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    • 5. 发明授权
    • Smart microscope system for radiation biodosimetry
    • US11501545B2
    • 2022-11-15
    • US17137317
    • 2020-12-29
    • Peter Keith RoganYanxin LiJin Liu
    • Peter Keith RoganYanxin LiJin Liu
    • G06V20/69G06T5/50G01T1/02G06T5/00
    • Automation of microscopic pathological diagnosis relies on digital image quality, which, in turn, affects the rates of false positive and negative cellular objects designated as abnormalities. Cytogenetic biodosimetry is a genotoxic assay that detects dicentric chromosomes (DCs) arising from exposure to ionizing radiation. The frequency of DCs is related to radiation dose received, so the inferred radiation dose depends on the accuracy of DC detection. To improve this accuracy, image segmentation methods are used to rank high quality cytogenetic images and eliminate suboptimal metaphase cell data in a sample based on novel quality measures. When sufficient numbers of high quality images are found, the microscope system is directed to terminate metaphase image collection for a sample. The International Atomic Energy Agency recommends at least 500 images be used to estimate radiation dose, however often many more images are collected in order to select the metaphase cells with good morphology for analysis. Improvements in DC recognition increase the accuracy of dose estimates, by reducing false positive (FP) DC detection. A set of chromosome morphology segmentation methods selectively filtered out false DCs, arising primarily from extended prometaphase chromosomes, sister chromatid separation and chromosome fragmentation. This reduced FPs by 55% and was highly specific to the abnormal structures (≥97.7%). Additional procedures were then developed to fully automate image review, resulting in 6 image-level filters that, when combined, selectively remove images with consistently unparsable or incorrectly segmented chromosome morphologies. Overall, these filters can eliminate half of the FPs detected by manual image review. Optimal image selection and FP DCs are minimized by combining multiple feature based segmentation filters and a novel image sorting procedure based on the known distribution of chromosome lengths. Consequently, the average dose estimation error was reduced from 0.4 Gy to
    • 7. 发明授权
    • Phosphate ester compound of hydroxy acid substituted phenol ester, preparation method and medical use thereof
    • 羟基酸取代苯酚酯的磷酸酯化合物,其制备方法和医疗用途
    • US09243009B2
    • 2016-01-26
    • US13702204
    • 2010-10-13
    • Wensheng ZhangJun YangJin Liu
    • Wensheng ZhangJun YangJin Liu
    • C07F9/09
    • C07F9/09C07F9/091
    • Phosphate ester compound of hydroxy acid substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), in which Y═C1-4 straight carbon chain, M1 and/or M2=H, alkali metal ion, protonated amine or protonated amino acid. The compound has good water solubility and high stability in its aqueous solution, and it can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2,6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2,6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis and/or anesthesia.
    • 提供羟基酸取代苯基酯的磷酸酯化合物,其制备方法和医疗用途。 标题化合物如式(I)所示,其中Y = C1-4直碳链,M1和/或M2 = H,碱金属离子,质子化胺或质子化氨基酸。 该化合物在其水溶液中具有良好的水溶性和高稳定性,并且可以在体内酶的作用下快速释放2,6-二异丙基苯酚,其具有镇静,催眠和/或麻醉的作用。 通过保护式(I)化合物中2,6-二异丙基苯酚的羟基,2,6-二异丙基苯酚的首过代谢活性降低,合成化合物可用于镇静,催眠和/或麻醉。
    • 8. 发明授权
    • Method for providing access to a service
    • 提供服务访问的方法
    • US08739256B2
    • 2014-05-27
    • US13121273
    • 2008-10-08
    • Uwe FoellJin Liu
    • Uwe FoellJin Liu
    • G06F7/04G06F15/16G06F17/30H04L29/06
    • H04L63/08G06F21/41H04L63/0815
    • A system is described comprising a service provider and an identity provider. A user requests access to the service provider and the service provider seeks user credentials from the identity provider. In use, the service provider issues an authentication request, which request specifies details of a plurality of acceptable authentication formats. The identity provider responds to the request either by providing authentication details for said user in one of the formats specified in the request, or by returning an error message indicating that it cannot support any of the specified authentication formats.
