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1. 发明授权

US09028544B2 Robotic heart valve annulus sizer 有权
标题翻译：机器人心脏瓣膜瓣膜大小
公开(公告)号：US09028544B2
公开(公告)日：2015-05-12
申请号：US13148168
申请日：2010-02-01
申请人： XueMei Li , Jack Lemmon
发明人： XueMei Li , Jack Lemmon
IPC分类号： A61F2/24 , A61B5/107
CPC分类号： A61F2/2496 , A61B5/1076
摘要： A heart valve annulus sizer is provided for measuring a valve to be fitted with an annuloplasty ring. The sizer may include a body having a peripheral portion defining an opening, at least one rib disposed within the opening and dividing the opening into at least a first opening and a second opening, and an anchor disposed on and projecting from the body. The sizer may include a length of suture connected to the body. The anchor may include an aperture adapted to receive the length of suture. A method of using the sizer is provided that includes grasping the sizer with an instrument and positioning the sizer adjacent to a valve into a position suitable to allow for measurement of the valve.
摘要翻译：提供心脏瓣膜环形分选器用于测量与瓣环成形术环配合的瓣膜。分级机可以包括具有限定开口的周边部分的主体，设置在开口内的至少一个肋条，并将开口分成至少第一开口和第二开口，以及锚定件，其设置在主体上并从主体突出。定径机可以包括连接到身体的一段缝线。锚定器可以包括适于接收缝合长度的孔。提供了一种使用分级器的方法，其包括用仪器抓住分级器并将分级器邻近阀定位到适于允许测量阀的位置。

2. 发明申请

US20120071968A1 ROBOTIC HEART VALVE ANNULUS SIZER 有权
标题翻译：机械式心脏瓣膜神经元大小
公开(公告)号：US20120071968A1
公开(公告)日：2012-03-22
申请号：US13148168
申请日：2010-02-01
申请人： XueMei Li , Jack Lemmon
发明人： XueMei Li , Jack Lemmon
IPC分类号： A61F2/24
CPC分类号： A61F2/2496 , A61B5/1076
摘要： A heart valve annulus sizer is provided for measuring a valve to be fitted with an annuloplasty ring. The sizer may include a body having a peripheral portion defining an opening, at least one rib disposed within the opening and dividing the opening into at least a first opening and a second opening, and an anchor disposed on and projecting from the body. The sizer may include a length of suture connected to the body. The anchor may include an aperture adapted to receive the length of suture. A method of using the sizer is provided that includes grasping the sizer with an instrument and positioning the sizer adjacent to a valve into a position suitable to allow for measurement of the valve.
摘要翻译：提供心脏瓣膜环形分选器用于测量与瓣环成形术环配合的瓣膜。分级机可以包括具有限定开口的周边部分的主体，设置在开口内的至少一个肋条，并将开口分成至少第一开口和第二开口，以及锚定件，其设置在主体上并从主体突出。定径机可以包括连接到身体的一段缝线。锚定器可以包括适于接收缝合长度的孔。提供了一种使用分级器的方法，其包括用仪器抓住分级器并将分级器邻近阀定位到适于允许测量阀的位置。

3. 发明授权

US07803186B1 Prosthetic heart valves with flexible leaflets and leaflet edge clamping 有权
标题翻译：假体心脏瓣膜带有柔性单张和小叶边缘夹紧
公开(公告)号：US07803186B1
公开(公告)日：2010-09-28
申请号：US11906181
申请日：2007-09-28
申请人： XueMei Li , Yi-Ren Woo
发明人： XueMei Li , Yi-Ren Woo
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2415 , A61F2220/005 , A61F2220/0075
摘要： A prosthetic heart valve includes an annular stent structure having a plurality of annularly spaced stent post regions, a plurality of leaflets that extend radially inward from the stent structure and that include radially outer portions that lie against a radially outer surface of the stent structure, and a clamping structure that is radially outside the other components and that clamps the radially outer portions of the leaflets against the radially outer surface of the stent structures to secure the leaflets to the stent structure. The above-described structural arrangement applies to the stent post regions as well as to other portions of the stent structure.
摘要翻译：假体心脏瓣膜包括环形支架结构，其具有多个环形间隔开的支架区域，多个叶片，其从支架结构径向向内延伸并且包括位于支架结构的径向外表面的径向外部部分，以及夹紧结构，其径向地位于其他部件外部，并将小叶的径向外部部分压靠在支架结构的径向外表面上以将小叶固定到支架结构。上述结构布置适用于支架支柱区域以及支架结构的其它部分。

