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1. 发明申请

US20130338099A1 MERCAPTO-MODIFIED BIOCOMPATIBLE MACROMOLECULE DERIVATIVES WITH LOW DEGREE OF MERCAPTO-MODIFICATION AND THE CROSS-LINKED MATERIALS AND USES THEREOF 有权
标题翻译：具有较低修饰程度的MERCAPTO改性的生物可分解的衍生物和交联材料及其用途
公开(公告)号：US20130338099A1
公开(公告)日：2013-12-19
申请号：US13821666
申请日：2011-08-04
申请人： Xiaozheng Shu , Weiping Zhong , Yunyun Wang , Meixia Yu
发明人： Xiaozheng Shu , Weiping Zhong , Yunyun Wang , Meixia Yu
IPC分类号： A61K31/737 , A61K45/06 , A61K31/728
CPC分类号： A61K31/737 , A61K9/0024 , A61K9/06 , A61K31/573 , A61K31/728 , A61K31/738 , A61K45/06 , A61L31/04 , C08B37/0069 , C08B37/0072 , C08F8/34 , C08J3/075 , C08J2301/00 , C08L101/02
摘要： The present invention discloses a mercapto-modified biocompatible macromolecule derivative with a low degree of modification. The mercapto-modified biocompatible macromolecule derivative not only maintains the initial structure, physiological function and biocompatibility as much as possible, but also allows the preparation of the biocompatible macromolecule cross-linked material with a low degree of cross-linking through the effectively chemical cross-linking with the introduced mercapto group. The present invention further discloses a disulfide-bond cross-linked biocompatible macromolecule material with a very low degree of cross-linking. The disulfide-bond cross-linked biocompatible macromolecule material not only maintains the initial structure, physiological function and biocompatibility of the biocompatible macromolecule as much as possible, but also effectively prolongs turn over and reduces the solubility of the biocompatible macromolecule in vivo, better meeting the requirements of various clinical applications. The present invention further relates to the application of the disulfide-bond cross-linked biocompatible macromolecule material in the field of medicine and pharmacy.
摘要翻译：本发明公开了一种巯基改性的生物相容性大分子衍生物，其改性程度较低。巯基改性的生物相容性高分子衍生物不仅可以尽可能维持初始结构，生理功能和生物相容性，而且可以通过有效的化学交联制备具有低交联度的生物相容性大分子交联材料，与引入的巯基连接。本发明还公开了具有非常低的交联度的二硫键交联的生物相容性大分子材料。二硫键交联生物相容性高分子材料不仅可以保持生物相容性大分子的初始结构，生理功能和生物相容性，而且有效延长生物相容性大分子在体内的溶解度，更好地满足各种临床应用要求。本发明还涉及二硫键交联生物相容性大分子材料在医药领域的应用。

