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1. 发明申请

US20080108600A1 Polycyclic Pyridines as Potassium Ion Channel Modulators 审中-公开
标题翻译：多环吡啶作为钾离子通道调节剂
公开(公告)号：US20080108600A1
公开(公告)日：2008-05-08
申请号：US10592985
申请日：2005-04-13
申请人： Xiaodong Wang , Kerry L. Spear , Alan B. Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo , Hideki Kubota , Jun-ichi Kazami
发明人： Xiaodong Wang , Kerry L. Spear , Alan B. Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo , Hideki Kubota , Jun-ichi Kazami
IPC分类号： A61K31/444 , C12N5/00 , A61P25/00 , A61P1/00 , A61P9/00 , A61K31/496 , A61K31/551 , A61K31/5377 , A61K31/497 , C07D417/14 , C07D401/14 , A61K31/4725
CPC分类号： C07D401/04 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C09B57/10
摘要： The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环吡啶属。本发明的调节剂在治疗和诊断方法中都有用。

2. 发明申请

US20050227989A1 Polycyclic thiazoles as potassium ion channel modulators 审中-公开
标题翻译：多环噻唑作为钾离子通道调节剂
公开(公告)号：US20050227989A1
公开(公告)日：2005-10-13
申请号：US11105665
申请日：2005-04-13
申请人： Xiaodong Wang , Kerry Spear , Alan Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo , Hideki Kubota
发明人： Xiaodong Wang , Kerry Spear , Alan Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo , Hideki Kubota
IPC分类号： A61K9/20 , A61K9/48 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , C07D417/02
CPC分类号： C07D417/14
摘要： The present invention provides a genus of polycyclic thiazoles that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环噻唑属。本发明的调节剂在治疗和诊断方法中都有用。

3. 发明授权

US07642354B2 Polycyclic pyrazines as potassium ion channel modulators 失效
标题翻译：多环吡嗪作为钾离子通道调节剂
公开(公告)号：US07642354B2
公开(公告)日：2010-01-05
申请号：US11105668
申请日：2005-04-13
申请人： Xiaodong Wang , Kerry Leigh Spear , Alan Bradley Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo
发明人： Xiaodong Wang , Kerry Leigh Spear , Alan Bradley Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo
IPC分类号： C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D401/14 , C07D213/73 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention provides a genus of polycyclic pyrazines of formula (I): wherein A and B are independently substituted or unsubstituted 5- or 6- membered heterocycloalkyl, or substituted or unsubstituted 5- or 6- membered heteroaryl, W1 is W2is —CH═, —NH—, —N═, —S—, or —O—; Z1 is Z2 is —CH═, —NH—, —N═, —S—, or —O—; Y is a bond, —CH═N—NH—, —NH—CH2, or —NR5—; s and t are independently integers from 1 to 4; and the substituents R1, R2A, R2B and R3 are as defined in the specification for compounds of formula (I). The polycyclic pyrazine compounds are useful as modulators of potassium ion channels in both therapeutic and diagnostic methods.
摘要翻译：本发明提供式（I）的多环吡嗪类：其中A和B独立地是取代或未取代的5-或6-元杂环烷基，或取代或未取代的5-或6-元杂芳基，W1是W2--CH- ，-NH-，-N-，-S-或-O-; Z 1是Z 2是-CH - ， - NH - ， - N - ， - S-或-O-; Y是键，-CH-N-NH-，-NH-CH 2或-NR 5 - ; s和t独立地为1至4的整数; 取代基R 1，R 2A，R 2B和R 3如式（I）化合物的说明书中所定义。多环吡嗪化合物可用作治疗和诊断方法中钾离子通道的调节剂。

4. 发明授权

US07560464B2 Polycyclic pyrimidines as potassium ion channel modulators 失效
标题翻译：多环嘧啶作为钾离子通道调节剂
公开(公告)号：US07560464B2
公开(公告)日：2009-07-14
申请号：US11105938
申请日：2005-04-13
申请人： Xiaodong Wang , Kerry Leigh Spear , Alan Bradley Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo
发明人： Xiaodong Wang , Kerry Leigh Spear , Alan Bradley Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo
IPC分类号： C07D401/14 , A61K31/444 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/28
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a genus of polycyclic pyrimidines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环嘧啶属。本发明的调节剂在治疗和诊断方法中都有用。

5. 发明申请

US20050267089A1 Polycyclic pyrimidines as potassium ion channel modulators 失效
标题翻译：多环嘧啶作为钾离子通道调节剂
公开(公告)号：US20050267089A1
公开(公告)日：2005-12-01
申请号：US11105938
申请日：2005-04-13
申请人： Xiaodong Wang , Kerry Spear , Alan Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo
发明人： Xiaodong Wang , Kerry Spear , Alan Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo
IPC分类号： A61K31/506 , A61K31/555 , C07D401/14 , C07D405/14 , C07D409/14 , C07D43/14
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a genus of polycyclic pyrimidines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环嘧啶属。本发明的调节剂在治疗和诊断方法中都有用。

