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1. 发明申请

WO2008095141A3 REDIRECTED, GENETICALLY-ENGINEERED T REGULATORY CELLS AND THEIR USE IN SUPPRESSION OF AUTOIMMUNE AND INFLAMMATORY DISEASE 审中-公开
标题翻译：重组遗传工程T调节细胞及其在抑制自身免疫和炎症疾病中的应用
公开(公告)号：WO2008095141A3
公开(公告)日：2008-12-11
申请号：PCT/US2008052724
申请日：2008-01-31
申请人： YEDA RES & DEV , GERAGHTY ERIN , ESHHAR ZELIG , ELINAV ERAN
发明人： ESHHAR ZELIG , ELINAV ERAN
IPC分类号： A61K39/00 , C12N5/0783
CPC分类号： C12N5/0636 , A61K39/0008 , A61K39/0011
摘要： A redirected Treg cell is endowed with specificity toward a selected target antigen or ligand. The cell contains a chimeric receptor polypeptide that is expressed in a single, continuous chain, with an extracellular recognition region displayed on the surface of the cell, a transmembrane region and an intracellular signaling region. The extracellular recognition region is specific for the selected target antigen or ligand. The intracellular signaling region includes a combination of T-cell signaling polypeptide moieties, which combination, upon binding of the extracellular recognition region to the selected target antigen or ligand, triggers activation of the redirected Treg cells to cause suppression of T-cell mediated immunity. Such redirected Treg cells may be used to suppress undesired activity of T effector cells thereby mediating an immune or inflammatory response. They are particularly useful in treating T effector cell-mediated diseases, such as inflammatory bowel disease, transplant rejection and GVH disease.
摘要翻译：重定向的Treg细胞赋予针对选择的靶抗原或配体的特异性。细胞含有在单个连续链中表达的嵌合受体多肽，细胞表面上展示细胞外识别区域，跨膜区域和细胞内信号传导区域。细胞外识别区域对选择的靶抗原或配体是特异性的。细胞内信号传导区域包括T细胞信号传导多肽部分的组合，当细胞外识别区域与选择的靶标抗原或配体结合时，该组合引发重定向的Treg细胞的活化，从而抑制T细胞介导的免疫。这种重定向的Treg细胞可用于抑制T效应细胞的不需要的活性，从而介导免疫或炎症反应。它们特别适用于治疗T效应细胞介导的疾病，如炎症性肠病，移植排斥和GVH疾病。

2. 发明申请

WO2011132189A3 HIGH AFFINITY LEPTINS AND LEPTIN ANTAGONISTS 审中-公开
标题翻译：高亲和力的瘦素和瘦素拮抗剂
公开(公告)号：WO2011132189A3
公开(公告)日：2011-12-22
申请号：PCT/IL2011000322
申请日：2011-04-17
申请人： YISSUM RES DEV CO , MEDICAL RES INFRASTRUCTURE & HEALTH SERVICES FUND TEL AVIV MEDICAL CT , GERTLER ARIEH , ELINAV ERAN , HALPERN ZAMIR
发明人： GERTLER ARIEH , ELINAV ERAN , HALPERN ZAMIR
IPC分类号： A61K38/16 , A61K38/22
CPC分类号： C07K14/5759 , A01K2217/00 , A61K31/05 , A61K31/575 , A61K38/22 , A61K38/2264 , A61K38/28 , A61K45/06 , A61K47/60 , A61K49/0008 , A61K2300/00
摘要： Leptin muteins, in particular leptin antagonists, with increased binding affinity to leptin receptor are provided. These compounds as well as pharmaceutical composition comprising them are useful for the treatment of any disorder in which a non-desirable or deleterious activity of endogenous leptin or an altered innate immune response is implicated.
摘要翻译：提供瘦素突变蛋白，特别是瘦素拮抗剂，其对瘦素受体具有增加的结合亲和力。这些化合物以及包含它们的药物组合物可用于治疗其中涉及内源性瘦素或改变的先天性免疫反应的非期望或有害活性的任何病症。

