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1. 发明申请

WO2005035729A2 A GENETIC SCREEN IN DROSOPHILA FOR METASTATIC BEHAVIOR 审中-公开
标题翻译：嗜人按蚊遗传学筛选转移行为的遗传学筛选
公开(公告)号：WO2005035729A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/033310
申请日：2004-10-07
申请人： YALE UNIVERSITY , XU, Tian , PAGLIARINI, Raymond , IGAKI, Tatsushi
发明人： XU, Tian , PAGLIARINI, Raymond , IGAKI, Tatsushi
IPC分类号： C12N
CPC分类号： A01K67/0339 , A01K67/0271 , A01K2217/075 , A01K2227/706 , A01K2267/0331 , C07K14/4702 , C07K14/82 , C12N9/1205 , C12N15/8509 , C12N2800/30
摘要： The disclosure provides, among other things, assays for identifying compounds and genes that affect metastatic behavior of cells.
摘要翻译：本公开内容提供了用于鉴定影响细胞转移行为的化合物和基因的测定法等。

2. 发明申请

WO2012078405A2 METHODS AND COMPOSITIONS FOR REGULATING GASTRIC EMPTYING 审中-公开
标题翻译：调节气体排放的方法和组合物
公开(公告)号：WO2012078405A2
公开(公告)日：2012-06-14
申请号：PCT/US2011/062373
申请日：2011-11-29
申请人： YALE UNIVERSITY , XU, Tian , NGUYEN, Duc , REN, Jing , LIU, Yan
发明人： XU, Tian , NGUYEN, Duc , REN, Jing , LIU, Yan
IPC分类号： A61K31/7024
CPC分类号： A61K31/7024
摘要： The present invention relates to compositions and methods useful for regulating gastric emptying by affecting contraction of the gastric pump. The present invention also relates to compositions and methods useful for restraining energy intake by inducing and/or increasing gastric emptying. Therefore, the present invention provides insight into the mechanisms that regulate gastric emptying and presents a platform for treating a subject having a disease or disorder that cam be alleviated, at least in part, by regulation of gastric emptying.
摘要翻译：本发明涉及通过影响胃泵的收缩来调节胃排空的组合物和方法。本发明还涉及通过诱导和/或增加胃排空来抑制能量摄入的组合物和方法。因此，本发明提供了对调节胃排空的机制的了解，并提供了至少部分通过调节胃排空来治疗具有减轻疾病或障碍的受试者的平台。

3. 发明申请

WO2020172266A1 TOPICAL RAPAMYCIN FORMULATIONS AND THEIR USE IN TREATING FACIAL ANGIOFIBROMAS AND OTHER SKIN DISORDERS 审中-公开
公开(公告)号：WO2020172266A1
公开(公告)日：2020-08-27
申请号：PCT/US2020/018816
申请日：2020-02-19
申请人： AI THERAPEUTICS, INC. , XU, Tian
发明人： XU, Tian , LICHENSTEIN, Henri , ROTHBERG, Jonathan M. , GROTZKE, Jeff , BECKETT, Paul , FANDRICK, Keith
IPC分类号： A61K9/06 , A61K47/32 , A61K47/38 , A61P17/02 , A61K31/436 , A61P17/00
摘要： The present disclosure provides gel compositions of rapamycin for topical administration and related compositions and methods including their use in the treatment of a skin condition, disease or disorder.

4. 发明申请

WO2006122442A1 PIGGYBAC AS A TOOL FOR GENETIC MANIPULATION AND ANALYSIS IN VERTEBRATES 审中-公开
标题翻译： PIGGYBAC作为一种工具用于在VERTEBRATES进行遗传操作和分析
公开(公告)号：WO2006122442A1
公开(公告)日：2006-11-23
申请号：PCT/CN2005/000674
申请日：2005-05-14
申请人： FUDAN UNIVERSITY , XU, Tian , HAN, Min , ZHUANG, Yuan , WU, Xiaohui , DING, Sheng , LI, Gang
发明人： XU, Tian , HAN, Min , ZHUANG, Yuan , WU, Xiaohui , DING, Sheng , LI, Gang
IPC分类号： C12N9/22 , C12N15/85 , C12N5/16 , C12N5/22 , C12N15/09 , C12N15/86
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/8509 , C12N2800/90
摘要： The present invention relates to transgenic vertebrate, including mammalian, cells, whose genomes comprise one or more elements of the piggyBac family transposon system. Transgenic non-human vertebrates, including transgenic non-human mammals, whose genomes comprise one or more elements of the piggyBac family transposon system, are also provided. Methods of making and using the cells and animals of the invention, including applications in the medical, veterinary, and agricultural fields, are additionally provided. The present invention also relates to kits useful for practicing such methods.
摘要翻译：本发明涉及转基因脊椎动物，包括哺乳动物细胞，其基因组包含piggyBac家族转座子系统的一个或多个元件。还提供了转基因非人脊椎动物，包括转基因非人哺乳动物，其基因组包含piggyBac家族转座子系统的一个或多个元件。另外提供了制造和使用本发明的细胞和动物的方法，包括在医疗，兽医和农业领域中的应用。本发明还涉及可用于实施这些方法的试剂盒。

