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1. 发明申请

US20090136587A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF NERVE DAMAGE COMPRISING BLOOD PLASMA OR SERUM 审中-公开
标题翻译：用于治疗包含血浆或血清的神经损伤的药物组合物
公开(公告)号：US20090136587A1
公开(公告)日：2009-05-28
申请号：US11995901
申请日：2006-08-08
申请人： Won Min Yoo , Nae Choon Yoo , Ki Chang Keum , Sang Yup Lee , Gene Lee
发明人： Won Min Yoo , Nae Choon Yoo , Ki Chang Keum , Sang Yup Lee , Gene Lee
IPC分类号： A61K35/16
CPC分类号： A61K35/16 , Y02A50/401
摘要： The present invention relates to a pharmaceutical composition for the treatment of nerve damage, and more particularly to a pharmaceutical composition for the treatment of nerve damage, which contains blood plasma or serum as an active ingredient. The inventive composition regenerates nerve cells after spinal nerve damage and provides complete structural continuity in the spinal nerve lesion sites. Thus, the composition is useful for the treatment of nerve damage.
摘要翻译：本发明涉及用于治疗神经损伤的药物组合物，更具体地涉及含有血浆或血清作为活性成分的用于治疗神经损伤的药物组合物。本发明组合物在脊髓神经损伤后再生神经细胞，并在脊神经损伤部位提供完整的结构连续性。因此，该组合物可用于治疗神经损伤。

2. 发明授权

US08017157B2 Method of treating a wound with acidified plasma or serum 失效
标题翻译：用酸化血浆或血清处理伤口的方法
公开(公告)号：US08017157B2
公开(公告)日：2011-09-13
申请号：US11638056
申请日：2006-12-12
申请人： Won Min Yoo , Kyung Hee Chang , Nae Choon Yoo , Ki Chang Keum , Sang Yup Lee , Gene Lee
发明人： Won Min Yoo , Kyung Hee Chang , Nae Choon Yoo , Ki Chang Keum , Sang Yup Lee , Gene Lee
IPC分类号： A61K35/16
CPC分类号： A61K35/16
摘要： The present invention relates to a pharmaceutical composition for the treatment of wounds containing blood plasma or serum and a method for treating wounds effectively by applying said composition to the wound site to normalize the tissue-environment around the site.
摘要翻译：本发明涉及用于治疗含有血浆或血清的伤口的药物组合物和通过将所述组合物施用于伤口部位来有效地治疗伤口的方法，以使得围绕该部位周围的组织环境归一化。

3. 发明申请

US20140005365A1 ANTIBODY TO A MUTANT G-CSF FOR DIAGNOSIS OF CANCER 审中-公开
标题翻译：抗体用于诊断癌症的G-CSF
公开(公告)号：US20140005365A1
公开(公告)日：2014-01-02
申请号：US13546975
申请日：2012-07-11
申请人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
IPC分类号： C07K16/24
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译：公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。

4. 发明申请

US20120322684A1 G-CSF PROTEIN HAVING A DELETION OF AN AMINO ACID SEQUENCE CORRESPONDING TO EXON 3 FOR USE AS A DIAGNOSTIC CANCER MARKER 审中-公开
标题翻译：具有相关性的氨基酸序列的G-CSF蛋白3用作诊断性癌症标记
公开(公告)号：US20120322684A1
公开(公告)日：2012-12-20
申请号：US13546972
申请日：2012-07-11
申请人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
IPC分类号： C07K14/535 , C12Q1/68 , C40B30/04 , C07H21/04
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译：公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。

5. 发明申请

US20100286381A1 DIAGNOSTIC METHOD FOR CANCER CHARACTERIZED IN THE DETECTION OF THE DELETION OF G-CSF EXON 3 审中-公开
标题翻译：检测G-CSF外显子3检测中的癌症诊断方法
公开(公告)号：US20100286381A1
公开(公告)日：2010-11-11
申请号：US12830085
申请日：2010-07-02
申请人： Sang Yup LEE , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup LEE , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译：公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。

6. 发明授权

US08324363B2 Microarray for detection of the deletion of exon 3 of the G-CSF gene 失效
标题翻译：用于检测G-CSF基因外显子3缺失的微阵列
公开(公告)号：US08324363B2
公开(公告)日：2012-12-04
申请号：US11058976
申请日：2005-02-16
申请人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
IPC分类号： C07H21/04 , C12Q1/68 , C07K14/535
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译：公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。

7. 发明授权

US07323184B2 Compositions and methods for the treatment of wounds and the reduction of scar formation 失效
标题翻译：用于治疗创伤和减少瘢痕形成的组合物和方法
公开(公告)号：US07323184B2
公开(公告)日：2008-01-29
申请号：US11476543
申请日：2006-06-28
申请人： Mary Ellen Freddo , Ki Chang Keum , Naechoon Yoo , Won Min Yoo
发明人： Mary Ellen Freddo , Ki Chang Keum , Naechoon Yoo , Won Min Yoo
IPC分类号： A61K9/00 , A61K9/50 , A61K33/00 , A01N43/04
CPC分类号： A61K33/00 , A61K31/728 , A61K45/06
摘要： The present invention relates to methods and compositions for inhibiting scar formation on wound region. In certain embodiments, the methods include administering an alkalinization agent in combination with hyaluronic acid to a wound site to reduce the formation of scars at the wound site. Suitable alkalization agents include sodium bicarbonate, sodium hydroxide and potassium hydroxide.
摘要翻译：本发明涉及用于抑制伤口区域上的瘢痕形成的方法和组合物。在某些实施方案中，所述方法包括向伤口部位施用与透明质酸组合的碱化剂以减少伤口位置处的瘢痕形成。合适的碱化剂包括碳酸氢钠，氢氧化钠和氢氧化钾。

8. 发明授权

US07255883B2 Agent for reduction of scar formation by using wound alkalinization 失效
标题翻译：通过使用伤口碱化来减少瘢痕形成的药剂
公开(公告)号：US07255883B2
公开(公告)日：2007-08-14
申请号：US10312097
申请日：2001-06-20
申请人： Ki Chang Keum , Naechoon Yoo , Won-min Yoo
发明人： Ki Chang Keum , Naechoon Yoo , Won-min Yoo
IPC分类号： A01N59/00 , A61K33/00
CPC分类号： A61K33/00
摘要： The present invention relates to an agent for reducing scar formation, which inhibits the scar formation by injecting sodium bicarbonate to the dermis tissue of the wound with a syringe to directly control pH of the wound site, namely, by alkalinizing the wound to inactivate TGF-β. According to the present invention, the agent for reducing scar formation by controlling the wound healing process can be clinically and immediately applied to the treatment of tylosis scar and keloid, etc., and is effective to the treatment of intractable fibrosis diseases. Also, the invention can be widely applied in many ways as an easy tool which can control the action of TGF-β in a living organism.
摘要翻译：本发明涉及一种用于减少瘢痕形成的药剂，其通过用注射器将碳酸氢钠注入伤口的真皮组织来抑制瘢痕形成，以直接控制伤口部位的pH，即通过使伤口碱化以使TGF- 测试版根据本发明，通过控制伤口愈合过程来减少瘢痕形成的药剂可以临床上立即应用于治疗泰乐菌瘢痕和瘢痕疙瘩等，对于治疗难治性纤维化疾病是有效的。此外，本发明可以以许多方式广泛应用，作为可以控制活体中TGF-β的作用的简单工具。

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