2. 发明授权

US09446067B2 Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof 有权
标题翻译：巯基改性的巯基改性生物相容性大分子衍生物和交联材料及其用途
公开(公告)号：US09446067B2
公开(公告)日：2016-09-20
申请号：US13821666
申请日：2011-08-04
申请人： Xiaozheng Shu , Weiping Zhong , Yunyun Wang , Meixia Yu
发明人： Xiaozheng Shu , Weiping Zhong , Yunyun Wang , Meixia Yu
IPC分类号： A61K31/737 , A61K31/728 , A61K31/573 , C08B37/00 , C08B37/08 , C08J3/075 , C08F8/34 , A61L31/04 , A61K45/06
CPC分类号： A61K31/737 , A61K9/0024 , A61K9/06 , A61K31/573 , A61K31/728 , A61K31/738 , A61K45/06 , A61L31/04 , C08B37/0069 , C08B37/0072 , C08F8/34 , C08J3/075 , C08J2301/00 , C08L101/02
摘要： The present invention discloses a mercapto-modified biocompatible macromolecule derivative with a low degree of modification. The mercapto-modified biocompatible macromolecule derivative not only maintains the initial structure, physiological function and biocompatibility as much as possible, but also allows the preparation of the biocompatible macromolecule cross-linked material with a low degree of cross-linking through the effectively chemical cross-linking with the introduced mercapto group. The present invention further discloses a disulfide-bond cross-linked biocompatible macromolecule material with a very low degree of cross-linking. The disulfide-bond cross-linked biocompatible macromolecule material not only maintains the initial structure, physiological function and biocompatibility of the biocompatible macromolecule as much as possible, but also effectively prolongs turn over and reduces the solubility of the biocompatible macromolecule in vivo, better meeting the requirements of various clinical applications. The present invention further relates to the application of the disulfide-bond cross-linked biocompatible macromolecule material in the field of medicine and pharmacy.
摘要翻译：本发明公开了一种巯基改性的生物相容性大分子衍生物，其改性程度较低。巯基改性的生物相容性高分子衍生物不仅可以尽可能维持初始结构，生理功能和生物相容性，而且可以通过有效的化学交联制备具有低交联度的生物相容性大分子交联材料，与引入的巯基连接。本发明还公开了具有非常低的交联度的二硫键交联的生物相容性大分子材料。二硫键交联生物相容性高分子材料不仅可以保持生物相容性大分子的初始结构，生理功能和生物相容性，而且有效延长生物相容性大分子在体内的溶解度，更好地满足要求各种临床应用。本发明还涉及二硫键交联生物相容性大分子材料在医药领域的应用。

3. 发明申请

US20120034271A1 INJECTABLE IN-SITU CROSSLINKED HYDROGEL AND METHODS OF MAKING AND USING THEREOF 有权
标题翻译：可接受的原位交联水凝胶及其制备和使用方法
公开(公告)号：US20120034271A1
公开(公告)日：2012-02-09
申请号：US13124412
申请日：2009-09-08
申请人： Xiaozheng Shu
发明人： Xiaozheng Shu
IPC分类号： A61K9/00 , A61P35/00 , A61P31/00 , A61K31/56
CPC分类号： A61K9/0019 , A61K9/0024 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/406 , A61L2300/416 , C08J3/075 , C08J3/24 , C08J2305/00
摘要： The present invention discloses an injectable in-situ crosslinked hydrogel and its preparation method. The preparation method is as below: Filling the crosslinking active solution of at least one kind of the biocompatible macromolecules containing more than two thiol groups on the side chains into an injectable container and sealing it, and forming the in-situ disulfide-bond crosslinked hydrogel under the action of the dissolved oxygen; through controlling such parameters as partial pressure of oxygen gas, temperature and time, regulating concentration of the oxygen dissolved in the crosslinking active solution, and optimizing the gelation process and the gel properties. The present invention further relates to application of the injectable in-situ crosslinked hydrogel in pharmaceutics or surgery. The present invention has many advantages, such as no need for a crosslinking agent, simple preparation process, convenient application, containing no impurities, good biocompatibility, no toxic and side effect, and wide application in the medical science.
摘要翻译：本发明公开了一种可注射的原位交联水凝胶及其制备方法。制备方法如下：将至少一种含有两个以上硫醇基的生物相容性大分子的交联活性溶液填充到可注射容器中并密封，并形成原位二硫键交联水凝胶在溶解氧的作用下; 通过控制氧气分压，温度和时间等参数，调节溶解在交联活性溶液中的氧浓度，优化凝胶化过程和凝胶性能。本发明还涉及可注射原位交联的水凝胶在药物或手术中的应用。本发明具有交联剂不需要，制备工艺简单，使用方便，不含杂质，生物相容性好，无毒副作用，在医学上广泛应用的优点。

