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1. 发明申请

US20100189181A1 METHOD AND DEVICE FOR VIDEO CODING AND DECODING 有权
标题翻译：用于视频编码和解码的方法和设备
公开(公告)号：US20100189181A1
公开(公告)日：2010-07-29
申请号：US12724076
申请日：2010-03-15
申请人： Xiaozhen ZHENG , Zhen MAO , Ziyuan WANG , Yun HE , Xiaozhong XU , Jianhua ZHENG
发明人： Xiaozhen ZHENG , Zhen MAO , Ziyuan WANG , Yun HE , Xiaozhong XU , Jianhua ZHENG
IPC分类号： H04N7/30
CPC分类号： H04N19/126 , H04N19/17 , H04N19/172 , H04N19/174 , H04N19/176 , H04N19/184 , H04N19/436 , H04N19/46 , H04N19/61 , H04N19/70
摘要： A method and device for coding and decoding are disclosed. The method includes: dividing a picture to be encoded into several slices, each containing macroblocks continuous in a designated scanning sequence in the picture; dividing slices in the picture into one or more slice sets according to attribute information of the slices, each slice set containing one or more slices; and encoding the slices in the slice sets according to slice and slice set division information to get a coded bit stream of the picture. The decoding method includes: obtaining slice and slice set division information from a bit stream to be decoded and decoding the bit stream according to the obtained slice and slice set division information. The invention improves the performance of video transmission effectively and realizes region based coding. The implementation of coding and decoding is simple and the complexity of coding and decoding systems is reduced.
摘要翻译：公开了一种用于编码和解码的方法和装置。该方法包括：将要编码的图像划分成若干片，每片包含图像中指定的扫描序列连续的宏块; 根据切片的属性信息将图片中的切片分成一个或多个切片组，每个切片组包含一个或多个切片; 并根据切片和切片集分割信息对切片集中的切片进行编码以获得图像的编码比特流。解码方法包括：从要解码的比特流获取切片和切片集分割信息，并根据获得的切片和切片集分割信息对比特流进行解码。本发明有效地提高了视频传输的性能，实现了基于区域的编码。编码和解码的实现简单，编码和解码系统的复杂度降低。

2. 发明申请

US20090022222A1 METHOD AND DEVICE FOR MULTI-VIEW ENCODING/DECODING USING DISPARITY VECTOR 有权
标题翻译：使用差分矢量进行多视图编码/解码的方法和装置
公开(公告)号：US20090022222A1
公开(公告)日：2009-01-22
申请号：US12239226
申请日：2008-09-26
申请人： Yun HE , Xiaozhong XU , Gang ZHU , Ping YANG , Jianhua ZHENG , Shujuan SHI , Xiaozhen ZHENG , Xinjian MENG
发明人： Yun HE , Xiaozhong XU , Gang ZHU , Ping YANG , Jianhua ZHENG , Shujuan SHI , Xiaozhen ZHENG , Xinjian MENG
IPC分类号： H04N7/12
CPC分类号： H04N19/597
摘要： A method of obtaining a disparity vector and its encoding/decoding in the multi-view coding process is disclosed. The present invention includes essentially: determining a disparity vector between two views during the multi-view image coding, and computing a disparity vector between the other two views according to the disparity vector between the two views and the known relative location information between each of the views. Thereafter, the disparity vector is used for multi-view encoding/decoding. The present invention further makes use of the correlation between the disparity vector and depth information of the spatial vector on one hand, and on the other hand makes use of the direct relationship between the disparity vector and the location of each of the cameras. It is experimentally proved that the disparity vector between several views can be accurately computed during the multi-view coding, thereby improving the performance of multi-view coding.
摘要翻译：公开了一种在多视图编码处理中获得视差矢量及其编码/解码的方法。本发明基本上包括：在多视图图像编码期间确定两个视图之间的视差向量，以及根据两个视图之间的视差矢量和每个视图之间的已知相对位置信息来计算其他两个视图之间的视差矢量意见此后，视差矢量用于多视图编码/解码。本发明进一步利用视差矢量与空间矢量的深度信息之间的相关性，另一方面利用视差矢量与每个摄像机的位置之间的直接关系。实验证明，可以在多视图编码期间精确地计算出几个视图之间的视差矢量，从而提高了多视图编码的性能。