4. 发明专利

IL156628A Use of nk t cells in the preparation of a therapeutic composition, compositions comprising said nk t cells and their use in the treatment of immune-related disorders 未知
公开(公告)号：IL156628A
公开(公告)日：2013-08-29
申请号：IL15662803
申请日：2003-06-24
申请人： ENZO THERAPEUTICS INC , ILAN YARON , MARGALIT MAYA , ELINAV ERAN , HADASIT MED RES SERVICE
发明人： ILAN YARON , MARGALIT MAYA , ELINAV ERAN
IPC分类号： A61K35/14 , A61K35/17 , A61K38/19 , A61K39/00 , A61P20060101 , C12N5/0783
摘要： The present invention relates to a method for the treatment of immune-related disorders in a mammalian subject in need of such treatment. This method comprises the step of manipulating the NK T cell population in said subject by suitable means, said manipulation of the NK T cell population resulting in modulation of the Th1/Th2 balance toward anti-inflammatory cytokine producing cells. Manipulation of the NK T cell population may be performed either by depletion of said cells by a suitable means or alternatively by ex vivo education of the NK T cells, such that the educated NK T cells have the capability to modulate the Th1/Th2 balance toward anti-inflammatory cytokine producing cells. The invention further relates to pharmaceutical compositions for the treatment of immune-related disorders in a mammalian subject. These compositions comprising as an effective ingredient an ex vivo educated NK T cell. The invention further provides for an ex vivo educated NK T cell and uses thereof in the treatment of immune-related disorders.

5. 发明专利

IL201889A Therapeutic compositions for the treatment of immune related disorders comprising antibodies that specifically recognize the nk 1.1 antigen or the cd56 antigen expressed by nk t cells 未知
公开(公告)号：IL201889A
公开(公告)日：2014-12-31
申请号：IL20188909
申请日：2009-11-02
申请人： ENZO THERAPEUTICS INC , ILAN YARON , MARGALIT MAYA , ELINAV ERAN , HADASIT MED RES SERVICE
发明人： ILAN YARON , MARGALIT MAYA , ELINAV ERAN
IPC分类号： A61K35/14 , A61K35/17 , A61K38/19 , A61K39/00 , C12N5/0783
摘要： The present invention relates to a method for the treatment of immune-related disorders in a mammalian subject in need of such treatment. This method comprises the step of manipulating the NK T cell population in said subject by suitable means, said manipulation of the NK T cell population resulting in modulation of the Th1/Th2 balance toward anti-inflammatory cytokine producing cells. Manipulation of the NK T cell population may be performed either by depletion of said cells by a suitable means or alternatively by ex vivo education of the NK T cells, such that the educated NK T cells have the capability to modulate the Th1/Th2 balance toward anti-inflammatory cytokine producing cells. The invention further relates to pharmaceutical compositions for the treatment of immune-related disorders in a mammalian subject. These compositions comprising as an effective ingredient an ex vivo educated NK T cell. The invention further provides for an ex vivo educated NK T cell and uses thereof in the treatment of immune-related disorders.

6. 发明申请

WO2016079731A3 METHOD OF ANALYZING MICROBIOME 审中-公开
标题翻译：分析微生物的方法
公开(公告)号：WO2016079731A3
公开(公告)日：2016-09-15
申请号：PCT/IL2015051102
申请日：2015-11-17
申请人： YEDA RES & DEV
发明人： SEGAL ERAN , ELINAV ERAN
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/68
CPC分类号： C12Q1/689 , C12Q1/04 , C12Q1/10 , G01N2333/245 , G01N2800/042 , G01N2800/044 , G01N2800/065
摘要： A method of assessing the growth dynamics of a bacterium in a microbiome is disclosed.
摘要翻译：公开了一种评估微生物组中细菌生长动态的方法。

