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1. 发明申请

US20110181884A1 OPTOFLUIDIC MICROSCOPE DEVICE WITH PHOTOSENSOR ARRAY 有权
标题翻译：带有光电传感器阵列的光学显微镜装置
公开(公告)号：US20110181884A1
公开(公告)日：2011-07-28
申请号：US12398050
申请日：2009-03-04
申请人： Xiquan Cui , Xin Heng , Lap Man Lee , Changhuei Yang
发明人： Xiquan Cui , Xin Heng , Lap Man Lee , Changhuei Yang
IPC分类号： G01N21/59
CPC分类号： G01N21/53 , G01N21/6458
摘要： Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique which may be used eliminates the aperture layer covering the light detector layer. Other techniques retain the aperture layer, reversing the relative position of the light source and light detector such that light passes through the aperture layer before passing through the fluid channel to the light detector. Another technique adds an optical tweezer for controlling the movement of objects moving through the fluid channel. Another technique adds an optical fiber bundle to relay light from light transmissive regions to a remote light detector. Another technique adds two electrodes at ends of the fluid channel to generate an electrical field capable of moving objects through the fluid channel while suppressing rotation. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.
摘要翻译：本发明的实施例涉及用于改进光流体显微镜（OFM）装置的技术。可以使用的一种技术消除了覆盖光检测器层的孔径层。其他技术保留孔径层，反转光源和光检测器的相对位置，使得光在通过流体通道之前通过孔层，到达光检测器。另一种技术增加了用于控制移动通过流体通道的物体运动的光学镊子。另一种技术增加了光纤束，以将来自光透射区域的光中继到远程光检测器。另一种技术在流体通道的端部添加两个电极，以产生能够通过流体通道移动物体同时抑制旋转的电场。这些技术可以单独使用或组合使用以提高OFM设备的能力。

2. 发明授权

US08314933B2 Optofluidic microscope device with photosensor array 有权
标题翻译：具有光电传感器阵列的光电显微镜装置
公开(公告)号：US08314933B2
公开(公告)日：2012-11-20
申请号：US12398050
申请日：2009-03-04
申请人： Xiquan Cui , Xin Heng , Lap Man Lee , Changhuei Yang
发明人： Xiquan Cui , Xin Heng , Lap Man Lee , Changhuei Yang
IPC分类号： G01N21/00
CPC分类号： G01N21/53 , G01N21/6458
摘要： Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique which may be used eliminates the aperture layer covering the light detector layer. Other techniques retain the aperture layer, reversing the relative position of the light source and light detector such that light passes through the aperture layer before passing through the fluid channel to the light detector. Another technique adds an optical tweezer for controlling the movement of objects moving through the fluid channel. Another technique adds an optical fiber bundle to relay light from light transmissive regions to a remote light detector. Another technique adds two electrodes at ends of the fluid channel to generate an electrical field capable of moving objects through the fluid channel while suppressing rotation. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.
摘要翻译：本发明的实施例涉及用于改进光流体显微镜（OFM）装置的技术。可以使用的一种技术消除了覆盖光检测器层的孔径层。其他技术保留孔径层，反转光源和光检测器的相对位置，使得光在通过流体通道之前通过孔层，到达光检测器。另一种技术增加了用于控制移动通过流体通道的物体运动的光学镊子。另一种技术增加了光纤束，以将来自光透射区域的光中继到远程光检测器。另一种技术在流体通道的端部添加两个电极，以产生能够通过流体通道移动物体同时抑制旋转的电场。这些技术可以单独使用或组合使用以提高OFM设备的能力。

3. 发明授权

US08325349B2 Focal plane adjustment by back propagation in optofluidic microscope devices 有权
标题翻译：通过光电显微镜装置中的反向传播进行焦平面调整
公开(公告)号：US08325349B2
公开(公告)日：2012-12-04
申请号：US12638518
申请日：2009-12-15
申请人： Xiquan Cui , Lap Man Lee , Changhuei Yang
发明人： Xiquan Cui , Lap Man Lee , Changhuei Yang
IPC分类号： G01N9/02
CPC分类号： G02B21/33
摘要： Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique that may be used employs surface tension at a hydrophobic surface to passively pump the fluid sample through the fluid channel. Another technique uses electrodes to adjust the position of objects in the fluid channel. Another technique computationally adjusts the focal plane of an image wavefront measured using differential interference contrast (DIC) based on Young's interference by back propagating the image wavefront from the detection focal plane to a different focal plane. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.
摘要翻译：本发明的实施例涉及用于改进光流体显微镜（OFM）装置的技术。可以使用的一种技术使用在疏水表面处的表面张力来动态地将流体样品泵送通过流体通道。另一种技术使用电极来调节物体在流体通道中的位置。另一种技术通过从检测焦平面反向传播图像波前到不同焦平面，基于杨氏干扰，使用差分干涉对比度（DIC）来计算地调整图像波前的焦平面。这些技术可以单独使用或组合使用以提高OFM设备的能力。

