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1. 发明授权

US08163530B2 Nucleic acids encoding respiratory syncytial virus subgroup B strain 9320 有权
标题翻译：编码呼吸道合胞病毒亚组B菌株9320的核酸
公开(公告)号：US08163530B2
公开(公告)日：2012-04-24
申请号：US12508075
申请日：2009-07-23
申请人： Xing Cheng , Hyun Jung Park , Hong Jin
发明人： Xing Cheng , Hyun Jung Park , Hong Jin
IPC分类号： C12N7/00 , C12N7/01 , C12N7/04 , A61K39/155
CPC分类号： C07K14/005 , A61K2039/525 , A61K2039/5254 , C07K16/1027 , C12N2760/18522
摘要： The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.
摘要翻译：提供了人呼吸道合胞病毒亚组B株9320基因组的完整多核苷酸序列。还提供了由该多核苷酸序列编码的蛋白质。还提供了分离或重组的RSV（例如减毒的重组RSV），核酸和多肽，例如包含附着蛋白G中的突变，包含这种分离的或重组的RSV，核酸和多肽的免疫原性组合物也是如此。还描述了相关方法。

2. 发明申请

US20090285853A1 Nucleic Acids Encoding Respiratory Syncytial Virus Subgroup B strain 9320 有权
标题翻译：编码呼吸道合胞病毒亚组B菌株9320的核酸
公开(公告)号：US20090285853A1
公开(公告)日：2009-11-19
申请号：US12508075
申请日：2009-07-23
申请人： Xing Cheng , Hyun Jung Park , Hong Jin
发明人： Xing Cheng , Hyun Jung Park , Hong Jin
IPC分类号： A61K39/12 , C12N15/00 , C12N7/01 , C12N15/63 , C07K14/005 , C07K16/08 , C07H21/04 , C07H21/02 , C07H21/00
CPC分类号： C07K14/005 , A61K2039/525 , A61K2039/5254 , C07K16/1027 , C12N2760/18522
摘要： The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.
摘要翻译：提供了人呼吸道合胞病毒亚组B株9320基因组的完整多核苷酸序列。还提供了由该多核苷酸序列编码的蛋白质。还提供了分离或重组的RSV（例如减毒的重组RSV），核酸和多肽，例如包含附着蛋白G中的突变，包含这种分离的或重组的RSV，核酸和多肽的免疫原性组合物也是如此。还描述了相关方法。

3. 发明申请

US20120263744A1 Compositions And Methods Involving Respiratory Syncytial Virus Subgroup B Strain 9320 审中-公开
标题翻译：组合和方法涉及呼吸道合胞病毒亚组B菌株9320
公开(公告)号：US20120263744A1
公开(公告)日：2012-10-18
申请号：US13449087
申请日：2012-04-17
申请人： Xing Cheng , Hyun Jung Park , Hong Jin
发明人： Xing Cheng , Hyun Jung Park , Hong Jin
IPC分类号： A61K39/155 , A61P31/14
CPC分类号： C07K14/005 , A61K2039/525 , A61K2039/5254 , C07K16/1027 , C12N2760/18522
摘要： The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.
摘要翻译：提供了人呼吸道合胞病毒亚组B株9320基因组的完整多核苷酸序列。还提供了由该多核苷酸序列编码的蛋白质。还提供了分离或重组的RSV（例如减毒的重组RSV），核酸和多肽，例如包含附着蛋白G中的突变，包含这种分离的或重组的RSV，核酸和多肽的免疫原性组合物也是如此。还描述了相关方法。

4. 发明授权

US07572904B2 Nucleic acids encoding respiratory syncytial virus subgroup B strain 9320 有权
标题翻译：编码呼吸道合胞病毒亚组B菌株9320的核酸
公开(公告)号：US07572904B2
公开(公告)日：2009-08-11
申请号：US10811508
申请日：2004-03-26
申请人： Xing Cheng , Hyun Jung Park , Hong Jin
发明人： Xing Cheng , Hyun Jung Park , Hong Jin
IPC分类号： C07H21/00 , A61K39/155
CPC分类号： C07K14/005 , A61K2039/525 , A61K2039/5254 , C07K16/1027 , C12N2760/18522
摘要： The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.
摘要翻译：提供了人呼吸道合胞病毒亚组B株9320基因组的完整多核苷酸序列。还提供了由该多核苷酸序列编码的蛋白质。还提供了分离的或重组的RSV（例如，减毒的重组RSV），核酸和多肽，例如包含附着蛋白G中的突变，以及包含这种分离或重组的RSV，核酸和多肽的免疫原性组合物。还描述了相关方法。

