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1. 发明申请

WO2008048521A2 BALLOON BRACHYTHERAPY APPLICATOR AND METHOD 审中-公开
标题翻译：气球加速器和方法
公开(公告)号：WO2008048521A2
公开(公告)日：2008-04-24
申请号：PCT/US2007021937
申请日：2007-10-12
申请人： XOFT INC , FRANCESCATTI DARIUS , HOFFMAN DAVID J , KLEIN MICHAEL , TREMBERTH SCOTT , JERVIS JAMES E , LOVOI PAUL A
发明人： FRANCESCATTI DARIUS , HOFFMAN DAVID J , KLEIN MICHAEL , TREMBERTH SCOTT , JERVIS JAMES E , LOVOI PAUL A
IPC分类号： A61M36/12
CPC分类号： A61N5/1015 , A61M2025/1063
摘要： Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.
摘要翻译：公开了用于近距离放射治疗患者，特别是切除腔中的腔周围的组织的方法和施用装置。在需要在连续辐射治疗之间恢复时间的治疗方案中，本发明的施用器保留在皮肤下，允许皮肤至少部分愈合，并且稍后重新进行一次或多次随后的治疗。为了减少患者的不适，麻醉剂可以通过施用器输注到患者组织，用于插入，球囊充气或去除涂抹器。

2. 发明申请

WO2008005435A3 ENDOSCOPIC/PERCUTANEOUS ELECTRONIC RADIATION APPLICATOR AND METHOD OF USE 审中-公开
标题翻译：内窥镜/经皮电子辐照敷用器及使用方法
公开(公告)号：WO2008005435A3
公开(公告)日：2008-07-31
申请号：PCT/US2007015361
申请日：2007-07-02
申请人： XOFT INC , FRANCESCATTI DARIUS , LOVOI PAUL A
发明人： FRANCESCATTI DARIUS , LOVOI PAUL A
IPC分类号： A61N5/00
CPC分类号： A61B1/005 , A61B1/015 , A61B1/12 , A61N5/1001 , A61N5/1002 , A61N5/1014
摘要： Treatment of lesions in any luminal or organ system of mammalian anatomy is performed using an electronic source of ionizing radiation and aided by an endoscopic or percutaneous approach.
摘要翻译：使用电离辐射的电子源并通过内窥镜或经皮途径辅助进行哺乳动物解剖结构的任何管腔或器官系统中的病变治疗。

3. 发明申请

WO2007149363A3 RADIATION THERAPY APPARATUS WITH SELECTIVE SHIELDING CAPABILITY 审中-公开
标题翻译：具有选择性屏蔽能力的放射治疗装置
公开(公告)号：WO2007149363A3
公开(公告)日：2008-07-31
申请号：PCT/US2007014151
申请日：2007-06-15
申请人： XOFT INC , SMITH PETER C , KLEIN MICHAEL , HAUSEN HEIKE , LOVOI PAUL A
发明人： SMITH PETER C , KLEIN MICHAEL , HAUSEN HEIKE , LOVOI PAUL A
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61B2017/22051 , A61B2090/0481 , A61N2005/1003 , A61N2005/1005 , A61N2005/1094
摘要： Brachytherapy applicators incorporate various forms of selective shielding devices for controlling the direction and intensity of radiation directed at a patient's tissue. In some forms the applicators include a retractable sheath, in some a series of retractable fingers. In other forms the applicator, having an inflatable balloon, has a shield which is retractable from a position adjacent to the balloon or retracted from the balloon, or a shield can itself be inflatable, separately or together with the balloon.
摘要翻译：近程放射治疗仪包括各种形式的选择性屏蔽装置，用于控制指向患者组织的辐射的方向和强度。在一些形式中，施用器包括可伸缩护套，在一些可伸缩的手指中。在其他形式中，具有可膨胀气囊的施用器具有可从邻近气囊的位置缩回或从球囊缩回的护罩，或者屏蔽件本身可以与气囊分开地或与气囊一起充气。

