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1. 发明申请

US20110166162A1 1,2-Benzisothiazole Compounds Useful for Combating Animal Pests 审中-公开
公开(公告)号：US20110166162A1
公开(公告)日：2011-07-07
申请号：US12999349
申请日：2009-06-17
申请人： Wolfgang von Deyn , Michael Puhl , Matthias Pohlman , Michael Rack , Liliana Parra Rapado , Jürgen Langewald , Douglas D. Anspaugh , Hassan Oloumi-Sadeghi , Gale F. Matt Hews , Deborah L. Culbertson , Nancy B. Rankl , Hennicke Kamp , Bennard van Ravenzwaay
发明人： Wolfgang von Deyn , Michael Puhl , Matthias Pohlman , Michael Rack , Liliana Parra Rapado , Jürgen Langewald , Douglas D. Anspaugh , Hassan Oloumi-Sadeghi , Gale F. Matt Hews , Deborah L. Culbertson , Nancy B. Rankl , Hennicke Kamp , Bennard van Ravenzwaay
IPC分类号： A01N43/54 , C07D417/06 , C07D401/06 , A01N43/40 , A01P11/00 , A01P15/00 , A01P7/04 , A01P5/00 , A01P7/00
CPC分类号： C07D417/06 , A01N43/80 , C02F1/001 , C02F2209/03 , C02F2303/16 , C07D417/14
摘要： The present invention relates to sulfonamide compounds of formula (I) wherein R1 is H, halogen, CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C4-alkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylthio, C2-C6-alkenylthio, C2-C6-alkynylthio, C1-C6-haloalkyl or C1-C6-haloalkoxy; R2 and R3 are H, halogen, CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C4-alkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylthio, C2-C6-alkenylthio, C2-C6-alkynylthio, C1-C6-haloalkyl or C1-C6-haloalkoxy; or R2 together with R3 form a fused 5 or 6-membered carbocycle or heterocycle; R4 is halogen, CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-haloalkylthio, C1-C6-haloalkylsulfinyl or C1-C6-haloalksulfonyl; n is 0, 1, 2 or 3; R5 is phenyl or a 5- or 6-membered heterocycle; X is O or NRx, wherein Rx is H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylcarbonyl or C1-C6-alkylcarbonyloxy; Y is N or C(Ry), wherein Ry is H, halogen, CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C3-7-cycloalkyl-C1-C4-alkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylthio, C2-C6-alkenylthio, C2-C6-alkynylthio, C1-C6-haloalkyl and C1-C6-haloalkoxy; and Z is a chemical bond, O or N(Rz), wherein Rz is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C1-C6-alkylcarbonyl or C1-C6-alkylcarbonyloxy; as well as to the N-oxides and salts thereof. These compounds are useful for combating animal pests. The invention also relates to a process for the preparation of these compounds and to intermediate compounds used in said process. The invention further relates to a method for controlling animal pests by using the compounds of formula (I), the N-oxides or the salts thereof, to plant propagation material and to an agricultural and veterinary composition comprising said compounds, the N-oxides or the salts thereof.

2. 发明申请

US20120209535A1 METHOD FOR GENERATING BIOMARKER REFERENCE PATTERNS 审中-公开
标题翻译：生物标记参考模式的生成方法
公开(公告)号：US20120209535A1
公开(公告)日：2012-08-16
申请号：US13503268
申请日：2010-10-14
申请人： Alexandre Prokoudine , Tilmann B. Walk , Jan C. Wiemer , Ralf Looser , Michael Manfred Herold , Bennard van Ravenzwaay , Werner Mellert , Eric Fabian , Volker Strauss , Hennicke Kamp
发明人： Alexandre Prokoudine , Tilmann B. Walk , Jan C. Wiemer , Ralf Looser , Michael Manfred Herold , Bennard van Ravenzwaay , Werner Mellert , Eric Fabian , Volker Strauss , Hennicke Kamp
IPC分类号： G06F19/28
CPC分类号： G16B20/00
摘要： The present invention relates to methods for evaluating biomarkers. In particular, the invention relates to a method for establishing at least one pattern for at least one pre-defined effector having at least one effect on a biological system, which effect is capable of being determined, to a method of establishing a class of effectors for a pre-defined effect or group of effects, to a method for identifying at least one effect of a pre-defined effector and to a computer program and a computer adapted to carry out these methods.
摘要翻译：本发明涉及评价生物标志物的方法。特别地，本发明涉及一种用于建立至少一个预定义效应器的至少一种模式的方法，所述至少一个预定义的效应器对生物系统具有至少一种影响，该效应能够被确定为建立一类效应器的方法用于预定义的效果或效果组，涉及用于识别预定义效应器和适用于执行这些方法的计算机程序和计算机的至少一种效果的方法。