4. 发明授权

US08067636B2 Dihydrazide compounds, preparation and uses thereof 有权
标题翻译：二酰肼化合物，其制备和用途
公开(公告)号：US08067636B2
公开(公告)日：2011-11-29
申请号：US12516108
申请日：2007-09-17
申请人： Xiaozheng Shu
发明人： Xiaozheng Shu
IPC分类号： C07C243/14 , C07C233/05 , A61K31/16
CPC分类号： C07C323/41 , C07C323/60
摘要： Disclosed are dihydrazide compounds having formula (I) or (II), wherein R1-R4 are alkylene, substituted alkylene, aryl or polyether radical. The preparation and uses for producing medical hydrogel and medicine controlled releasing carrier of said dihydrazide compounds are provided.
摘要翻译：公开了具有式（I）或（II）的二酰肼化合物，其中R 1 -R 4是亚烷基，取代的亚烷基，芳基或聚醚基。提供了用于制备所述二酰肼化合物的医用水凝胶和药物释放载体的制备和用途。

5. 发明申请

US20100048952A1 DIHYDRAZIDE COMPOUNDS, PREPARATION AND USES THEREOF 有权
标题翻译：二氢化合物，其制备及其用途
公开(公告)号：US20100048952A1
公开(公告)日：2010-02-25
申请号：US12516108
申请日：2007-09-17
申请人： Xiaozheng Shu
发明人： Xiaozheng Shu
IPC分类号： C07C381/00
CPC分类号： C07C323/41 , C07C323/60
摘要： Disclosed are dihydrazide compounds having formula (I) or (II), wherein R1-R4 are alkylene, substituted alkylene, aryl or polyether radical. The preparation and uses for producing medical hydrogel and medicine controlled releasing carrier of said dihydrazide compounds are provided.
摘要翻译：公开了具有式（I）或（II）的二酰肼化合物，其中R 1 -R 4是亚烷基，取代的亚烷基，芳基或聚醚基。提供了用于制备所述二酰肼化合物的医用水凝胶和药物释放载体的制备和用途。

6. 发明授权

US09220676B2 Injectable in-situ crosslinked hydrogel and methods of making and using thereof 有权
标题翻译：可注射的原位交联水凝胶及其制备和使用方法
公开(公告)号：US09220676B2
公开(公告)日：2015-12-29
申请号：US13124412
申请日：2009-09-08
申请人： Xiaozheng Shu
发明人： Xiaozheng Shu
IPC分类号： A61K31/56 , A61P35/00 , A61P31/00 , A61K9/00 , A61L27/52 , A61L27/54 , A61L31/14 , A61L31/16 , C08J3/075 , C08J3/24
CPC分类号： A61K9/0019 , A61K9/0024 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/406 , A61L2300/416 , C08J3/075 , C08J3/24 , C08J2305/00
摘要： The present invention discloses an injectable in-situ crosslinked hydrogel and its preparation method. The preparation method is as below: Filling the crosslinking active solution of at least one kind of the biocompatible macromolecules containing more than two thiol groups on the side chains into an injectable container and sealing it, and forming the in-situ disulfide-bond crosslinked hydrogel under the action of the dissolved oxygen; through controlling such parameters as partial pressure of oxygen gas, temperature and time, regulating concentration of the oxygen dissolved in the crosslinking active solution, and optimizing the gelation process and the gel properties. The present invention further relates to application of the injectable in-situ crosslinked hydrogel in pharmaceutics or surgery. The present invention has many advantages, such as no need for a crosslinking agent, simple preparation process, convenient application, containing no impurities, good biocompatibility, no toxic and side effect, and wide application in the medical science.
摘要翻译：本发明公开了一种可注射的原位交联水凝胶及其制备方法。制备方法如下：将至少一种含有两个以上硫醇基的生物相容性大分子的交联活性溶液填充到可注射容器中并密封，并形成原位二硫键交联水凝胶在溶解氧的作用下; 通过控制氧气分压，温度和时间等参数，调节溶解在交联活性溶液中的氧浓度，优化凝胶化过程和凝胶性能。本发明还涉及可注射原位交联的水凝胶在药物或手术中的应用。本发明具有交联剂不需要，制备工艺简单，使用方便，不含杂质，生物相容性好，无毒副作用，在医学上广泛应用的优点。