4. 发明申请

WO2007064900A3 TREATMENT OF LESIONS OR IMPERFECTIONS IN MAMMALIAN SKIN OR NEAR-SKIN TISSUES OR IN OR NEAR OTHER ANATOMIC SURFACES 审中-公开
标题翻译：治疗哺乳动物皮肤或近侧皮肤组织或其他解剖表面的伤害或影响
公开(公告)号：WO2007064900A3
公开(公告)日：2009-04-30
申请号：PCT/US2006046019
申请日：2006-12-01
申请人： XOFT INC , AXELROD STEVE , LOVOI PAUL A
发明人： AXELROD STEVE , LOVOI PAUL A
IPC分类号： A61N1/00
CPC分类号： A61N5/1001 , A61B90/37 , A61N5/103 , A61N5/1048
摘要： A method of treatment for lesions or imperfections in or near exposed anatomic surfaces such as skin using low- level ionizing radiation includes, in one embodiment, acquisition by computer of the location and geometry of the anatomic region to be treated, creation of a treatment plan by a therapist to achieve the desired therapeutic effect within the region, and execution of the treatment plan by the energy source. Verification of the treatment to plan and safety methods are disclosed.
摘要翻译：在一个实施方案中，使用低级电离辐射治疗暴露解剖表面（例如皮肤）或附近的损伤或缺陷的方法包括在计算机上获取待治疗的解剖区域的位置和几何形状，创建治疗计划由治疗师在该区域内实现期望的治疗效果，以及由能量源执行治疗计划。公开了对计划和安全方法的处理的验证。

5. 发明申请

WO2007079227A3 GYNECOLOGICAL BRACHYTHERAPY APPLICATOR AND SYSTEM 审中-公开
公开(公告)号：WO2007079227A3
公开(公告)日：2008-03-13
申请号：PCT/US2006049579
申请日：2006-12-29
申请人： XOFT INC , LIM ALEX , LOVOI PAUL A , HAUSEN HEIKE , STEWART DAREN L
发明人： LIM ALEX , LOVOI PAUL A , HAUSEN HEIKE , STEWART DAREN L
IPC分类号： A61N5/00 , A61N5/10
CPC分类号： A61N5/1016 , A61N5/1048 , A61N2005/1005
摘要： A vaginal brachytherapy applicator is versatile to different anatomies and more comfortable to the patient than prior applicators . An inflatable balloon on a shaft may be inelastic or elastic. In one embodiment the shaft is rotatable relative to the balloon for enabling a ring or band of dose delivery, for versatility in radiation placement . Alternatively, the source can be rotated and pulled back within a stationary shaft. An adjustment is provided for reducing the length of balloon that inflates, to accommodate different anatomies and positions. Although isotope radiation sources can be used in the applicator, an electronic source is preferred, and the- system and method include procedures for using the applicator with an electronic source .
摘要翻译：阴道近距离放射治疗仪对于不同的解剖结构是多功能的，对于患者而言比以前的给药者更舒适。轴上的可膨胀气球可能是无弹性的或弹性的。在一个实施例中，轴可相对于球囊旋转，以实现用于辐射放置的多功能性的剂量递送环或带。或者，源可以在固定轴内旋转和拉回。提供了一种减小气囊膨胀长度的调整，以适应不同的解剖结构和位置。虽然同位素辐射源可以用于施用器中，但优选电子源，并且系统和方法包括使用具有电子源的施加器的程序。

