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1. 发明申请

US20110126325A1 RECOMBINANT CELLS AND METHODS FOR HYDROXYLATING FATTY ACIDS 审中-公开
标题翻译：重组细胞和用于羟化脂肪酸的方法
公开(公告)号：US20110126325A1
公开(公告)日：2011-05-26
申请号：US12989377
申请日：2009-04-24
申请人： Xue-Rong Zhou , Surinder Pal Singh , Allan Green , Anthony Richard Ashton , Andrew John William Rodgers , Geoffrey John Dumsday , Florian Hans Maximilian Graichen
发明人： Xue-Rong Zhou , Surinder Pal Singh , Allan Green , Anthony Richard Ashton , Andrew John William Rodgers , Geoffrey John Dumsday , Florian Hans Maximilian Graichen
IPC分类号： A01H5/10 , C12Q1/68 , C12Q1/02 , C12P1/00 , C12P7/64 , C12N9/02 , C12N5/04 , C12N1/00 , C12N15/63 , C07H21/00 , C12N15/53 , C07C57/00
CPC分类号： C12N9/0071 , C11C3/00 , C12N15/8247
摘要： The present invention relates to enzymes which possess hydroxylase activity, in particular 42 hydroxylase activity, that can be used in methods of synthesizing modified fatty acids.
摘要翻译：本发明涉及可用于合成改性脂肪酸的方法中具有羟化酶活性，特别是42羟化酶活性的酶。

2. 发明授权

US11124737B2 High oleic acid oils 有权
公开(公告)号：US11124737B2
公开(公告)日：2021-09-21
申请号：US16411697
申请日：2019-05-14
申请人： Craig Christopher Wood , Qing Liu , Xue-Rong Zhou , Allan Green , Surinder Pal Singh , Shijiang Cao
发明人： Craig Christopher Wood , Qing Liu , Xue-Rong Zhou , Allan Green , Surinder Pal Singh , Shijiang Cao
IPC分类号： C12N15/82 , A23D9/00 , C11B1/10 , C12N9/02
摘要： The present invention relates to extracted lipid with high levels, for example 90% to 95% by weight, oleic acid. The present invention also provides genetically modified plants, particularly oilseeds such as safflower, which can used to produce the lipid. Furthermore, provided are methods for genotyping and selecting plants which can be used to produce the lipid.

3. 发明申请

US20110190521A1 Synthesis of fatty acids 有权
标题翻译：脂肪酸的合成
公开(公告)号：US20110190521A1
公开(公告)日：2011-08-04
申请号：US12310645
申请日：2007-08-29
申请人： Katherine Damcevski , Karen Glover , Allan Green , Victoria S. Haritos , Irene Horne , Surinder Pal Singh , Craig C. Wood , Xue-Rong Zhou
发明人： Katherine Damcevski , Karen Glover , Allan Green , Victoria S. Haritos , Irene Horne , Surinder Pal Singh , Craig C. Wood , Xue-Rong Zhou
IPC分类号： C11B1/06 , C11B1/00
CPC分类号： C12P7/6427 , C11B1/10 , C12N9/0004 , C12N9/0071 , C12N9/48 , C12N15/8247
摘要： The present invention relates to enzymes which possess desaturase, conjugase, epoxidase and/or hydroxylase activity that can be used in methods of synthesizing fatty acids.
摘要翻译：本发明涉及可用于合成脂肪酸的方法中具有去饱和酶，共轭酶，环氧酶和/或羟化酶活性的酶。

4. 发明申请

US20150045567A1 SYNTHESIS OF FATTY ACIDS 审中-公开
标题翻译：脂肪酸合成
公开(公告)号：US20150045567A1
公开(公告)日：2015-02-12
申请号：US14467942
申请日：2014-08-25
申请人： Katherine Damcevski , Karen Glover , Allan Green , Victoria S. Haritos , Irene Horne , Surinder Pal Singh , Craig C. Wood , Xue-Rong Zhou
发明人： Katherine Damcevski , Karen Glover , Allan Green , Victoria S. Haritos , Irene Horne , Surinder Pal Singh , Craig C. Wood , Xue-Rong Zhou
IPC分类号： C12P7/64 , C11B1/10
CPC分类号： C12P7/6427 , C11B1/10 , C12N9/0004 , C12N9/0071 , C12N9/48 , C12N15/8247
摘要： The present invention relates to enzymes which possess desaturase, conjugase, epoxidase and/or hydroxylase activity that can be used in methods of synthesizing fatty acids.
摘要翻译：本发明涉及可用于合成脂肪酸的方法中具有去饱和酶，共轭酶，环氧酶和/或羟化酶活性的酶。

