , EYAL NURIT
IPC分类号： A23L1/305 , A23L3/3526 , A61K38/00 , A61P17/00 , A61P31/04 , A61P35/00 , C07K7/08 , C07K14/435 , A61K38/10
CPC分类号： C07K7/08 , A23L3/3526 , A23L33/18 , A61K38/00
摘要： The invention provides diastereomeric peptides with a net positive charge greater than +1, and cyclic analogues thereof, having at least 15 amino acid residues, wherein said residues are selected from: (i) leucine and lysine; (ii) leucine, lysine and arginine; (iii) glycine, serine, spargine, threonine, or glutamine optionally present at the N-terminus; (iv) and/or lysine, arginine, glycine, or serine optionally present at the C-terminus. The diastereomeric peptides are suitable for treatment of cancer and for treatment, particularly topical treatment, of infections caused by pathogenic organisms such as bacteria and fungi. In addition, they may be used for controlling mycoplasma infection in cell cultures and for food preservation, as food supplements and as alternative to antibiotics for animal nutrition.
摘要翻译：本发明提供具有大于+1的净正电荷的非对映多肽及其具有至少15个氨基酸残基的其环状类似物，其中所述残基选自：（i）亮氨酸和赖氨酸; （ii）亮氨酸，赖氨酸和精氨酸; （iii）N-末端任选存在的甘氨酸，丝氨酸，神经氨酸，苏氨酸或谷氨酰胺; （iv）和/或任选存在于C末端的赖氨酸，精氨酸，甘氨酸或丝氨酸。非对映体肽适用于治疗由病原体如细菌和真菌引起的感染的癌症和治疗，特别是局部治疗。此外，它们可用于控制细胞培养物中的支原体感染和食品保藏，作为食品补充剂和用于动物营养的抗生素的替代物。

6. 发明申请

WO2007074457A3 HISTIDINE-CONTAINING DIASTEREOMERIC PEPTIDES AND USES THEREOF 审中-公开
标题翻译：含有西地丁的地肤多肽及其用途
公开(公告)号：WO2007074457A3
公开(公告)日：2007-11-01
申请号：PCT/IL2006001496
申请日：2006-12-27
申请人： YEDA RES & DEV , SHAI YECHIEL , MAKOVITZKI ARIK
发明人： SHAI YECHIEL , MAKOVITZKI ARIK
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： C07K7/08 , A61K38/00
摘要： Diastereomeric peptides with a net positive charge greater than +1, and cyclic derivatives thereof, are provided, having at least 13 amino acid residues, comprising histidine and one or more hydrophobic amino acid residues, optionally esterified or amidated at the C-terminus and/or acylated at the N-terminus. The peptides may contain other amino acid residues including non-natural amino acids. The peptides are particularly useful in the treatment of cancer.
摘要翻译：提供具有大于+1的净正电荷的非对映异构肽及其环状衍生物，其具有至少13个氨基酸残基，其包含组氨酸和一个或多个疏水性氨基酸残基，任选在C端被酯化或酰胺化和/ 或在N-末端酰化。肽可以含有其他氨基酸残基，包括非天然氨基酸。这些肽特别适用于治疗癌症。

7. 发明申请

WO2005060350A3 DIASTEREOMERIC PEPTIDES USEFUL AS INHIBITORS OF MEMBRANE PROTEIN ASSEMBLY 审中-公开
标题翻译：作为膜蛋白质组装的抑制剂有用的二酯类抗生素
公开(公告)号：WO2005060350A3
公开(公告)日：2005-10-06
申请号：PCT/IL2004001157
申请日：2004-12-22
申请人： YEDA RES & DEV , SHAI YECHIEL
发明人： SHAI YECHIEL
IPC分类号： A61K38/00 , C07K14/16 , C07K14/195
CPC分类号： C07K14/195 , A61K38/00 , C07K14/005 , C12N2740/16122
摘要： The present invention relates to membrane binding diastereomeric peptides comprising amino acid sequences corresponding to a fragment of a transmembrane proteins, wherein at least two amino acid residues of the diastereomeric peptides being in a D-isomer configuration. The diastereomeric peptides are useful in inhibiting fusion membrane protein events, including specifically viral replication and transmission.
摘要翻译：本发明涉及包含对应于跨膜蛋白片段的氨基酸序列的膜结合非对映体肽，其中非对映体肽的至少两个氨基酸残基为D-异构体构型。非对映体肽可用于抑制融合膜蛋白事件，特别是病毒复制和传播。

