专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08999933B2 Photodynamic cosmetic procedure and healing method 有权
标题翻译：光动力美容手术和治疗方法
公开(公告)号：US08999933B2
公开(公告)日：2015-04-07
申请号：US11650207
申请日：2007-01-05
申请人： Wolfgang Neuberger , Volker Albrecht , Danilo Castro
发明人： Wolfgang Neuberger , Volker Albrecht , Danilo Castro
IPC分类号： A61K9/127 , A61K8/65 , A61K8/49 , A61K31/407 , A61K31/555 , A61L27/24 , A61L27/54 , A61Q19/06 , A61Q19/08 , A61K41/00 , A61K38/00
CPC分类号： A61K8/65 , A61K8/4946 , A61K9/1271 , A61K31/407 , A61K31/555 , A61K41/0071 , A61K2800/434 , A61K2800/81 , A61L27/24 , A61L27/54 , A61L2300/414 , A61L2300/604 , A61Q19/06 , A61Q19/08
摘要： Innovative non-surgical methods and compositions are provided for administering PDT to promote tissue regeneration or augmentation while minimizing scarring and risk of infection. Among several areas of application, is the treatment of acute and chronic wounds which have afflicted epidermal and connective tissue layers of the body. Another application area is as cosmetic surgery/treatments, including: reducing wrinkles, sulcus, scars (acne or traumatic caused), sequelae cellulite, as well as for other skin irregularities, to give a smoother skin surface. This invention consists of a collagen based or other suitable biodegradable supporting matrix which is embedded with a liposomal loaded photosensitizer. In one embodiment of this invention a liposomal formulated photosensitizer is first injected at the site followed by collagen implantation and PDT treatment. In another embodiment a liposomal formulated photosensitizer is incorporated in the collagen. Generally 30 minutes after collagen is mixed with photosensitizer the light activation is done. The matrix may also carry important growth factors and cytokines, which promote fibroblast cell migration and proliferation, to the wound site. Microbial infection at the wound site can also be controlled by antibacterial PDT.
摘要翻译：提供创新的非手术方法和组合物用于施用PDT以促进组织再生或增强，同时最小化瘢痕形成和感染风险。在几个应用领域中，治疗急性和慢性伤害已经影响了身体的表皮和结缔组织层。另一个应用领域是整容手术/治疗，包括：减少皱纹，沟，疤痕（引起痤疮或创伤），后遗症，以及其他皮肤不规则，使皮肤表面光滑。本发明由胶原基或其它合适的可生物降解的支撑基质组成，其中嵌有脂质体加载的光敏剂。在本发明的一个实施方案中，首先在该部位注射脂质体配制的光敏剂，随后进行胶原植入和PDT处理。在另一个实施方案中，脂质体配制的光敏剂掺入胶原蛋白。一般30分钟后，胶原与光敏剂混合，光激活完成。基质还可以携带重要的生长因子和促进成纤维细胞迁移和增殖的细胞因子到伤口部位。伤口部位的微生物感染也可以通过抗菌PDT来控制。