3. 发明申请

US20080231483A1 BINARIZING METHOD AND DEVICE THEREOF 有权
标题翻译：二进制方法及其装置
公开(公告)号：US20080231483A1
公开(公告)日：2008-09-25
申请号：US12132959
申请日：2008-06-04
申请人： Yun HE , Ping YANG , Wei YU , Xinjian MENG , Jianhua ZHENG
发明人： Yun HE , Ping YANG , Wei YU , Xinjian MENG , Jianhua ZHENG
IPC分类号： H03M7/00
CPC分类号： H04N19/517 , H04N19/139 , H04N19/50 , H04N19/91
摘要： A binary coding and decoding method and apparatus for MVD (Motion Vector Difference) absolute values, includes: dividing symbols for MVD absolute values to be coded into a plurality of subsets according to probability distribution properties; assigning a binary codeword for each subset; assigning a binary codeword for each symbol in each subset; concatenating and outputting the binary codeword for each subset and the binary codeword for each symbol in the subset, as the binary coding result. At the decoding side, decoding operations are performed by using a principle corresponding to that at the coding side. In this manner, the invention makes full use of the source properties on one hand, and effectively prevents the codeword length from being too long on the other hand. It has been experimentally testified that a better compression effect may be achieved during arithmetic coding process and thus the image coding performance may be improved effectively.
摘要翻译：用于MVD（运动矢量差）绝对值的二进制编码和解码方法和装置包括：根据概率分布特性将要编码的MVD绝对值的符号划分成多个子集; 为每个子集分配二进制码字; 为每个子集中的每个符号分配二进制码字; 作为二进制编码结果，连接并输出每个子集的二进制码字和子集中每个符号的二进制码字。在解码侧，通过使用与编码侧对应的原理进行解码操作。以这种方式，本发明一方面充分利用了源特性，另一方面有效地防止了码字长度过长。已经通过实验证明，在算术编码过程中可以获得更好的压缩效果，因此可以有效地提高图像编码性能。

4. 发明申请

US20120170859A1 METHOD AND APPARATUS FOR REALIZING ADAPTIVE QUANTIZATION IN PROCESS OF IMAGE CODING 有权
标题翻译：用于在图像编码过程中实现自适应量化的方法和装置
公开(公告)号：US20120170859A1
公开(公告)日：2012-07-05
申请号：US13418063
申请日：2012-03-12
申请人： Jianhua ZHENG , Yun HE , Jianwen CHEN
发明人： Jianhua ZHENG , Yun HE , Jianwen CHEN
IPC分类号： G06K9/36
CPC分类号： H04N19/124 , H04N19/107 , H04N19/139 , H04N19/159 , H04N19/176 , H04N19/196 , H04N19/61
摘要： A method and apparatus for realizing adaptive quantization in the process of image/video coding, which includes the following steps: acquiring the parameter information of the neighbor blocks of the current block; determining the quantization mode of the current block according to the parameter information of the neighbor blocks; and performing quantization processing on transform coefficients of the current block by using the determined quantization mode. Wherein, block coding type and motion vector of the neighbor blocks are used as the parameter information for determining the quantization mode of the current block. An apparatus for adaptive quantization in process of image/video coding is provided. The invention can use different quantization mode for adaptive quantization in different image content of an image sequence, thereby improving the subjective quality of the compressed images at the same bit rate.
摘要翻译：一种在图像/视频编码过程中实现自适应量化的方法和装置，包括以下步骤：获取当前块的相邻块的参数信息; 根据相邻块的参数信息确定当前块的量化模式; 以及通过使用所确定的量化模式对当前块的变换系数进行量化处理。其中，使用相邻块的块编码类型和运动矢量作为用于确定当前块的量化模式的参数信息。提供了一种用于图像/视频编码过程中的自适应量化的装置。本发明可以在图像序列的不同图像内容中使用不同的量化模式进行自适应量化，从而以相同的比特率提高压缩图像的主观质量。