6. 发明申请

WO2007079226A3 BRACHYTHERAPY APPLICATOR FOR DELIVERY AND ASSESSMENT OF LOW-LEVEL IONIZING RADIATION THERAPY AND METHODS OF USE 审中-公开
标题翻译：用于交付和评估低水平离子辐射治疗的BRACHYTHERAPY应用者及其使用方法
公开(公告)号：WO2007079226A3
公开(公告)日：2007-11-08
申请号：PCT/US2006049578
申请日：2006-12-29
申请人： XOFT INC , LOVOI PAUL A
发明人： LOVOI PAUL A
IPC分类号： A61N5/00 , A61N5/10
CPC分类号： A61N5/1015 , A61N5/1048 , A61N2005/1018
摘要： Applicators for ionizing radiation therapy and their methods of use are provided for expedient preparation of precise treatment plans and for quantitative assessment of therapy delivered to natural or surgically- created, intra - corporeal cavities or lumina. Feedback capability is provided for timely treatment control and for verification of treatment to plan using sensors on the applicators .
摘要翻译：提供用于电离辐射治疗的施用者及其使用方法，以便于准确地制定精确的治疗计划以及用于定量评估递送至天然或手术产生的体内腔或腔的治疗。提供反馈能力以及时进行治疗控制和验证治疗计划，使用涂抹器上的传感器。

7. 发明申请

WO2007079194A3 HDR ADAPTER FOR ELECTRONIC RADIATION SOURCE APPLICATOR 审中-公开
标题翻译：电子辐射源适配器的HDR适配器
公开(公告)号：WO2007079194A3
公开(公告)日：2007-12-21
申请号：PCT/US2006049509
申请日：2006-12-29
申请人： XOFT INC , LOVOI PAUL A , LIM ALEX
发明人： LOVOI PAUL A , LIM ALEX
IPC分类号： A61N5/00 , A61N5/10
CPC分类号： A61N5/1015 , A61N2005/1008
摘要： An applicator designed for use with a miniature electronic x-ray source, having a relatively large guide for the electronic source, is modified by an adapter inserted into the source guide to produce a narrower-diameter guide that will receive a standard afterloader that irradiates with isotopes.
摘要翻译：设计用于具有用于电子源的相对较大的引导件的微型电子x射线源的施加器被插入到源引导件中的适配器改变以产生更窄直径的引导件，该引导件将接收标准的后加载器，该引导器将与同位素。

8. 发明申请

WO2004112890A9 METHOD FOR INTRAOPERATIVE RADIATION TREATMENT OF BREAST CANCER 审中-公开
标题翻译：乳腺癌治疗放射治疗方法
公开(公告)号：WO2004112890A9
公开(公告)日：2005-02-03
申请号：PCT/US2004019621
申请日：2004-06-18
申请人： XOFT MICROTUBE INC , LOVOI PAUL A
发明人： LOVOI PAUL A
IPC分类号： A61N5/10 , A61N
CPC分类号： A61N5/1015 , A61N5/103 , A61N5/1048 , A61N2005/1018
摘要： Breast cancer patients are treated intraoperatively with radiation shortly after excision of a tumor. Pathology of the tissue is determined with a nearly instantaneous method, further excision is performed if needed, and the patient, still anesthetized and preferably unmoved, is then treated with radiation therapy. In a preferred embodiment an applicator is inserted into the excision cavity, the cavity is threedimensionally mapped using radiation sources and a sensor, a radiation treatment plan is developed using a radiation prescription and the determined shape and location of the cavity, and the treatment plan is executed, all while the patient remains under anesthesia.
摘要翻译：乳腺癌患者在切除肿瘤后不久就用放射治疗。使用几乎瞬时的方法确定组织的病理学，如果需要进行进一步切除，然后用放射疗法治疗仍然被麻醉并优选不动的患者。在优选实施例中，将施用器插入到切除腔中，使用辐射源和传感器对空腔进行三维映射，使用辐射处方和确定的腔的形状和位置开发辐射治疗计划，并且治疗计划是所有这一切，同时病人仍然在麻醉下。

