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1. 发明申请

WO2007001457A2 ANTIBODIES OPERABLY LINKED TO SELECTED CHEMOATTRACTANTS 审中-公开
标题翻译：抗体可以与选择的化合物连接
公开(公告)号：WO2007001457A2
公开(公告)日：2007-01-04
申请号：PCT/US2005/041221
申请日：2005-11-14
申请人： XENCOR, INC. , ABEL, Kenton , CHIRINO, Arthur, J. , VAFA, Omid
发明人： ABEL, Kenton , CHIRINO, Arthur, J. , VAFA, Omid
CPC分类号： C07K16/30 , A61K47/65 , A61K47/6813 , A61K47/6851 , C07K16/00 , C07K2317/55 , C07K2319/00 , C07K2319/30
摘要： An antibody or fragment thereof operably linked to a one or more chemoattractants selected from the group consisting of: C5a or fragments thereof; C3a or fragments thereof; C4a or fragments thereof; and, formyl-Met-Leu-Phe (fMLP).
摘要翻译：与一种或多种选自C5a或其片段的化学引诱物可操作地连接的抗体或其片段; C3a或其片段; C4a或其片段; 和甲酰基-Mlu-Leu-Phe（fMLP）。

2. 发明申请

WO2005113599A1 C1Q FAMILY MEMBER PROTEINS WITH ALTERED IMMUNOGENICITY 审中-公开
标题翻译：具有改变的免疫原性的C1Q家族成员蛋白质
公开(公告)号：WO2005113599A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/017379
申请日：2005-05-17
申请人： XENCOR, INC. , MARSHALL, Shannon, Alicia , MOORE, Gregory, L. , CHIRINO, Arthur, J. , DESJARLAIS, John, R.
发明人： MARSHALL, Shannon, Alicia , MOORE, Gregory, L. , CHIRINO, Arthur, J. , DESJARLAIS, John, R.
IPC分类号： C07K14/78
CPC分类号： C07K14/5759 , A61K38/00 , C07K14/78
摘要： The present invention relates to non-naturally occurring variant C1q Super Family member proteins with reduced immunogenicity. More specifically, the present invention relates to variant adiponectin and CTRP1 proteins with reduced immunogenicity.
摘要翻译：本发明涉及具有降低的免疫原性的非天然存在的C1q超级家族成员蛋白质。更具体地，本发明涉及具有降低的免疫原性的变体脂联素和CTRP1蛋白。

3. 发明申请

WO2006042333A2 PREDICTION AND ASSESSMENT OF IMMUNOGENICITY 审中-公开
标题翻译：免疫球蛋白的预测和评价
公开(公告)号：WO2006042333A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/037123
申请日：2005-10-12
申请人： XENCOR, INC. , BARBOSA, Maria, D.F.S. , CHIRINO, Arthur, J.
发明人： BARBOSA, Maria, D.F.S. , CHIRINO, Arthur, J.
CPC分类号： G01N33/56977 , G01N33/6803 , G01N2333/70539
摘要： A system and method to predict and assess immunogenicity, especially prior to on-set of immunogenic conditions. Also disclosed are methods to identify relevant peptides associated with the formation of antibodies in patients treated with a given protein therapeutic. In various aspects, the present application is directed to methods of determining the immunological compatibility of a subject with a therapeutic agent such as a proteinaceous therapeutic agent, methods of determining vaccine efficacy by determining the immunological compatibility of a subject with a therapeutic agent, and selecting a therapeutic agent for a subject in need of treatment. Methods of designing a therapeutic agent with reduced immunogenicity for a subject and methods for designing vaccines with enhanced immunogenicity for a subject are also contemplated.
摘要翻译：预防和评估免疫原性的系统和方法，特别是在免疫原性条件下。还公开了鉴定与给定蛋白质治疗剂治疗的患者中抗体形成相关的相关肽的方法。在各个方面，本申请涉及确定受试者与治疗剂如蛋白质治疗剂的免疫相容性的方法，通过确定受试者与治疗剂的免疫相容性来确定疫苗功效的方法，以及选择用于需要治疗的受试者的治疗剂。还考虑了设计具有针对受试者的免疫原性降低的治疗剂的方法和设计具有增强的免疫原性的疫苗的方法。