5. 发明申请

US20090034612A1 QUANTIZATION METHOD AND APPARATUS IN ENCODING/DECODING 有权
标题翻译：编码/解码中的量化方法和装置
公开(公告)号：US20090034612A1
公开(公告)日：2009-02-05
申请号：US12210890
申请日：2008-09-15
申请人： Jianhua ZHENG , Jianwen CHEN , Yun HE , Xinjian MENG
发明人： Jianhua ZHENG , Jianwen CHEN , Yun HE , Xinjian MENG
IPC分类号： H04N7/26
CPC分类号： H04N19/174 , H04N19/126 , H04N19/154 , H04N19/176 , H04N19/177 , H04N19/18 , H04N19/46 , H04N19/61 , H04N19/70
摘要： A method and apparatus is provided for implementing quantization in encoding/decoding. Firstly, the quantization on the picture transformed coefficient matrix is performed using a quantization parameter model, that is, the coefficient matrix is modeled as a parameter model represented by only several parameters, in which the parameter model includes two sorts of parameters, frequency band distribution parameters and frequency band weighting parameters. Thus, a quantization matrix conforming to the human vision system can be obtained by controlling the model parameters and the subjective quality of the encoded picture can be easily controlled. Secondly, the method does not need to store or transfer the quantization matrix in the bitstream which help to improve the encoding efficiency. Finally, the quantization on picture transformed coefficients using the method is well adapted to the content information of the picture to be encoded. Therefore, the present invention can improve the subjective quality of the encoded picture.
摘要翻译：提供了一种用于在编码/解码中实现量化的方法和装置。首先，使用量化参数模型来执行对图像变换系数矩阵的量化，即，将系数矩阵建模为仅由几个参数表示的参数模型，其中参数模型包括两种参数，频带分布参数和频带加权参数。因此，可以通过控制模型参数来获得符合人类视觉系统的量化矩阵，并且可以容易地控制编码图像的主观质量。其次，该方法不需要存储或传送比特流中的量化矩阵，这有助于提高编码效率。最后，使用该方法的图像变换系数的量化很好地适应于要编码的图像的内容信息。因此，本发明可以提高编码图像的主观质量。

6. 发明申请

US20090010557A1 METHOD AND APPARATUS FOR REALIZING ADAPTIVE QUANTIZATION IN PROCESS OF IMAGE CODING 有权
标题翻译：用于在图像编码过程中实现自适应量化的方法和装置
公开(公告)号：US20090010557A1
公开(公告)日：2009-01-08
申请号：US12210939
申请日：2008-09-15
申请人： Jianhua ZHENG , Yun HE , Jianwen CHEN
发明人： Jianhua ZHENG , Yun HE , Jianwen CHEN
IPC分类号： G06K9/36
CPC分类号： H04N19/124 , H04N19/107 , H04N19/139 , H04N19/159 , H04N19/176 , H04N19/196 , H04N19/61
摘要： A method and apparatus for realizing adaptive quantization in the process of image/video coding, which includes the following steps: acquiring the parameter information of the neighbor blocks of the current block; determining the quantization mode of the current block according to the parameter information of the neighbor blocks; and performing quantization processing on transform coefficients of the current block by using the determined quantization mode. Wherein, block coding type and motion vector of the neighbor blocks are used as the parameter information for determining the quantization mode of the current block. An apparatus for adaptive quantization in process of image/video coding is provided. The invention can use different quantization mode for adaptive quantization in different image content of an image sequence, thereby improving the subjective quality of the compressed images at the same bit rate.
摘要翻译：一种在图像/视频编码过程中实现自适应量化的方法和装置，包括以下步骤：获取当前块的相邻块的参数信息; 根据相邻块的参数信息确定当前块的量化模式; 以及通过使用所确定的量化模式对当前块的变换系数进行量化处理。其中，使用相邻块的块编码类型和运动矢量作为用于确定当前块的量化模式的参数信息。提供了一种用于图像/视频编码过程中的自适应量化的装置。本发明可以在图像序列的不同图像内容中使用不同的量化模式进行自适应量化，从而以相同的比特率提高压缩图像的主观质量。