2. 发明申请

US20070166369A1 Photodynamic cosmetic procedure and healing method 有权
标题翻译：光动力美容手术和治疗方法
公开(公告)号：US20070166369A1
公开(公告)日：2007-07-19
申请号：US11650207
申请日：2007-01-05
申请人： Wolfgang Neuberger , Volker Albrecht , Danilo Castro
发明人： Wolfgang Neuberger , Volker Albrecht , Danilo Castro
IPC分类号： A61K31/555 , A61K31/407 , A61K9/127 , A61K9/14
CPC分类号： A61K8/65 , A61K8/4946 , A61K9/1271 , A61K31/407 , A61K31/555 , A61K41/0071 , A61K2800/434 , A61K2800/81 , A61L27/24 , A61L27/54 , A61L2300/414 , A61L2300/604 , A61Q19/06 , A61Q19/08
摘要： Innovative non-surgical methods and compositions are provided for administering PDT to promote tissue regeneration or augmentation while minimizing scarring and risk of infection. Among several areas of application, is the treatment of acute and chronic wounds which have afflicted epidermal and connective tissue layers of the body. Another application area is as cosmetic surgery/treatments, including: reducing wrinkles, sulcus, scars (acne or traumatic caused), sequelae cellulite, as well as for other skin irregularities, to give a smoother skin surface. This invention consists of a collagen based or other suitable biodegradable supporting matrix which is embedded with a liposomal loaded photosensitizer. In one embodiment of this invention a liposomal formulated photosensitizer is first injected at the site followed by collagen implantation and PDT treatment. In another embodiment a liposomal formulated photosensitizer is incorporated in the collagen. Generally 30 minutes after collagen is mixed with photosensitizer the light activation is done. The matrix may also carry important growth factors and cytokines, which promote fibroblast cell migration and proliferation, to the wound site. Microbial infection at the wound site can also be controlled by antibacterial PDT.
摘要翻译：提供创新的非手术方法和组合物用于施用PDT以促进组织再生或增强，同时最小化瘢痕形成和感染风险。在几个应用领域中，治疗急性和慢性伤害已经影响了身体的表皮和结缔组织层。另一个应用领域是整容手术/治疗，包括：减少皱纹，沟，疤痕（引起痤疮或创伤），后遗症，以及其他皮肤不规则，使皮肤表面光滑。本发明由胶原基或其它合适的可生物降解的支撑基质组成，其中嵌有脂质体加载的光敏剂。在本发明的一个实施方案中，首先在该部位注射脂质体配制的光敏剂，随后进行胶原植入和PDT处理。在另一个实施方案中，脂质体配制的光敏剂掺入胶原蛋白。一般30分钟后，胶原与光敏剂混合，光激活完成。基质还可以携带重要的生长因子和促进成纤维细胞迁移和增殖的细胞因子到伤口部位。伤口部位的微生物感染也可以通过抗菌PDT来控制。

3. 发明授权

US08414880B2 PDT treatment method for cellulites and cosmetic use 失效
标题翻译：用于脂肪团和化妆品使用的PDT处理方法
公开(公告)号：US08414880B2
公开(公告)日：2013-04-09
申请号：US12899003
申请日：2010-10-06
申请人： Danilo Castro , Wolfgang Neuberger
发明人： Danilo Castro , Wolfgang Neuberger
IPC分类号： A01N63/00
CPC分类号： A61K31/555 , A61K8/494 , A61K31/409 , A61K2800/81 , A61Q19/06
摘要： Photosensitizer mixtures and method of treating cellulites by light illumination are presented. Photosensitizer is combined with cellular products, e.g. adipose cells, collagen, previously removed by liposuction. Concentrations used depend on treatment area, cellulite stage and whether cellulites are in depressed or elevated skin areas. The cosmetic treatment reduces/removes localized lipodystrophies, flaccidity, cellulite using localized laser, LED, etc emissions. Applied light energy destroys “fat” cells by a combination of chemical reactions primarily, and temperature, wherein cell walls break releasing cell fluid. Transmission devices guide radiation to the treatment site. One or more light sources like laser diodes or LEDs may be coupled into one or more optical fibers to increase the covered area and increase the amount of radiation in that area. Optical fibers can be introduced percutaneously or interstitially. Cell fluid in the treatment area is removed by a combination of techniques.
摘要翻译：提出了光敏剂混合物和通过光照照治疗脂肪团的方法。光敏剂与蜂窝产品结合，例如脂肪细胞，胶原蛋白，预先通过吸脂除去。使用的浓度取决于治疗区域，脂肪团阶段以及是否在脂肪团处于抑郁或升高的皮肤区域。化妆处理减少/消除了使用局部激光，LED等排放的局部脂肪营养不良，松弛，脂肪团。应用光能主要通过化学反应的组合和温度破坏脂肪细胞，其中细胞壁破坏释放细胞液体。传输装置将辐射引导到治疗部位。诸如激光二极管或LED的一个或多个光源可以耦合到一个或多个光纤中，以增加覆盖面积并增加该区域中的辐射量。光纤可经皮或间质引入。通过技术的组合来去除处理区域中的细胞液。

