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    • 3. 发明申请
    • Creatinol o-phosphate and synthesis method thereof
    • 磷酸肌醇及其合成方法
    • US20110105786A1
    • 2011-05-05
    • US12590140
    • 2009-11-02
    • Guoji ZhangJiashu Zhang
    • Guoji ZhangJiashu Zhang
    • C07F9/06C07C277/00
    • C07C279/08C07F9/091
    • A creatinol O-phosphate is formed by chemically reacting a creatinol sulfate of creatinol compound with sulfuric acid to form a protected creatinol sulfate as a transition state of the synthesis process of the creatinol O-phosphate, wherein the protected creatinol is further reacted with one of P2O5, CIPO3H2, and POCl3 to form the creatinol O-phosphate. The method of producing the protected creatinol sulfate includes a step of adding sulfuric acid into a creatinol sulfate to form a protected creatinol sulfate as the protected functional group. Therefore, the creatinol O-phosphate is formed by the process including the steps of chemically reacting the protected creatinol sulfate with one of POCl3, CIPO3OH2, and P2O5 to form a creatinol O-phosphate solution; and crystallizing the creatinol O-phosphate solution to obtain crystallized creatinol O-phosphate.
    • 通过使肌酸酐化合物的硫酸肌酸酐与硫酸化学反应形成硫酸肌酸酐作为肌醇酐磷酸酯的合成过程的过渡态,形成肌酸酐O-磷酸酯,其中保护的肌醇酐进一步与 P2O5,CIPO3H2和POCl3,以形成磷酸肌醇酐。 生产受保护的硫酸肌酸酐的方法包括将硫酸加入到硫酸肌酐中以形成受保护的硫酸肌酸酐作为受保护的官能团的步骤。 因此,通过使保护的硫酸肌酸酐与POCl 3,CIPO 3 OH 2和P 2 O 5中的一种化学反应的方法形成磷酸肌酸酐溶液,从而形成磷酸肌酸酐。 并使肌酸酐O-磷酸盐溶液结晶,得到结晶的磷酸肌酐。
    • 4. 发明授权
    • Production process of dicreatine malate
    • 苹果酸肌酸的生产过程
    • US07339077B2
    • 2008-03-04
    • US10842800
    • 2004-05-10
    • Guoji Zhang
    • Guoji Zhang
    • C07C241/00
    • C07C277/08C07C279/14
    • A process of producing dicreatine malate with high purity, includes the steps of providing a predetermined amount of malic acid, agitating a predetermined amount of anhydrous alcohol to the malic acid to obtain a first solution, filtering the first solution to form a clear solution, agitating a predetermined amount of creatine to the clear solution to obtain a second solution, centrifuging the second solution to obtain a wet dicreatine malate and a separated alcohol, and drying the wet dicreatine malate to produce a dicreatine. Because of its low energy consumption, this process produces dicreatine malate effectively.
    • 制备高纯度苹果酸肌酐的方法包括以下步骤:提供预定量的苹果酸,向苹果酸中搅拌预定量的无水醇以获得第一溶液,过滤第一溶液以形成澄清溶液,搅拌 将预定量的肌酸提供到透明溶液中以获得第二溶液,离心第二溶液以获得湿的苹果酸湿的苹果酸和分离的醇,并干燥湿的肌酸二苹果酸酯以产生肌酸。 由于其能量消耗低,该方法有效地产生苹果酸肌酸酐。
    • 5. 发明授权
    • Process for preparation of L-Arginine α-ketoglutarate 1:1 and 2:1
    • L-精氨酸α-酮戊二酸1:1和2:1的制备方法
    • US08754256B2
    • 2014-06-17
    • US12925125
    • 2010-10-13
    • Guoji Zhang
    • Guoji Zhang
    • C07C229/26
    • C07C277/08C07C51/02C07C51/41C07C51/412C07C51/43C07C51/47C07C67/347C07C279/14C07C59/347C07C69/63
    • A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1 includes the following steps. Provide a α-ketoglutaratic acid aqueous solution at an adjusted concentration. Add one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution. Stir and allow reaction under a controlled temperature. Obtain a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3˜4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5˜7. Obtain a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner.