7. 发明申请

US20080240597A1 METHOD AND APPARATUS FOR REALIZING ARITHMETIC CODING/DECODING 有权
标题翻译：用于实现算术编码/解码的方法和装置
公开(公告)号：US20080240597A1
公开(公告)日：2008-10-02
申请号：US12133222
申请日：2008-06-04
申请人： Yun HE , Wei YU , Ping YANG , Xinjian MENG
发明人： Yun HE , Wei YU , Ping YANG , Xinjian MENG
IPC分类号： G06K9/36
CPC分类号： H03M7/4006 , H04N19/91
摘要： A method and apparatus for performing arithmetic encoding/decoding in an arithmetic encoder is disclosed. It comprises: firstly, when performing binary arithmetic encoding/decoding in the arithmetic encoder, an interval update process for arithmetic encoding/decoding to be performed in the original domain is mapped to the logarithm domain, and the interval update computation is implemented with direct add/subtract operations; during arithmetic encoding/decoding in the logarithm domain, data conversions between the original domain and the logarithm domain are performed by approximations; and after encoding/decoding a symbol, its probability is updated when necessary, the update being performed with add/subtract operations in the logarithm domain. It can be seen that with the arithmetic encoding/decoding solutions of the disclosure, the arithmetic encoding/decoding process and the probability estimation involved therein are mapped to the logarithm domain. Data conversions between the original domain and the logarithm domain are performed by means of approximation equations. Accordingly, complicated computations and table looking-up are avoided effectively. Therefore, the disclosure provides a simple, efficient and suitable solution for performing arithmetic encoding/decoding.
摘要翻译：公开了一种用于在算术编码器中执行算术编码/解码的方法和装置。它包括：首先，当在算术编码器中进行二进制算术编码/解码时，将在原始域中执行的算术编码/解码的间隔更新处理被映射到对数域，并且间隔更新计算用直接加法 /减操作; 在对数域中的算术编码/解码期间，通过近似来执行原始域和对数域之间的数据转换; 并且在对符号进行编码/解码之后，必要时更新其概率，通过对数域中的加/减操作执行更新。可以看出，利用本公开的算术编码/解码解决方案，算术编码/解码处理及其中涉及的概率估计被映射到对数域。原始域和对数域之间的数据转换通过近似方程来执行。因此，有效地避免了复杂的计算和表查找。因此，本公开提供了一种用于执行算术编码/解码的简单，有效和合适的解决方案。

8. 发明申请

US20160355583A1 ANTIBODIES TARGETING BONE MORPHOGENETIC PROTEIN 9 (BMP9) AND METHODS THEREFOR 审中-公开
标题翻译：靶向骨形态蛋白9（BMP9）的抗体及其方法
公开(公告)号：US20160355583A1
公开(公告)日：2016-12-08
申请号：US15165150
申请日：2016-05-26
申请人： Zijun CHEN , Sujun DENG , Yun HE , Dagang HUANG , Markus KUGLER , Qian LI , Chris Xiangyang LU , Xiao LUO , Yongqiang SHAN , Kathrin Ulrike TISSOT-DAGUETTE , Jing WU
发明人： Zijun CHEN , Sujun DENG , Yun HE , Dagang HUANG , Markus KUGLER , Qian LI , Chris Xiangyang LU , Xiao LUO , Yongqiang SHAN , Kathrin Ulrike TISSOT-DAGUETTE , Jing WU
IPC分类号： C07K16/22 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/155 , A61K31/355 , A61K31/4439 , A61K31/4725 , A61K31/497 , A61K31/513 , A61K31/522 , A61K31/575 , A61K31/675 , A61K31/7072 , A61K38/1875 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C12N15/09 , C12N15/63 , A61K2300/00
摘要： The present invention relates to isolated antibodies and antigen-binding fragments thereof which bind human BMP9 and compositions and methods of use thereof.
摘要翻译：本发明涉及结合人BMP9的分离的抗体及其抗原结合片段及其组合物及其使用方法。