5. 发明申请

US20140187743A1 SURFACE-ACTIVE COLLAGEN MEMBRANE BY PEPTIDE 有权
标题翻译：表皮活性胶原膜
公开(公告)号：US20140187743A1
公开(公告)日：2014-07-03
申请号：US14112929
申请日：2011-12-16
申请人： Chong-Pyoung Chung , Yoon-Jeong Park , Jue-Yeon Lee , In Kyong Shim , Hyun Jung Park
发明人： Chong-Pyoung Chung , Yoon-Jeong Park , Jue-Yeon Lee , In Kyong Shim , Hyun Jung Park
IPC分类号： C07K14/78 , C07K14/00
CPC分类号： C07K14/001 , A61K38/00 , A61L27/24 , A61L27/54 , A61L27/60 , A61L2300/252 , A61L2300/404 , A61L2300/80 , A61L2430/02 , C07K14/4723 , C07K14/485 , C07K14/49 , C07K14/51 , C07K14/78 , C07K2319/00 , C12N15/62
摘要： The present invention relates to a membrane having bound thereto an antibacterial peptide that binds to collagen, and more particularly to a collagen membrane comprising a fusion peptide of a collagen-binding peptide and an antibacterial peptide, fixed to the collagen surface.The present invention provides a collagen membrane having surface activity by a fusion peptide bound to the surface thereof. When the collagen membrane is transplanted in vivo, the retention time of the fusion peptide in a local region can increase, and the fusion peptide can promote the cell migration, proliferation and differentiation associated with bone tissue regeneration, thereby maximizing the ability to regenerate bone tissue. Thus, the collagen membrane contributes to the development of therapeutic technology for bone induction and regeneration. Also, the fusion peptide may be applied to other types of graft materials made of collagen. In addition, the collagen-binding peptide of the fusion peptide can also be bound to peptides having the effect of regenerating other tissues, and thus can be applied as a biomaterial for regeneration of other tissues such as the skin.
摘要翻译：本发明涉及一种与胶原结合的抗菌肽结合的膜，更具体地涉及一种固定在胶原表面上的胶原膜，其包含胶原结合肽和抗菌肽的融合肽。本发明提供了具有与其表面结合的融合肽的表面活性的胶原膜。当胶原膜在体内移植时，融合肽在局部区域的停留时间可以增加，并且融合肽可以促进与骨组织再生相关的细胞迁移，增殖和分化，从而最大化再生骨组织的能力。因此，胶原膜有助于骨诱导和再生的治疗技术的发展。此外，融合肽可以应用于由胶原蛋白制成的其他类型的移植材料。此外，融合肽的胶原结合肽也可以与具有再生其他组织的作用的肽结合，因此可以用作其它组织如皮肤的再生的生物材料。

6. 发明授权

US07781592B2 Thione derivative, method for the preparation thereof, and pharmaceutical composition containing the same 有权
标题翻译：噻吩衍生物，其制备方法和含有它的药物组合物
公开(公告)号：US07781592B2
公开(公告)日：2010-08-24
申请号：US10580454
申请日：2003-11-25
申请人： Il Hwan Cho , Myeong Yun Chae , Young Hoon Kim , Kyu Jeong Yeon , Chun Seon Lyu , Jong Hoon Kim , Sung Hak Jung , Sang Wook Park , Hyung Chul Ryu , Ji Young Noh , Hyun Jung Park , Jie Eun Park , Young Mee Chung
发明人： Il Hwan Cho , Myeong Yun Chae , Young Hoon Kim , Kyu Jeong Yeon , Chun Seon Lyu , Jong Hoon Kim , Sung Hak Jung , Sang Wook Park , Hyung Chul Ryu , Ji Young Noh , Hyun Jung Park , Jie Eun Park , Young Mee Chung
IPC分类号： C07D339/02 , C07D411/10
CPC分类号： C07D231/18 , C07C317/44 , C07D213/55 , C07D339/04 , C07D409/04
摘要： A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.
摘要翻译：提供式1的1,2,4-三唑衍生物或其无毒盐，其制备方法和含有该衍生物或盐作为有效成分的药物组合物。

