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1. 发明授权

US08741594B2 Mitochondrial enoyl coenzyme A hydratase 1 as marker for diagnosing stomach cancer 有权
标题翻译：线粒体烯酰辅酶A水合酶1作为诊断胃癌的标记物
公开(公告)号：US08741594B2
公开(公告)日：2014-06-03
申请号：US12009350
申请日：2008-01-17
申请人： Won Sun Park , Jae-Hong Ko , Na Ri Kim , Jin Han , Hyoung Kyu Kim , Mohamad Warda
发明人： Won Sun Park , Jae-Hong Ko , Na Ri Kim , Jin Han , Hyoung Kyu Kim , Mohamad Warda
IPC分类号： C12Q1/26
CPC分类号： G01N33/57446 , C12N9/88 , C12Y402/01017 , G01N33/573 , G01N2500/00
摘要： The present invention relates to mitochondrial protein that can be used as a marker for diagnosing stomach cancer. According to the present invention, the marker for diagnosing stomach cancer comprises mitochondrial enoyl coenzyme A hydratase 1.
摘要翻译：本发明涉及可用作诊断胃癌的标记物的线粒体蛋白质。根据本发明，用于诊断胃癌的标记物包括线粒体烯酰辅酶A水合酶1。

2. 发明申请

US20080213816A1 Mitochondrial enoyl coenzyme a hydratase 1 as marker for diagnosing stomach cancer 有权
标题翻译：线粒体烯酰辅酶A水合酶1作为诊断胃癌的标志物
公开(公告)号：US20080213816A1
公开(公告)日：2008-09-04
申请号：US12009350
申请日：2008-01-17
申请人： Won Sun Park , Jae-Hong Ko , Na Ri Kim , Jin Han , Hyoung Kyu Kim , Mohamad Warda
发明人： Won Sun Park , Jae-Hong Ko , Na Ri Kim , Jin Han , Hyoung Kyu Kim , Mohamad Warda
IPC分类号： C12Q1/26 , C12N9/02 , C07K16/18
CPC分类号： G01N33/57446 , C12N9/88 , C12Y402/01017 , G01N33/573 , G01N2500/00
摘要： The present invention relates to mitochondrial protein that can be used as a marker for diagnosing stomach cancer. According to the present invention, the marker for diagnosing stomach cancer comprises mitochondrial enoyl coenzyme A hydratase 1.
摘要翻译：本发明涉及可用作诊断胃癌的标记物的线粒体蛋白质。根据本发明，用于诊断胃癌的标记物包括线粒体烯酰辅酶A水合酶1。

3. 发明申请

US20090226908A1 Biomarker and composition for diagnosis of preeclampsia 审中-公开
标题翻译：用于诊断先兆子痫的生物标志物和组成
公开(公告)号：US20090226908A1
公开(公告)日：2009-09-10
申请号：US12218218
申请日：2008-07-10
申请人： Won Sun Park , Na Ri Kim , Mohamad Warda , Jin Han
发明人： Won Sun Park , Na Ri Kim , Mohamad Warda , Jin Han
IPC分类号： C12Q1/68 , C12N9/10
CPC分类号： C12Q1/6883 , C12Q1/686 , C12Q2600/158
摘要： The present invention relates to a biomarker and a composition for diagnosis of preeclampsia. In accordance with one aspect of the present invention, there is provided a biomarker for diagnosis of preeclampsia using an enzyme selected from the group consisting of placental chondroitin 4-O-sulfotransferase 1 (C4ST), chondroitin 6-sulfotransferase (C6S), heparan sulfate 6-O-sulfotransferase 1 (HS6S), and dermatan/chondroitin sulfate 2-sulfotransferase (CS-2OST), or uronic acid-2-sulfate (UA2S).
摘要翻译：本发明涉及用于诊断先兆子痫的生物标志物和组合物。根据本发明的一个方面，提供了一种用于使用选自胎盘软骨素4-O-磺基转移酶1（C4ST），软骨素6-磺基转移酶（C6S），硫酸乙酰肝素的酶的酶进行先兆子痫诊断的生物标志物 6-O-磺基转移酶1（HS6S）和皮肤素/硫酸软骨素2-磺基转移酶（CS-2OST）或糖醛酸-2-硫酸酯（UA2S）。