4. 发明申请

US20090163849A1 Photodynamic Foam Composition and Sclerosis Treatment 审中-公开
标题翻译：光动力泡沫组合物和硬化症治疗
公开(公告)号：US20090163849A1
公开(公告)日：2009-06-25
申请号：US12226892
申请日：2007-05-08
申请人： Danilo Castro , Wolfgang Neuberger
发明人： Danilo Castro , Wolfgang Neuberger
IPC分类号： A61N5/00
CPC分类号： A61K31/407 , A61K41/0042 , A61K41/0071 , A61K49/00 , A61N5/062 , A61N2005/0602
摘要： A photodynamic composition and a method for in vivo photonic treatments that is minimally invasive, versatile and precise are described. The invention allows for photonic treatments with only minimal insertions into the area of treatment, often a single one. The invention may be used with a standard insertion component making the system inexpensive and easy for doctors to use. The invention has applications in several areas of treatment. In vivo treatment of aesthetic skin blemishes such as varicose veins can be performed with minimal external effects. A predetermined amount of a photodynamic composition, as a foam, is injected into the vein or structure of concern. The composition is a sclerosis foam including a photosensitizer. By external compression, where applicable, the photodynamic composition is forced to remain in the vein or structure. After a predetermined time, radiation of appropriate wavelength from a light source is delivered directly to the vascular structure. Among the key benefits of the present invention are the elimination of targeted varicose veins, without need for anesthesia along the length of the vein; no edema; no skin reaction; and tactile appreciation.
摘要翻译：描述了光动力学组合物和微创，多功能和精确的体内光子处理方法。本发明允许光子治疗，只有最少的插入到治疗区域，通常是单一治疗。本发明可以与标准的插入部件一起使用，使得该系统便于医生使用。本发明在几个治疗领域都有应用。美容皮肤瑕疵如静脉曲张的体内治疗可以以最小的外部作用进行。将预定量的作为泡沫的光动力学组合物注入到关注的静脉或结构中。该组合物是包含光敏剂的硬化泡沫。通过外部压缩，如果适用，光动力学组合物被迫保持在静脉或结构中。在预定时间之后，从光源的适当波长的辐射直接传送到血管结构。本发明的主要优点之一是消除目标静脉曲张，而不需要沿着静脉的长度麻醉; 无水肿; 无皮肤反应; 和触觉欣赏。

5. 发明申请

US20090028926A1 Method and mixture for in vivo photochemical cross-linking of collagen 审中-公开
标题翻译：胶原蛋白体内光化学交联的方法和混合物
公开(公告)号：US20090028926A1
公开(公告)日：2009-01-29
申请号：US11880973
申请日：2007-07-25
申请人： Susanna Grafe , Wolfgang Neuberger , Danilo Castro
发明人： Susanna Grafe , Wolfgang Neuberger , Danilo Castro
IPC分类号： A61K38/00 , A61K31/33 , A61K9/70 , A61L15/00 , A61P17/00
CPC分类号： A61K31/33 , A61K9/0019 , A61K9/127 , A61K47/24
摘要： A method and a composition for photochemical cross linking of collagen by photoactive agent in-vivo are presented. The method includes a non-toxic photoactive formulation of the composition with collagen, which is administered to treatment area locally; followed by irradiation with suitable wavelength. In one of the embodiment liposomal formulated mTHPC is added to the collagen and is irradiated with a 652 nm laser, resulting in producing efficient collagen scaffolds with strengthen and stabilized microstructure, thus improving the physiochemical properties of the collagen scaffold. It improves the thermostability, mechanical property and swelling ratio of newly formed scaffold. Photochemical cross-linked collagens shows antimicrobial effect, when irradiated with suitable wavelength it disinfects the treatment site and curbs microbial growth.
摘要翻译：提出了通过光活性剂在体内对胶原蛋白的光化学交联的方法和组合物。该方法包括具有胶原蛋白的组合物的无毒光活性制剂，其局部施用于治疗区域; 然后用合适的波长照射。在其中一个实施方案中，将脂质体配制的mTHPC加入到胶原中并用652nm激光照射，从而产生具有强化和稳定的微结构的有效的胶原支架，从而改善胶原支架的物理化学性质。提高新型脚手架的热稳定性，机械性能和溶胀比。光化学交联胶原显示抗菌效果，当用合适的波长照射时，其消毒处理部位并抑制微生物生长。

