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1. 发明申请

US20070112005A1 Fused bicyclic mTOR inhibitors 有权
标题翻译：融合双环mTOR抑制剂
公开(公告)号：US20070112005A1
公开(公告)日：2007-05-17
申请号：US11599663
申请日：2006-11-15
申请人： Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
发明人： Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
IPC分类号： A61K31/498 , A61K31/53 , C07D487/12
CPC分类号： C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译：由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。

2. 发明申请

US20070129364A1 Pyrrolopyridine kinase inhibiting compounds 审中-公开
标题翻译：吡咯并吡啶激酶抑制化合物
公开(公告)号：US20070129364A1
公开(公告)日：2007-06-07
申请号：US11634003
申请日：2006-12-05
申请人： Han-Qing Dong , Kenneth Foreman , An-Hu Li , Mark Mulvihill , Bijoy Panicker , Arno Steinig , Kathryn Stolz , Qinghua Weng , Meizhong Jin , Brian Volk , Jing Wang , Ti Wang , James Beard
发明人： Han-Qing Dong , Kenneth Foreman , An-Hu Li , Mark Mulvihill , Bijoy Panicker , Arno Steinig , Kathryn Stolz , Qinghua Weng , Meizhong Jin , Brian Volk , Jing Wang , Ti Wang , James Beard
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least one of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Met, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译：由式（I）表示的化合物或其立体异构体或其药学上可接受的盐是Abl，Aurora-A，Blk，c-Raf，cSRC，Src，PRK2，FGFR3，Flt3，Lck，Mek1，PDK中的至少一种的抑制剂 -1，GSK3beta，EGFR，p70S6K，BMX，SGK，CaMKII，Tie-2，IGF-1R，Ron，Met和KDR激酶，用于治疗和/或预防各种疾病和病症，癌症。

3. 发明申请

US20120116583A1 Mobile, climbing endless track robotic system to perform remote inspections on structures 审中-公开
标题翻译：移动，攀爬无尽的轨道机器人系统，对结构进行远程检查
公开(公告)号：US20120116583A1
公开(公告)日：2012-05-10
申请号：US13291876
申请日：2011-11-08
申请人： James Beard , Stephen Canfield , Steve Glovsky
发明人： James Beard , Stephen Canfield , Steve Glovsky
IPC分类号： B25J13/00 , B25J19/00 , B25J13/08 , B25J19/02 , B62D55/06 , B25J9/10
CPC分类号： B62D55/265 , B62D55/108 , B62D55/202 , B62D55/305
摘要： An endless-track type mobile climbing vehicle containing a suspension apparatus, transducer manipulator and surface cleaning system to perform non-destructive examination of structures while traversing the structure in all positions. The invention is able to conform to large range of irregularities of the climbing surface while maintaining contact between the track and adhering members and uniformly distributing the climbing loads on the adhering members giving the system a high payload to weight ratio. The invention is moves the inspection transducer over the surface while maintaining correct alignment of the tool relative to the surface. The invention allows an operator to perform an inspection on structures that require cleaning or other preparation prior to inspection. The invention allows an operator to perform an inspection remotely.
摘要翻译：一种包括悬挂装置，换能器操纵器和表面清洁系统的无轨道式移动爬坡车辆，可在所有位置穿过结构物时进行结构的非破坏性检查。本发明能够符合爬坡表面的大范围的不规则性，同时保持轨道和粘接构件之间的接触，并将爬坡载荷均匀地分布在附着构件上，使系统具有高的有效负载重量比。本发明将检查传感器移动到表面上，同时保持工具相对于表面的正确对准。本发明允许操作者在检查之前对需要清洁或其它制备的结构进行检查。本发明允许操作者远程执行检查。

4. 发明授权

US10315715B2 Mobile, climbing endless track robotic system to perform remote inspections on structures 有权
公开(公告)号：US10315715B2
公开(公告)日：2019-06-11
申请号：US13291876
申请日：2011-11-08
申请人： James Beard , Stephen Canfield , Steve Glovsky
发明人： James Beard , Stephen Canfield , Steve Glovsky
IPC分类号： B62D55/265 , B62D55/30 , B62D55/108 , B62D55/20
摘要： An endless-track type mobile climbing vehicle containing a suspension apparatus, transducer manipulator and surface cleaning system to perform non-destructive examination of structures while traversing the structure in all positions. The invention is able to conform to large range of irregularities of the climbing surface while maintaining contact between the track and adhering members and uniformly distributing the climbing loads on the adhering members giving the system a high payload to weight ratio. The invention is moves the inspection transducer over the surface while maintaining correct alignment of the tool relative to the surface. The invention allows an operator to perform an inspection on structures that require cleaning or other preparation prior to inspection. The invention allows an operator to perform an inspection remotely.

