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1. 发明授权

US09371283B2 Polycyclic tetracycline compounds 有权
标题翻译：多环四环素类化合物
公开(公告)号：US09371283B2
公开(公告)日：2016-06-21
申请号：US13075886
申请日：2011-03-30
申请人： Xiao-Yi Xiao , Roger Clark , Diana Hunt , Magnus Rönn , Louis Plamondon , Minsheng He , Joyce Sutcliffe , Trudy Grossman
发明人： Xiao-Yi Xiao , Roger Clark , Diana Hunt , Magnus Rönn , Louis Plamondon , Minsheng He , Joyce Sutcliffe , Trudy Grossman
IPC分类号： C07D209/56 , C07D209/58 , C07D221/18 , C07D243/10 , C07D405/04 , C07D405/06 , C07D487/04
CPC分类号： C07D209/58 , C07D221/18 , C07D243/10 , C07D403/06 , C07D405/04 , C07D405/06 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
摘要翻译：本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。结构式（I）的变量在本文中定义。还描述了包含结构式（I）的化合物及其治疗用途的药物组合物。

2. 发明申请

US20110269714A1 Polycyclic Tetracycline Compounds 有权
标题翻译：多环四环素类化合物
公开(公告)号：US20110269714A1
公开(公告)日：2011-11-03
申请号：US13075886
申请日：2011-03-30
申请人： Xiao-Yi Xiao , Roger Clark , Diana Hunt , Magnus Rönn , Louis Plamondon , Minsheng He , Joyce Sutcliffe , Trudy Grossman
发明人： Xiao-Yi Xiao , Roger Clark , Diana Hunt , Magnus Rönn , Louis Plamondon , Minsheng He , Joyce Sutcliffe , Trudy Grossman
IPC分类号： A61K31/695 , A61K31/65 , C07D413/10 , A61P11/00 , C07D261/20 , C07D209/56 , A61P31/04 , A61P17/00 , C07D243/10 , C07D487/04
CPC分类号： C07D209/58 , C07D221/18 , C07D243/10 , C07D403/06 , C07D405/04 , C07D405/06 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
摘要翻译：本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。结构式（I）的变量在本文中定义。还描述了包含结构式（I）的化合物及其治疗用途的药物组合物。

3. 发明授权

US07964622B2 Indole acetic acid derivatives and their use as pharmaceutical agents 失效
标题翻译：吲哚乙酸衍生物及其作为药剂的用途
公开(公告)号：US07964622B2
公开(公告)日：2011-06-21
申请号：US12508314
申请日：2009-07-23
申请人： Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
发明人： Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
IPC分类号： A61K31/425 , A61K31/42 , C07D417/00 , C07D277/20 , C07D498/00 , C07D263/30
CPC分类号： C07D403/12 , C07D209/08 , C07D401/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要： This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
摘要翻译：本发明涉及吲哚乙酸衍生物及其在药物组合物中用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的用途。本发明还涉及可用于制备吲哚乙酸衍生物的中间体和制备方法。

4. 发明授权

US07797898B2 Portable panel construction and method for making the same 有权
公开(公告)号：US07797898B2
公开(公告)日：2010-09-21
申请号：US12433271
申请日：2009-04-30
申请人： Roger Clark , George Gula
发明人： Roger Clark , George Gula
IPC分类号： E04C2/54
CPC分类号： F16B5/0092 , Y10T428/234 , Y10T428/236 , Y10T428/24149 , Y10T428/24165 , Y10T428/254
摘要： Disclosed herein is a portable panel having numerous favorable characteristics. The panel comprises a core having a length, a width, a first side and a second side. A first fiber layer is attached to the first side while a second fiber layer is attached to the second side. A first polyurethane layer is impregnated in the first fiber layer while a second polyurethane layer is impregnated into the second fiber layer. A first skin is attached to the first polyurethane layer while a second skin is attached to the second polyurethane layer. The panel can be used in the manufacture of tables, flooring, risers, stages, bleachers, and the like.

