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1. 发明公开

EP0512965A1 Endoscopic imaging system for diseased tissue 有权
标题翻译： Endoskopisches Bilderzeugungssystemfürerkranktes Gewebe。
公开(公告)号：EP0512965A1
公开(公告)日：1992-11-11
申请号：EP92850098.2
申请日：1992-05-05
申请人： XILLIX TECHNOLOGIES CORPORATION
发明人： Palcic, Branko , Jaggi, Bruno , Profio, Amedeus Edward , Macaulay, Calum , Lam, Stephen , Hung, Jaclyn
IPC分类号： A61B5/00
CPC分类号： A61B1/043 , A61B1/00186 , A61B1/042 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084 , G01N2021/6463
摘要： Apparatus for imaging diseases in tissue comprising a light source for generating excitation light that includes wavelengths capable of generating characteristic autofluorescence for abnormal and normal tissue. A fibreoptic illuminating light guide is used to illuminate tissue with light that includes at least the excitation light thereby exciting the tissue to emit the characteristic autofluorescence. An imaging bundle collects emitted autofluorescence light from the tissue. The autofluorescence light is filtered into spectral bands in which the autofluorescence intensity for abnormal tissue is substantially different from normal tissue and the autofluorescence intensity for abnormal tissue is substantially similar to normal tissue. An optical system is used to intercept the filtered autofluorescence light to acquire at least two filtered emitted autofluorescence images of the tissue. The acquired images are displayed in real time on a display monitor in such a manner as to delineate abnormal and normal tissue.
摘要翻译：用于在组织中成像疾病的装置，包括用于产生激发光的光源，所述激发光包括能够产生用于异常和正常组织的特征性自发荧光的波长。光纤照明光引导件用于用至少包括激发光的光照射组织，从而激发组织以发出特征自发荧光。成像束从组织收集发射的自发荧光。自发荧光被过滤到光谱带，其中异常组织的自发荧光强度与正常组织显着不同，异常组织的自发荧光强度基本上与正常组织相似。光学系统用于截取滤波的自发荧光以获得组织的至少两个经滤波的发射的自发荧光图像。所获取的图像以描绘异常和正常组织的方式在显示监视器上实时显示。

2. 发明授权

EP0920831B1 Apparatus for imaging diseased tissue using integrated autofluorescence 失效
标题翻译：使用集成的自发荧光装置用于成像患病组织
公开(公告)号：EP0920831B1
公开(公告)日：2005-08-17
申请号：EP99103430.7
申请日：1995-03-24
申请人： XILLIX TECHNOLOGIES CORPORATION
发明人： Palcic, Branko , Macaulay, Calum , Lam, Stephen , Jaggi, Bruno
IPC分类号： A61B1/05 , A61B5/00
CPC分类号： A61B1/043 , A61B1/05 , A61B5/0071 , A61B5/0084 , A61B5/0086 , H04N2005/2255

3. 发明公开

EP1472972A1 Apparatus and method for imaging diseased tissue using integrated autofluorescence 失效
标题翻译：使用集成的自发荧光的方法和装置用于成像患病组织
公开(公告)号：EP1472972A1
公开(公告)日：2004-11-03
申请号：EP04018813.8
申请日：1995-03-24
申请人： XILLIX TECHNOLOGIES CORPORATION
发明人： Palcic, Branko , Lam, Stephen , Macaulay, Calum , Jaggi, Bruno
IPC分类号： A61B5/00 , A61B1/05
CPC分类号： A61B1/043 , A61B1/05 , A61B5/0071 , A61B5/0084 , A61B5/0086 , H04N2005/2255
摘要： An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the one end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.
摘要翻译：用于成像组织的疾病的装置和方法被呈现。该装置采用一个光源，用于产生激发光来激发组织，以产生自体荧光光以及用于产生照明光，以产生反射并返回来自所述组织的散射光（汇款光）。光学传感器用于接收所述自体荧光光以及汇款光收集自发荧光光图像和一个汇款光图像。的过滤器的作用是自发荧光图像在波长范围内的，其中用于正常组织自体荧光强度是从自体荧光强度基本上不同的用于患病组织对组织的自体荧光的集成图像建立集成。汇款光提供的背景图像以标准化的自发荧光图像，以考虑图像不均匀由于在距离，角度和照明强度的变化。监视器显示集成自身荧光图像和汇款光图像，以产生归一化的图像，其中病变组织是从正常组织区分开来。该光学传感器可被安装为邻近插入到体腔内的内窥镜探头的一端。一种用于成像使用积分荧光图像和正火汇款图像患病组织的方法因此是游离缺失盘。