5. 发明申请

WO1995019779A1 DELTEX PROTEINS, NUCLEIC ACIDS, AND ANTIBODIES, AND RELATED METHODS AND COMPOSITIONS 审中-公开
标题翻译： DELTEX蛋白，核酸和抗体及相关方法和组合物
公开(公告)号：WO1995019779A1
公开(公告)日：1995-07-27
申请号：PCT/US1995000825
申请日：1995-01-20
申请人： YALE UNIVERSITY
发明人： YALE UNIVERSITY , ARTAVANIS-TSAKONAS, Spyridon , BUSSEAU, Isabelle , DIEDERICH, Robert, J. , XU, Tian , MATSUNO, Kenji
IPC分类号： A61K35/12
CPC分类号： C07H21/00 , A61K38/00 , C07K14/435 , C07K14/47 , C07K16/18 , C07K2319/00
摘要： The present invention relates to nucleotide sequences of deltex genes, and amino acid sequences of the encoded deltex proteins. The invention further relates to fragments and other derivatives, and analogs, of deltex proteins, as well as antibodies thereto. Nucleic acids encoding such fragments or derivatives are also within the scope of the invention. Production of the foregoing proteins and derivatives, e.g., by recombinant methods, is provided. In a specific embodiment, the invention relates to Drosophila deltex nucleic acids and proteins. In another embodiment, the invention relates to human deltex nucleic acids and proteins. In specific embodiments, the invention relates to deltex protein derivatives and analogs of the invention which are functionally active, or which comprise one or more domains of a deltex protein, including but not limited to the Glu-rich clusters, SH3 binding domains, domains which mediate binding to Notch or to a Notch derivative containing Notch cdc10/SW16/ankyrin ("ANK") repeats, domains which mediate binding to a second deltex protein, or any combination of the foregoing. The present invention also relates to therapeutic and diagnostic methods and compositions based on deltex proteins, nucleic acids, and antibodies.
摘要翻译：本发明涉及deltex基因的核苷酸序列和编码的deltex蛋白的氨基酸序列。本发明还涉及脱落蛋白的片段和其它衍生物和类似物，以及其抗体。编码这种片段或衍生物的核酸也在本发明的范围内。提供了上述蛋白质和衍生物的生产，例如通过重组方法。在具体实施方案中，本发明涉及果蝇脱粒酶核酸和蛋白质。在另一个实施方案中，本发明涉及人类脱屑酶核酸和蛋白质。在具体实施方案中，本发明涉及在功能上有活性或包含一个或多个deltex蛋白结构域的本发明的脱胶蛋白衍生物和类似物，包括但不限于富含Glu的簇，SH3结合结构域，介导与Notch或含有Notch cdc10 / SW16 / ankyrin（“ANK”）的Notch衍生物的结合重复，介导与第二脱胶蛋白结合的结构域或前述的任何组合。本发明还涉及基于脱胶蛋白，核酸和抗体的治疗和诊断方法和组合物。

6. 发明申请

WO2015073990A1 COMPOSITIONS AND METHODS OF USING TRANSPOSONS 审中-公开
标题翻译：组合物和使用传染媒介的方法
公开(公告)号：WO2015073990A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/065997
申请日：2014-11-17
申请人： YALE UNIVERSITY
发明人： XU, Tian , QIAN, Feng , LANDRETTE, Sean
IPC分类号： C12N5/10
CPC分类号： C12Q1/6886 , A61K45/06 , C12N5/0693 , C12N2501/724 , C12N2510/00 , C12Q2600/156 , C12Q2600/158
摘要： The present invention provides compositions and methods of using transposons. In one aspect, methods are disclosed that are useful for identifying negatively selected genes in an insertional mutagenesis screen. In another aspect, compositions for reducing proliferation of a tumor cell expressing an oncogenic RAS include an activator of a WNT pathway. Pharmaceutical compositions for reducing proliferation of tumor cells in a subject in need thereof by administering an effective amount of an activator of a WNT pathway to the tumor cells of the subject are also disclosed.
摘要翻译：本发明提供了使用转座子的组合物和方法。在一个方面，公开了可用于在插入诱变筛选中鉴定负选择的基因的方法。另一方面，用于降低表达致癌RAS的肿瘤细胞增殖的组合物包括WNT途径的活化剂。还公开了通过向受试者的肿瘤细胞施用有效量的WNT途径的活化剂来减少有需要的受试者中肿瘤细胞增殖的药物组合物。

7. 发明公开

EP3071689A1 COMPOSITIONS AND METHODS OF USING TRANSPOSONS 审中-公开
标题翻译：组合物和方法中应用的转座子
公开(公告)号：EP3071689A1
公开(公告)日：2016-09-28
申请号：EP14861901.8
申请日：2014-11-17
申请人： Yale University
发明人： XU, Tian , QIAN, Feng , LANDRETTE, Sean
IPC分类号： C12N5/10
CPC分类号： C12Q1/6886 , A61K45/06 , C12N5/0693 , C12N2501/724 , C12N2510/00 , C12Q2600/156 , C12Q2600/158
摘要： The present invention provides compositions and methods of using transposons. In one aspect, methods are disclosed that are useful for identifying negatively selected genes in an insertional mutagenesis screen. In another aspect, compositions for reducing proliferation of a tumor cell expressing an oncogenic RAS include an activator of a WNT pathway. Pharmaceutical compositions for reducing proliferation of tumor cells in a subject in need thereof by administering an effective amount of an activator of a WNT pathway to the tumor cells of the subject are also disclosed.