4. 发明申请

US20130018456A1 TECHNIQUES FOR ATTACHING FLEXIBLE LEAFLETS OF PROSTHETIC HEART VALVES TO SUPPORTING STRUCTURES 有权
标题翻译：连接灵活的心脏瓣膜支持结构的技术
公开(公告)号：US20130018456A1
公开(公告)日：2013-01-17
申请号：US11796471
申请日：2007-04-26
申请人： XueMei Li , Yi-Ren Woo
发明人： XueMei Li , Yi-Ren Woo
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409
摘要： A prosthetic heart valve has an annular valve-perimeter-shape-defining structure having a radially outer surface. A clip structure is provided on the outer surface. This clip structure is used to attach flexible valve leaflets to the shape-defining structure. One or more retainer members may be used to help hold the leaflets in the clip structure.
摘要翻译：假体心脏瓣膜具有具有径向外表面的环形阀周边形状限定结构。夹子结构设置在外表面上。该夹子结构用于将柔性瓣叶附接到形状限定结构。可以使用一个或多个保持器构件来帮助将传单保持在夹子结构中。

5. 发明授权

US08092523B2 Prosthetic heart valves with flexible leaflets 有权
标题翻译：假性心脏瓣膜带柔性单张
公开(公告)号：US08092523B2
公开(公告)日：2012-01-10
申请号：US11717305
申请日：2007-03-12
申请人： XueMei Li , Yi-Ren Woo
发明人： XueMei Li , Yi-Ren Woo
IPC分类号： A61F2/24
CPC分类号： A61F2/2415
摘要： A prosthetic heart valve of the type that includes a hollow annular stent and a plurality of flexible leaflets that are attached to the stent. One or more fixture structures are used to attach the leaflets to the stent so that sutures do not have to be used for that purpose. The fixture structures preferably extend annularly at least substantially all the way around the valve. Surfaces of the fixture structures that can come into contact with portions of the leaflets that move during use of the valve can be shaped to help beneficially shape those leaflet portions during their movements.
摘要翻译：一种假体心脏瓣膜，其类型包括中空环形支架和附接到支架的多个柔性小叶。使用一个或多个夹具结构将传单附接到支架上，使得缝合线不必用于该目的。固定结构优选地至少基本上围绕阀全部地环向延伸。能够与使用阀门期间移动的小叶的部分接触的夹具结构的表面可以被成形为有助于在移动过程中有利地塑造这些叶片部分。

6. 发明授权

US09011527B2 Valve leaflet attachment in collapsible prosthetic valves 有权
标题翻译：可折叠人造瓣膜中的小叶附件
公开(公告)号：US09011527B2
公开(公告)日：2015-04-21
申请号：US13237237
申请日：2011-09-20
申请人： XueMei Li , Peter Nicholas Braido
发明人： XueMei Li , Peter Nicholas Braido
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2230/008
摘要： A prosthetic heart valve includes a stent having a collapsed condition and an expanded condition. The stent includes a plurality of cells, each cell being formed by a plurality of struts, and a plurality of commissure features. The heart valve further includes a valve assembly secured to the stent and including a cuff and a plurality of leaflets, each leaflet being attached to adjacent commissure features and to the stent struts and/or the cuff.
摘要翻译：假体心脏瓣膜包括具有折叠状态和扩张状态的支架。支架包括多个细胞，每个细胞由多个支柱形成，以及多个连合特征。心脏瓣膜还包括固定到支架上并包括袖带和多个小叶的瓣膜组件，每个小叶附着到相邻的连合部分以及支架支柱和/或袖带。

7. 发明申请

US20140167308A1 DIPPING MANDREL WITH A GAP 有权
标题翻译：带有差距的扒手
公开(公告)号：US20140167308A1
公开(公告)日：2014-06-19
申请号：US14235560
申请日：2012-07-19
申请人： XueMei Li
发明人： XueMei Li
IPC分类号： B29C41/14
CPC分类号： A61F2/2415 , A61F2/2412 , A61F2240/005 , B29C41/14 , B29C41/38 , B29K2105/0073 , B29L2031/7534
摘要： A mandrel (5) for molding polymer valve leaflets for heart valve prostheses is disclosed, including a body portion (52) including an outer surface with ridges (60) and contoured surfaces (64) corresponding to the leaflets, the upper edge of the contoured surfaces corresponding to the free upper edge of the leaflets, and the mandrel including a mandrel extension (54) above the body portion, and a gap (68) extending around the mandrel between the upper edge of the contoured surface and the mandrel extension. A process for producing these polymer valve leaflets is also disclosed by dip coating with this mandrel and re-moving the polymer film created at the gap, preferably by applying suction or blowing thereto.
摘要翻译：公开了一种用于模制用于心脏瓣膜假体的聚合物瓣膜小叶的心轴（5），包括主体部分（52），其包括具有脊（60）的外表面和对应于小叶的轮廓表面（64），轮廓的表面对应于小叶的自由上边缘，并且心轴包括在主体部分上方的心轴延伸部（54），以及在成形表面的上边缘和心轴延伸部之间围绕心轴延伸的间隙（68）。通过用该心轴进行浸渍涂覆也可以公开制造这些聚合物瓣叶的方法，并且重新移动在间隙处产生的聚合物膜，优选通过施加吸力或吹送。

