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1. 发明申请

WO0240529A3 DIASTEREOMERIC PEPTIDES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开
标题翻译：二甲酯类和包含它们的药物组合物
公开(公告)号：WO0240529A3
公开(公告)日：2003-03-20
申请号：PCT/IL0101036
申请日：2001-11-07
申请人： YEDA RES & DEV , SHAI YECHIEL , OREN ZIV , SHAHAR MICHAL , EYAL NURIT
发明人： SHAI YECHIEL , OREN ZIV , SHAHAR MICHAL , EYAL NURIT
IPC分类号： A23L1/305 , A23L3/3526 , A61K38/00 , A61P17/00 , A61P31/04 , A61P35/00 , C07K7/08 , C07K14/435 , A61K38/10
CPC分类号： C07K7/08 , A23L3/3526 , A23L33/18 , A61K38/00
摘要： The invention provides diastereomeric peptides with a net positive charge greater than +1, and cyclic analogues thereof, having at least 15 amino acid residues, wherein said residues are selected from: (i) leucine and lysine; (ii) leucine, lysine and arginine; (iii) glycine, serine, spargine, threonine, or glutamine optionally present at the N-terminus; (iv) and/or lysine, arginine, glycine, or serine optionally present at the C-terminus. The diastereomeric peptides are suitable for treatment of cancer and for treatment, particularly topical treatment, of infections caused by pathogenic organisms such as bacteria and fungi. In addition, they may be used for controlling mycoplasma infection in cell cultures and for food preservation, as food supplements and as alternative to antibiotics for animal nutrition.
摘要翻译：本发明提供具有大于+1的净正电荷的非对映多肽及其具有至少15个氨基酸残基的其环状类似物，其中所述残基选自：（i）亮氨酸和赖氨酸; （ii）亮氨酸，赖氨酸和精氨酸; （iii）N-末端任选存在的甘氨酸，丝氨酸，神经氨酸，苏氨酸或谷氨酰胺; （iv）和/或任选存在于C末端的赖氨酸，精氨酸，甘氨酸或丝氨酸。非对映体肽适用于治疗由病原体如细菌和真菌引起的感染的癌症和治疗，特别是局部治疗。此外，它们可用于控制细胞培养物中的支原体感染和食品保藏，作为食品补充剂和用于动物营养的抗生素的替代物。

2. 发明专利

IL155910A DIASTEREOMERIC PEPTIDES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 未知
公开(公告)号：IL155910A
公开(公告)日：2006-10-31
申请号：IL15591003
申请日：2003-05-14
申请人： YEDA RES & DEV , EYAL NURIT , SHAI YECHIEL , OREN ZIV , SHAHAR MICHAL
发明人： EYAL NURIT , SHAI YECHIEL , OREN ZIV , SHAHAR MICHAL
IPC分类号： A23L1/305 , A23L3/3526 , A61K38/00 , A61P17/00 , A61P31/04 , A61P35/00 , C07K7/08
摘要： The invention provides diastereomeric peptides with a net positive charge greater than +1, and cyclic analogues thereof, having at least 15 amino acid residues, wherein said residues are selected from: (i) leucine and lysine;, (ii) leucine, lysine and arginine; (iii) glycine, serine, spargine, threonine, or glutamine optionally present at the N-terminus; (iv) and/or lysine, arginine, glycine, or serine optionally present at the C-terminus. The diastereomeric peptides are suitable for treatment of cancer and for treatment, particularly topical treatment, of infections caused by pathogenic organisms such as bacteria and fungi. In addition, they may be used for controlling, mycoplasma infection in cell cultures and for food preservation as food supplements and as alternative to antibiotics for animal nutrition.