4. 发明申请

WO2005113598A3 TNF SUPER FAMILY MEMBERS WITH ALTERED IMMUNOGENICITY 审中-公开
公开(公告)号：WO2005113598A3
公开(公告)日：2005-12-01
申请号：PCT/US2005/018130
申请日：2005-05-23
申请人： XENCOR, INC. , MARSHALL, Shannon, Alicia , MOORE, Gregory, L. , CHIRINO, Arthur, J. , DESJARLAIS, John, R.
发明人： MARSHALL, Shannon, Alicia , MOORE, Gregory, L. , CHIRINO, Arthur, J. , DESJARLAIS, John, R.
IPC分类号： C07K14/705
摘要： The present invention relates to non-naturally occurring variant Tumor Necrosis Factor Super Family member proteins with reduced immunogenicity. More specifically, the present invention relates to variant BAFF, RANKL, TRAIL, CD40L and APRIL proteins with reduced immunogenicity.

5. 发明公开

EP1581904A3 NOVEL PROTEINS WITH ALTERED IMMUNOGENICITY 审中-公开
标题翻译：具有改变的免疫原性的新蛋白质
公开(公告)号：EP1581904A3
公开(公告)日：2005-12-28
申请号：EP04700873.5
申请日：2004-01-08
申请人： Xencor, Inc.
发明人： CHIRINO, Arthur, J. , DAHIYAT, Bassil, I. , DESJARLAIS, John, Rudolph , MARSHALL, Shannon, Alicia
IPC分类号： G06F19/00

6. 发明授权

EP1553975B1 OPTIMIZED FC VARIANTS AND METHODS FOR THEIR GENERATION 有权转让
标题翻译：优化的Fc变体及其制造方法
公开(公告)号：EP1553975B1
公开(公告)日：2012-01-18
申请号：EP03773056.1
申请日：2003-09-26
申请人： Xencor Inc.
发明人： LAZAR, Gregory, Alan , CHIRINO, Arthur, J. , DANG, Wei , DESJARLAIS, John, Rudolph , DOBERSTEIN, Stephen, Kohl , HAYES, Robert, J. , KARKI, Sher, Bahadur , VAFA, Omid
IPC分类号： C07K16/00 , C07K16/30 , C07K16/28 , C07K16/24
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K2317/34 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/94
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

7. 发明公开

EP1581904A2 NOVEL PROTEINS WITH ALTERED IMMUNOGENICITY 审中-公开
标题翻译：与修饰免疫原性新的蛋白质
公开(公告)号：EP1581904A2
公开(公告)日：2005-10-05
申请号：EP04700873.5
申请日：2004-01-08
申请人： Xencor, Inc.
发明人： CHIRINO, Arthur, J. , DAHIYAT, Bassil, I. , DESJARLAIS, John, Rudolph , MARSHALL, Shannon, Alicia
IPC分类号： G06F19/00
CPC分类号： G06F19/16
摘要： The present invention provides methods for combining computational methods for modulating protein immunogenicity with computational methods for identifying sequences with desired structural and functional properties. More specifically, the methods of the present invention may be used to identify modifications that increase or decrease the immunogenicity of a protein by affecting antigen uptake, MHC binding, T-cell binding, or antibody binding, while retaining or enhancing functional properties.

8. 发明公开

EP1620467A2 OPTIMIZED FC VARIANTS AND METHODS FOR THEIR GENERATION 审中-公开
标题翻译：优化的Fc变异及其生产方法
公开(公告)号：EP1620467A2
公开(公告)日：2006-02-01
申请号：EP04760504.3
申请日：2004-03-26
申请人： Xencor, Inc.
发明人： LAZAR, Gregory, Alan , CHIRINO, Arthur, J. , DANG, Wei , DESJARLAIS, John, Rudolph , DOBERSTEIN, Stephen, Kohl , HAYES, Robert, J. , KARKI, Sher, Bahadur , VAFA, Omid
IPC分类号： C07K16/00 , C07K16/30 , C07K16/28 , C07K16/24
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

9. 发明公开

EP1553975A2 OPTIMIZED FC VARIANTS AND METHODS FOR THEIR GENERATION 有权转让
标题翻译：优化的Fc变体及其制造方法
公开(公告)号：EP1553975A2
公开(公告)日：2005-07-20
申请号：EP03773056.1
申请日：2003-09-26
申请人： Xencor Inc.
发明人： LAZAR, Gregory, Alan , CHIRINO, Arthur, J. , DANG, Wei , DESJARLAIS, John, Rudolph , DOBERSTEIN, Stephen, Kohl , HAYES, Robert, J. , KARKI, Sher, Bahadur , VAFA, Omid
IPC分类号： A61K39/00 , C07K16/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K2317/34 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/94
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

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