4. 发明申请

US20110170105A1 Techniques for Improving Optofluidic Microscope Devices 有权
标题翻译：改进光电显微镜装置的技术
公开(公告)号：US20110170105A1
公开(公告)日：2011-07-14
申请号：US12638518
申请日：2009-12-15
申请人： Xiquan Cui , Lap Man Lee , Changhuei Yang
发明人： Xiquan Cui , Lap Man Lee , Changhuei Yang
IPC分类号： G01N21/05 , G01N21/85
CPC分类号： G02B21/33
摘要： Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique that may be used employs surface tension at a hydrophobic surface to passively pump the fluid sample through the fluid channel. Another technique uses electrodes to adjust the position of objects in the fluid channel. Another technique computationally adjusts the focal plane of an image wavefront measured using differential interference contrast (DIC) based on Young's interference by back propagating the image wavefront from the detection focal plane to a different focal plane. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.
摘要翻译：本发明的实施例涉及用于改进光流体显微镜（OFM）装置的技术。可以使用的一种技术使用在疏水表面处的表面张力来动态地将流体样品泵送通过流体通道。另一种技术使用电极来调节物体在流体通道中的位置。另一种技术通过从检测焦平面反向传播图像波前到不同焦平面，基于杨氏干扰，使用差分干涉对比度（DIC）来计算地调整图像波前的焦平面。这些技术可以单独使用或组合使用以提高OFM设备的能力。

5. 发明申请

US20090225319A1 METHODS OF USING OPTOFLUIDIC MICROSCOPE DEVICES 审中-公开
标题翻译：使用光学显微镜装置的方法
公开(公告)号：US20090225319A1
公开(公告)日：2009-09-10
申请号：US12398098
申请日：2009-03-04
申请人： Lap Man Lee , Xiquan Cui , Changhuei Yang
发明人： Lap Man Lee , Xiquan Cui , Changhuei Yang
IPC分类号： G01N21/00
CPC分类号： G01N21/6458 , G01N15/1475 , G01N2015/008 , G01N2015/1497 , G01N2021/6439
摘要： An embodiment of a method comprises providing a fluid sample having objects to an optofluidic microscope device comprising a fluid channel and a light detector, and receiving time varying light data from the fluid sample. The embodiment of the method also comprises determining one or more characteristics of the objects based on the time varying light data, and determining one or more phenotypes associated with the objects based on the determined characteristics.
摘要翻译：一种方法的实施方案包括向具有流体通道和光检测器的光流体显微镜装置提供具有物体的流体样品，并从流体样品接收时变光数据。该方法的实施例还包括基于时变光数据确定对象的一个或多个特征，以及基于所确定的特征来确定与对象相关联的一个或多个表型。

6. 发明申请

US20110063623A1 ON-CHIP PHASE MICROSCOPE/BEAM PROFILER BASED ON DIFFERENTIAL INTERFERENCE CONTRAST AND/OR SURFACE PLASMON ASSISTED INTERFERENCE 有权
标题翻译：基于差分干涉对比和/或表面质谱辅助干扰的片上相位显微镜/光束分布器
公开(公告)号：US20110063623A1
公开(公告)日：2011-03-17
申请号：US12823201
申请日：2010-06-25
申请人： Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer , Demetri Psaltis
发明人： Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer , Demetri Psaltis
IPC分类号： G01B9/02
CPC分类号： G02B21/0056 , G01N21/553 , G02B21/18 , G02B21/361
摘要： A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface wave assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector.
摘要翻译：差分干涉对比度（DIC）确定装置和方法利用照明源，具有一对两个孔的层，其接收来自照明源的照明，以及光电检测器，用于接收来自穿过该对两个孔的照明的杨氏干扰。此外，表面波辅助光流体显微镜和方法利用照明源，具有至少一个孔的层作为表面的流体通道，以及基于穿过孔的照明而接收信号的光电检测器。该层是波纹状的（例如通过制造），并且波纹的参数优化了在光电检测器上接收的信号。