3. 发明申请

WO9731019A2 ANTIPATHOGENIC PEPTIDES AND COMPOSITIONS COMPRISING THEM 审中-公开
标题翻译：抗病毒肽及其组合物
公开(公告)号：WO9731019A2
公开(公告)日：1997-08-28
申请号：PCT/IL9700066
申请日：1997-02-20
申请人： YEDA RES & DEV , SHAI YECHIEL , OREN ZIV
发明人： SHAI YECHIEL , OREN ZIV
IPC分类号： A61K38/00 , A61K31/00 , A61K38/04 , A61K38/17 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , C07K20060101 , C07K14/00 , C07K14/435 , C07K14/46
CPC分类号： C07K14/461 , A61K38/00 , C07K14/001 , C07K14/43572
摘要： Peptides which have a net positive charge and none or only a partial alpha -helix configuration were found to have a non-hemolytic selective cytolytic activity. The peptides may be derived from natural peptides such as pardaxin and mellitin and fragments thereof in which L-amino acid residues are replaced by corresponding D-amino acid residues, and cyclic derivatives of the foregoing, or are diastereomers of linear peptides composed of varying ratios of at least one positively charged amino acid and at least one hydrophobic amino acid, and in which at least one of the amino acid residues is a D-amino acid, and preferably at least one third of the sequence is composed of D-amino acid residues. Pharmaceutical compositions comprising the non-hemolytic cytolytic peptides can be used for the treatment of several diseases caused by pathogens including antibacterial, fungal, viral, mycoplasma and protozoan infections and for the treatment of cancer.
摘要翻译：发现具有净正电荷且没有或仅部分α-螺旋构型的肽具有非溶血性选择性溶细胞活性。肽可以衍生自其中L-氨基酸残基被相应的D-氨基酸残基替代的天然肽，例如泛珠蛋白和麦角蛋白及其片段，以及前述的环状衍生物，或者是由不同比例组成的线性肽的非对映异构体的至少一个带正电荷的氨基酸和至少一个疏水性氨基酸，并且其中至少一个氨基酸残基是D-氨基酸，并且优选该序列的至少三分之一由D-氨基酸组成残留物。包含非溶血性溶细胞肽的药物组合物可用于治疗由包括抗菌，真菌，病毒，支原体和原生动物感染在内的病原体引起的几种疾病和用于治疗癌症。

6. 发明专利

AU730069B2 Antipathogenic peptides and compositions comprising them 未知
公开(公告)号：AU730069B2
公开(公告)日：2001-02-22
申请号：AU1731997
申请日：1997-02-20
申请人： YEDA RES & DEV
发明人： SHAI YECHIEL , OREN ZIV
IPC分类号： A61K38/00 , A61K31/00 , A61K38/04 , A61K38/17 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , C07K20060101 , C07K14/00 , C07K14/435 , C07K14/46
摘要： Peptides which have a net positive charge and none or only a partial a-helix configuration were found to have a non-hemolytic selective cytolytic activity. The peptides may be derived from natural peptides such as pardaxin and mellitin and fragments thereof in which L-amino acid residues are replaced by corresponding D-amino acid residues, and cyclic derivatives of the foregoing, or are diastereomers of linear peptides composed of varying ratios of at least one positively charged amino acid and at least one hydrophobic amino acid, and in which at least one of the amino acid residues is a D-amino acid, and preferably at least one third of the sequence is composed of D-amino acid residues. Pharmaceutical compositions comprising the non-hemolytic cytolytic peptides can be used for the treatment of several diseases caused by pathogens including antibacterial, fungal, viral, mycoplasma and protozoan infections and for the treatment of cancer.

7. 发明专利

CZ264398A3 ANTIPATHOGENIC PEPTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH PEPTIDES 未知
公开(公告)号：CZ264398A3
公开(公告)日：1999-01-13
申请号：CZ264398
申请日：1997-02-20
申请人： YEDA RES & DEV
发明人： SHAI YECHIEL , OREN ZIV
IPC分类号： A61K38/00 , A61K31/00 , A61K38/04 , A61K38/17 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , C07K20060101 , C07K14/00 , C07K14/435 , C07K14/46
摘要： Peptides which have a net positive charge and none or only a partial a-helix configuration were found to have a non-hemolytic selective cytolytic activity. The peptides may be derived from natural peptides such as pardaxin and mellitin and fragments thereof in which L-amino acid residues are replaced by corresponding D-amino acid residues, and cyclic derivatives of the foregoing, or are diastereomers of linear peptides composed of varying ratios of at least one positively charged amino acid and at least one hydrophobic amino acid, and in which at least one of the amino acid residues is a D-amino acid, and preferably at least one third of the sequence is composed of D-amino acid residues. Pharmaceutical compositions comprising the non-hemolytic cytolytic peptides can be used for the treatment of several diseases caused by pathogens including antibacterial, fungal, viral, mycoplasma and protozoan infections and for the treatment of cancer.

