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1. 发明申请

US20050249815A1 Process for producing a plasma protein-containing medicament 有权
标题翻译：用于制备含血浆蛋白的药物的方法
公开(公告)号：US20050249815A1
公开(公告)日：2005-11-10
申请号：US11151295
申请日：2005-06-14
申请人： Wolfgang Teschner , Yendra Linnau , Sonja Svatos , Herwig Igel
发明人： Wolfgang Teschner , Yendra Linnau , Sonja Svatos , Herwig Igel
IPC分类号： A61K35/14 , A61K38/00 , A61K38/17 , C07K14/76 , C07K16/06 , A61K35/16
CPC分类号： A61K35/16 , A61K38/1709 , C07K14/76 , C07K16/06
摘要： There is disclosed a method of preparing a plasma-protein-containing medicament from citrated plasma or from a citrate-containing plasma fraction, the medicament being substantially free from undesired metals, which method comprises the following steps: exchanging the citrate and optionally citrate-bound metals in a plasma-protein-containing solution for a water-soluble mono- or dicarboxylate or for an organic mono- or dicarboxylic acid under non-precipitating conditions, recovering the plasma protein or the plasma proteins, and finishing the medicament.
摘要翻译：公开了一种从柠檬酸盐血浆或含柠檬酸盐血浆级分制备含血浆蛋白的药物的方法，该药物基本上不含不期望的金属，该方法包括以下步骤：将柠檬酸盐和任选的柠檬酸盐结合用于水溶性单羧酸盐或二羧酸盐的含血浆蛋白的溶液中的金属或非沉淀条件下的有机单羧酸或二羧酸的金属，回收血浆蛋白或血浆蛋白，以及整理药物。

2. 发明授权

US08709492B2 Process for producing a plasma protein-containing medicament with reduced concentration of citrate and metals 有权
标题翻译：用于生产具有降低的柠檬酸盐和金属浓度的含血浆蛋白的药物的方法
公开(公告)号：US08709492B2
公开(公告)日：2014-04-29
申请号：US11151295
申请日：2005-06-14
申请人： Wolfgang Teschner , Yendra Linnau , Sonja Svatos , Herwig Igel
发明人： Wolfgang Teschner , Yendra Linnau , Sonja Svatos , Herwig Igel
IPC分类号： A61K35/16
CPC分类号： A61K35/16 , A61K38/1709 , C07K14/76 , C07K16/06
摘要： There is disclosed a method of preparing a plasma-protein-containing medicament from citrated plasma or from a citrate-containing plasma fraction, the medicament being substantially free from undesired metals, which method comprises the following steps: exchanging the citrate and optionally citrate-bound metals in a plasma-protein-containing solution for a water-soluble mono- or dicarboxylate or for an organic mono- or dicarboxylic acid under non-precipitating conditions, recovering the plasma protein or the plasma proteins, and finishing the medicament.
摘要翻译：公开了一种从柠檬酸盐血浆或含柠檬酸盐血浆级分制备含血浆蛋白的药物的方法，该药物基本上不含不期望的金属，该方法包括以下步骤：将柠檬酸盐和任选的柠檬酸盐结合用于水溶性单羧酸盐或二羧酸盐的含血浆蛋白的溶液中的金属或非沉淀条件下的有机单羧酸或二羧酸的金属，回收血浆蛋白或血浆蛋白，以及整理药物。

