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1. 发明申请

WO2007044100A1 METHODS FOR PREPARING GLUTAMIC ACID DERIVATIVES 审中-公开
标题翻译：制备谷氨酸衍生物的方法
公开(公告)号：WO2007044100A1
公开(公告)日：2007-04-19
申请号：PCT/US2006/026892
申请日：2006-07-11
申请人： WYETH , MICHALAK, Ronald, S. , ZELDIS, Joseph , JENNINGS, Mel , BLUM, David, M. , DOYLE, Timothy
发明人： MICHALAK, Ronald, S. , ZELDIS, Joseph , JENNINGS, Mel , BLUM, David, M. , DOYLE, Timothy
IPC分类号： C07C269/06 , C07C271/22 , C07C231/12 , C07C237/22
CPC分类号： C07C237/06 , C07C231/12 , C07C237/04 , C07C237/22 , C07C271/22 , C07C2603/18
摘要： The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
摘要翻译：本发明涉及制备谷氨酸衍生物的新方法及其中间体，以及通过新方法制备的这些化合物。

2. 发明公开

EP1917270A2 PROCESS FOR PREPARING BETA-LACTAMASE INHIBITORS 审中-公开
标题翻译： PROCESS beta-内酰胺酶抑制剂的制备
公开(公告)号：EP1917270A2
公开(公告)日：2008-05-07
申请号：EP06824832.7
申请日：2006-08-22
申请人： Wyeth
发明人： MICHALAK, Ronald, S. , GALANTE, Rocco , BLUM, David, M. , ROUTEL, Lisa , DURUTLIC, Haris , GUINOSSO, Charles , CONSIDINE, John , KREMER, Ken
IPC分类号： C07D513/04
CPC分类号： C07D513/04 , C07D277/60
摘要： The present invention relates to processes for preparing β-alkylidene penem derivatives that can be important as broad spectrum β-lactamase inhibitors and anti-bacterial agents.

3. 发明公开

EP1934171A1 METHODS FOR PREPARING GLUTAMIC ACID DERIVATIVES 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VONGLUTAMINSÄUREDERIVATEN
公开(公告)号：EP1934171A1
公开(公告)日：2008-06-25
申请号：EP06786899.2
申请日：2006-07-11
申请人： Wyeth
发明人： MICHALAK, Ronald, S. , ZELDIS, Joseph , JENNINGS, Mel , BLUM, David, M. , DOYLE, Timothy
IPC分类号： C07C269/06 , C07C271/22 , C07C231/12 , C07C237/22
CPC分类号： C07C237/06 , C07C231/12 , C07C237/04 , C07C237/22 , C07C271/22 , C07C2603/18
摘要： The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
摘要翻译：本发明涉及制备谷氨酸衍生物的新方法及其中间体，以及通过新方法制备的这些化合物。

4. 发明公开

EP1963330A1 DIMERS AND ADDUCTS OF 6-[SUBSTITUTED) PHENYL] TRIAZOLOPYRIMIDINES USEFUL AS ANTICANCER AGENTS 审中-公开
标题翻译：二聚体和6- [取代的）苯基] -TRIAZOLOPYRIMIDINEN的加合物作为一种手段对抗癌症
公开(公告)号：EP1963330A1
公开(公告)日：2008-09-03
申请号：EP06845599.7
申请日：2006-12-15
申请人： Wyeth
发明人： WU, Yanzhong , BLUM, David, M. , BEYER, Carl
IPC分类号： C07D487/04 , A61K31/519 , A61P35/04
CPC分类号： C07D487/04
摘要： Certain adducts and dimers of 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals, are disclosed. Also disclosed is a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. Also disclosed is a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.

5. 发明公开

EP2027126A2 CRYSTALLINE FORMS OF 5-CHLORO-6- (2, 6-DIFLUORO-4-[3- (METHYLAMINO) PROPOXY] PHENYL)-N-((1S)-2, 2, 2,-TRIFLUORO-1-METHYLETHYL][1,2,4]TRIAZOLO [1,5-A]PYRIMIDIN-7-AMINE SALTS 审中-公开
标题翻译：（（1S）-2,2,2-三氟-1-甲基乙基] - 5-氯-6-（2,6-二氟-4- [3-（甲基氨基）丙氧基]苯基）-N-结晶形式 - [1,2,4] -TRIAZOL- [1,5-a]嘧啶-7-氨基盐
公开(公告)号：EP2027126A2
公开(公告)日：2009-02-25
申请号：EP07794976.6
申请日：2007-05-17
申请人： Wyeth Holdings Corporation
发明人： QI, Fang, Fang , KU, Mannching Sherry , WU, Yanzhong , BLUM, David, M.
IPC分类号： C07D487/04 , A61K31/519 , A61P35/04
CPC分类号： C07D487/04
摘要： The present invention relates to crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3- (methylamino)propoxy]phenyl}-N-[(1S)-2,2,2- trifluoro- 1 - methylethyl][l,2,4]triazolo[l,5-a]pyrimidin-7-amine salts; processes for the production thereof; pharmaceutical compositions thereof; and methods for inhibiting tumor growth therewith.