7. 发明授权

US07364940B2 Organic thin film transistor including fluorine-based polymer thin film and method of fabricating the same 有权
标题翻译：包含氟基聚合物薄膜的有机薄膜晶体管及其制造方法
公开(公告)号：US07364940B2
公开(公告)日：2008-04-29
申请号：US11296704
申请日：2005-12-08
申请人： Joo Young Kim , Eun Kyung Lee , Bang Lin Lee , Bon Won Koo , Hyun Jung Park , Sang Yoon Lee
发明人： Joo Young Kim , Eun Kyung Lee , Bang Lin Lee , Bon Won Koo , Hyun Jung Park , Sang Yoon Lee
IPC分类号： H01L51/40
CPC分类号： H01L21/0212 , H01L21/02282 , H01L21/3127 , H01L21/31691 , H01L51/0036 , H01L51/052 , H01L51/0529 , H01L51/0541 , H01L51/0545
摘要： An organic thin film transistor including a fluorine-based polymer thin film and method of fabricating the same. The organic thin film transistor may include a gate electrode, a gate insulating layer, an organic semiconductor layer, source electrode, and a drain electrode formed on a substrate wherein a fluorine-based polymer thin film may be formed (or deposited) at the interface between the gate insulating layer and the organic semiconductor layer. The organic thin film transistor may have higher charge carrier mobility and/or higher on/off current ratio (Ion/Ioff). In addition, a polymer organic semiconductor may be used to form the insulating layer and the organic semiconductor layer by wet processes, so the organic thin film transistor may be fabricated by simplified procedure(s) at reduced costs.
摘要翻译：包含氟基聚合物薄膜的有机薄膜晶体管及其制造方法。有机薄膜晶体管可以包括形成在基板上的栅电极，栅极绝缘层，有机半导体层，源电极和漏电极，其中可以在界面处形成（或沉积）氟基聚合物薄膜在栅绝缘层和有机半导体层之间。有机薄膜晶体管可具有较高的电荷载流子迁移率和/或较高的导通/截止电流比（I />）。此外，可以使用聚合物有机半导体通过湿法形成绝缘层和有机半导体层，因此有机薄膜晶体管可以通过简化的程序以降低的成本制造。

8. 发明申请

US20080090875A1 Thione Derivative, Method For The Preparation Thereof, And Pharmaceutical Composition Containing The Same 有权
标题翻译：硫代衍生物，其制备方法及含有其的药物组合物
公开(公告)号：US20080090875A1
公开(公告)日：2008-04-17
申请号：US10580454
申请日：2003-11-25
申请人： Il Hwan Cho , Myeong Yun Chae , Young Hoon , Kyu Jeong Yeon , Chun Seon Lyu , Jong Hoon Kim , Sung Hak Jung , Sang Wook Park , Hyung Chul Ryu , Ji Young Noh , Hyun Jung Park , Jie Eun Park , Young Mee Chung
发明人： Il Hwan Cho , Myeong Yun Chae , Young Hoon , Kyu Jeong Yeon , Chun Seon Lyu , Jong Hoon Kim , Sung Hak Jung , Sang Wook Park , Hyung Chul Ryu , Ji Young Noh , Hyun Jung Park , Jie Eun Park , Young Mee Chung
IPC分类号： A61K31/385 , A61K31/4365 , A61P25/04 , A61P29/00 , C07C317/44 , C07D213/55 , C07D231/18 , C07D339/04 , C07D409/04
CPC分类号： C07D231/18 , C07C317/44 , C07D213/55 , C07D339/04 , C07D409/04
摘要： A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.
摘要翻译：提供式1的1,2,4-三唑衍生物或其无毒盐，其制备方法和含有该衍生物或盐作为有效成分的药物组合物。