8. 发明专利

CA2281204A1 ANTIPATHOGENIC SYNTHETIC PEPTIDES AND COMPOSITIONS COMPRISING THEM 未知
公开(公告)号：CA2281204A1
公开(公告)日：1998-08-27
申请号：CA2281204
申请日：1998-02-19
申请人： YEDA RES & DEV
发明人： OREN ZIV , SHAI YECHIEL
IPC分类号： A61K38/00 , A61K20060101 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , C07K7/52 , C07K14/00 , C07K14/435 , C07K14/46 , C07K14/47 , A61K38/04 , A61K38/16
摘要： Non-hemolytic cytolytic agents selected from peptides, complexes of bundled peptides, mixtures of peptides or random peptide copolymers have a selective cytolytic activity manifested in that they have a cytolytic activity on pathogenic cells, being cells which are non-naturally occurring within the body consisting of microbial pathogenic organisms and malignant cells; and are non-hemolytic, having no cytolytic effect on red blood cells. The peptides may be cyclic derivatives of natural peptides such as pardaxin and mellitin and fragments thereof in which L-amino acid residues are replaced by corresponding D-amino acid residues, or are diastereomers of linear peptides composed of varying ratios of at least one positively charged amino acid and at least one hydrophobic amino acid, and in which at least one of the amino acid residues is a D-amino acid. Pharmaceutical compositions comprising the non-hemolytic cytolytic agents can be used for the treatment of several diseases caused by pathogens including antibacterial, fungal, viral, mycoplasma and protozoan infections and for the treatment of cancer.

9. 发明专利

DE60125809D1 未知
公开(公告)号：DE60125809D1
公开(公告)日：2007-02-15
申请号：DE60125809
申请日：2001-11-07
申请人： YEDA RES & DEV
发明人： SHAI YECHIEL , OREN ZIV , SHAHAR MICHAL , EYAL NURIT
IPC分类号： C07K14/435 , A23L1/305 , A23L3/3526 , A61K38/00 , A61K38/10 , A61P17/00 , A61P31/04 , A61P35/00 , C07K7/08
摘要： The invention provides diastereomeric peptides with a net positive charge greater than +1, and cyclic analogues thereof, having at least 15 amino acid residues, wherein said residues are selected from: (i) leucine and lysine;, (ii) leucine, lysine and arginine; (iii) glycine, serine, spargine, threonine, or glutamine optionally present at the N-terminus; (iv) and/or lysine, arginine, glycine, or serine optionally present at the C-terminus. The diastereomeric peptides are suitable for treatment of cancer and for treatment, particularly topical treatment, of infections caused by pathogenic organisms such as bacteria and fungi. In addition, they may be used for controlling, mycoplasma infection in cell cultures and for food preservation as food supplements and as alternative to antibiotics for animal nutrition.

10. 发明专利

CZ9802643A3 ANTIPATHOGENIC PEPTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH PEPTIDES 未知
公开(公告)号：CZ9802643A3
公开(公告)日：1999-01-13
申请号：CZ264398
申请日：1997-02-20
申请人： YEDA RES & DEV
发明人： SHAI YECHIEL , OREN ZIV
IPC分类号： A61K38/00 , A61K31/00 , A61K38/04 , A61K38/17 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , C07K20060101 , C07K14/00 , C07K14/435 , C07K14/46
CPC分类号： C07K14/461 , A61K38/00 , C07K14/001 , C07K14/43572

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