3. 发明申请

US20150011423A1 MEANS AND METHODS FOR ASSESSING KIDNEY TOXICITY 审中-公开
标题翻译：用于评估KIDNEY毒性的方法和方法
公开(公告)号：US20150011423A1
公开(公告)日：2015-01-08
申请号：US14344277
申请日：2012-09-14
申请人： Hennicke Kamp , Tilmann B. Walk , Bennard van Ravenzwaay , Werner Mellert , Eric Fabian , Volker Strauss , Jan C. Wiemer , Ralf Looser , Michael Manfred Herold , Alexandre Prokoudine
发明人： Hennicke Kamp , Tilmann B. Walk , Bennard van Ravenzwaay , Werner Mellert , Eric Fabian , Volker Strauss , Jan C. Wiemer , Ralf Looser , Michael Manfred Herold , Alexandre Prokoudine
IPC分类号： G01N33/50 , G01N33/62 , G01N33/68 , G01N33/92 , G01N33/70
CPC分类号： G01N33/5014 , G01N33/62 , G01N33/6893 , G01N33/70 , G01N33/92 , G01N2500/04 , G01N2800/347 , Y10T436/171538 , Y10T436/173845 , Y10T436/24
摘要： The present invention pertains to the field of diagnostics for kidney toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing kidney toxicity. It also relates to a method for determining whether a compound is capable of inducing such kidney toxicity in a subject and to a method of identifying a drug for treating kidney toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing kidney toxicity.
摘要翻译：本发明涉及用于化学化合物的危险分层的肾毒性和毒理学评估的诊断领域。具体地说，涉及诊断肾毒性的方法。它还涉及一种用于确定化合物是否能够在受试者中诱导这种肾毒性的方法以及鉴定用于治疗肾毒性的药物的方法。此外，本发明涉及用于诊断肾毒性的装置和试剂盒。

4. 发明申请

US20110129933A1 MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION 失效
标题翻译：评估增加的过度增殖的手段和方法
公开(公告)号：US20110129933A1
公开(公告)日：2011-06-02
申请号：US12994705
申请日：2009-05-26
申请人： Bennard Van Ravenzwaay , Werner Mellert , Eric Fabian , Volker Strauss , Tilmann B. Walk , Ralf Looser , Edgar Leibold , Hennicke Kamp , Georgia Coelho Palermo Cunha , Michael Manfred Herold , Jan C. Wiemer , Alexandre Prokoudine
发明人： Bennard Van Ravenzwaay , Werner Mellert , Eric Fabian , Volker Strauss , Tilmann B. Walk , Ralf Looser , Edgar Leibold , Hennicke Kamp , Georgia Coelho Palermo Cunha , Michael Manfred Herold , Jan C. Wiemer , Alexandre Prokoudine
IPC分类号： G01N33/92 , G01N33/68
CPC分类号： G01N33/487 , G01N33/50 , G01N33/68 , G01N33/6812 , G01N33/82 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/046 , G01N2800/10 , G01N2800/24 , G01N2800/60 , H01J49/0036 , Y10T436/200833 , Y10T436/24
摘要： The present invention pertains to the field of toxicological as for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions. The metabolite markers of the metabolome are selected from: Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyprolme, Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Lmoleic acid (C18:cis (9, 12) 2), 14-Methylhexadecanoic acid, gamma-Linoleic acid (C18:cis (6, 9, 12) 3), Threonic acid, Cytosine, Phosphatidyl-choline (C18:0/C22:6). Different multimarker sets are proposed for male and female subjects.
摘要翻译：本发明涉及化学化合物的危险分层的毒理学领域。具体而言，涉及用于（i）诊断，（ii）确定化合物是否能够诱导，（iii）鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断的系统和装置。最后，本发明涉及一组代谢物或装置用于制造诊断装置或组合物的用途。代谢组胺的代谢物标记选自：辅酶Q10,16-甲基十七烷酸，17-甲基十八烷酸，二十碳三烯酸（C20：3），苏氨酸，脯氨酸，酪氨酸，反式-4-羟基丙酸，泛酸，辅酶Q9，甘油，棕榈酸（C16：0），Lmoleic acid（C18：顺式（9,12）2），14-甲基十六烷酸，γ-亚油酸（C18：顺式（6,9,12）3），苏氨酸，，磷脂酰胆碱（C18：0 / C22：6）。男性和女性受试者提出了不同的多标记组合。