4. 发明授权

EP0380904B1 Solid state microscope 失效
标题翻译：半导体显微镜。
公开(公告)号：EP0380904B1
公开(公告)日：1994-05-04
申请号：EP89850028.5
申请日：1989-02-01
申请人： XILLIX TECHNOLOGIES CORPORATION
发明人： Jaggi, Bruno , Deen, Mohamed J. , Palcic, Branko
IPC分类号： G02B21/00
CPC分类号： G02B21/002 , G01N21/5911 , G01N2021/5938 , G01N2021/5957 , G01N2201/103

5. 发明公开

EP0920831A1 Apparatus and method for imaging diseased tissue using integrated autofluorescence 失效
标题翻译：使用集成的自发荧光装置用于成像患病组织
公开(公告)号：EP0920831A1
公开(公告)日：1999-06-09
申请号：EP99103430.7
申请日：1995-03-24
申请人： XILLIX TECHNOLOGIES CORPORATION
发明人： Palcic, Branko , Macaulay, Calum , Lam, Stephen , Jaggi, Bruno
IPC分类号： A61B1/05 , A61B5/00
CPC分类号： A61B1/043 , A61B1/05 , A61B5/0071 , A61B5/0084 , A61B5/0086 , H04N2005/2255
摘要： An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the one end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.
摘要翻译：用于成像组织的疾病的装置和方法被呈现。该装置采用一个光源，用于产生激发光来激发组织，以产生自体荧光光以及用于产生照明光，以产生反射并返回来自所述组织的散射光（汇款光）。光学传感器用于接收所述自体荧光光以及汇款光收集自发荧光光图像和一个汇款光图像。的过滤器的作用是自发荧光图像在波长范围内的，其中用于正常组织自体荧光强度是从自体荧光强度基本上不同的用于患病组织对组织的自体荧光的集成图像建立集成。汇款光提供的背景图像以标准化的自发荧光图像，以考虑图像不均匀由于在距离，角度和照明强度的变化。监视器显示集成自身荧光图像和汇款光图像，以产生归一化的图像，其中病变组织是从正常组织区分开来。该光学传感器可被安装为邻近插入到体腔内的内窥镜探头的一端。一种用于成像使用积分荧光图像和正火汇款图像患病组织的方法因此是游离缺失盘。

6. 发明授权

EP0512965B1 Endoscopic imaging system for diseased tissue 有权
标题翻译：用于患病组织内窥镜成像系统
公开(公告)号：EP0512965B1
公开(公告)日：1996-07-24
申请号：EP92850098.2
申请日：1992-05-05
申请人： XILLIX TECHNOLOGIES CORPORATION
发明人： Palcic, Branko , Jaggi, Bruno , Profio, Amedeus Edward , Macaulay, Calum , Lam, Stephen , Hung, Jaclyn
IPC分类号： A61B5/00
CPC分类号： A61B1/043 , A61B1/00186 , A61B1/042 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084 , G01N2021/6463