7. 发明申请

WO2015166489A9 METHOD AND APPARATUS FOR PREDICTING RESPONSE TO FOOD 审中-公开
标题翻译：用于预测食物反应的方法和装置
公开(公告)号：WO2015166489A9
公开(公告)日：2016-01-28
申请号：PCT/IL2015050439
申请日：2015-04-28
申请人： YEDA RES & DEV
发明人： SEGAL ERAN , ELINAV ERAN
IPC分类号： G06F19/00
CPC分类号： G06F19/345 , G06F19/3475 , G06N99/005 , G16H50/20 , G16H50/70 , Y02A90/26
摘要： Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.
摘要翻译：公开了预测受试者对食物的反应的方法。该方法包括：选择对象的反应未知的食物; 访问具有描述所述对象的数据的第一数据库，而不是所述对象对所选食物的响应; 访问具有与其他受试者对食物有关的数据的第二数据库，其他受试者的反应包括至少一个其他受试者对所选择的食物的反应或类似于所述选择的食物的食物; 以及基于所选择的食物分析数据库以估计受试者对所选食物的反应。

8. 发明申请

WO2015166492A2 MICROBIOME RESPONSE TO AGENTS 审中-公开
标题翻译：微生物对药剂的反应
公开(公告)号：WO2015166492A2
公开(公告)日：2015-11-05
申请号：PCT/IL2015050442
申请日：2015-04-28
申请人： YEDA RES & DEV
发明人： ELINAV ERAN , SEGAL ERAN
IPC分类号： C12Q1/02 , A61B5/00 , A61K35/66 , A61K35/741 , C12Q1/04 , C12Q1/68 , G01N33/68
CPC分类号： A61K35/741 , A61B5/411 , A61K35/66 , C12Q1/025 , C12Q1/04 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/68 , G01N2570/00
摘要： A method of determining tolerance to an agent in a healthy subject is disclosed. The method comprises: (a) determining a signature of a microbiome in a sample of the healthy subject who has been subjected to the agent or condition; and (b) comparing the signature of the microbiome of the healthy subject to at least one reference signature of a pathological microbiome, wherein when the signature of the microbiome of the healthy subject is statistically significantly similar to the reference signature of the pathological microbiome, it is indicative that the healthy subject is intolerant to the agent.
摘要翻译：公开了一种确定健康受试者对药剂的耐受性的方法。该方法包括：（a）确定已经受试剂或病症的健康受试者的样品中的微生物组的签名; 和（b）将健康受试者的微生物组的标记与病理微生物组的至少一个参考标记进行比较，其中当健康受试者的微生物组的标记与病理微生物组的参考标记在统计学上显着相似时，表明健康受试者对代理人不耐受。

9. 发明申请

WO2015166489A2 METHOD AND APPARATUS FOR PREDICTING RESPONSE TO FOOD 审中-公开
标题翻译：用于预测食物反应的方法和装置
公开(公告)号：WO2015166489A2
公开(公告)日：2015-11-05
申请号：PCT/IL2015050439
申请日：2015-04-28
申请人： YEDA RES & DEV
发明人： SEGAL ERAN , ELINAV ERAN
IPC分类号： G06F19/00
CPC分类号： G06F19/345 , G06F19/3475 , G06N99/005 , G16H50/20 , G16H50/70 , Y02A90/26
摘要： Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.
摘要翻译：公开了预测受试者对食物的反应的方法。该方法包括：选择对象的反应未知的食物; 访问具有描述所述对象的数据的第一数据库，而不是所述对象对所选食物的响应; 访问具有与其他受试者对食物有关的数据的第二数据库，其他对象的反应包括至少一个其他受试者对所选食物的反应或类似于所述选择的食物的食物; 以及基于所选择的食物分析数据库以估计受试者对所选食物的反应。

10. 发明专利

HK1245172A1 促進健康的細菌種群未知
公开(公告)号：HK1245172A1
公开(公告)日：2018-08-24
申请号：HK18104545
申请日：2018-04-06
申请人： YEDA RES & DEV
发明人： SEGAL ERAN , ELINAV ERAN
IPC分类号： A61P20060101 , A61K20060101

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