5. 发明申请

US20080124501A1 PORTABLE PANEL CONSTRUCTION AND METHOD FOR MAKING THE SAME 有权
标题翻译：便携式面板结构及其制作方法
公开(公告)号：US20080124501A1
公开(公告)日：2008-05-29
申请号：US11564075
申请日：2006-11-28
申请人： Roger Clark , George Gula
发明人： Roger Clark , George Gula
IPC分类号： F16B5/07
CPC分类号： F16B5/0092 , Y10T428/234 , Y10T428/236 , Y10T428/24149 , Y10T428/24165 , Y10T428/254
摘要： Disclosed herein is a portable panel having numerous favorable characteristics. The panel comprises a core having a length, a width, a first side and a second side. A first fiber layer is attached to the first side while a second fiber layer is attached to the second side. A first polyurethane layer is impregnated in the first fiber layer while a second polyurethane layer is impregnated into the second fiber layer. A first skin is attached to the first polyurethane layer while a second skin is attached to the second polyurethane layer. The panel can be used in the manufacture of tables, flooring, risers, stages, bleachers, and the like.
摘要翻译：本文公开了具有许多有利特征的便携式面板。面板包括具有长度，宽度，第一侧和第二侧的芯。第一纤维层附接到第一侧，而第二纤维层附接到第二侧。将第一聚氨酯层浸渍在第一纤维层中，同时将第二聚氨酯层浸渍到第二纤维层中。将第一皮肤附着到第一聚氨酯层，而第二皮肤附着到第二聚氨酯层。该面板可用于制造桌子，地板，立管，台阶，漂白机等。

6. 发明申请

US20070265298A1 Preparation and Use of Biphenyl-4-Yl-Carbonylamino Acid Derivatives for the Treatment of Obesity 失效
标题翻译：联苯-4-基羰基氨基酸衍生物用于治疗肥胖症的制备与应用
公开(公告)号：US20070265298A1
公开(公告)日：2007-11-15
申请号：US11665317
申请日：2005-10-14
申请人： Roger Smith , Stephen O'Connor , Philip Coish , Derek Lowe , Roger Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
发明人： Roger Smith , Stephen O'Connor , Philip Coish , Derek Lowe , Roger Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
IPC分类号： A61K31/435 , A61K31/421 , A61K31/44 , C07D277/00 , C07D471/02 , A61P7/12 , A61K31/426
CPC分类号： C07D235/30 , C07D263/58 , C07D277/82 , C07D513/04
摘要： This invention relates to certain biphenyl-4-yl carbonylamino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译：本发明涉及某些联苯-4-基羰基氨基酸化合物，组合物和治疗或预防肥胖症及相关疾病的方法。

7. 发明申请

US20070051855A1 Lift augmentation system and associated method 有权
标题翻译：提升增强系统及相关方法
公开(公告)号：US20070051855A1
公开(公告)日：2007-03-08
申请号：US11200506
申请日：2005-08-09
申请人： Arvin Shmilovich , Yoram Yadlin , Roger Clark
发明人： Arvin Shmilovich , Yoram Yadlin , Roger Clark
IPC分类号： B64C21/04
CPC分类号： B64C9/16 , B64C9/22 , B64C21/025 , B64C2230/04 , B64C2230/06 , B64C2230/18 , Y02T50/166 , Y02T50/32 , Y02T50/44
摘要： A system and method for generating lift provided by a multi-element aircraft wing are provided. The system includes a main wing element, a slat interconnected to the main wing element, and a flap interconnected to the main wing element. The system also includes at least one port defined in at least one of the slat, main wing element, and flap. In addition, the system includes at least one fluidic device operable to regulate fluid flow into and out of the at least one port to control boundary layer flow over at least one of the slat, main wing element, and flap.
摘要翻译：提供了一种用于产生由多元件飞机机翼提供的升降机的系统和方法。该系统包括主翼元件，与主翼元件相互连接的板条以及与主翼元件互连的翼片。该系统还包括限定在板条，主翼元件和翼片中的至少一个中的至少一个端口。此外，该系统包括至少一个流体装置，其可操作以调节进入和离开至少一个端口的流体流动，以控制边界层在板条，主翼元件和翼片中的至少一个上的流动。