6. 发明申请

US20090131499A1 PHOTODYNAMIC THERAPY FOR SKIN RELATED PROBLEMS 审中-公开
标题翻译：皮肤相关问题的光化疗法
公开(公告)号：US20090131499A1
公开(公告)日：2009-05-21
申请号：US12271708
申请日：2008-11-14
申请人： Danilo Castro , Wolfgang Neuberger
发明人： Danilo Castro , Wolfgang Neuberger
IPC分类号： A61K31/407
CPC分类号： A61K41/0071
摘要： PhotoDynamic Therapy method is used to treat problems associated with pilosebaceous units including acne and other skin conditions. At least one liposomal-formulated, hydrophobic photosensitizer, such as a dihydro- or tetrahydro-porphyrin, is topically applied to acne affected regions, and is allowed to penetrate the hair follicle before being irradiated with a suitable wavelength of light energy overlapping the absorption spectrum of the selected photosensitizer. The photoactivated agent initiates a cytotoxic effect in the sebaceous gland, reducing excess oil production and destroying bacterial growth in the follicle thus subsiding inflammatory action. Scarring of the skin is minimized and the skin heals faster due to collagen cell stimulation.
摘要翻译： PhotoDynamic Therapy方法用于治疗与皮脂腺单位相关的问题，包括痤疮和其他皮肤病症。将至少一种脂质体配制的疏水性光敏剂，例如二氢或四氢卟啉，局部施用于痤疮受影响的区域，并且在用合适的波长的能量与吸收光谱重叠之前，允许穿透毛囊的所选光敏剂。光活化剂在皮脂腺中引发细胞毒性作用，减少多余的油产生并破坏卵泡中的细菌生长，从而消除炎症反应。由于胶原细胞刺激，皮肤的疤痕被最小化，皮肤愈合愈快。

7. 发明申请

US20080275432A1 Photodynamic foam composition and sclerosis treatment 审中-公开
标题翻译：光动力泡沫组合物和硬化症治疗
公开(公告)号：US20080275432A1
公开(公告)日：2008-11-06
申请号：US11800400
申请日：2007-05-04
申请人： Danilo Castro , Wolfgang Neuberger
发明人： Danilo Castro , Wolfgang Neuberger
IPC分类号： A61B6/00 , A61K31/407 , A61K47/26
CPC分类号： A61K31/407 , A61K41/0042 , A61K41/0071 , A61K49/00 , A61N5/062 , A61N2005/0602
摘要： A photodynamic composition and a method for in vivo photonic treatments that is minimally invasive, versatile and precise are described. The invention allows for photonic treatments with only minimal insertions into the area of treatment, often a single one. The invention may be used with a standard insertion component making the system inexpensive and easy for doctors to use. The invention has applications in several areas of treatment. In vivo treatment of aesthetic skin blemishes such as varicose veins can be performed with minimal external effects. A predetermined amount of a photodynamic composition, as a foam, is injected into the vein or structure of concern. The composition is a sclerosis foam including a photosensitizer. By external compression, where applicable, the photodynamic composition is forced to remain in the vein or structure. After a predetermined time, radiation of appropriate wavelength from a light source is delivered directly to the vascular structure. Among the key benefits of the present invention are the elimination of targeted varicose veins, without need for anesthesia along the length of the vein; no edema; no skin reaction; and tactile appreciation.
摘要翻译：描述了光动力学组合物和微创，多功能和精确的体内光子处理方法。本发明允许光子治疗，只有最少的插入到治疗区域，通常是单一治疗。本发明可以与标准的插入部件一起使用，使得该系统便于医生使用。本发明在几个治疗领域都有应用。美容皮肤瑕疵如静脉曲张的体内治疗可以以最小的外部作用进行。将预定量的作为泡沫的光动力学组合物注入到关注的静脉或结构中。该组合物是包含光敏剂的硬化泡沫。通过外部压缩，如果适用，光动力学组合物被迫保持在静脉或结构中。在预定时间之后，从光源的适当波长的辐射直接传送到血管结构。本发明的主要优点之一是消除目标静脉曲张，而不需要沿着静脉的长度麻醉; 无水肿; 无皮肤反应; 和触觉欣赏。