6. 发明申请

US20050239800A1 Polycyclic pyrazines as potassium ion channel modulators 失效
标题翻译：多环吡嗪作为钾离子通道调节剂
公开(公告)号：US20050239800A1
公开(公告)日：2005-10-27
申请号：US11105668
申请日：2005-04-13
申请人： Xiaodong Wang , Kerry Spear , Alan Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo
发明人： Xiaodong Wang , Kerry Spear , Alan Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo
IPC分类号： A61K31/497 , A61P43/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D43/02
CPC分类号： C07D401/14 , C07D213/73 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention provides a genus of polycyclic pyrazines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供可用作钾离子通道调节剂的多环吡嗪属。本发明的调节剂在治疗和诊断方法中都有用。

7. 发明授权

US08207199B2 Azole compound 有权
标题翻译：唑类化合物
公开(公告)号：US08207199B2
公开(公告)日：2012-06-26
申请号：US13054057
申请日：2009-07-13
申请人： Satoshi Aoki , Ryosuke Munakata , Noriyuki Kawano , Kiyohiro Samizu , Hiromasa Oka , Takahiro Ishii , Takashi Sugane
发明人： Satoshi Aoki , Ryosuke Munakata , Noriyuki Kawano , Kiyohiro Samizu , Hiromasa Oka , Takahiro Ishii , Takashi Sugane
IPC分类号： A61K31/4545 , C07D417/14 , C07D401/14 , C07D413/14
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： A compound which is useful as an active ingredient of a pharmaceutical composition for treating neuropathic pain is provided. The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that an azole compound substituted with an N-(pyridine-3-yl)oxycarbonyl-piperidin-4-yl group and a phenyl group or a pharmaceutically acceptable salt thereof has an excellent FAAH inhibitory activity, thereby completing the present invention. The compound of the present invention is confirmed to have an excellent FAAH inhibitory activity and an antiallodynic effect in rat models with neuropathic pain, and thus is useful as an agent for preventing and/or an agent for treating neuropathic pain.
摘要翻译：提供了可用作治疗神经性疼痛的药物组合物的活性成分的化合物。本发明人对具有FAAH抑制活性的化合物进行了广泛的研究，结果发现被N-（吡啶-3-基）氧基羰基 - 哌啶-4-基和苯基取代的唑化合物或其药学上可接受的盐具有优异的FAAH抑制活性，从而完成了本发明。确认本发明的化合物在具有神经性疼痛的大鼠模型中具有优异的FAAH抑制活性和抗异常性疼痛作用，因此可用作预防剂和/或治疗神经性疼痛的药剂。

8. 发明授权

US08149913B2 Moving picture converting apparatus and method, and computer program 失效
标题翻译：运动图像转换装置和方法以及计算机程序
公开(公告)号：US08149913B2
公开(公告)日：2012-04-03
申请号：US11434876
申请日：2006-05-17
申请人： Takahiro Ishii
发明人： Takahiro Ishii
IPC分类号： H04N7/12 , H04N11/04
CPC分类号： H04N19/577 , H04N19/44 , H04N19/53 , H04N19/537 , H04N19/573 , H04N19/59
摘要： A restored image is reconstructed from a thinned image to which no motion vector is incident. There is provided a moving picture converting apparatus for restoring a string of thinned images resulted from thinning pixels of an original-image string, which includes an input unit to receive the thinned-image string, an initial motion vector detector to detect a string of motion vector images on the basis of the thinned-image string, a reconstructing unit to reconstruct, each time a new motion vector image string is detected, a string of restored images on the basis of the new restored-image string and previous detected-motion vector image strings, a motion vector detector to detect, each time a new string of restored images is reconstructed, a new string of motion vector images based on the new restored-image string and previous detected-motion vector image strings, and a process terminating unit to terminate the reconstructing process by the reconstructing unit and motion vector detecting process by the motion vector detector and output a restored image, which has been restored, of the restored-image string obtained at the time of deciding the process termination.
摘要翻译：从没有运动矢量入射的稀疏图像重建恢复的图像。提供了一种运动图像转换装置，用于恢复由原始图像串的细化像素产生的一系列变薄图像，该原始图像串包括用于接收稀疏图像串的输入单元，初始运动矢量检测器，用于检测运动线基于所述稀疏图像串的矢量图像，每当检测到新的运动矢量图像串时，重建单元，基于所述新的恢复图像串和先前检测到的运动矢量，恢复一段恢复图像图像串，运动矢量检测器，每次重构新的恢复图像串时，检测基于新的恢复图像串和先前检测到的运动矢量图像串的新的运动矢量图像串，以及处理终止单元通过重建单元终止重建处理，并通过运动矢量检测器进行运动矢量检测处理，并输出恢复后的图像，在确定处理终止时获得的还原图像串。