6. 发明申请

WO2007089669A2 PROCESSES FOR THE PREPARATION OF COMPOUNDS 审中-公开
标题翻译：化合物的制备方法
公开(公告)号：WO2007089669A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/002323
申请日：2007-01-25
申请人： WYETH , KRISHNAN, Lalitha , BLUM, David, M. , DILLEY, Anja, Susanne , PAN, Sherry , POTOSKI, John, R. , SHAH, Uresh, S. , SHARMA, Archana , STRONG, Henry, Lee , WU, Yanzhong , ZHANG, Mei-Yi
发明人： KRISHNAN, Lalitha , BLUM, David, M. , DILLEY, Anja, Susanne , PAN, Sherry , POTOSKI, John, R. , SHAH, Uresh, S. , SHARMA, Archana , STRONG, Henry, Lee , WU, Yanzhong , ZHANG, Mei-Yi
IPC分类号： C07D213/61 , C07D333/70 , C07D409/12 , C07C271/24 , C07F5/02
CPC分类号： C07D409/12 , C07D213/61 , C07D333/70
摘要： The present invention provides improved synthetic methods for the preparation of compounds that modulate proliferation or differentiation in a cell or tissue.
摘要翻译：本发明提供了用于制备调节细胞或组织中的增殖或分化的化合物的改进的合成方法。

7. 发明申请

WO2007024859A2 PROCESS FOR PREPARING BETA-LACTAMASE INHIBITORS 审中-公开
标题翻译：制备β-乳酸酶抑制剂的方法
公开(公告)号：WO2007024859A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032781
申请日：2006-08-22
申请人： WYETH , MICHALAK, Ronald, S. , GALANTE, Rocco , BLUM, David, M. , ROUTEL, Lisa , DURUTLIC, Haris , GUINOSSO, Charles , CONSIDINE, John , KREMER, Ken
发明人： MICHALAK, Ronald, S. , GALANTE, Rocco , BLUM, David, M. , ROUTEL, Lisa , DURUTLIC, Haris , GUINOSSO, Charles , CONSIDINE, John , KREMER, Ken
CPC分类号： C07D513/04 , C07D277/60
摘要： The present invention relates to processes for preparing β-alkylidene penem derivatives that can be important as broad spectrum β-lactamase inhibitors and anti-bacterial agents.
摘要翻译：本发明涉及制备β-亚烷基半乳聚糖衍生物的方法，其可以作为广谱β-内酰胺酶抑制剂和抗菌剂是重要的。

8. 发明申请

WO2007136692A2 CRYSTALLINE FORMS OF 5-CHLORO-6- (2, 6-DIFLUORO-4- [3- (METHYLAMINO) PROPOXY] PHENYL)-N-((1S)-2, 2, 2,-TRIFLUORO-1-METHYLETHYL] [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-AMINE SALTS 审中-公开
标题翻译： 5-二氯-6-（2,6-二氟-4- [3-（甲基氨基）丙氧基]苯基）-N - （（1S）-2,2,2-三氟-1-甲基乙基] 1,2,4]三唑[1,5-A]嘧啶-7-胺盐
公开(公告)号：WO2007136692A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/011817
申请日：2007-05-17
申请人： WYETH HOLDINGS CORPORATION , QI, Fang, Fang , KU, Mannching, Sherry , WU, Yanzhong , BLUM, David, M.
发明人： QI, Fang, Fang , KU, Mannching, Sherry , WU, Yanzhong , BLUM, David, M.
IPC分类号： C07D487/04 , A61K31/519 , A61P35/04
CPC分类号： C07D487/04
摘要： The present invention relates to crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3- (methylamino)propoxy]phenyl}-N-[(1S)-2,2,2- trifluoro- 1 - methylethyl][l,2,4]triazolo[l,5-a]pyrimidin-7-amine salts; processes for the production thereof; pharmaceutical compositions thereof; and methods for inhibiting tumor growth therewith.
摘要翻译：本发明涉及5-氯-6- {2,6-二氟-4- [3-（甲基氨基）丙氧基]苯基} -N - [（1S）-2,2,2-三氟-1 - 甲基乙基] [1,2,4]三唑并[1,5-a]嘧啶-7-胺盐; 生产过程; 其药物组合物; 以及抑制肿瘤生长的方法。

9. 发明申请

WO2007075465A1 DIMERS AND ADDUCTS OF 6-[SUBSTITUTED) PHENYL] TRIAZOLOPYRIMIDINES USEFUL AS ANTICANCER AGENTS 审中-公开
标题翻译： 6- [取代的]苯基的二聚体和添加剂作为抗原剂有用的三唑并嘧啶
公开(公告)号：WO2007075465A1
公开(公告)日：2007-07-05
申请号：PCT/US2006/048013
申请日：2006-12-15
申请人： WYETH , WU, Yanzhong , BLUM, David, M. , BEYER, Carl
发明人： WU, Yanzhong , BLUM, David, M. , BEYER, Carl
IPC分类号： C07D487/04 , A61K31/519 , A61P35/04
CPC分类号： C07D487/04
摘要： Certain adducts and dinners of 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals, are disclosed. Also disclosed is a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. Also disclosed is a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
摘要翻译： 6 - [（取代）苯基]三唑并嘧啶化合物或其药学上可接受的盐的某些加合物和晚餐，以及含有所述化合物或其药学上可接受的盐的组合物，其中所述化合物是可用于治疗哺乳动物癌症的抗癌剂披露。还公开了一种治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，以及用于治疗或预防哺乳动物表达多重耐药性（MDR）或由于MDR抗性的癌性肿瘤的方法在需要时，该方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。还公开了通过促进微管聚合来治疗或抑制有需要的哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，其包括向所述哺乳动物施用有效量的所述化合物及其药学上可接受的盐。

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