5. 发明授权

US08658427B2 Means and methods for assessing increased peroxisomal proliferation 失效
标题翻译：评估增加的过氧化物酶体增殖的方法和方法
公开(公告)号：US08658427B2
公开(公告)日：2014-02-25
申请号：US12994705
申请日：2009-05-26
申请人： Bennard van Ravenzwaay , Werner Mellert , Eric Fabian , Volker Strauss , Tilmann B. Walk , Ralf Looser , Edgar Leibold , Hennicke Kamp , Georgia Coelho Palermo Cunha , Michael Manfred Herold , Jan C Wiemer , Alexandre Prokoudine
发明人： Bennard van Ravenzwaay , Werner Mellert , Eric Fabian , Volker Strauss , Tilmann B. Walk , Ralf Looser , Edgar Leibold , Hennicke Kamp , Georgia Coelho Palermo Cunha , Michael Manfred Herold , Jan C Wiemer , Alexandre Prokoudine
IPC分类号： G01N33/92 , G01N33/68
CPC分类号： G01N33/487 , G01N33/50 , G01N33/68 , G01N33/6812 , G01N33/82 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/046 , G01N2800/10 , G01N2800/24 , G01N2800/60 , H01J49/0036 , Y10T436/200833 , Y10T436/24
摘要： The present invention pertains to the field of toxicological assessments of risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection of characteristic values of at least five metabolites, a data storage medium for the data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体而言，涉及诊断增加的过氧化物酶体增殖的方法。它还涉及确定化合物是否能够诱导受试者中这种过氧化物酶体增殖的方法以及鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。此外，本发明涉及至少五种代谢物的特征值的数据收集，用于数据收集的数据存储介质，以及用于诊断增加的过氧化物酶体增殖的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者中增加的过氧化物酶体增殖的诊断装置或组合物的用途。

6. 发明授权

US08597875B2 Method for diagnosing liver toxicity with sex specific biomarkers 失效
标题翻译：用性别特异性生物标志物诊断肝毒性的方法
公开(公告)号：US08597875B2
公开(公告)日：2013-12-03
申请号：US12994642
申请日：2009-05-26
申请人： Bennard van Ravenzwaay , Werner Mellert , Georgia Coelho Palermo Cunha , Eric Fabian , Volker Strauss , Hennicke Kamp , Tilmann B. Walk , Ralf Looser , Michael Manfred Herold , Jan C Wiemer , Alexandre Prokoudine , Edgar Leibold
发明人： Bennard van Ravenzwaay , Werner Mellert , Georgia Coelho Palermo Cunha , Eric Fabian , Volker Strauss , Hennicke Kamp , Tilmann B. Walk , Ralf Looser , Michael Manfred Herold , Jan C Wiemer , Alexandre Prokoudine , Edgar Leibold
IPC分类号： C12Q1/00
CPC分类号： G01N33/92 , G01N2500/00 , G01N2560/00 , G01N2800/085 , G01N2800/60 , Y02A90/26
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol, myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (d18:1, C24:1), Ceramide (d18:2, C24:0), Sphingomyelin (d18:1, C16:0), 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, Coenzyme Q9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体地说，涉及一种诊断肝毒性的方法。它还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝毒性的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者的肝脏毒性的诊断装置或组合物的用途。对于每个性别，公开了不同的代谢组织模式，即不同的分析物组。肝脏毒性标志物主要选自游离脂肪酸，还包括各种磷脂酰胆碱，羟基苯丙酮酸，α-生育酚，胆固醇，肌醇-2-单磷酸，4-羟基鞘氨醇，神经酰胺（d18：1，C24：1）神经酰胺（d18：2，C24：0），鞘磷脂（d18：1，C16：0），1,2-二油酰-sn-甘油-3-磷脂酰-L-丝氨酸，18:1溶血磷脂酰胆碱，辅酶Q9，葡萄糖，甘油，磷酸甘油酯，磷酸酯，5-甲氧基肌营养蛋白，红细胞素，苏氨酸，二酰基甘油酯和三酰基甘油酯。