9. 发明申请

WO2011106093A2 ELECTRODE AND CONNECTOR ATTACHMENTS FOR A CYLINDRICAL GLASS FIBER FINE WIRE LEAD 审中-公开
标题翻译：用于圆柱形玻璃纤维细导线的电极和连接器附件
公开(公告)号：WO2011106093A2
公开(公告)日：2011-09-01
申请号：PCT/US2011000340
申请日：2011-02-23
申请人： CARDIA ACCESS INC , WALSH ROBERT G , LOVOI PAUL A , SHIMADA JIN , ANDERSON KIMBERLY
发明人： WALSH ROBERT G , LOVOI PAUL A , SHIMADA JIN , ANDERSON KIMBERLY
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/056 , H01R4/187 , H01R43/0221 , H01R2201/12
摘要： A cardiac pacemaker or other CRT device has one or more fine wire leads to the heart. Formed of a glass, silica, sapphire or crystalline quartz fiber with a metal coating, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar fine wire leads can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included. The fine wire lead incorporates a thin metal conductor, which poses unique challenges for attachment to standardized connectors, as well as stimulation electrodes. The present invention describes means and materials for creating robust and durable electrically conductive connections between the fine wire lead body and a proximal standardized connector and distal ring and tip electrodes.
摘要翻译：心脏起搏器或其他CRT设备具有一根或多根细导线至心脏。由金属涂层形成的玻璃，硅石，蓝宝石或结晶石英纤维，单极引线可具有小至约300微米或甚至更小的外径。金属缓冲涂层可以直接沉积在玻璃/二氧化硅纤维上，或者在玻璃/二氧化硅纤维与金属之间的由碳和/或聚合物组成的中间层上。由此产生的金属化玻璃纤维/硅石纤维非常耐用，可以通过小半径弯曲，即使从数百万次的弯曲迭代中也不会疲劳。双极细导线可以包括多个并排排列的绝缘金属化玻璃/石英光纤，或者可以与两个或更多个绝缘金属导电路径同轴。可以包括柔性聚合物材料的外护套。细导线采用薄金属导体，这对连接标准连接器以及刺激电极提出了独特的挑战。本发明描述了用于在细线引线主体和近侧标准化连接器以及远侧环和尖端电极之间产生坚固耐用的导电连接的装置和材料。

10. 发明申请

WO2009025769A1 NON-INVASIVE CHARACTERIZATION OF HUMAN VASCULATURE 审中-公开
标题翻译：人体血管非侵入性表征
公开(公告)号：WO2009025769A1
公开(公告)日：2009-02-26
申请号：PCT/US2008009802
申请日：2008-08-15
申请人： JAN MEDICAL INC , LOVOI PAUL A , MURPHY KIERAN , JARVELA JEFF , NEILD PETE , THOMAS JOHN , SCHUMACHER RAY , MACVEAN CHARLIE
发明人： LOVOI PAUL A , MURPHY KIERAN , JARVELA JEFF , NEILD PETE , THOMAS JOHN , SCHUMACHER RAY , MACVEAN CHARLIE
IPC分类号： A61B5/026
CPC分类号： A61B7/04 , A61B5/02007 , A61B5/4076 , A61B5/6814 , A61B5/7267 , G06F19/324 , G16H50/20 , G16H50/50
摘要： Vascular conditions are detected non-invasively in the human body using a collection of pressure wave/motion stimulation information from small local regions of the vasculature. An array of accelerometers or other sensors are attached to the head or other points of interest of a patient and blood flow sounds are recorded. Vibration signatures of vessel structures such as branches, aneurysms, stenosis, etc. using random, periodic, band limited or transient analysis provides a library for further processing. The signature library is used to localize the origin of the recognized vascular feature, and the localized feature is presented to the physician in a clinically relevant manner.
摘要翻译：使用从脉管系统的小局部区域的压力波/运动刺激信息的集合在人体内非侵入性地检测血管病变。一组加速度计或其他传感器附着在患者的头部或其他感兴趣点上，并记录血流声音。使用随机，周期，带限或瞬态分析的血管结构如分支，动脉瘤，狭窄等的振动特征提供了进一步处理的文库。签名库用于定位识别的血管特征的起源，并且以临床相关的方式向局部特征提供局部特征。

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