5. 发明授权

US10323209B2 High oleic acid oils 有权
公开(公告)号：US10323209B2
公开(公告)日：2019-06-18
申请号：US13869763
申请日：2013-04-24
申请人： Craig Christopher Wood , Qing Liu , Xue-Rong Zhou , Allan Green , Surinder Pal Singh , Shijiang Cao
发明人： Craig Christopher Wood , Qing Liu , Xue-Rong Zhou , Allan Green , Surinder Pal Singh , Shijiang Cao
IPC分类号： A23D9/00 , C11B1/10 , C12N15/82 , C12N9/02
摘要： The present invention relates to extracted lipid with high levels, for example 90% to 95% by weight, oleic acid. The present invention also provides genetically modified plants, particularly oilseeds such as safflower, which can used to produce the lipid. Furthermore, provided are methods for genotyping and selecting plants which can be used to produce the lipid.

6. 发明授权

US08816106B2 Synthesis of fatty acids 有权
标题翻译：脂肪酸的合成
公开(公告)号：US08816106B2
公开(公告)日：2014-08-26
申请号：US12310645
申请日：2007-08-29
申请人： Katherine Damcevski , Karen Glover , Allan Green , Victoria S. Haritos , Irene Horne , Surinder Pal Singh , Craig C. Wood , Xue-Rong Zhou
发明人： Katherine Damcevski , Karen Glover , Allan Green , Victoria S. Haritos , Irene Horne , Surinder Pal Singh , Craig C. Wood , Xue-Rong Zhou
IPC分类号： C11B1/10 , C12N5/10 , C12N15/82
CPC分类号： C12P7/6427 , C11B1/10 , C12N9/0004 , C12N9/0071 , C12N9/48 , C12N15/8247
摘要： The present invention relates to enzymes which possess desaturase, conjugase, epoxidase and/or hydroxylase activity that can be used in methods of synthesizing fatty acids.
摘要翻译：本发明涉及可用于合成脂肪酸的方法中具有去饱和酶，共轭酶，环氧酶和/或羟化酶活性的酶。

7. 发明申请

US20110218348A1 POLYPEPTIDES AND METHODS FOR PRODUCING TRIACYLGLYCEROLS COMPRISING MODIFIED FATTY ACIDS 审中-公开
标题翻译：生产包含改性脂肪酸的三乙基胆固醇的多肽和方法
公开(公告)号：US20110218348A1
公开(公告)日：2011-09-08
申请号：US12989405
申请日：2009-04-24
申请人： Xue-Rong Zhou , Surinder Pal Singh , Allan Green
发明人： Xue-Rong Zhou , Surinder Pal Singh , Allan Green
IPC分类号： C07D303/42
CPC分类号： C12N15/8247 , A23D9/00 , C12N9/0004 , C12N9/0071 , C12N9/1029 , C12N9/18 , C12N9/20 , C12P7/6463 , C12P7/6472 , C12P17/02
摘要： The present invention relates to methods of producing modified fatty acids comprising a functional group which is a hydroxyl group, an epoxy group, an acetylenic group or a conjugated double bond. For example, seeds, seedoil and methods of making seedoil are provided wherein at least 23% (mol %) of the fatty acid content of the seed or seedoil comprises the functional group. Also provided are novel polypeptides, and polynucleotides thereof, which can be used to produce the modified fatty acids, particularly in transgenic plants and cells suitable for fermentation.
摘要翻译：本发明涉及包含羟基，环氧基，炔基或共轭双键的官能团的改性脂肪酸的制造方法。例如，提供种子，种子油和制备种子油的方法，其中种子或种子油的脂肪酸含量的至少23％（摩尔％）包含官能团。还提供了新的多肽及其多核苷酸，其可用于产生修饰的脂肪酸，特别是在适于发酵的转基因植物和细胞中。