9. 发明授权

US06689805B2 Pyrazole-3-one derivative, method for preparing the same, and pharmaceutical composition containing the same 失效
标题翻译：吡唑-3-酮衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06689805B2
公开(公告)日：2004-02-10
申请号：US10461978
申请日：2003-06-13
申请人： Il Hwan Cho , Ji Young Noh , Sang Wook Park , Hyung Chul Ryu , Jee Woong Lim , Jong Hoon Kim , Myeong Yun Chae , Dal Hyun Kim , Sung Hak Jung , Hyun Jung Park , Young Hoon Kim , In Ki Min
发明人： Il Hwan Cho , Ji Young Noh , Sang Wook Park , Hyung Chul Ryu , Jee Woong Lim , Jong Hoon Kim , Myeong Yun Chae , Dal Hyun Kim , Sung Hak Jung , Hyun Jung Park , Young Hoon Kim , In Ki Min
IPC分类号： A61K314152
CPC分类号： C07D231/20 , C07D231/18 , C07D231/22
摘要： A pyrazole-3-one derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: wherein: R1 and R2 each independently represent C1-C3 alkyl, aryl, or substituted aryl; R3 represents amino or methyl; R4 and R5 each independently represent hydrogen, C1-C3 alkyl, halogen, methyl substituted with halogen, C1-C3 alkoxy, cyano, or nitro; or a non-toxic salt thereof.
摘要翻译：提供式1的吡唑-3-酮衍生物或其无毒盐，其制备方法和含有该衍生物或盐作为活性成分的药物组合物：其中：R1和R2各自独立地表示C1- C3烷基，芳基或取代的芳基; R3表示氨基或甲基; R4和R5各自独立地表示氢，C1-C3烷基，卤素，被卤素取代的甲基，C1-C3烷氧基，氰基或硝基;或无毒的盐。

10. 发明申请

US20130203131A1 METHOD FOR PREPARING 2-PYRROLIDONE USING BIOMASS 有权
标题翻译：使用生物质制备2-吡咯烷酮的方法
公开(公告)号：US20130203131A1
公开(公告)日：2013-08-08
申请号：US13876926
申请日：2011-09-30
申请人： Dong Cheol Park , Ki Kueon King , Hyun Jung Park , Seo Hyoung Kim , Jae Young Oh
发明人： Dong Cheol Park , Ki Kueon King , Hyun Jung Park , Seo Hyoung Kim , Jae Young Oh
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C07D207/26 , C12N9/88 , C12P13/005 , C12P2203/00
摘要： The present invention relates to a method for preparing 2-pyrrolidone using biomass, comprising: a step (a) of culturing a microorganism which contains glutamate decarboxylase as a whole-cell catalyst in a culture medium containing glutamic acid or glutamate so as to prepare 4-amino butyric acid; a step (b) of filtering the 4-amino butyric acid from the culture medium in order to obtain the 4-amino butyric acid; and a step (c) of converting the 4-amino butyric acid into 2-pyrrolidone. The present invention provides a series of processes for preparing 2-pyrrolidone from glutamic acid or glutamate using biomass. According to the present invention, 4-amino butyric acid is prepared using a microorganism as a whole cell, and preferably, 4-amino butyric acid which has not undergone a complicated refining process such as a crystallization process is directly used to prepare 2-pyrrolidone at a high yield rate in an economically advantageous manner. According to the present invention, 2-pyrrolidone may be mass-produced at a high yield rate and low production costs. The method of the present invention simplifies processes for preparing 2-pyrrolidone, and thus is suitable for mass production at an industrial scale.
摘要翻译：本发明涉及使用生物质制备2-吡咯烷酮的方法，包括：（a）在含谷氨酸或谷氨酸的培养基中培养含谷氨酸脱羧酶作为全细胞催化剂的微生物，以制备4 - 氨基丁酸; 从培养基中过滤4-氨基丁酸以获得4-氨基丁酸的步骤（b）; 和将4-氨基丁酸转化为2-吡咯烷酮的步骤（c）。本发明提供了使用生物质从谷氨酸或谷氨酸制备2-吡咯烷酮的一系列方法。根据本发明，使用微生物作为全细胞制备4-氨基丁酸，优选直接使用未经历复杂精制方法如结晶过程的4-氨基丁酸制备2-吡咯烷酮以高收益率以经济上有利的方式。根据本发明，2-吡咯烷酮可以高产率大批量生产，生产成本低。本发明的方法简化了制备2-吡咯烷酮的方法，因此适用于工业规模的批量生产。

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