8. 发明申请

US20070045476A1 Apparatus and method for the control of trailing wake flows 有权
标题翻译：用于控制尾流尾流的装置和方法
公开(公告)号：US20070045476A1
公开(公告)日：2007-03-01
申请号：US11332835
申请日：2006-01-13
申请人： Arvin Shmilovich , Yoram Yadlin , Roger Clark , Donald Leopold
发明人： Arvin Shmilovich , Yoram Yadlin , Roger Clark , Donald Leopold
IPC分类号： B64C23/06
CPC分类号： B64C23/076 , B64C23/065 , Y02T50/164
摘要： A system and method for dissipating vortices that form at the wingtips on aircraft and from other airfoils. A jet air stream is discharged in a location at or proximate to the outer end portion of the airfoil into the vortex flow, and the jet air stream is moved cyclically back and forth. The cyclic movement can be at lower or higher frequencies to alleviate at least in part intensity of the vortex or accelerate instability of the vortex which leads to vortex dissipation.
摘要翻译：一种用于消散在飞机和其他翼型上的翼尖处形成的涡流的系统和方法。喷气空气流在翼型的外端部分处或附近的位置被排放到涡流中，并且喷气流被循环地前后移动。循环运动可以在较低或更高的频率以减轻涡流的至少部分强度或加速导致涡流耗散的涡流的不稳定性。

9. 发明申请

US20070034746A1 System for aerodynamic flows and associated method 有权
标题翻译：气动流量系统及相关方法
公开(公告)号：US20070034746A1
公开(公告)日：2007-02-15
申请号：US11200515
申请日：2005-08-09
申请人： Arvin Shmilovich , Yoram Yadlin , Roger Clark , David Manley
发明人： Arvin Shmilovich , Yoram Yadlin , Roger Clark , David Manley
IPC分类号： B64C21/00 , B64C21/04 , B64C9/16
CPC分类号： B64C9/16 , B64C9/22 , B64C21/02 , B64C21/04 , B64C2230/04 , B64C2230/06 , Y02T50/166 , Y02T50/32
摘要： A system and method for controlling boundary layer flow over an aircraft wing are provided. The system includes at least one wing element, and a plurality of ports defined in the wing element and in fluid communication with one another. The system also includes at least one fluidic device operable to continuously ingest the fluid through at least one of the ports and eject the fluid out of at least one other port to control boundary layer flow of the fluid over the wing element.
摘要翻译：提供一种用于控制飞机机翼上的边界层流动的系统和方法。该系统包括至少一个翼元件和限定在翼元件中并且彼此流体连通的多个端口。该系统还包括至少一个流体装置，其可操作以通过至少一个端口连续摄取流体并将流体从至少一个其它端口排出，以控制流体在翼元件上的边界层流动。

10. 发明申请

US20060192626A1 High stability double oven crystal oscillator 有权
标题翻译：高稳定性双炉晶体振荡器
公开(公告)号：US20060192626A1
公开(公告)日：2006-08-31
申请号：US11362649
申请日：2006-02-25
申请人： Bryan Milliren , Roger Clark
发明人： Bryan Milliren , Roger Clark
IPC分类号： H03B5/32
CPC分类号： H03B5/04 , H03B5/366 , H03L1/04
摘要： A double oven crystal oscillator (DOCXO) is disclosed which is highly stable by incorporating means to reduce the effects of ambient pressure changes on the frequency of the oscillator. The oscillator crystal is mounted in a temperature controlled inner oven to reduce the effects on the frequency stability of the oscillator. The oscillator circuitry and all circuitry associated with the inner oven is mounted in good thermal contact with the inner oven. A Faraday shield at ground potential is placed over the oscillator circuitry to minimize the effects of stray capacitance between the oscillator components and the case wall of the inner oven. The effects of minor deformations in the case walls within the oscillator caused by ambient pressure changes and other factors causing pressure changes are thereby greatly minimized. To further reduce effects on oscillator frequency stability the ovens of the DOCXO are temperature controlled, cases are hermetically sealed, the case walls are rigid, and ovens and cases may be evacuated.
摘要翻译：公开了一种双炉晶体振荡器（DOCXO），其通过并入降低环境压力变化对振荡器频率的影响的方法而具有高度的稳定性。振荡器晶体安装在温度控制的内部烘箱中，以减少对振荡器的频率稳定性的影响。振荡器电路和与内部烘箱相关的所有电路与内部烘箱良好的热接触。接地电位的法拉第屏蔽放置在振荡器电路上，以最小化振荡器部件与内部烘箱的壳体壁之间的杂散电容的影响。由环境压力变化引起的振荡器外壳壁内的微小变形和导致压力变化的其他因素的影响因此大大降低。为了进一步减少对振荡器频率稳定性的影响，DOCXO的炉子是温度控制的，壳体被气密密封，壳体壁是刚性的，并且炉子和壳体可能被排空。

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