9. 发明申请

US20110081708A1 Method of Sequence Optimization for Improved Recombinant Protein Expression using a Particle Swarm Optimization Algorithm 有权
标题翻译：使用粒子群优化算法改进重组蛋白表达的序列优化方法
公开(公告)号：US20110081708A1
公开(公告)日：2011-04-07
申请号：US12894401
申请日：2010-09-30
申请人： Xiaowu LIU , Yun HE , Zhuying WANG , Chunjiao WANG , Zhibing LIU , Tianhui XIA , Luquan WANG , Fang Liang ZHANG
发明人： Xiaowu LIU , Yun HE , Zhuying WANG , Chunjiao WANG , Zhibing LIU , Tianhui XIA , Luquan WANG , Fang Liang ZHANG
IPC分类号： C12N1/21 , C07H21/04 , C12N15/63 , G06F19/00
CPC分类号： G06F19/22 , G06F19/20
摘要： An improved gene sequence optimization method, the systematic optimization method, is described for boosting the recombinant expression of genes in bacteria, yeast, insect and mammalian cells. This general method takes into account of multiple, preferably most or all, of the parameters and factors affecting protein expression including codon usage, tRNA usage, GC-content, ribosome binding sequences, promoter, 5′-UTR, ORF and 3′-UTR sequences of the genes to improve and optimize the gene sequences to boost the protein expression of the genes in bacteria, yeast, insect and mammalian cells. In particular, the invention relates to a system and a method for sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm. The improved systematic optimization method can be incorporated into a software for more efficient optimization.
摘要翻译：描述了改进的基因序列优化方法，该系统优化方法用于增强细菌，酵母，昆虫和哺乳动物细胞中基因的重组表达。这种一般方法考虑到影响蛋白质表达的参数和因子的多个，优选大多数或全部，包括密码子使用，tRNA使用，GC含量，核糖体结合序列，启动子，5'-UTR，ORF和3'-UTR 改进和优化基因序列以增强细菌，酵母，昆虫和哺乳动物细胞中基因的蛋白质表达的基因序列。特别地，本发明涉及使用粒子群优化算法改进重组蛋白表达的序列优化的系统和方法。改进的系统优化方法可以被并入软件中以进行更有效的优化。

10. 发明申请

US20090137570A1 INHIBITORS OF CATHEPSIN S 失效
标题翻译： CATHEPSIN的抑制剂
公开(公告)号：US20090137570A1
公开(公告)日：2009-05-28
申请号：US12361287
申请日：2009-01-28
申请人： Hong LIU , Arnab K. CHATTERJEE , David C. TULLY , Phillip B. ALPER , Badry BURSULAYA , Jianhua GUO , David H. WOODMANSEE , Daniel MUTNICK , Donald S. KARANEWSKY , Yun HE
发明人： Hong LIU , Arnab K. CHATTERJEE , David C. TULLY , Phillip B. ALPER , Badry BURSULAYA , Jianhua GUO , David H. WOODMANSEE , Daniel MUTNICK , Donald S. KARANEWSKY , Yun HE
IPC分类号： A61K31/5377 , C07D413/12 , C07D295/145 , C07D413/14 , C07D279/12 , C07D241/04 , C07D417/12 , A61K31/454 , A61K31/404 , A61K31/495 , C07D403/12 , C07D401/12 , C07D209/08 , A61K31/541 , A61K31/54
CPC分类号： C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
摘要翻译：本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。

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