7. 发明申请

US20120132797A1 MEANS AND METHODS FOR DIAGNOSING THYROID DISORDERS 审中-公开
标题翻译：用于诊断甲状腺疾病的方法和方法
公开(公告)号：US20120132797A1
公开(公告)日：2012-05-31
申请号：US13389274
申请日：2010-07-13
申请人： Volker Strauss , Hennicke Kamp , Eric Fabian , Georgia Coelho Palermo Cunha , Werner Mellert , Bennard van Ravenzwaay , Tilmann B. Walk , Ralf Looser , Michael Manfred Herold , Jan C. Weimer , Alexandre Prokoudine , Edgar Leibold
发明人： Volker Strauss , Hennicke Kamp , Eric Fabian , Georgia Coelho Palermo Cunha , Werner Mellert , Bennard van Ravenzwaay , Tilmann B. Walk , Ralf Looser , Michael Manfred Herold , Jan C. Weimer , Alexandre Prokoudine , Edgar Leibold
IPC分类号： H01J49/26
CPC分类号： G01N33/6893 , G01N2800/046
摘要： The present invention relates to a method for diagnosing thyroid disorders. It also relates to a method of determining whether a compound is capable of inducing a thyroid disorder in a subject and to a method of identifying a drug for treating a thyroid disorder. Furthermore, the present invention relates a device for diagnosing a thyroid disorder and diagnostic uses.
摘要翻译：本发明涉及一种诊断甲状腺疾病的方法。它还涉及确定化合物是否能够诱导受试者中的甲状腺疾病的方法以及鉴定用于治疗甲状腺疾病的药物的方法。此外，本发明涉及用于诊断甲状腺障碍和诊断用途的装置。

8. 发明申请

US20110091929A1 MEANS AND METHODS FOR ASSESSING LIVER ENZYME INDUCTION 有权
标题翻译：用于评估肝脏酶诱导的方法和方法
公开(公告)号：US20110091929A1
公开(公告)日：2011-04-21
申请号：US12994655
申请日：2009-05-25
申请人： Bennard van Ravenzwaay , Werner Mellert , Georgia CoelhoPalermo Cunha , Eric Fabian , Volker Strauss , Hennicke Kamp , Tilmann B. Walk , Ralf Looser , Michael Manfred Herold , Jan C. Wiemer , Alexandre Prokoudine , Edgar Leibold
发明人： Bennard van Ravenzwaay , Werner Mellert , Georgia CoelhoPalermo Cunha , Eric Fabian , Volker Strauss , Hennicke Kamp , Tilmann B. Walk , Ralf Looser , Michael Manfred Herold , Jan C. Wiemer , Alexandre Prokoudine , Edgar Leibold
IPC分类号： C12Q1/02
CPC分类号： G01N33/66 , G01N33/84 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/085 , G01N2800/50 , G01N2800/60
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction. Finally, the present invention pertains to the use of a group of analytes or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing the pro-pathological effect of liver enzyme induction in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver enzyme induction markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, galactose, 3- and 5-Methoxysphingosine, Cholesterol, Threonic acid, 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, Glycerol, Glycerophosphate, Dodecanol, myo-Inositol-2-monophosphate.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体地说，涉及一种用于诊断诱导肝酶的化合物的前病理作用的方法。本发明还涉及确定化合物能否通过受试者的酶诱导对肝脏表现出前病理作用的方法以及鉴定用于治疗肝酶诱导的病理学作用的药物的方法。此外，本发明涉及包含至少五种分析物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝脏酶诱导的原病毒作用的系统和装置。最后，本发明涉及一组分析物或方法用于制备诊断装置或组合物用于诊断受试者中肝酶诱导的原病毒作用的用途。对于每个性别，公开了不同的代谢组织模式，即不同的分析物组。肝酶诱导标记主要选自游离脂肪酸，还包括各种磷脂酰胆碱，半乳糖，3-和5-甲氧基鞘氨醇，胆固醇，苏氨酸，1,2-二油酰-sn-甘油-3-磷脂酰-L-丝氨酸甘油，甘油磷酸酯，十二烷醇，肌醇-2-单磷酸酯。