7. 发明授权

US08647670B2 Biocompatible rapid-gelating hydrogel and associated preparation method of spray 有权
标题翻译：生物相容性快速胶凝水凝胶及其相关制备方法
公开(公告)号：US08647670B2
公开(公告)日：2014-02-11
申请号：US12452441
申请日：2008-06-10
申请人： Xiaozheng Shu
发明人： Xiaozheng Shu
IPC分类号： A61K9/14 , A61K31/74 , C07H7/02
CPC分类号： A61L27/52 , C08G75/04 , C08G75/045
摘要： This invention discloses a preparation method for biocompatible rapid-gelating hydrogel. Wherein, hydrogel is formed by rapid chemical-crosslinking using the mixing and chemical-crosslinking reaction under specified conditions between several active compound components. The preparation method comprises the following steps: (1) The solution containing biocompatible thiolated macromolecular derivatives (component A) and biocompatible thiol reactive crosslinking agents (component B) mutually mix to form reactive mixture with specified crosslinking conditions; (2) the reactive mixture forms the hydrogel. The invention also discloses a preparation method for novel rapid-gelating hydrogel spray and an application in medical field. This invention has the advantages of good biocompatibility, no by-products, good stability, convenient use, small amount of raw materials used, suitable for many medical application, etc.
摘要翻译：本发明公开了一种生物相容性快速胶凝水凝胶的制备方法。其中，水凝胶通过在几种活性化合物组分之间的特定条件下的混合和化学交联反应的快速化学交联形成。制备方法包括以下步骤：（1）含有生物相容性硫醇化大分子衍生物（A组分）和生物相容性硫醇反应性交联剂（B组分）的溶液相互混合，形成具有规定交联条件的反应性混合物; （2）反应混合物形成水凝胶。本发明还公开了一种新型快速凝胶化水凝胶喷雾的制备方法及其在医学领域的应用。本发明具有生物相容性好，无副产物，稳定性好，使用方便，使用少量原料，适用于多种医疗用途等优点。

8. 发明申请

US20100144902A1 BIOCOMPATIBLE RAPID-GELATING HYDROGEL AND ASSOCIATED PREPARATION METHOD OF SPRAY 有权
标题翻译：生物降解快速凝胶水凝胶和相关的喷射制备方法
公开(公告)号：US20100144902A1
公开(公告)日：2010-06-10
申请号：US12452441
申请日：2008-06-10
申请人： Xiaozheng Shu
发明人： Xiaozheng Shu
IPC分类号： A61K47/42 , A61K47/30 , A61K47/36 , A61P17/02
CPC分类号： A61L27/52 , C08G75/04 , C08G75/045
摘要： This invention discloses a preparation method for biocompatible rapid-gelating hydrogel. Wherein, hydrogel is formed by rapid chemical-crosslinking using the mixing and chemical-crosslinking reaction under specified conditions between several active compound components. The preparation method comprises the following steps: (1) The solution containing biocompatible thiolated macromolecular derivatives (component A) and biocompatible thiol reactive crosslinking agents (component B) mutually mix to form reactive mixture with specified crosslinking conditions; (2) the reactive mixture forms the hydrogel. The invention also discloses a preparation method for novel rapid-gelating hydrogel spray and an application in medical field. This invention has the advantages of good biocompatibility, no by-products, good stability, convenient use, small amount of raw materials used, suitable for many medical application, etc.
摘要翻译：本发明公开了一种生物相容性快速胶凝水凝胶的制备方法。其中，水凝胶通过在几种活性化合物组分之间的特定条件下的混合和化学交联反应的快速化学交联形成。制备方法包括以下步骤：（1）含有生物相容性硫醇化大分子衍生物（A组分）和生物相容性硫醇反应性交联剂（B组分）的溶液相互混合，形成具有规定交联条件的反应性混合物; （2）反应混合物形成水凝胶。本发明还公开了一种新型快速凝胶化水凝胶喷雾的制备方法及其在医学领域的应用。本发明具有生物相容性好，无副产物，稳定性好，使用方便，使用少量原料，适用于多种医疗用途等优点。

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