    • 描述了包括服务提供商和身份提供者的系统。 用户请求对服务提供商的访问,并且服务提供商从身份提供商寻求用户凭证。 在使用中,服务提供商发出认证请求,该请求指定多个可接受的认证格式的细节。 身份提供者通过以请求中指定的格式之一提供所述用户的身份验证细节,或通过返回指示其不能支持任何指定的认证格式的错误消息来响应该请求。
    • 9. 发明申请
    • METHOD OF CONFIGURING AN APERIODIC SOUNDING REFERENCE SIGNAL
    • 配置APERIODIC SOUNDING REFERENCE SIGNAL的方法
    • US20130286994A1
    • 2013-10-31
    • US13979523
    • 2011-11-08
    • Jin Liu
    • Jin Liu
    • H04L5/00
    • H04L5/0048H04L5/001H04L5/0051H04L5/0053H04L5/0085H04L5/0092H04W24/00H04W28/18H04W72/00H04W88/08
    • The present invention relates to a method of configuring an aperiodic sounding reference signal. In an embodiment of the method of configuring an aperiodic sounding reference signal, the parameters of the aperiodic sounding reference signal are categorized into two parts. The first part of parameters can be configured by radio resource control signaling, and the second part can be configured dynamically via the indication in downlink control information format 4. The second part of the parameters includes at most three of the following parameter set: cyclic shift, the number of antenna ports, carrier aggregation, sounding reference signal bandwidth, frequency-domain position, sounding reference signal hopping bandwidth, multi-shot sounding reference signal duration, and transmission comb. The first part of the parameters includes sounding reference signal configuration index and the remaining part of the parameter set. With the method of the present invention, the second part of the parameters of an aperiodic sounding reference signal can be flexibly configured to adapt to various application scenarios.
    • 本发明涉及一种配置非周期探测参考信号的方法。 在配置非周期性探测参考信号的方法的实施例中,非周期性探测参考信号的参数被分为两部分。 参数的第一部分可以通过无线电资源控制信令进行配置,第二部分可以通过下行链路控制信息格式4中的指示进行动态配置。第二部分参数包括以下三个参数集:循环移位 ,天线端口数,载波聚合,探测参考信号带宽,频域位置,探测参考信号跳频带宽,多播探测参考信号持续时间和传输梳。 参数的第一部分包括探测参考信号配置索引和参数集的剩余部分。 利用本发明的方法,可以灵活地配置非周期性探测参考信号的参数的第二部分以适应各种应用场景。
    • 10. 发明申请
    • METHODS AND APPARATUSES FOR PROCESSING SCHEDULING OF APERIODIC INFORMATION TRANSMISSION
    • 用于处理APERIODIC信息传输调度的方法和装置
    • US20130142163A1
    • 2013-06-06
    • US13817221
    • 2011-03-18
    • Jin LiuXudong Zhu
    • Jin LiuXudong Zhu
    • H04W72/04
    • H04W72/04H04L1/0026H04L1/0027H04L1/0028H04L5/001H04L5/0053H04L5/0057H04W72/0413
    • Embodiments of the present invention disclose triggering methods and apparatuses of aperiodic channel state information CSI and an aperiodic sounding reference signal SRS for a carrier aggregation system. The method comprises: (1) pre-assigning a corresponding relationship between bits of the CSI request field in an uplink grant and multiple downlink component carriers DL CCs of user equipment, wherein the number of bits of the CSI request field is greater than 1 and less than the maximum allowed number of DL CCs in the system; (2) determining the DL CC for which aperiodic CSI reporting is to be triggered; and (3) mapping the CSI request field in the uplink grant according to the pre-assigned corresponding relationship to mark the value of the bit corresponding to the determined DL CC as “trigger”.
    • 本发明的实施例公开了用于载波聚合系统的非周期信道状态信息CSI和非周期性探测参考信号SRS的触发方法和装置。 该方法包括:(1)预先分配上行链路许可中的CSI请求字段的比特与用户设备的多个下行链路分量载波DL CC之间的对应关系,其中CSI请求字段的比特数大于1, 小于系统中DL CC的最大允许数量; (2)确定要触发非周期性CSI报告的DL CC; 以及(3)根据预分配的对应关系在上行链路授权中映射CSI请求字段,以将与所确定的DL CC相对应的比特的值标记为“触发”。