3. 发明授权

US5608038A Highly concentrated immunoglobulin preparation and method for its production 失效
标题翻译：高度浓缩的免疫球蛋白制备及其生产方法
公开(公告)号：US5608038A
公开(公告)日：1997-03-04
申请号：US359901
申请日：1994-12-20
申请人： Johann Eibl , Yendra Linnau , Wolfgang Teschner
发明人： Johann Eibl , Yendra Linnau , Wolfgang Teschner
IPC分类号： A61K47/26 , A61K9/08 , A61K39/395 , A61K47/36 , A61P37/02 , C07K16/00
CPC分类号： A61K9/0019 , A61K39/39591 , A61K47/02 , A61K47/26
摘要： A stable, highly concentrated intravenously tolerable immunoglobulin preparation is described having an immunoglobulin content from 13.5 to 17.5% (w/v), an osmolarity from 250 to 600 mOs/l and a viscosity of no more than 9 cP. The immunoglobulin preparation possesses an exceptional imperishability and also is used as a highly concentrated preparation without problems due to its low viscosity.
摘要翻译：描述了稳定的，高度浓缩的静脉内可耐受的免疫球蛋白制剂，其免疫球蛋白含量为13.5至17.5％（w / v），摩尔渗透压浓度为250至600mOs / l，粘度不超过9cP。免疫球蛋白制剂具有优异的不均匀性，并且由于其低粘度而被用作高度浓缩的制剂而没有问题。

4. 发明授权

US5714370A Thrombin and method of producing the same 失效
标题翻译：凝血酶及其生产方法
公开(公告)号：US5714370A
公开(公告)日：1998-02-03
申请号：US458082
申请日：1995-06-01
申请人： Johann Eibl , Yendra Linnau
发明人： Johann Eibl , Yendra Linnau
IPC分类号： A61K38/48 , A61K35/00 , A61K38/00 , A61K38/46 , A61P7/04 , C07K1/00 , C12N9/74 , C12Q1/56
CPC分类号： C12N9/6429 , C12Y304/21005 , A61K38/00
摘要： A thrombin of human or animal origin is free of infectious agents and is produced by activation of prothrombin subjected to a heat treatment for the inactivation of infectious agents.
摘要翻译：人或动物来源的凝血酶没有感染因子，并且通过活化经过热处理的凝血酶原来灭活感染因子而产生。

5. 发明授权

US4814435A Method of producing a factor VIII (AHF) containing fraction 失效
$Method of producing a factor VIII (AHF) containing fraction$
标题翻译：制备含有因子VIII（AHF）的级分的方法
公开(公告)号：US4814435A
公开(公告)日：1989-03-21
申请号：US108458
申请日：1987-10-15
申请人： Otto Schwarz , Yendra Linnau
发明人： Otto Schwarz , Yendra Linnau
IPC分类号： A61K35/14 , A61K38/00 , A61K38/43 , A61P7/04 , C07K1/30 , C07K14/435 , C07K14/745 , C07K14/755 , A61K35/16 , C07K15/14
CPC分类号： C07K14/755 , A61K38/00 , Y10S530/83
摘要： There is disclosed a method of producing a Factor VIII (AHF) containing fraction having a specific activity of at least 2.5 units of Factor VIII/mg protein as well as a portion of immunoglobulin G (IgG) of 10 mg/1000 units of Factor VIII at the most. Its risk of transmission of viral or bacterial infections is to be avoided or largely reduced. The method consists in that undesired proteins are at first precipitated from a Factor VIII (AHF) containing plasma fraction in the presence of SPS. The purified Factor VIII containing solution is treated with suitable salts or salt mixtures in order to obtain a Factor VIII containing precipitate. This precipitate is dissolved, lyophilized and finally heat-treated.
摘要翻译：公开了一种生产含有至少2.5单位因子VIII / mg蛋白的比活性的因子VIII（AHF）的部分以及10mg / 1000单位因子VIII的免疫球蛋白G（IgG）的一部分的方法至多，最多。其传播病毒或细菌感染的风险是要避免或大大降低。该方法包括在SPS存在下首先从含有血浆级分的因子VIII（AHF）沉淀不需要的蛋白质。用合适的盐或盐混合物处理纯化的含Ⅷ因子的溶液，以获得含Ⅷ因子的沉淀物。将该沉淀溶解，冻干，最后进行热处理。