4. 发明申请

US20120309009A1 METHOD FOR THE DIAGNOSIS OF PREECLAMPSIA 审中-公开
标题翻译：用于诊断前列腺炎的方法
公开(公告)号：US20120309009A1
公开(公告)日：2012-12-06
申请号：US13488232
申请日：2012-06-04
申请人： Won Sun Park , Na Ri Kim , Mohamad Warda , Jin Han
发明人： Won Sun Park , Na Ri Kim , Mohamad Warda , Jin Han
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/686 , C12Q2600/158
摘要： The present invention relates to a biomarker and a composition for diagnosis of preeclampsia. In accordance with one aspect of the present invention, there is provided a biomarker for diagnosis of preeclampsia using an enzyme selected from the group consisting of placental chondroitin 4-O-sulfotransferase 1 (C4ST), chondroitin 6-sulfotransferase (C6S), heparan sulfate 6-O-sulfotransferase 1 (HS6S), and dermatan/chondroitin sulfate 2-sulfotransferase (CS-2OST), or uronic acid-2-sulfate (UA2S).
摘要翻译：本发明涉及用于诊断先兆子痫的生物标志物和组合物。根据本发明的一个方面，提供了一种用于使用选自胎盘软骨素4-O-磺基转移酶1（C4ST），软骨素6-磺基转移酶（C6S），硫酸乙酰肝素的酶的酶进行先兆子痫诊断的生物标志物 6-O-磺基转移酶1（HS6S）和皮肤素/硫酸软骨素2-磺基转移酶（CS-2OST）或糖醛酸-2-硫酸酯（UA2S）。

5. 发明授权

US08211641B2 Method for the diagnosis of preeclampsia 有权
标题翻译：先兆子痫诊断方法
公开(公告)号：US08211641B2
公开(公告)日：2012-07-03
申请号：US13037141
申请日：2011-02-28
申请人： Won Sun Park , Na Ri Kim , Mohamad Warda , Jin Han
发明人： Won Sun Park , Na Ri Kim , Mohamad Warda , Jin Han
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q1/686 , C12Q2600/158
摘要： The present invention relates to a biomarker and a composition for diagnosis of preeclampsia. In accordance with one aspect of the present invention, there is provided a biomarker for diagnosis of preeclampsia using an enzyme selected from the group consisting of placental chondroitin 4-O-sulfotransferase 1 (C4ST), chondroitin 6-sulfotransferase (C6S), heparan sulfate 6-O-sulfotransferase 1 (HS6S), and dermatan/chondroitin sulfate 2-sulfotransferase (CS-2OST), or uronic acid-2-sulfate (UA2S).
摘要翻译：本发明涉及用于诊断先兆子痫的生物标志物和组合物。根据本发明的一个方面，提供了一种用于使用选自胎盘软骨素4-O-磺基转移酶1（C4ST），软骨素6-磺基转移酶（C6S），硫酸乙酰肝素的酶的酶进行先兆子痫的诊断的生物标志物 6-O-磺基转移酶1（HS6S）和皮肤素/硫酸软骨素2-磺基转移酶（CS-2OST）或糖醛酸-2-硫酸酯（UA2S）。

6. 发明申请

US20110269136A1 BIOMARKER AND COMPOSITION FOR DIAGNOSIS OF PREECLAMPSIA AND METHOD FOR USING THE SAME 有权
标题翻译：用于诊断前体的生物标记物和组合物及其使用方法
公开(公告)号：US20110269136A1
公开(公告)日：2011-11-03
申请号：US13037141
申请日：2011-02-28
申请人： Won Sun Park , Na Ri Kim , Mohamad Warda , Jin Han
发明人： Won Sun Park , Na Ri Kim , Mohamad Warda , Jin Han
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/686 , C12Q2600/158
摘要： The present invention relates to a biomarker and a composition for diagnosis of preeclampsia. In accordance with one aspect of the present invention, there is provided a biomarker for diagnosis of preeclampsia using an enzyme selected from the group consisting of placental chondroitin 4-O-sulfotransferase 1 (C4ST), chondroitin 6-sulfotransferase (C6S), heparan sulfate 6-O-sulfotransferase 1 (HS6S), and dermatan/chondroitin sulfate 2-sulfotransferase (CS-2OST), or uronic acid-2-sulfate (UA2S).
摘要翻译：本发明涉及用于诊断先兆子痫的生物标志物和组合物。根据本发明的一个方面，提供了一种用于使用选自胎盘软骨素4-O-磺基转移酶1（C4ST），软骨素6-磺基转移酶（C6S），硫酸乙酰肝素的酶的酶进行先兆子痫诊断的生物标志物 6-O-磺基转移酶1（HS6S）和皮肤素/硫酸软骨素2-磺基转移酶（CS-2OST）或糖醛酸-2-硫酸酯（UA2S）。

