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1. 发明授权

US6156346A Urease-responsive delivery systems for diagnostic and therapeutic applications 失效
标题翻译：用于诊断和治疗应用的尿素反应递送系统
公开(公告)号：US6156346A
公开(公告)日：2000-12-05
申请号：US15502
申请日：1998-01-29
申请人： Xiaoru Chen , P. Jay Pasricha , Kam W. Leong
发明人： Xiaoru Chen , P. Jay Pasricha , Kam W. Leong
IPC分类号： G01N33/569 , A61K9/00 , A61K9/16 , A61K31/4164 , A61K31/43 , A61K31/4439 , A61K31/65 , A61K38/00 , A61K47/48 , A61P31/04 , C07K5/06 , C12Q1/04 , A61K9/14 , A61K9/50
CPC分类号： A61K31/43 , A61K31/4164 , A61K31/4439 , A61K31/65 , A61K47/48876 , A61K49/0021 , A61K49/0091 , A61K9/1635 , A61K9/1658
摘要： A delivery system that releases a diagnostic marker or therapeutic agent in a manner sensitive to the concentration of urease in a physiological compartment, particularly the gastrointestinal tract, and methods of use.
摘要翻译：递送系统以对生理隔室，特别是胃肠道中的脲酶浓度敏感的方式和使用方法释放诊断标记物或治疗剂。

2. 发明授权

US08795979B2 Hydrolase enzyme substrates and uses thereof 有权
标题翻译：水解酶酶底物及其用途
公开(公告)号：US08795979B2
公开(公告)日：2014-08-05
申请号：US13352273
申请日：2012-01-17
申请人： Chong-Sheng Yuan , Xiaoru Chen
发明人： Chong-Sheng Yuan , Xiaoru Chen
IPC分类号： C12Q1/34 , C12Q1/44 , G01N33/53 , C07H15/10 , C07H15/18
CPC分类号： C12Q1/34 , C07H15/10 , C07H15/18 , C07H15/203 , C12Q1/42 , C12Q1/44 , C12Q1/6876 , G01N33/573 , G01N2333/938 , G01N2458/00
摘要： The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions and methods that provide highly sensitive assay methods for such hydrolytic enzymes.
摘要翻译：本发明提供用于基于酶的新基质确定样品中水解酶的存在或量的新方法，并且还提供了为这种水解酶提供高度灵敏的测定方法的组合物和方法。

3. 发明申请

US20110256155A1 METHODS TO MOLECULARLY CHARACTERIZE CIRCULATING TUMOR CELLS 审中-公开
标题翻译：分子生物学特性的循环肿瘤细胞的方法
公开(公告)号：US20110256155A1
公开(公告)日：2011-10-20
申请号：US13088751
申请日：2011-04-18
申请人： Jiaqi Huang , Haifeng Bao , Philip Brohawn , Patricia Burke , Xiaoru Chen , Theresa Lavallee , Yihong Yao
发明人： Jiaqi Huang , Haifeng Bao , Philip Brohawn , Patricia Burke , Xiaoru Chen , Theresa Lavallee , Yihong Yao
IPC分类号： A61K39/395 , A61P35/00 , C12Q1/68
CPC分类号： C12Q1/6806 , C12Q2600/158 , C12Q2521/537
摘要： The invention relates to a rapid, sensitive method to obtain a gene expression profile from a target cell population in a blood sample. The target cells can be circulating tumor cells. Disclosed are methods and kits for obtaining such profiles.
摘要翻译：本发明涉及从血液样品中的靶细胞群获得基因表达谱的快速，灵敏的方法。靶细胞可以循环肿瘤细胞。公开了用于获得这种简档的方法和工具包。