5. 发明申请

US20120111649A1 Suspension for an endless track climbing machine 有权
标题翻译：悬挂无尽的爬坡机
公开(公告)号：US20120111649A1
公开(公告)日：2012-05-10
申请号：US13291890
申请日：2011-11-08
申请人： James Beard , Stephen Canfield , Steve Glovsky
发明人： James Beard , Stephen Canfield , Steve Glovsky
IPC分类号： B62D55/08 , B62D55/112 , B62D55/26 , B62D55/104
CPC分类号： B62D55/305 , B62D55/108 , B62D55/202 , B62D55/26
摘要： An endless-track type climbing vehicle containing a multi-link suspension apparatus to uniformly distribute the forces on the on the adhering members while traversing irregular climbing surfaces. The multi-links suspension apparatus is able to conform to large range of surface irregularities while providing push and pulling forces on the adhering members to uniformly distribute the climbing loads on the adhering members. The result is a climbing machine that can accommodate large surface irregularities while maximizing the climbing payload with a minimum number and size of adhering members.
摘要翻译：一种包括多连杆悬挂装置的环形轨道式攀爬车辆，用于在穿过不规则的爬坡表面时均匀地将力分布在粘附构件上。多连杆悬挂装置能够符合大范围的表面凹凸，同时在附着构件上提供推力和拉力，以均匀地将爬坡载荷分布在附着构件上。结果是可以容纳大的表面不规则性的爬坡机，同时以最小数量和尺寸的附着构件最大化攀爬有效载荷。

6. 发明申请

US20080112868A1 CARBONATION OF METAL SILICATES FOR LONG-TERM CO2 SEQUESTRATION 有权
标题翻译：用于长期二氧化碳测序的金属硅酸盐的碳化
公开(公告)号：US20080112868A1
公开(公告)日：2008-05-15
申请号：US12016098
申请日：2008-01-17
申请人： James Blencoe , Donald Palmer , Lawrence Anovitz , James Beard
发明人： James Blencoe , Donald Palmer , Lawrence Anovitz , James Beard
IPC分类号： B01J8/02
CPC分类号： B01D53/62 , B01D2251/30 , B01D2251/604 , B01D2258/02 , C01B32/60 , C01F5/24 , C01F11/18 , C01F11/181 , Y02C10/04 , Y02P20/152
摘要： In a preferred embodiment, the invention relates to a process of sequestering carbon dioxide. The process comprises the steps of: (a) reacting a metal silicate with a caustic alkali-metal hydroxide to produce a hydroxide of the metal formerly contained in the silicate; (b) reacting carbon dioxide with at least one of a caustic alkali-metal hydroxide and an alkali-metal silicate to produce at least one of an alkali-metal carbonate and an alkali-metal bicarbonate; and (c) reacting the metal hydroxide product of step (a) with at least one of the alkali-metal carbonate and the alkali-metal bicarbonate produced in step (b) to produce a carbonate of the metal formerly contained in the metal silicate of step (a).
摘要翻译：在优选的实施方案中，本发明涉及隔离二氧化碳的方法。该方法包括以下步骤：（a）使金属硅酸盐与苛性碱金属氢氧化物反应以产生以前包含在硅酸盐中的金属的氢氧化物; （b）使二氧化碳与苛性碱金属氢氧化物和碱金属硅酸盐中的至少一种反应以产生碱金属碳酸盐和碱金属碳酸氢盐中的至少一种; 和（c）使步骤（a）的金属氢氧化物产物与步骤（b）中制备的碱金属碳酸盐和碱金属碳酸氢盐中的至少一种反应，以产生以前包含在金属硅酸盐中的金属的碳酸盐步骤（a）。

7. 发明申请

US20120111843A1 Mobile, climbing robotic system to perform remote welds on ferrous materials 审中-公开
标题翻译：移动式爬坡机器人系统对黑色金属材料进行远程焊接
公开(公告)号：US20120111843A1
公开(公告)日：2012-05-10
申请号：US13291791
申请日：2011-11-08
申请人： James Beard , Stephen Canfield , Steven Glovsky
发明人： James Beard , Stephen Canfield , Steven Glovsky
IPC分类号： B23K9/32
CPC分类号： B23K9/173 , B23K37/0241 , B23K37/0264 , B23K37/0282 , B23K2101/006 , B23K2103/04
摘要： An endless-track type mobile climbing vehicle containing a suspension apparatus and tool manipulator to perform trackless, guide-free welding in all positions or other manufacturing tasks. The invention can conform to a wide range of surface irregularities while maintaining contact between the track and adhering members and uniformly distributing the climbing loads on the adhering members giving the system a high payload to weight ratio. The vehicle with tool manipulator provides all necessary tool motion and stabilizes tool motion for tasks with strict requirements such as welding. The invention allows an operator to supervise and control the weld process through a controller. The invention allows the operator to specify weld motion control parameters for five axes and provides closed loop motion control to track the settings input by the welding operator. The invention also provides closed-loop tracking control to maintain the position of the robot along the longitudinal weld seam.
摘要翻译：一种包含悬挂装置和工具操纵器的环形轨道式移动爬坡车，用于在所有位置或其他制造任务中执行无轨，无引导焊接。本发明可以符合宽范围的表面不规则性，同时保持轨道和粘附构件之间的接触，并且均匀地将爬坡载荷分布在附着构件上，使系统具有高的有效负载重量比。具有刀具操纵器的车辆提供了所有必要的刀具运动，并稳定了具有严格要求（如焊接）的任务的刀具运动。本发明允许操作者通过控制器来监督和控制焊接过程。本发明允许操作者为五个轴指定焊接运动控制参数，并且提供闭环运动控制以跟踪由焊接操作者输入的设置。本发明还提供闭环跟踪控制，以保持机器人沿着纵向焊缝的位置。

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