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1. 发明申请

WO2003067221A3 COMPOSITIONS AND METHODS FOR RESTORING IMMUNE RESPONSIVENESS IN PATIENTS WITH IMMUNOLOGICAL DEFECTS 审中-公开
公开(公告)号：WO2003067221A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/005850
申请日：2003-02-07
申请人： XCYTE THERAPIES, INC. , BONYHADI, Mark , BERENSON, Ronald, J.
发明人： BONYHADI, Mark , BERENSON, Ronald, J.
IPC分类号： C12N5/00
摘要： The present invention relates generally to methods for stimulating, activating, and maintaining or increasing the polyclonality of expressed TCRs in a population of T cells. In the various embodiments, cells are stimulated with a surface, wherein the surface has attached thereto one or more agents that ligate a cell surface moiety of at least a portion of the T cells and stimulates at least a portion of the T cells, yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement. Also provided are methods for producing T-cells for the use in diagnostics and the treatment of a variety of indications, including cancer, viral infection, and immune related disorders. Compositions of cells having increased polyclonality produced by these processes are further provided.

2. 发明申请

WO2006110582A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF BURNS AND SEPSIS 审中-公开
标题翻译：用于治疗痤疮和食欲的组合物和方法
公开(公告)号：WO2006110582A1
公开(公告)日：2006-10-19
申请号：PCT/US2006/013154
申请日：2006-04-07
申请人： XCYTE THERAPIES, INC. , BERENSON, Ronald, J. , BONYHADI, Mark
发明人： BERENSON, Ronald, J. , BONYHADI, Mark
IPC分类号： C07K16/28 , C12N5/06
CPC分类号： C07K16/2809 , A61K35/17 , A61K2039/505 , C07K16/2818
摘要： The present invention relates generally to methods for treating burns and sepsis, in particular for treating immune dysfunction associated with burns and sepsis. The present invention also relates to activating and expanding T cells for the treatment of burns and sepsis.
摘要翻译：本发明一般涉及治疗烧伤和败血症的方法，特别是用于治疗与烧伤和败血症相关的免疫功能障碍。本发明还涉及用于治疗烧伤和败血症的活化和扩张T细胞。

3. 发明申请

WO2004065590A2 ACTIVATION AND EXPANSION OF CELLS 审中-公开
标题翻译：细胞的活化和扩增
公开(公告)号：WO2004065590A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/001349
申请日：2004-01-20
申请人： XCYTE THERAPIES INC. , BERENSON, Ronald, J. , LAW, Che , BONYHADI, Mark , SAUND, Narinder , CRAIG, Stewart , HARDWICK, Alan , KALAMASZ, Dale , MCMILLEN, David , CHANA, Harjinder, Singh
发明人： BERENSON, Ronald, J. , LAW, Che , BONYHADI, Mark , SAUND, Narinder , CRAIG, Stewart , HARDWICK, Alan , KALAMASZ, Dale , MCMILLEN, David , CHANA, Harjinder, Singh
IPC分类号： C12N5/08
CPC分类号： C12N5/0087 , A61K2035/124 , A61K2039/5158 , A61K2039/57 , A61L27/3804 , A61L27/3895 , C07K16/2803 , C07K16/2806 , C07K16/2809 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2821 , C07K16/2827 , C07K16/2833 , C07K16/2845 , C07K16/2854 , C07K16/2866 , C07K16/2875 , C07K16/2878 , C07K16/289 , C07K16/2896 , C12N5/0635 , C12N5/0636 , C12N5/0647 , C12N2500/32 , C12N2501/23 , C12N2501/51 , C12N2501/515 , C12N2501/53 , C12N2501/59 , C12N2533/12 , C12N2533/14 , C12N2533/18 , C12N2533/30 , C12N2533/40 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C12N2533/90
摘要： The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in a short period of time. In certain embodiments, cells are activated and expanded to very high numbers of cells in a short period of time. Compositions of cells activated and expanded by the methods herein are further provided.
摘要翻译：本发明总体上涉及激活和扩增细胞的方法，更具体地涉及活化和/或刺激细胞的新方法，其使这些细胞的扩增最大化以实现显着高的密度。在各种实施方案中，细胞在短时间内被激活并扩展至非常高的密度。在某些实施方案中，细胞在短时间内被激活并扩增到非常高数量的细胞。进一步提供了通过本文方法活化和扩增的细胞组合物。