4. 发明申请

US20120190013A1 HYDROLASE ENZYME SUBSTRATES AND USES THEREOF 有权
标题翻译：水解酶基材及其用途
公开(公告)号：US20120190013A1
公开(公告)日：2012-07-26
申请号：US13352273
申请日：2012-01-17
申请人： Chong-Sheng Yuan , Xiaoru Chen
发明人： Chong-Sheng Yuan , Xiaoru Chen
IPC分类号： C12Q1/34 , G01N33/53 , C12Q1/44 , C12Q1/68 , C07H15/18 , C07H15/10
CPC分类号： C12Q1/34 , C07H15/10 , C07H15/18 , C07H15/203 , C12Q1/42 , C12Q1/44 , C12Q1/6876 , G01N33/573 , G01N2333/938 , G01N2458/00
摘要： The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions and methods that provide highly sensitive assay methods for such hydrolytic enzymes.
摘要翻译：本发明提供用于基于酶的新基质确定样品中水解酶的存在或量的新方法，并且还提供了为这种水解酶提供高度灵敏的测定方法的组合物和方法。

5. 发明授权

US06861103B2 Synthesis of functional polymers and block copolymers on silicon oxide surfaces by nitroxide-mediated living free radical polymerization in vapor phase 失效
标题翻译：在氧化硅表面通过硝基氧介导的自由基聚合在气相中合成官能聚合物和嵌段共聚物
公开(公告)号：US06861103B2
公开(公告)日：2005-03-01
申请号：US10360443
申请日：2003-02-07
申请人： Ying Chih Chang , Jun Li , Xiaoru Chen
发明人： Ying Chih Chang , Jun Li , Xiaoru Chen
IPC分类号： B05D7/24 , C08F2/46 , C08F4/00 , C08F283/12 , C08F289/00 , C08F293/00 , C08L51/08 , H01L21/312
CPC分类号： B05D1/60 , C08F4/00 , C08F283/12 , C08F289/00 , C08F293/005 , C08F2438/02 , C08L51/08 , C08L51/085 , H01L21/02118 , H01L21/02271 , H01L21/312
摘要： Nitroxide mediated free radical polymerization of vaporized vinyl monomers, including acrylic acid (AAc), styrene (St), N-2-(hydroxypropyl)methacrylamide (HPMA) and N-isopropyl acrylamide (NIPAAm), on silicon wafers is demonstrated. FTIR, ellipsometry and contact angle goniometry were used to characterize the chemical structures, thickness and hydrophilicity of the films. The growth of film is linearly proportional to its reaction time, leading to the easy and exact control of polymer film thickness from nanometers to submicrons. The capability of polymerizing various monomers allows us to fabricate various functional polymer brushes. The reversible thermo-responsiveness of a 200 nm thick grafted poly(NIPAAm) film in aqueous solution is demonstrated with over 50% change in thickness at its lower critical solution temperature. A tri-block copolymer of poly(AAc)-b-polySt-b-poly(HPMA) is successfully synthesized, proving the renewability of TEMPO-mediated polymerization at vapor phase. Surface polymer composition and morphology is thus controlled at nanoscale by utilizing vapor phase surface-initiated controlled polymerization.
摘要翻译：证明了在硅晶片上的气化乙烯基单体，包括丙烯酸（AAc），苯乙烯（St），N-2-（羟丙基）甲基丙烯酰胺（HPMA）和N-异丙基丙烯酰胺（NIPAAm））的自由基聚合。使用FTIR，椭偏仪和接触角测角法来表征膜的化学结构，厚度和亲水性。膜的生长与其反应时间成线性比例，导致聚合物膜厚度从纳米到亚微米的容易和准确的控制。聚合各种单体的能力使我们能够制造各种功能性聚合物刷。 200nm厚接枝聚（NIPAAm）膜在水溶液中的可逆热响应性被证明在其较低的临界溶液温度下具有超过50％的厚度变化。成功地合成了聚（AAc）-b-polySt-b-聚（HPMA）的三嵌段共聚物，证明了TEMPO介导的气相聚合的可再生性。因此，通过使用气相表面引发的受控聚合，表面聚合物组成和形态由纳米尺度控制。

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