7. 发明授权

US07768654B2 On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference 有权
标题翻译：基于差分干涉对比和/或表面等离子体辅助干涉的片上相位显微镜/光束轮廓仪
公开(公告)号：US07768654B2
公开(公告)日：2010-08-03
申请号：US11743581
申请日：2007-05-02
申请人： Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer , Demetri Psaltis
发明人： Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer , Demetri Psaltis
IPC分类号： G01B9/02
CPC分类号： G02B21/0056 , G01N21/553 , G02B21/18 , G02B21/361
摘要： A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface plasmon assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector.
摘要翻译：差分干涉对比度（DIC）确定装置和方法利用照明源，具有一对两个孔的层，其接收来自照明源的照明，以及光电检测器，用于接收来自穿过该对两个孔的照明的杨氏干扰。此外，表面等离子体激元辅助光流体显微镜和方法利用照明源，具有至少一个孔的层作为表面的流体通道，以及基于穿过孔的照明而接收信号的光电检测器。该层是波纹状的（例如通过制造），并且波纹的参数优化了在光电检测器上接收的信号。

8. 发明申请

US20120250027A1 Surface Wave Assisted Structures and Systems 有权
标题翻译：表面波辅助结构和系统
公开(公告)号：US20120250027A1
公开(公告)日：2012-10-04
申请号：US13344550
申请日：2012-01-05
申请人： Guoan Zheng , Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer
发明人： Guoan Zheng , Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer
IPC分类号： G01B9/02 , G02B5/18 , G01J3/46
CPC分类号： G02B6/1226 , B82Y20/00 , G01N21/554 , G02B5/008 , G02B21/0032 , G02B21/004 , G02B21/0056 , G02B21/0068 , G02B21/14 , G02B27/52
摘要： A surface wave assisted system having an aperture layer with a surface and an aperture, and a plurality of grooves around the aperture. The plurality of grooves is configured to generate an optical transfer function at the aperture by inducing a surface wave for interfering with transmission of light of a range of spatial frequency.
摘要翻译：表面波辅助系统，具有具有表面和孔径的孔层，以及围绕孔的多个凹槽。多个槽被配置为通过诱导表面波来干扰空间频率范围的光的透射来在孔处产生光学传递函数。

9. 发明申请

US20070258096A1 ON-CHIP PHASE MICROSCOPE/BEAM PROFILER BASED ON DIFFERENTIAL INTERFERENCE CONTRAST AND/OR SURFACE PLASMON ASSISTED INTERFERENCE 有权
标题翻译：基于差分干涉对比和/或表面质谱辅助干扰的片上相位显微镜/光束分布器
公开(公告)号：US20070258096A1
公开(公告)日：2007-11-08
申请号：US11743581
申请日：2007-05-02
申请人： Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer , Demetri Psaltis
发明人： Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer , Demetri Psaltis
IPC分类号： G01B9/02
CPC分类号： G02B21/0056 , G01N21/553 , G02B21/18 , G02B21/361
摘要： A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface plasmon assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector.
摘要翻译：差分干涉对比度（DIC）确定装置和方法利用照明源，具有一对两个孔的层，其接收来自照明源的照明，以及光电检测器，用于接收来自穿过该对两个孔的照明的杨氏干扰。此外，表面等离子体激元辅助光流体显微镜和方法利用照明源，具有至少一个孔作为表面的层的流体通道，以及基于穿过孔的照明而接收信号的光电检测器。该层是波纹状的（例如通过制造），并且波纹的参数优化了在光电检测器上接收的信号。

10. 发明授权

US07982883B2 On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference 有权
标题翻译：基于差分干涉对比和/或表面等离子体辅助干涉的片上相位显微镜/光束轮廓仪
公开(公告)号：US07982883B2
公开(公告)日：2011-07-19
申请号：US12823201
申请日：2010-06-25
申请人： Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer , Demetri Psaltis
发明人： Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer , Demetri Psaltis
IPC分类号： G01B9/02
CPC分类号： G02B21/0056 , G01N21/553 , G02B21/18 , G02B21/361
摘要： A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface wave assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector.
摘要翻译：差分干涉对比度（DIC）确定装置和方法利用照明源，具有一对两个孔的层，其接收来自照明源的照明，以及光电检测器，用于接收来自穿过该对两个孔的照明的杨氏干扰。此外，表面波辅助光流体显微镜和方法利用照明源，具有至少一个孔的层作为表面的流体通道，以及基于穿过孔的照明而接收信号的光电检测器。该层是波纹状的（例如通过制造），并且波纹的参数优化了在光电检测器上接收的信号。

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