7. 发明申请

US20080233579A1 PRIMER SET FOR DETECTING OVEREXPRESSION OF KATP CHANNEL AND KIT COMPRISING SAID PRIMER SET 审中-公开
标题翻译：用于检测KATP通道和包含上位机组的套件的前置集
公开(公告)号：US20080233579A1
公开(公告)日：2008-09-25
申请号：US11965687
申请日：2007-12-27
申请人： Won Sun Park , Na Ri Kim , Jae-Hong Ko , Jin Han
发明人： Won Sun Park , Na Ri Kim , Jae-Hong Ko , Jin Han
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a primer set for confirming an increase of mRNA in an ATP-sensitive potassium channel (KATP channel)(Kir6.1) having an effect of protecting heart from hypoxia or an ischemic disease; a kit including the primer set; and a method of identifying an agent for treating an ischemic heart disease.
摘要翻译：本发明涉及一种用于确认具有保护心脏免受缺氧或缺血性疾病作用的ATP敏感钾通道（K ATP通道）（Kir6.1）中的mRNA增加的引物组 ; 包括引物组的试剂盒; 以及鉴定用于治疗缺血性心脏病的药剂的方法。

8. 发明申请

US20110318809A1 METHOD OF SCREENING PLACENTAL PROTEINS RESPONSIBLE FOR PATHOPHYSIOLOGY OF PREECLAMPSIA, AND MARKER FOR EARLY DIAGNOSIS AND PREDICTION OF PREECLAMPSIA 审中-公开
标题翻译：筛选前列腺炎病理学的平面蛋白质的筛选方法及早期诊断及预后评估标记
公开(公告)号：US20110318809A1
公开(公告)日：2011-12-29
申请号：US13154774
申请日：2011-06-07
申请人： Won Sun Park , Na Ri Kim , Jin Han
发明人： Won Sun Park , Na Ri Kim , Jin Han
IPC分类号： C12N9/96 , C12N9/04 , C07K16/18 , C12N9/10 , C07K14/435 , C12N9/50 , C12N9/90
CPC分类号： G01N33/6893 , G01N33/689 , G01N2550/00 , G01N2800/368
摘要： The present invention relates to a method of screening placental proteins responsible for pathophysiology of preeclampsia, and a marker for early diagnosis and prediction of preeclampsia. In accordance with one aspect of the present invention, there is provided a method of screening placental proteins responsible for pathophysiology of preeclampsia by 2D E-proteomics analysis, comprising: isolating placental proteins from a placental tissue; separating the isolated proteins two-dimensionally through 2D electrophoresis; and comparing and analyzing the separated proteins based on scanned gel images and differences in the images between normal placental proteins and preeclamptic placental proteins, wherein the comparison and analysis of the placental proteins based on the scanned gel images and differences in the images are accomplished by selecting proteins with differences of 140% or more between two placentas.
摘要翻译：本发明涉及筛选负责先兆子痫的病理生理学的胎盘蛋白的方法以及先兆子痫的早期诊断和预测的标志物。根据本发明的一个方面，提供了通过2D E-蛋白质组学分析筛选负责先兆子痫的病理生理学的胎盘蛋白的方法，其包括：从胎盘组织分离胎盘蛋白; 通过2D电泳二维分离分离的蛋白质; 并且基于扫描的凝胶图像和正常胎盘蛋白和先兆子痫胎盘蛋白之间的图像的差异来比较和分析分离的蛋白质，其中基于扫描的凝胶图像和图像差异的胎盘蛋白质的比较和分析通过选择蛋白质在两个胎盘之间具有140％以上的差异。