9. 发明申请

US20110163226A1 MEANS AND METHODS FOR ASSESSING LIVER TOXICITY 失效
标题翻译：用于评估肝脏毒性的方法和方法
公开(公告)号：US20110163226A1
公开(公告)日：2011-07-07
申请号：US12994642
申请日：2009-05-26
申请人： Bennard van Ravenzwaay , Werner Mellert , Georgia Coelho Palermo Cunha , Eric Fabian , Volker Strauss , Hennicke Kamp , Tilmann B. Walk , Ralf Looser , Michael Manfred Herold , Jan C. Wiemer , Alexandre Prokoudine , Edgar Leibold
发明人： Bennard van Ravenzwaay , Werner Mellert , Georgia Coelho Palermo Cunha , Eric Fabian , Volker Strauss , Hennicke Kamp , Tilmann B. Walk , Ralf Looser , Michael Manfred Herold , Jan C. Wiemer , Alexandre Prokoudine , Edgar Leibold
IPC分类号： H01J49/26 , G01N30/02
CPC分类号： G01N33/92 , G01N2500/00 , G01N2560/00 , G01N2800/085 , G01N2800/60 , Y02A90/26
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol, myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (d18:1, C24:1), Ceramide (d18:2, C24:0), Sphingomyelin (d18:1, C16:0), 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, Coenzyme Q9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体地说，涉及一种诊断肝毒性的方法。它还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝毒性的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者的肝脏毒性的诊断装置或组合物的用途。对于每个性别，公开了不同的代谢组织模式，即不同的分析物组。肝脏毒性标志物主要选自游离脂肪酸，还包括各种磷脂酰胆碱，羟基苯丙酮酸，α-生育酚，胆固醇，肌醇-2-单磷酸，4-羟基鞘氨醇，神经酰胺（d18：1，C24：1）神经酰胺（d18：2，C24：0），鞘磷脂（d18：1，C16：0），1,2-二油酰-sn-甘油-3-磷脂酰-L-丝氨酸，18:1溶血磷脂酰胆碱，辅酶Q9，葡萄糖，甘油，磷酸甘油酯，磷酸酯，5-甲氧基肌营养蛋白，红细胞素，苏氨酸，二酰基甘油酯和三酰基甘油酯。

10. 发明申请

US20160169863A1 Means and Methods for Assessing Increased Peroxisomal Proliferation 审中-公开
标题翻译：评估增加过氧化物酶体增殖的方法和方法
公开(公告)号：US20160169863A1
公开(公告)日：2016-06-16
申请号：US15053189
申请日：2016-02-25
申请人： Bennard van Ravenzwaay , Werner Mellert , Eric Fabian , Volker Strasse , Tilmann Walk , Ralf Looser , Edgar Leibold , Hennicke Kamp , Georgia Coelho Palermo Cunha , Michael Herold , Jan C Wiemer , Alexander Prokudin
发明人： Bennard van Ravenzwaay , Werner Mellert , Eric Fabian , Volker Strasse , Tilmann Walk , Ralf Looser , Edgar Leibold , Hennicke Kamp , Georgia Coelho Palermo Cunha , Michael Herold , Jan C Wiemer , Alexander Prokudin
IPC分类号： G01N33/487 , H01J49/00
CPC分类号： G01N33/487 , G01N33/50 , G01N33/68 , G01N33/6812 , G01N33/82 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/046 , G01N2800/10 , G01N2800/24 , G01N2800/60 , H01J49/0036 , Y10T436/200833 , Y10T436/24
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体而言，涉及诊断增加的过氧化物酶体增殖的方法。它还涉及确定化合物是否能够诱导受试者中这种过氧化物酶体增殖的方法以及鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断增加的过氧化物酶体增殖的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者中增加的过氧化物酶体增殖的诊断装置或组合物的用途。

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