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    • 3. 发明申请
    • Method of Chemical Substance Separation
    • 化学物质分离方法
    • US20080017585A1
    • 2008-01-24
    • US10589423
    • 2005-02-10
    • Kazuhiro Chiba
    • Kazuhiro Chiba
    • C02F1/52
    • B01J20/289B01J20/3204B01J20/3206B01J20/3219B01J20/3242B01J20/3251B01J20/3253B01J20/3255B01J20/3287B01J20/3289B01J20/3425B01J20/3483C07K1/32G01N30/54G01N2030/8831
    • The present invention provides a method of separating substances utilizing a solid phase wherein a substance fixed to a solid phase can be easily separated without the application of a chemical process, biochemical process, exposure to light, electrical excitation, or the like. Disclosed is a method of separating a reaction product generated by the reaction of a first substance and a second substance comprising the steps of: (a) mixing the first substance with a temperature-sensitive carrier residing in a liquid-phase state; (b) fixing an anchor region of the first substance to the temperature-sensitive carrier by converting the temperature-sensitive carrier to a solid-phase state by changing the temperature of the reaction system; (c) generating a reaction product by reacting the second substance with a reaction region of the first substance that is fixed to the temperature-sensitive carrier; (d) removing impurities from the reaction system; and (e) releasing the anchor region of the reaction product from the temperature-sensitive carrier by converting the temperature-sensitive carrier to a liquid-phase state by changing the temperature of the reaction system.
    • 本发明提供一种使用固相分离物质的方法,其中固定在固相上的物质可以容易地分离,而不需要施加化学过程,生化过程,曝光,电激发等。 公开了分离由第一物质和第二物质的反应产生的反应产物的方法,包括以下步骤:(a)将第一物质与位于液相状态的温度敏感载体混合; (b)通过改变反应体系的温度,将温度敏感载体转变成固相状态,将第一物质的锚定区域固定在温度敏感载体上; (c)通过使所述第二物质与固定在所述感温载体上的所述第一物质的反应区域反应而产生反应产物; (d)从反应体系中除去杂质; 和(e)通过改变反应体系的温度,将温度敏感载体转变成液相状态,释放反应产物的锚定区域与温度敏感载体。
    • 6. 发明授权
    • Compatible-multiphase organic solvent system
    • 兼容多相有机溶剂体系
    • US08344103B2
    • 2013-01-01
    • US11556492
    • 2006-11-03
    • Kazuhiro ChibaYusuke Kono
    • Kazuhiro ChibaYusuke Kono
    • C07K1/00C07K1/01
    • C07C69/757C07B61/00C07C43/23C07C2602/28
    • A solvent system which comprises two or more single organic solvents or two or more mixed organic solvents, characterized in that the state of the solvent system can be reversibly changed, with changing temperature conditions, from one state which is a homogeneously compatibilized mixed solvent system in which the two or more single or more mixed organic solvents constituting the solvent system have been homogeneously compatibilized and mixed to the other state which is a separated solvent system made up of two or more separated phases respectively consisting mainly of the two or more single or mixed organic solvents constituting solvent system, and that when the solvent system is the homogeneously mixed solvent system, a chemical component which is soluble in only one of the single or mixed organic solvents can be evenly dissolved in the system; and a process for producing a compound with the solvent system.
    • 一种包含两种或多种单一有机溶剂或两种或更多种混合有机溶剂的溶剂体系,其特征在于,随着温度条件的变化,溶剂体系的状态可以从均匀相容的混合溶剂体系的一种状态 构成溶剂体系的两种以上的单一或多种混合有机溶剂已被均匀相容化并混合到另一状态,其中分离的溶剂体系由两个或更多个分离相组成,分别主要由两种或多种单一或混合 构成溶剂体系的有机溶剂,当溶剂体系为均匀混合溶剂体系时,只能溶解于单一或混合有机溶剂中的一种的化学成分可以均匀地溶解在体系中; 以及用该溶剂体系制备化合物的方法。
    • 9. 发明申请
    • COMPATIBLE-MULTIPHASE ORGANIC SOLVENT SYSTEM
    • 兼容多相有机溶剂系统
    • US20070066799A1
    • 2007-03-22
    • US11556492
    • 2006-11-03
    • Kazuhiro ChibaYusuke Kono
    • Kazuhiro ChibaYusuke Kono
    • C07K1/02
    • C07C69/757C07B61/00C07C43/23C07C2602/28
    • A solvent system which comprises two or more single organic solvents or two or more mixed organic solvents, characterized in that the state of the solvent system can be reversibly changed, with changing temperature conditions, from one state which is a homogeneously compatibilized mixed solvent system in which the two or more single or more mixed organic solvents constituting the solvent system have been homogeneously compatibilized and mixed to the other state which is a separated solvent system made up of two or more separated phases respectively consisting mainly of the two or more single or mixed organic solvents constituting solvent system, and that when the solvent system is the homogeneously mixed solvent system, a chemical component which is soluble in only one of the single or mixed organic solvents can be evenly dissolved in the system; and a process for producing a compound with the solvent system.
    • 一种包含两种或多种单一有机溶剂或两种或更多种混合有机溶剂的溶剂体系,其特征在于,随着温度条件的变化,溶剂体系的状态可以从均匀相容的混合溶剂体系的一种状态 构成溶剂体系的两种以上的单一或多种混合有机溶剂已被均匀相容化并混合到另一状态,其中分离的溶剂体系由两个或更多个分离相组成,分别主要由两种或多种单一或混合 构成溶剂体系的有机溶剂,当溶剂体系为均匀混合溶剂体系时,只能溶解于单一或混合有机溶剂中的一种的化学成分可以均匀地溶解在体系中; 以及用该溶剂体系制备化合物的方法。
    • 10. 发明申请
    • Methods and device for substance separation using compatible multiphase solvent system
    • 使用兼容多相溶剂系统进行物质分离的方法和装置
    • US20060207935A1
    • 2006-09-21
    • US10566727
    • 2004-08-03
    • Kazuhiro Chiba
    • Kazuhiro Chiba
    • B01D15/08
    • G01N30/30G01N2030/3015G01N2030/065
    • To provide a method and a device for separating object substances from a mixture without requiring an ultrasonic generator and a centrifugal separator. [MEANS FOR SOLVING PROBLEMS] In this method of separating the object substances from the mixture by using a first solvent and a second solvent, the first solvent and the second solvent are reversibly changed from a state of being separated into two phases to a state of being mutually dissolved into one phase by changing their temperatures. The upstream portion and the center portion of a column including the first solvent are held in a temperature range in which the solvents are mutually dissolved into one phase, and the downstream portion of the column is held in a temperature range in which the solvents are separated into two phases. The second solvent in which the mixture is dissolved is changed from the upstream portion of the column into the column, and the separated second solvent phase is taken out from the downstream portion of the column.
    • 提供一种用于从混合物中分离物体的方法和装置,而不需要超声发生器和离心分离器。 解决问题的手段在通过使用第一溶剂和第二溶剂从混合物中分离目标物质的方法中,第一溶剂和第二溶剂从分离成两相的状态可逆地改变为 通过改变其温度而相互溶解成一相。 包含第一溶剂的塔的上游部分和中心部分保持在溶剂相互溶解成一相的温度范围内,并且塔的下游部分保持在溶剂分离的温度范围内 分为两个阶段 将混合物溶解的第二溶剂从塔的上游部分改变为塔,并且从塔的下游部分取出分离的第二溶剂相。