9. 发明申请

US20090023168A1 Method of screening placental proteins responsible for pathophysiology of preeclampsia, and marker for early diagnosis and prediction of preeclampsia 有权
标题翻译：筛选负责先兆子痫的病理生理学的胎盘蛋白的方法，以及先兆子痫的早期诊断和预测的标志物
公开(公告)号：US20090023168A1
公开(公告)日：2009-01-22
申请号：US12218767
申请日：2008-07-16
申请人： Won Sun Park , Na Ri Kim , Jin Han
发明人： Won Sun Park , Na Ri Kim , Jin Han
IPC分类号： C12Q1/48 , G01N33/00 , C12Q1/32 , C12N9/02 , C12N9/14 , C12N9/10 , C12Q1/34 , C12Q1/26
CPC分类号： G01N33/6893 , G01N33/689 , G01N2550/00 , G01N2800/368
摘要： The present invention relates to a method of screening placental proteins responsible for pathophysiology of preeclampsia, and a marker for early diagnosis and prediction of preeclampsia. In accordance with one aspect of the present invention, there is provided a method of screening placental proteins responsible for pathophysiology of preeclampsia by 2D E-proteomics analysis, comprising: isolating placental proteins from a placental tissue; separating the isolated proteins two-dimensionally through 2D electrophoresis; and comparing and analyzing the separated proteins based on scanned gel images and differences in the images between normal placental proteins and preeclamptic placental proteins, wherein the comparison and analysis of the placental proteins based on the scanned gel images and differences in the images are accomplished by selecting proteins with differences of 140% or more between two placentas.
摘要翻译：本发明涉及筛选负责先兆子痫的病理生理学的胎盘蛋白的方法以及先兆子痫的早期诊断和预测的标志物。根据本发明的一个方面，提供了通过2D E-蛋白质组学分析筛选负责先兆子痫的病理生理学的胎盘蛋白的方法，其包括：从胎盘组织分离胎盘蛋白; 通过2D电泳二维分离分离的蛋白质; 并且基于扫描的凝胶图像和正常胎盘蛋白和先兆子痫胎盘蛋白之间的图像的差异来比较和分析分离的蛋白质，其中基于扫描的凝胶图像和图像差异的胎盘蛋白质的比较和分析通过选择蛋白质在两个胎盘之间具有140％以上的差异。

10. 发明授权

US07998508B2 Method of screening placental proteins responsible for pathophysiology of preeclampsia, and marker for early diagnosis and prediction of preeclampsia 有权
标题翻译：筛选负责先兆子痫的病理生理学的胎盘蛋白的方法，以及先兆子痫的早期诊断和预测的标志物
公开(公告)号：US07998508B2
公开(公告)日：2011-08-16
申请号：US12218767
申请日：2008-07-16
申请人： Won Sun Park , Na Ri Kim , Jin Han
发明人： Won Sun Park , Na Ri Kim , Jin Han
IPC分类号： A61K35/12
CPC分类号： G01N33/6893 , G01N33/689 , G01N2550/00 , G01N2800/368
摘要： The present invention relates to a method of screening placental proteins responsible for pathophysiology of preeclampsia, and a marker for early diagnosis and prediction of preeclampsia. In accordance with one aspect of the present invention, there is provided a method of screening placental proteins responsible for pathophysiology of preeclampsia by 2D E-proteomics analysis, comprising: isolating placental proteins from a placental tissue; separating the isolated proteins two-dimensionally through 2D electrophoresis; and comparing and analyzing the separated proteins based on scanned gel images and differences in the images between normal placental proteins and preeclamptic placental proteins, wherein the comparison and analysis of the placental proteins based on the scanned gel images and differences in the images are accomplished by selecting proteins with differences of 140% or more between two placentas.
摘要翻译：本发明涉及筛选负责先兆子痫的病理生理学的胎盘蛋白的方法以及先兆子痫的早期诊断和预测的标志物。根据本发明的一个方面，提供了通过2D E-蛋白质组学分析筛选负责先兆子痫的病理生理学的胎盘蛋白的方法，其包括：从胎盘组织分离胎盘蛋白; 通过2D电泳二维分离分离的蛋白质; 并且基于扫描的凝胶图像和正常胎盘蛋白和先兆子痫胎盘蛋白之间的图像的差异来比较和分析分离的蛋白质，其中基于扫描的凝胶图像和图像差异的胎盘蛋白质的比较和分析通过选择蛋白质在两个胎盘之间具有140％以上的差异。

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