8. 发明申请

US20050273885A1 Synthesis of long-chain polyunsaturated fatty acids by recombinant cells 有权
标题翻译：通过重组细胞合成长链多不饱和脂肪酸
公开(公告)号：US20050273885A1
公开(公告)日：2005-12-08
申请号：US11112882
申请日：2005-04-22
申请人： Surinder Singh , Stanley Robert , Peter Nichols , Susan Ellis Blackburn , Xue-Rong Zhou , James Petrie , Allan Green
发明人： Surinder Singh , Stanley Robert , Peter Nichols , Susan Ellis Blackburn , Xue-Rong Zhou , James Petrie , Allan Green
IPC分类号： A01H1/00 , C12N5/04 , C12N9/02 , C12N9/10 , C12N15/82 , C12P7/64
CPC分类号： C12P7/6427 , C07C51/42 , C11B1/025 , C11B1/06 , C11B3/006 , C12N9/0083 , C12N9/1029 , C12N15/8247 , C12P7/6472 , Y02P20/52
摘要： The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain poly unsaturated fatty acids.
摘要翻译：本发明涉及在重组细胞如酵母或植物细胞中合成长链多不饱和脂肪酸，特别是二十碳五烯酸，二十二碳五烯酸和二十二碳六烯酸的方法。还提供了产生长链多不饱和脂肪酸的重组细胞或植物。此外，本发明涉及可用于合成长链多不饱和脂肪酸的方法的一组具有去饱和酶或延伸酶活性的新酶。

9. 发明授权

US07834248B2 Plant seed comprising vernolic acid 有权
标题翻译：含有种子酸的植物种子
公开(公告)号：US07834248B2
公开(公告)日：2010-11-16
申请号：US11699817
申请日：2007-01-30
申请人： Allan Green , Surinder Singh , Marit Lenman , Sten Stymne
发明人： Allan Green , Surinder Singh , Marit Lenman , Sten Stymne
IPC分类号： A01H5/00
CPC分类号： C12N9/0071 , C12N9/0004 , C12N15/8247 , C12P7/6409 , C12P7/6427 , C12P7/6472
摘要： The present invention relates generally to novel genetic sequences that encode fatty acid epoxygenase enzymes, in particular fatty acid Δ12-epoxygenase enzymes from plants that are mixed function monooxygenase enzymes. More particularly, the present invention exemplifies cDNA sequences from Crepis spp. and Vernonia galamensis that encode fatty acid Δ12-epoxygenases. The genetic sequences of the present invention provide the means by which fatty acid metabolism may be altered or manipulated in organisms, such as, for example, yeasts, moulds, bacteria, insects, birds, mammals and plants, and more particularly in plants. The invention also extends to genetically modified oil-accumulating organisms transformed with the subject genetic sequences and to the oils derived therefrom. The oils thus produced provide the means for the cost-effective raw materials for use in the efficient production of coatings, resins, glues, plastics, surfactants and lubricants.
摘要翻译：本发明一般涉及从作为混合功能单加氧酶的植物编码脂肪酸环氧化酶，特别是脂肪酸和Dgr 12-环氧化酶的新型遗传序列。更具体地，本发明举例说明了来自Crepis spp的cDNA序列。和Vernonia galamensis编码脂肪酸和Dgr; 12-环氧化酶。本发明的遗传序列提供了在生物体例如酵母，霉菌，细菌，昆虫，鸟类，哺乳动物和植物中，更具体地在植物中可以改变或操纵脂肪酸代谢的方法。本发明还延伸到用受试者遗传序列转化的转基因油积聚生物和由其衍生的油。因此生产的油为用于有效生产涂料，树脂，胶水，塑料，表面活性剂和润滑剂的成本效益好的原材料提供了手段。

10. 发明申请

US20070078082A1 Methods and compositions to treat glycosaminoglycan-associated molecular interactions 审中-公开
标题翻译：治疗糖胺聚糖相关分子相互作用的方法和组合物
公开(公告)号：US20070078082A1
公开(公告)日：2007-04-05
申请号：US11523811
申请日：2006-09-19
申请人： Robert Kisilevsky , Allan Green , Francine Gervais
发明人： Robert Kisilevsky , Allan Green , Francine Gervais
IPC分类号： A61K38/16
CPC分类号： A61K31/472 , A61K31/185 , A61K31/437 , A61K31/737 , Y02A50/478
摘要： Therapeutic compounds and methods for inhibiting a glycosaminoglycan (GAG)-associated molecular interaction in a subject, whatever its clinical setting, are described
摘要翻译：描述了用于抑制受试者中的糖胺聚糖（GAG）相关分子相互作用的治疗化合物和方法，无论其临床情况如何

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