8. 发明申请

WO1998008933A1 KUZ, A NOVEL FAMILY OF METALLOPROTEASES 审中-公开
标题翻译： KUZ，一个新的金属家族
公开(公告)号：WO1998008933A1
公开(公告)日：1998-03-05
申请号：PCT/US1997015099
申请日：1997-08-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , YALE UNIVERSITY
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , YALE UNIVERSITY , RUBIN, Gerald, M. , PAN, Duojia , ROOKE, Jenny , YAVARI, Reza , XU, Tian
IPC分类号： C12N01/20
CPC分类号： C12N9/6489 , C12N9/6402 , C12Q1/37 , G01N33/573
摘要： Members of a novel family of polypeptides, the KUZ family, are metalloproteases involved in neuronal partitioning and neuronal development. The invenetion provides KUZ polypeptides, antibodies that bind the KUZ polypeptides, KUZ encoding nucleic acids, methods for identifying cells expressing the KUZ polypeptides, methods of identifying ligands that bind to the subject proteins and methods of blocking KUZ polypeptide/ligand interactions.
摘要翻译：新型多肽家族（KUZ家族）的成员是参与神经元分化和神经元发育的金属蛋白酶。本发明提供了KUZ多肽，结合KUZ多肽的抗体，编码KUZ核酸的方法，用于鉴定表达KUZ多肽的细胞的方法，鉴定与受试蛋白结合的配体的方法和阻断KUZ多肽/配体相互作用的方法。

9. 发明公开

EP1105160A1 LATS KNOCK-OUT ANIMAL MODELS AND THEIR USES 审中-公开
标题翻译： LATS-“敲除”动物模型和它们的用途
公开(公告)号：EP1105160A1
公开(公告)日：2001-06-13
申请号：EP99945126.3
申请日：1999-08-18
申请人： YALE UNIVERSITY
发明人： XU, Tian , TAO, Wufan , ST. JOHN, Maie, A., R. , FEI, Xiaolan , FUKUMOTO, Royd, K. , ZHANG, Sheng , TURENCHALK, Gregory, S. , STEWART, Rodney, A.
IPC分类号： A61K39/395 , C07H21/04 , A01N61/00 , A01N37/18 , A01N43/04 , C12N5/00 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , A61K38/00 , C07K14/4703
摘要： A recombinant non-human animal having an inactivated lats gene is described. A lats knock-out mouse is exemplified. Because mice disrupted for the lats gene develop a variety of tumors, are susceptible to induction of skin tumors by exposure to carcinogens, and exhibit pituitary dysfunction, they have utility in screening for compounds effective to treat or prevent cancer or pituitary disorders. Compounds can be screened for activity in treating or preventing skin cancer in recombinant non-human animals which have an inactivated and in which skin tumors have been induced by exposure to carcinogens. Methods for treatment of cancers refractory to treatment with chemotherapy or radiation therapy by using a therapeutic that promotes lats function are also described. Additional methods are described for the treatment or prevention of diseases and disorders associated with aberrant levels of cdc2 activity with a therapeutic that either promotes, inhibits or antagonizes lats function.

10. 发明公开

EP0817798A1 NUCLEOTIDE AND PROTEIN SEQUENCES OF LATS GENES AND METHODS BASED THEREON 失效
标题翻译：核苷酸和基因和蛋白序列以事实为依据LATS-PROCESS
公开(公告)号：EP0817798A1
公开(公告)日：1998-01-14
申请号：EP96911423.0
申请日：1996-03-26
申请人： YALE UNIVERSITY
发明人： XU, Tian , TAO, Wufan , WANG, Weiyi , ZHANG, Sheng , YU, Wan
IPC分类号： C07K14 , C12N9 , C12N15 , C12P21 , A61K38 , A61K48
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C07K14/43581 , C07K14/4703 , C07K2319/00 , C12N15/8206 , Y10S435/81 , Y10S435/925
摘要： The present invention relates to a tumor suppressor gene, termed large tumor suppressor (lats), and methods for identifying tumor suppressor genes. The method provides nucleotide sequences of lats genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the lats protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of lats which comprise one or more domains of a lats protein. Antibodies to lats, its derivatives and analogs, are additionally provided. Methods of production of the lats proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. The invention also relates to recombinant plants and animals and methods of increasing the growth of edible plants and animals. In specific examples, isolated lats genes, from Drosophila, mouse, and human, and the sequences thereof, are provided.

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