8. 发明申请

US20120078359A1 ADJUSTABLE ANNULOPLASTY RING SUPPORT 有权
标题翻译：可调节的ANNOLOPLASTY戒指支持
公开(公告)号：US20120078359A1
公开(公告)日：2012-03-29
申请号：US13147240
申请日：2010-02-01
申请人： XueMei Li , Melinda K. Kovach , Susan E. Clegg , Scott Martin , Rebecca Volovsek
发明人： XueMei Li , Melinda K. Kovach , Susan E. Clegg , Scott Martin , Rebecca Volovsek
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/0095 , A61F2/2427 , A61F2/2466
摘要： A support for an adjustable annuloplasty ring generally includes a body and a groove. The body has a first end, a second end and an outer surface. The body may also include an inner surface defining a longitudinal bore. The outer surface is configured to slidably receive an annuloplasty ring and a length of adjustable suture. The groove is formed along at least a portion of the outer surface of the body and is dimensioned to receive at least a portion of the suture.
摘要翻译：可调环形成形术环的支撑件通常包括主体和凹槽。主体具有第一端，第二端和外表面。主体还可以包括限定纵向孔的内表面。外表面被构造成可滑动地容纳瓣环成形术环和一定长度的可调缝合线。凹槽沿着主体的外表面的至少一部分形成并且被设计成容纳至少一部分缝合线。

9. 发明授权

US08784484B2 Adjustable annuloplasty ring support 有权
标题翻译：可调环瓣成形环支撑
公开(公告)号：US08784484B2
公开(公告)日：2014-07-22
申请号：US13147240
申请日：2010-02-01
申请人： XueMei Li , Melinda K. Kovach , Susan E. Clegg , Scott Martin , Rebecca Volovsek
发明人： XueMei Li , Melinda K. Kovach , Susan E. Clegg , Scott Martin , Rebecca Volovsek
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/0095 , A61F2/2427 , A61F2/2466
摘要： A support for an adjustable annuloplasty ring generally includes a body and a groove. The body has a first end, a second end and an outer surface. The body may also include an inner surface defining a longitudinal bore. The outer surface is configured to slidably receive an annuloplasty ring and a length of adjustable suture. The groove is formed along at least a portion of the outer surface of the body and is dimensioned to receive at least a portion of the suture.
摘要翻译：可调环形成形术环的支撑件通常包括主体和凹槽。主体具有第一端，第二端和外表面。主体还可以包括限定纵向孔的内表面。外表面被构造成可滑动地容纳瓣环成形术环和一定长度的可调缝合线。凹槽沿着主体的外表面的至少一部分形成并且被设计成容纳至少一部分缝合线。

10. 发明申请

US20100249922A1 FIBER-REINFORCED SYNTHETIC SHEETS FOR PROSTHETIC HEART VALVE LEAFLETS 审中-公开
标题翻译：纤维增强合成片用于预防心脏瓣膜
公开(公告)号：US20100249922A1
公开(公告)日：2010-09-30
申请号：US12733762
申请日：2008-09-19
申请人： XueMei Li , Yi-Ren Woo
发明人： XueMei Li , Yi-Ren Woo
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2415 , A61F2250/0018
摘要： A structure for use as a prosthetic heart valve leaflet includes a two-dimensional array that is made up of one or more fiber strands and that is covered by a web of polymer material to produce a sheet that is impervious to blood. This sheet is stretchable along two axes that lie in the plane of the sheet and that are at an angle to one another. The sheet may be more easily stretched along one of these axes than along the other axis. Along each axis the amount of force required to produce initial increments of stretch may be less than the amount of force required to produce subsequent increments of stretch (i.e., increments of stretch beyond the initial increments).
摘要翻译：用作假体心脏瓣膜小叶的结构包括由一根或多根纤维束组成并由聚合物材料的网覆盖以产生不透血液的片的二维阵列。该片材沿着位于片材平面中并且彼此成角度的两个轴线是可拉伸的。该片材可以沿着这些轴线沿着另一个轴线更容易地拉伸。沿着每个轴，产生初始拉伸增量所需的力的量可以小于产生随后的拉伸增量所需的力的量（即，超出初始增量的拉伸增量）。

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