    • 制备α-酮戊二酸,α-酮戊二酸L-精氨酸1:1和2:1的方法包括以下步骤。 提供调节浓度的α-酮戊二酸水溶液。 向α-酮戊二酸水溶液中加入1当量的固体L-精氨酸。 搅拌并允许在受控温度下进行反应。 得到pH约为3〜4的所得L-精氨酸α-酮戊二酸1:1溶液或pH约为6.5〜7的L-精氨酸α-酮戊二酸2:1溶液。 通过干燥干燥获得1 - 1或2:1 L-精氨酸α-酮戊二酸的最终产物。 通过该过程,最终产物的L-精氨酸α-酮戊二酸酯的产率为约94%,α-酮戊二酸L-精氨酸为1:1。 消除大量的溶剂,缩短反应时间,提高产率,从而以成本和时间有效的方式实现反应堆的批量生产。
    • 6. 发明申请
    • Production process of dicreatine malate
    • 苹果酸肌酸的生产过程
    • US20050250962A1
    • 2005-11-10
    • US10842800
    • 2004-05-10
    • Guoji Zhang
    • Guoji Zhang
    • C07C277/00C07C277/08C07C279/14
    • C07C277/08C07C279/14
    • A process of producing dicreatine malate with high purity, includes the steps of providing a predetermined amount of malic acid, agitating a predetermined amount of anhydrous alcohol to the malic acid to obtain a first solution, filtering the first solution to form a clear solution, agitating a predetermined amount of creatine to the clear solution to obtain a second solution, centrifuging the second solution to obtain a wet dicreatine malate and a separated alcohol, and drying the wet dicreatine malate to produce a dicreatine. Because of its low energy consumption, this process produces dicreatine malate effectively.
    • 制备高纯度苹果酸肌酐的方法包括以下步骤:提供预定量的苹果酸,向苹果酸中搅拌预定量的无水醇以获得第一溶液,过滤第一溶液以形成澄清溶液,搅拌 将预定量的肌酸提供到透明溶液中以获得第二溶液,离心第二溶液以获得湿的苹果酸湿的苹果酸和分离的醇,并干燥湿的肌酸二苹果酸酯以产生肌酸。 由于其能量消耗低,该方法有效地产生苹果酸肌酸酐。
    • 8. 发明申请
    • Process for preparation of L-Arginine alpha-ketoglutarate 1:1 and 2:1
    • L-精氨酸α-酮戊二酸1:1和2:1的制备方法
    • US20120095260A1
    • 2012-04-19
    • US12925125
    • 2010-10-13
    • Guoji Zhang
    • Guoji Zhang
    • C07C277/00
    • C07C277/08C07C51/02C07C51/41C07C51/412C07C51/43C07C51/47C07C67/347C07C279/14C07C59/347C07C69/63
    • A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: providing a α-ketoglutaratic acid aqueous solution at an adjusted concentration; adding one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution; stirring and allowing reaction under a controlled temperature; (e) obtaining a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3˜4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5˜7; and obtaining a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner.
    • 一种制备α-酮戊二酸,α-酮戊二酸L-精氨酸1:1和2:1的方法,包括以下步骤:提供调节浓度的α-酮戊二酸水溶液; 向α-酮戊二酸水溶液中加入1当量的固体L-精氨酸; 搅拌并允许在受控温度下反应; (e)获得pH约为3〜4的所得L-精氨酸α-酮戊二酸1:1溶液或pH约6.5〜7的L-精氨酸α-酮戊二酸2:1溶液; 并通过干燥干燥获得α-酮戊二酸L-精氨酸1:1或2:1的最终产物。 通过该过程,最终产物的L-精氨酸α-酮戊二酸酯的产率为约94%,α-酮戊二酸L-精氨酸为1:1。 消除大量的溶剂,缩短反应时间,提高产率,从而以成本和时间有效的方式实现反应堆的批量生产。
    • 9. 发明申请
    • Process for preparation of l-arginine alpha-ketoglutarate 1:1 and 2:1
    • 制备α-精氨酸α-酮戊二酸1:1和2:1的方法
    • US20140187815A1
    • 2014-07-03
    • US13694727
    • 2012-12-28
    • Guoji Zhang
    • Guoji Zhang
    • C07C277/08
    • C07C277/08C07C51/412C07C227/08C07C279/14C07C59/347
    • A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: providing a α-ketoglutaratic acid aqueous solution at an adjusted concentration; adding one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution; stirring and allowing reaction under a controlled temperature; (e) obtaining a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3˜4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5˜7; and obtaining a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner.
    • 一种制备α-酮戊二酸,α-酮戊二酸L-精氨酸1:1和2:1的方法,包括以下步骤:提供调节浓度的α-酮戊二酸水溶液; 向α-酮戊二酸水溶液中加入1当量的固体L-精氨酸; 搅拌并允许在受控温度下反应; (e)获得pH约为3〜4的所得L-精氨酸α-酮戊二酸1:1溶液或pH约6.5〜7的L-精氨酸α-酮戊二酸2:1溶液; 并通过干燥干燥获得α-酮戊二酸L-精氨酸1:1或2:1的最终产物。 通过该过程,最终产物的L-精氨酸α-酮戊二酸酯的产率为约94%,α-酮戊二酸L-精氨酸为1:1。 消除大量的溶剂,缩短反应时间,提高产率,从而以成本和时间有效的方式实现反应堆的批量生产。