4. 发明申请

WO2002098361A3 T CELL INDUCED TISSUE REPAIR AND REGENERATION 审中-公开
公开(公告)号：WO2002098361A3
公开(公告)日：2002-12-12
申请号：PCT/US2002/017647
申请日：2002-06-03
申请人： XCYTE THERAPIES, INC. , BONYHADI, Mark , BERENSON, Ronald
发明人： BONYHADI, Mark , BERENSON, Ronald
IPC分类号： A61K39/395
摘要： The present invention relates to methods for the use of T cells or supernatants therefrom, and more particularly, activated T cells, in facilitating and/or regulating the differentiation, de-differentiation, maturation, organization, repair, and regeneration of various cells/tissues. Methods for inducing tissue repair and regeneration in vitro and in vivo are disclosed. The present invention also relates to compositions of cells, including activated T cells and/or cells resulting from the co-culture with activated T cells, and their use in inducing tissue repair and regeneration in vivo.

5. 发明申请

WO2006105219A2 T CELL THERAPY FOR THE TREATMENT OF CACHEXIA AND CHRONIC DISEASES 审中-公开
标题翻译：用于治疗慢性病和慢性疾病的细胞疗法
公开(公告)号：WO2006105219A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011502
申请日：2006-03-28
申请人： XCYTE THERAPIES, INC. , BONYHADI, Mark , BERENSON, Ronald, J.
发明人： BONYHADI, Mark , BERENSON, Ronald, J.
IPC分类号： A61K35/14 , A61P9/00 , A61P11/00 , A61P13/12 , A61P1/16
CPC分类号： A61K35/17 , A61K38/2013 , A61K2300/00
摘要： The present invention relates to compositions and methods for the use of T cells and more particularly, activated T cells, in the treatment and/or amelioration of diseases associated with a proinflammatory state, such as cachexia, chronic diseases such as chronic renal failure, and hepatitis.
摘要翻译：本发明涉及使用T细胞的组合物和方法，更具体地说，涉及活化的T细胞，用于治疗和/或改善与促炎状态相关的疾病，例如恶病质，慢性疾病如慢性肾衰竭和肝炎。

6. 发明申请

WO2002087627A1 MATURATION OF ANTIGEN-PRESENTING CELLS USING ACTIVATED T CELLS 审中-公开
标题翻译：使用活化T细胞的抗原递呈细胞的成熟
公开(公告)号：WO2002087627A1
公开(公告)日：2002-11-07
申请号：PCT/US2002/013616
申请日：2002-04-29
申请人： XCYTE THERAPIES, INC. , BERENSON, Ronald, Jay , BONYHADI, Mark , CRAIG, Stewart , KALAMASZ, Dale , MONJI, Tatsue
发明人： BERENSON, Ronald, Jay , BONYHADI, Mark , CRAIG, Stewart , KALAMASZ, Dale , MONJI, Tatsue
IPC分类号： A61K48/00
CPC分类号： C12N5/0639 , A61K2039/5154 , A61K2039/5158 , C12N5/16 , C12N2501/22 , C12N2501/23 , C12N2501/51 , C12N2501/515
摘要： The present invention relates to methods for maturing antigen-presenting cells, and more particularly, to methods for maturing antigen-presenting cells. Methods for generating mature and/or maturing antigen-presenting cells in vitro and in vivo are disclosed. The present invention also relates to compositions of cells, including mature antigen-presenting cells and/or activated T cells and their use in generating immune responses in vivo, and inhibiting the development of or preventing infectious diseases and cancers.
摘要翻译：本发明涉及成熟抗原呈递细胞的方法，更具体地涉及用于成熟抗原呈递细胞的方法。公开了在体外和体内产生成熟和/或成熟的抗原呈递细胞的方法。本发明还涉及细胞的组合物，包括成熟的抗原呈递细胞和/或活化的T细胞及其在体内产生免疫应答中的用途，以及抑制传染病和癌症的发展或预防。