6. 发明授权

US4640834A Method of inactivating reproducible filterable pathogens in blood products as well as a method of producing blood products 失效
标题翻译：灭活血液制品中可再生可过滤病原体的方法以及生产血液制品的方法
公开(公告)号：US4640834A
公开(公告)日：1987-02-03
申请号：US705691
申请日：1985-02-26
申请人： Johann Eibl , Otto Schwarz , Fritz Elsinger , Gunter Wober , Anton Philapitsch , Yendra Linnau , Friedrich Dorner , Karl Trambauer , Wolfgang Frechinger
发明人： Johann Eibl , Otto Schwarz , Fritz Elsinger , Gunter Wober , Anton Philapitsch , Yendra Linnau , Friedrich Dorner , Karl Trambauer , Wolfgang Frechinger
IPC分类号： A61K39/395 , A61K35/14 , A61K35/16 , A61K38/16 , A61K38/48 , A61K38/55 , A61L2/00 , A61L2/04 , C12N9/68 , A61K37/465 , A61K37/48
CPC分类号： A61K35/16 , A61L2/0023
摘要： A method of inactivating viruses in blood products is described, wherein the blood products are heat-treated in a humid or in a solid state in the presence of inorganic or organic hydroxyl group-containing compounds having an H.sup.+ -dissociation constant of
摘要翻译：描述了一种在血液制品中灭活病毒的方法，其中血液制品在H + - 解离常数<10-11的无机或有机羟基化合物存在下，以潮湿或固态热处理浓度大于0.05（5重量％）且小于0.70（70重量％）。含羟基的化合物可以是水，甲醇，乙醇或甘露醇。温度可能高达121℃，热处理可能持续1秒至100小时。灭活方法可以用于产生选自酶，包括凝血因子，酶抑制剂，免疫球蛋白，白蛋白，纤溶酶原，纤维蛋白原，纤连蛋白或血浆的酶的血液制品，灭活破坏可能存在的任何可再现的可过滤病原体。

7. 发明授权

US4404131A Method of producing a factor-VIII(AHF)-high-concentrate 失效
标题翻译：生产因子VIII（AHF） - 高浓缩物的方法
公开(公告)号：US4404131A
公开(公告)日：1983-09-13
申请号：US287912
申请日：1981-07-29
申请人： Otto Schwarz , Yendra Linnau
发明人： Otto Schwarz , Yendra Linnau
IPC分类号： C07K14/745 , A61K35/14 , A61K38/00 , A61K38/16 , A61K38/43 , C07K14/435 , C07K14/755 , C07G7/00
CPC分类号： C07K14/755 , A61K38/00 , Y10S530/83 , Y10S530/831
摘要： In a method of producing a factor-VIII(AHF)-high-concentrate having a specific activity of at least 2.5 units AHF and a fibrinogen content of less than 0.25 mg/mg protein from human or animal plasma, the plasma is subjected to a multi-step fractionation. The fraction purified by these fractionation measures and enriched in factor VIII (AHF) is subjected to a cryoalcohol precipitation and the resulting precipitate is processed into a stable form.
摘要翻译：在生产具有至少2.5单位AHF的比活性和来自人或动物血浆的纤维蛋白原含量小于0.25mg / mg蛋白质的因子VIII（AHF） - 高浓缩物的方法中，将等离子体进行多步分馏。通过这些分级测量纯化并富集因子VIII（AHF）的级分进行冷冻醇沉淀，并将所得沉淀物加工成稳定的形式。

8. 发明授权

US5393666A Method of activating prothrombin 失效
标题翻译：激活凝血酶原的方法
公开(公告)号：US5393666A
公开(公告)日：1995-02-28
申请号：US34778
申请日：1993-03-19
申请人： Yendra Linnau
发明人： Yendra Linnau
IPC分类号： C12N9/74 , C12N9/64 , C12N9/76 , C12N11/00 , C12N9/00 , C12N11/16 , A61K37/547
CPC分类号： C12N9/6429 , C12N9/6427 , C12N9/647 , C12Y304/21005
摘要： There is disclosed a method of activating prothrombin by means of trypsin, wherein the prothrombin is recovered from a blood or plasma fraction, treated with trypsin immobilized on a water-insoluble carrier, and separated from the immobilized trypsin after activation.
摘要翻译：公开了一种通过胰蛋白酶激活凝血酶原的方法，其中从固定在水不溶性载体上的胰蛋白酶处理的血液或血浆级分中回收凝血酶原，并在活化后与固定的胰蛋白酶分离。