7. 发明公开

EP0380904A1 Solid state microscope 失效
标题翻译： Halbleiter Mikroskop。
公开(公告)号：EP0380904A1
公开(公告)日：1990-08-08
申请号：EP89850028.5
申请日：1989-02-01
申请人： XILLIX TECHNOLOGIES CORPORATION
发明人： Jaggi, Bruno , Deen, Mohamed J. , Palcic, Branko
IPC分类号： G02B21/00
CPC分类号： G02B21/002 , G01N21/5911 , G01N2021/5938 , G01N2021/5957 , G01N2201/103
摘要： A quantitative light microscope for viewing and scanning microscopic objects that uses a solid state detector (7) in the primary image plane. The microscope has a light source (1) with a condensor (2) and diffusion filter (3). A moveable stage (5) is provided to allow X, Y, Z plane displacements in order to scan objects under the microscope. There is an objective (6) to magnify the image of the object and project this image onto a two dimensional solid state image sensor (7) positioned in the primary image plane of the objective. The solid state image sensor (7) sends signals to an analog-to-digital converter (8) where the signals are digitized and sent to a frame memory (9). A monitor (10) is used to display the image of the object as stored in frame memory. The present invention can be interfaced with a computer (12) to allow for automatic focusing and scanning of an image. The computer also houses storage means to store images. Methods of scanning an object are also described. A prism element can be used to obtain spectral scans of an object. In another scanning method, a first edge row of pixels is used to detect an object of interest in the scanned image. This first detection row activates an area of the sensor array at a later time to capture the entire image. In this way, only relevant information is collected and processed.
摘要翻译：用于观察和扫描在主像平面中使用固态检测器（7）的微观物体的定量光学显微镜。显微镜具有带有冷凝器（2）和扩散过滤器（3）的光源（1）。提供可移动台（5）以允许X，Y，Z平面位移，以便在显微镜下扫描物体。有一个目标（6）放大对象的图像并将该图像投影到位于物镜的主像平面中的二维固态图像传感器（7）上。固态图像传感器（7）向模数转换器（8）发送信号，信号被数字化并发送到帧存储器（9）。监视器（10）用于显示存储在帧存储器中的对象的图像。本发明可以与计算机（12）接口以允许图像的自动聚焦和扫描。计算机还容纳存储图像的存储装置。还描述了扫描对象的方法。可以使用棱镜元件来获得物体的光谱扫描。在另一扫描方法中，使用第一边缘行像素来检测扫描图像中的感兴趣对象。该第一检测行在稍后时间激活传感器阵列的区域以捕获整个图像。以这种方式，只收集和处理相关信息。

8. 发明公开

EP0595506A3 Automated detection of cancerous or precancerous tissue by measuring malignancy associated changes 失效转让
标题翻译：通过测量变化的自动检测癌症或恶性vorkanzerogenem组织。
公开(公告)号：EP0595506A3
公开(公告)日：1994-12-07
申请号：EP93308210.9
申请日：1993-10-14
申请人： XILLIX TECHNOLOGIES CORPORATION
发明人： MacAulay, Calum , Palcic, Branko , Garner, David , Harrison, Alan , Jaggi, Bruno
IPC分类号： G01N33/483 , G01N15/10 , G01N21/00
CPC分类号： G01N33/5091 , G01N15/1475 , G01N33/5017 , G06K9/00127
摘要： An appatatus and a method for detecting malignancy associated changes relies on use of the microscope having a high sampling density light transducer. Images of the cell nuclei are obtained in precise focus. The images are segmented using a relocation algorithm for precisely locating the edge of the nucleus. The features of the images including DNA distribution are analyzed using multivariate analysis to detect malignance associated changes.

9. 发明公开

EP0595506A2 Automated detection of cancerous or precancerous tissue by measuring malignancy associated changes 失效转让
标题翻译：通过测量变化的自动检测癌症或恶性vorkanzerogenem组织。
公开(公告)号：EP0595506A2
公开(公告)日：1994-05-04
申请号：EP93308210.9
申请日：1993-10-14
申请人： XILLIX TECHNOLOGIES CORPORATION
发明人： MacAulay, Calum , Palcic, Branko , Garner, David , Harrison, Alan , Jaggi, Bruno
IPC分类号： G01N33/483 , G01N15/10 , G01N21/00
CPC分类号： G01N33/5091 , G01N15/1475 , G01N33/5017 , G06K9/00127
摘要： An appatatus and a method for detecting malignancy associated changes relies on use of the microscope having a high sampling density light transducer. Images of the cell nuclei are obtained in precise focus. The images are segmented using a relocation algorithm for precisely locating the edge of the nucleus. The features of the images including DNA distribution are analyzed using multivariate analysis to detect malignance associated changes.
摘要翻译：在appatatus和用于检测恶性肿瘤相关的变化的方法依赖于使用具有高采样密度的光传感器的显微镜。细胞核的图像被获得的聚焦准确度。该图像是使用重定位算法精确定位核的边缘分段。包括DNA分布的图像的特征被使用多变量分析，以检测恶性相关的变化进行分析。

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