7. 发明申请

WO2003067221A2 COMPOSITIONS AND METHODS FOR RESTORING IMMUNE RESPONSIVENESS IN PATIENTS WITH IMMUNOLOGICAL DEFECTS 审中-公开
标题翻译：在免疫缺陷患者中恢复免疫应答的组合物和方法
公开(公告)号：WO2003067221A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/005850
申请日：2003-02-07
申请人： XCYTE THERAPIES, INC. , BONYHADI, Mark , BERENSON, Ronald, J.
发明人： BONYHADI, Mark , BERENSON, Ronald, J.
IPC分类号： G01N
CPC分类号： C07K16/2818 , A61K2039/5158 , A61K2039/57 , C07K16/2809 , C12N5/0636 , C12N2501/51 , C12N2501/515
摘要： The present invention relates generally to methods for stimulating, activating, and maintaining or increasing the polyclonality of expressed TCRs in a population of T cells. In the various embodiments, cells are stimulated with a surface, wherein the surface has attached thereto one or more agents that ligate a cell surface moiety of at least a portion of the T cells and stimulates at least a portion of the T cells, yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement. Also provided are methods for producing T-cells for the use in diagnostics and the treatment of a variety of indications, including cancer, viral infection, and immune related disorders. Compositions of cells having increased polyclonality produced by these processes are further provided.
摘要翻译：本发明一般涉及用于刺激，激活和维持或增加T细胞群体中表达的TCR的多克隆性的方法。在各种实施方案中，用表面刺激细胞，其中所述表面附着有一种或多种与T细胞的至少一部分的细胞表面部分连接并且刺激至少一部分T细胞的试剂，产生增强的增殖，细胞信号转导和/或细胞表面部分聚集。在某些方面，通过细胞表面部分连接来刺激细胞群体例如T细胞群体的方法通过使细胞群与表面连接，提供一种或多种连接细胞表面部分从而诱导细胞的试剂刺激，细胞表面部分聚集和/或受体信号传导增强。还提供了用于产生用于诊断和治疗各种适应症（包括癌症，病毒感染和免疫相关疾病）的T细胞的方法。还提供了由这些方法产生的具有增加的多克隆性的细胞的组成。

8. 发明申请

WO2004003142A3 COMPOSITIONS AND METHODS FOR RESTORING IMMUNE REPERTOIRE IN PATIENTS WITH IMMUNOLOGICAL DEFECTS RELATED TO AUTOIMMUNITY AND ORGAN OR HEMATOPOIETIC STEM CELL TRANSPLANTATION 审中-公开
公开(公告)号：WO2004003142A3
公开(公告)日：2004-01-08
申请号：PCT/US2003/019842
申请日：2003-06-24
申请人： XCYTE THERAPIES, INC. , BERENSON, Ronald , BONYHADI, Mark , KALAMASZ, Dale
发明人： BERENSON, Ronald , BONYHADI, Mark , KALAMASZ, Dale
IPC分类号： C12N5/00
摘要： The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g. autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.

9. 发明申请

WO2003024989A3 ACTIVATION AND EXPANSION OF CELLS 审中-公开
公开(公告)号：WO2003024989A3
公开(公告)日：2003-03-27
申请号：PCT/US2002/028161
申请日：2002-09-04
申请人： XCYTE THERAPIES, INC. , BERENSON, Ronald , LAW, Che , BONYHADI, Mark , SAUND, Narinder , CRAIG, Stewart , HARDWICK, Alan, R. , KALAMASZ, Dale , MCMILLEN, David , CHANA, Harjinder, Singh
发明人： BERENSON, Ronald , LAW, Che , BONYHADI, Mark , SAUND, Narinder , CRAIG, Stewart , HARDWICK, Alan, R. , KALAMASZ, Dale , MCMILLEN, David , CHANA, Harjinder, Singh
IPC分类号： C12N5/00
摘要： The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in a short period of time. In certain embodiments, cells are activated and expanded to very high numbers of cells in a short period of time. Compositions of cells activated and expanded by the methods herein are further provided.

10. 发明申请

WO2004104185A1 GENERATION AND ISOLATION OF ANTIGEN-SPECIFIC T CELLS 审中-公开
标题翻译：抗原特异性T细胞的产生和分离
公开(公告)号：WO2004104185A1
公开(公告)日：2004-12-02
申请号：PCT/US2003/041212
申请日：2003-12-19
申请人： XCYTE THERAPIES, INC. , BONYHADI, Mark , KALAMASZ, Dale
发明人： BONYHADI, Mark , KALAMASZ, Dale
IPC分类号： C12N5/00
CPC分类号： C12N5/0636 , A61K2035/122 , A61K2035/124 , A61K2039/515 , A61K2039/5158 , C12N2501/515 , C12N2501/58 , C12N2501/599
摘要： The present invention relates generally to methods for generating, expanding, and isolating antigen-specific T cells. Compositions of antigen-specific T cells activated and expanded by the methods herein are further provided.
摘要翻译：本发明一般涉及产生，扩增和分离抗原特异性T细胞的方法。进一步提供通过本文方法活化和扩增的抗原特异性T细胞的组合物。

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