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    • 5. 发明申请
    • BIO-DEGRADABLE/ ABSORBABLE POLYMER HAVING REDUCED METAL CATALYST CONTENT, AND PROCESS FOR PRODUCTION THEREOF
    • 具有降低金属催化剂含量的生物降解/可吸收聚合物及其生产方法
    • US20090171064A1
    • 2009-07-02
    • US12305104
    • 2007-06-18
    • Hidetoshi ArimuraYoshitake TakahashiKoji Yamauchi
    • Hidetoshi ArimuraYoshitake TakahashiKoji Yamauchi
    • C08G63/08
    • C08G63/823A61L17/12A61L27/18A61L27/58A61L31/148C08G63/08C08G63/90C08L67/04
    • The present invention provides a safe biodegradable and bioabsorbable polymer having an extremely low metal catalyst content, while retaining the properties desired for a medical implant or the like; and a process for producing the same. The present invention further provides a method for reducing the content of a metal catalyst in a biodegradable and absorbable polymer that can be applied on an industrial scale. A method for producing a biodegradable and bioabsorbable polymer having a metal catalyst content of less than 1 ppm in terms of a metal comprising the steps of (1) copolymerizing lactide and ε-caprolactone at a molar ratio ranging from 40/60 to 60/40 in the presence of the metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a volume ratio ranging from 25/75 to 45/55 at less than 40° C., and drying the copolymer. 13. A method for producing a biodegradable and bioabsorbable polymer having a metal catalyst content of less than 1 ppm in terms of a metal comprising the steps of (1) copolymerizing lactide and ε-caprolactone at a molar ratio ranging from 65/35 to 85/15 in the presence of the metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a volume ratio ranging from 45/55 to 55/45 at less than 40° C., and drying the copolymer.
    • 本发明提供一种具有极低金属催化剂含量的安全的可生物降解和生物可吸收的聚合物,同时保持医用植入物等所需的性质; 及其制造方法。 本发明还提供一种降低能够以工业规模应用的生物可降解和可吸收的聚合物中的金属催化剂的含量的方法。 一种制备金属催化剂含量小于1ppm的可生物降解和生物可吸收聚合物的方法,包括以下步骤:(1)以40/60至60/40的摩尔比共聚丙交酯和ε-己内酯 在金属催化剂存在下制备共聚物; 和(2)在低于40℃下,用包含乙酸和异丙醇的混合溶剂以25/75〜45/55的体积比洗涤共聚物,并干燥该共聚物。 13.一种用于生产金属催化剂含量小于1ppm的可生物降解和生物可吸收聚合物的方法,包括以下步骤:(1)以65/35至85的摩尔比共聚丙交酯和ε-己内酯 / 15,在金属催化剂的存在下制备共聚物; 和(2)在低于40℃的体积比为45/55至55/45的范围内用包含乙酸和异丙醇的混合溶剂洗涤共聚物,并干燥该共聚物。