9. 发明授权

US5371007A Method of producing lys-plasminogen 失效
标题翻译：产生溶酶原纤溶酶原的方法
公开(公告)号：US5371007A
公开(公告)日：1994-12-06
申请号：US41332
申请日：1993-04-01
申请人： Yendra Linnau , Ernst Hetzl
发明人： Yendra Linnau , Ernst Hetzl
IPC分类号： A61K38/46 , A61P7/02 , C12N9/68 , C12S3/14 , C12P21/00 , C12N9/00
CPC分类号： C12N9/6435 , C12Y304/21007
摘要： To produce lys-plasminogen having a specific activity of at least 17.5 caseinolytic units/mg protein and at least 50 mymoles/g protein nitrogen as well as an electrophoretic purity of at least 90%, plasminogen from plasma, a plasminogen-containing fraction or a tissue culture is adsorbed on immobilized lysine for the purpose of purification, is eluted and is recovered from the eluate by a protein precipitating agent. A solution of the thus purified plasminogen is adjusted to a plasmin activity ranging between 0.005 and 0.2 mymoles/ml min relative to chromogenic substrate H-D-valyl-L-leucyl-L-lysine-p-nitroanilide dihydrochloride, is maintained at a temperature of from +1.degree. C. to +20.degree. C. for a period of from 6 to 60 hours in order to provoke an enzymatic-proteolytic conversion of plasminogen into lys-plasminogen, whereupon the enzymatic action is interrupted and lys-plasminogen is isolated.
摘要翻译：为了产生具有至少17.5个酪蛋白分解单位/ mg蛋白和至少50 mymoles / g蛋白质氮的比活性以及至少90％的电泳纯度的溶血纤溶酶原，血浆中的纤溶酶原，含纤溶酶原的级分或组织培养物被吸附在固定的赖氨酸上用于纯化，被洗脱并通过蛋白质沉淀剂从洗脱液中回收。将如此纯化的纤溶酶原的溶液调节至相对于显色底物HD-缬氨酰-L-亮氨酰-L-赖氨酸 - 对硝基苯胺二盐酸盐在0.005至0.2 mymoles / ml min范围内的纤溶酶活性维持在 +1℃至+ 20℃，时间为6至60小时，以引起纤溶酶原转化为溶酶原纤维蛋白溶酶原的酶 - 蛋白水解转化，由此中断酶促作用并分离裂解纤溶酶原。

10. 发明授权

US5234685A Method of determining incompatibility-reaction-causing substances in blood products as well as a method of inactivating said incompatibility-reaction-causing substances 失效
标题翻译：测定血液制品中不相容反应物质的方法以及灭活所述不相容反应物质的方法
公开(公告)号：US5234685A
公开(公告)日：1993-08-10
申请号：US412999
申请日：1989-09-26
申请人： Johann Eibl , Yendra Linnau , Otto Schwarz
发明人： Johann Eibl , Yendra Linnau , Otto Schwarz
IPC分类号： A61K35/16 , A61K38/00 , C07K16/06
CPC分类号： C07K16/065 , A61K35/16 , A61K38/00
摘要： There is disclosed a method of determining the presence of incompatibility-reaction-causing substances in blood products. There is also disclosed a method of inactivating incompatibility-reaction-causing substances in blood products to be applied therapeutically and prophylactically. For this purpose, a fraction obtained from human or animal blood is treated with pancreas enzymes bound to water insoluble carrier material and, optionally, the fraction is subjected to further fractionation and concentration.
摘要翻译：公开了一种测定血液制品中不相容反应物质的存在的方法。还公开了一种使治疗和预防性应用的血液制品中不相容反应物质失活的方法。为此，从与人或动物血液获得的级分用与水不溶性载体材料结合的胰腺酶处理，并且任选地，将级分进一步分级和浓缩。

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