9. 发明授权

US07609900B2 Moving picture converting apparatus and method, and computer program 失效
标题翻译：运动图像转换装置和方法以及计算机程序
公开(公告)号：US07609900B2
公开(公告)日：2009-10-27
申请号：US11445342
申请日：2006-06-02
申请人： Takahiro Ishii , Seiji Kobayashi
发明人： Takahiro Ishii , Seiji Kobayashi
IPC分类号： G06K9/36 , G06K9/00
CPC分类号： H04N19/563 , H04N19/587 , H04N19/59 , H04N19/85
摘要： It is intended to restore moving-picture data whose pixels have been thinned rapidly with a small-capacity memory and with prevention of image deterioration. There is provided a moving picture converting apparatus for reconstructing an original moving picture from compressed moving-picture data, which includes an input unit to receive compressed moving-picture data including a thinned image consisting of invalid pixels and valid pixels and a forward motion vector incident to the thinned image, an intra-frame interpolator for interpolating the invalid pixels in a present frame to be restored on the basis of the valid pixels of the thinned image in the present frame to produce a padded image, and a frame rendering unit to produce a rendered image by making preceding-frame rendering to restore pixels of the padded image on the basis of valid pixels in a preceding frame and subsequent-frame rendering to restore pixels of the padded image on the basis of valid pixels in a subsequent frame, the frame rendering unit making the preceding-frame rendering to restore a pixel at an end point of tracing in the padded image on the basis of valid pixels detected in the process of tracing, started at a pixel in the preceding frame, in a sequence from the preceding frame to the present frame according to the forward motion vector, and the subsequent-frame rendering to restore a pixel at the start point of the tracing in the padded image on the basis of valid pixels detected in the process of tracing, started at an invalid pixel of the padded image in the present frame, in a sequence from the present frame to the subsequent frame according to the forward motion vector.
摘要翻译：旨在恢复其像素已经用小容量存储器快速减薄并且防止图像劣化的运动图像数据。提供一种运动图像转换装置，用于从压缩运动图像数据重建原始运动图像，该运动图像数据包括输入单元，用于接收包括由无效像素和有效像素组成的稀疏图像的压缩运动图像数据和向前运动矢量入射根据当前帧中的稀疏图像的有效像素，内插用于恢复的当前帧中的无效像素以产生填充图像的帧内插入器，以及生成通过基于前一帧中的有效像素和后续帧渲染，通过进行前帧渲染以恢复填充图像的像素，以基于随后帧中的有效像素恢复填充图像的像素，渲染图像，帧渲染单元使得前帧渲染基于有效像素d在填充图像中的跟踪终点处恢复像素在跟踪的过程中，根据前向运动矢量以从前一帧到当前帧的序列开始在前一帧中的像素处的跟踪过程，以及后续帧渲染以恢复在前一帧的起点处的像素基于在跟踪过程中检测到的有效像素在当前帧中以填充图像的无效像素开始，根据前向运动矢量从当前帧到后续帧的序列中跟踪填充图像。

10. 发明申请

US20060280250A1 Moving picture converting apparatus and method, and computer program 失效
标题翻译：运动图像转换装置和方法以及计算机程序
公开(公告)号：US20060280250A1
公开(公告)日：2006-12-14
申请号：US11434876
申请日：2006-05-17
申请人： Takahiro Ishii
发明人： Takahiro Ishii
IPC分类号： H04N11/02 , H04N7/12 , H04B1/66 , H04N11/04
CPC分类号： H04N19/577 , H04N19/44 , H04N19/53 , H04N19/537 , H04N19/573 , H04N19/59
摘要： A restored image is reconstructed from a thinned image to which no motion vector is incident. There is provided a moving picture converting apparatus for restoring a string of thinned images resulted from thinning pixels of an original-image string, which includes an input unit to receive the thinned-image string, an initial motion vector detector to detect a string of motion vector images on the basis of the thinned-image string, a reconstructing unit to reconstruct, each time a new motion vector image string is detected, a string of restored images on the basis of the new restored-image string and previous detected-motion vector image strings, a motion vector detector to detect, each time a new string of restored images is reconstructed, a new string of motion vector images based on the new restored-image string and previous detected-motion vector image string, and a process terminating unit to terminate the reconstructing process by the reconstructing unit and motion vector detecting process by the motion vector detector and output a restored image, which has been to be restored, of the restored-image string obtained at the time of deciding the process termination.
摘要翻译：从没有运动矢量入射的稀疏图像重建恢复的图像。提供一种运动图像转换装置，用于恢复由原始图像串的细化像素导致的一系列变薄图像，该原始图像串包括用于接收稀疏图像串的输入单元，用于检测运动线的初始运动矢量检测器基于所述稀疏图像串的矢量图像，每当检测到新的运动矢量图像串时，重建单元，基于所述新的恢复图像串和先前检测到的运动矢量，恢复一段恢复图像图像串，运动矢量检测器，每次重建新的恢复图像串时，检测基于新的恢复图像串和先前检测的运动矢量图像串的新的运动矢量图像串，以及处理终止单元通过重建单元终止重建处理，并通过运动矢量检测器进行运动矢量检测处理，并输出已被保持的恢复图像在确定处理终止时获得的还原图像字符串。

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