8. 发明申请

WO2004110341A3 ANTIMICROBIAL AND ANTICANCER LIPOPEPTIDES 审中-公开
标题翻译：抗生素和抗癌药物
公开(公告)号：WO2004110341A3
公开(公告)日：2005-09-09
申请号：PCT/IL2004000544
申请日：2004-06-18
申请人： YEDA RES & DEV , SHAI YECHIEL , AVRAHAMI DORIT
发明人： SHAI YECHIEL , AVRAHAMI DORIT
IPC分类号： A61K20060101 , A61K38/00
CPC分类号： C07K5/06086 , A61K38/00 , A61K47/542 , C07K5/0815 , C07K5/1019 , C07K7/06 , C07K7/08 , C07K14/46
摘要： The invention provides lipophilic conjugates comprising a peptide coupled to a fatty acid, the peptide comprising at least two positively charged amino acid residues, said peptide after conjugation to the fatty acid possessing antibacterial, antifungal, and/or anticancer activity higher than prior to conjugation. The lipophilic conjugates are suitable for treatment of infections caused by pathogenic organisms such as bacteria and fungi. The lipophilic conjugates are also suitable for sanitation, as disinfectants, or for food preservation.
摘要翻译：本发明提供了亲脂性缀合物，其包含与脂肪酸偶联的肽，所述肽包含至少两个带正电荷的氨基酸残基，所述肽与缀合之后具有比缀合之前更高的抗细菌，抗真菌和/或抗癌活性的脂肪酸缀合。亲脂性缀合物适用于治疗由病原体如细菌和真菌引起的感染。亲脂性缀合物也适用于卫生，消毒剂或食品保鲜。

9. 发明申请

WO2005060350A8 DIASTEREOMERIC PEPTIDES USEFUL AS INHIBITORS OF MEMBRANE PROTEIN ASSEMBLY 审中-公开
标题翻译：可用作膜蛋白组装抑制剂的地那吡那多肽
公开(公告)号：WO2005060350A8
公开(公告)日：2005-09-01
申请号：PCT/IL2004001157
申请日：2004-12-22
申请人： YEDA RES & DEV , SHAI YECHIEL
发明人： SHAI YECHIEL
IPC分类号： A61K38/00 , C07K14/16 , C07K14/195
CPC分类号： C07K14/195 , A61K38/00 , C07K14/005 , C12N2740/16122
摘要： The present invention relates to membrane binding diastereomeric peptides comprising amino acid sequences corresponding to a fragment of a transmembrane proteins, wherein at least two amino acid residues of the diastereomeric peptides being in a D-isomer configuration. The diastereomeric peptides are useful in inhibiting fusion membrane protein events, including specifically viral replication and transmission.
摘要翻译：本发明涉及包含对应于跨膜蛋白片段的氨基酸序列的膜结合非对映异构肽，其中非对映异构肽的至少两个氨基酸残基为D-异构体构型。非对映异构肽可用于抑制融合膜蛋白质事件，包括特异性病毒复制和传播。

10. 发明申请

WO9731019A2 ANTIPATHOGENIC PEPTIDES AND COMPOSITIONS COMPRISING THEM 审中-公开
标题翻译：抗病毒肽及其组合物
公开(公告)号：WO9731019A2
公开(公告)日：1997-08-28
申请号：PCT/IL9700066
申请日：1997-02-20
申请人： YEDA RES & DEV , SHAI YECHIEL , OREN ZIV
发明人： SHAI YECHIEL , OREN ZIV
IPC分类号： A61K38/00 , A61K31/00 , A61K38/04 , A61K38/17 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , C07K20060101 , C07K14/00 , C07K14/435 , C07K14/46
CPC分类号： C07K14/461 , A61K38/00 , C07K14/001 , C07K14/43572
摘要： Peptides which have a net positive charge and none or only a partial alpha -helix configuration were found to have a non-hemolytic selective cytolytic activity. The peptides may be derived from natural peptides such as pardaxin and mellitin and fragments thereof in which L-amino acid residues are replaced by corresponding D-amino acid residues, and cyclic derivatives of the foregoing, or are diastereomers of linear peptides composed of varying ratios of at least one positively charged amino acid and at least one hydrophobic amino acid, and in which at least one of the amino acid residues is a D-amino acid, and preferably at least one third of the sequence is composed of D-amino acid residues. Pharmaceutical compositions comprising the non-hemolytic cytolytic peptides can be used for the treatment of several diseases caused by pathogens including antibacterial, fungal, viral, mycoplasma and protozoan infections and for the treatment of cancer.
摘要翻译：发现具有净正电荷且没有或仅部分α-螺旋构型的肽具有非溶血性选择性溶细胞活性。肽可以衍生自其中L-氨基酸残基被相应的D-氨基酸残基替代的天然肽，例如泛珠蛋白和麦角蛋白及其片段，以及前述的环状衍生物，或者是由不同比例组成的线性肽的非对映异构体的至少一个带正电荷的氨基酸和至少一个疏水性氨基酸，并且其中至少一个氨基酸残基是D-氨基酸，并且优选该序列的至少三分之一由D-氨基酸组成残留物。包含非溶血性溶细胞肽的药物组合物可用于治疗由包括抗菌，真菌，病毒，支原体和原生动物感染在内的病原体引起的几种疾病和用于治疗癌症。

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