8. 发明授权

US08263557B2 Method and mixture for in vivo photochemical cross-linking of collagen 有权
标题翻译：胶原蛋白体内光化学交联的方法和混合物
公开(公告)号：US08263557B2
公开(公告)日：2012-09-11
申请号：US12227079
申请日：2007-07-27
申请人： Susanna Gräfe , Wolfgang Neuberger , Danilo Castro
发明人： Susanna Gräfe , Wolfgang Neuberger , Danilo Castro
IPC分类号： A61K38/17 , C07D487/22 , A61N5/06
CPC分类号： A61K31/33 , A61K9/0019 , A61K9/127 , A61K47/24
摘要： A method and a composition for photochemical cross linking of collagen by photoactive agent in-vivo are presented. The method includes a non-toxic photoactive formulation of the composition with collagen, which is administered to treatment area locally; followed by irradiation with suitable wavelength. In one of the embodiment liposomal formulated mTHPC is added to the collagen and is irradiated with a 652 nm laser, resulting in producing efficient collagen scaffolds with strengthen and stabilized microstructure, thus improving the physiochemical properties of the collagen scaffold. It improves the thermostability, mechanical property and swelling ratio of newly formed scaffold. Photochemical cross-linked collagens shows antimicrobial effect, when irradiated with suitable wavelength it disinfects the treatment site and curbs microbial growth.
摘要翻译：提出了通过光活性剂在体内对胶原蛋白的光化学交联的方法和组合物。该方法包括具有胶原蛋白的组合物的无毒光活性制剂，其局部施用于治疗区域; 然后用合适的波长照射。在其中一个实施方案中，将脂质体配制的mTHPC加入到胶原中并用652nm激光照射，从而产生具有强化和稳定的微结构的有效的胶原支架，从而改善胶原支架的物理化学性质。提高新型脚手架的热稳定性，机械性能和溶胀比。光化学交联胶原显示抗菌效果，当用合适的波长照射时，其消毒处理部位并抑制微生物生长。

9. 发明申请

US20110152745A1 PDT TREATMENT METHOD FOR CELLULITES AND COSMETIC USE 失效
标题翻译：用于细胞和化妆品用途的PDT处理方法
公开(公告)号：US20110152745A1
公开(公告)日：2011-06-23
申请号：US12899003
申请日：2010-10-06
申请人： Danilo Castro , Wolfgang Neuberger
发明人： Danilo Castro , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61K8/98 , A61K8/14 , A61K8/65 , A61K8/60 , A61Q19/06
CPC分类号： A61K31/555 , A61K8/494 , A61K31/409 , A61K2800/81 , A61Q19/06
摘要： Methods of treating cellulite by means of percutaneous application of a photosensitizer composition into the area of cellulite buildup followed by light illumination are presented. The photosensitizer can be combined with one or more cellular products including adipose cells and/or collagen that have been previously removed by liposuction. The cosmetic treatment method substantially reduces or removes localized lipodystrophies and/or flaccidity and/or cellulite by localized laser, LED, or other light irradiation of the area of treatment containing a photosensitizer, while minimizing trauma.
摘要翻译：提出了通过将光敏剂组合物经皮施加到脂肪团累积区域中进行光照射处理脂肪团的方法。光敏剂可以与一种或多种细胞产品组合，包括先前通过吸脂除去的脂肪细胞和/或胶原蛋白。化妆品处理方法通过局部激光，LED或包含光敏剂的处理区域的其它光照射，在最小化创伤的同时，显着地减少或去除局部的脂肪营养不良和/或脂肪酸和/或脂肪团。

10. 发明申请

US20090171262A1 Method and Mixture for In Vivo Photochemical Cross-Linking of Collagen 有权
标题翻译：胶原蛋白体内光化学交联的方法和混合物
公开(公告)号：US20090171262A1
公开(公告)日：2009-07-02
申请号：US12227079
申请日：2007-07-27
申请人： Susanna Gräfe , Wolfgang Neuberger , Danilo Castro
发明人： Susanna Gräfe , Wolfgang Neuberger , Danilo Castro
IPC分类号： A61N5/06 , A61K38/16
CPC分类号： A61K31/33 , A61K9/0019 , A61K9/127 , A61K47/24
摘要： A method and a composition for photochemical cross linking of collagen by photoactive agent in-vivo are presented. The method includes a non-toxic photoactive formulation of the composition with collagen, which is administered to treatment area locally; followed by irradiation with suitable wavelength. In one of the embodiment liposomal formulated mTHPC is added to the collagen and is irradiated with a 652 nm laser, resulting in producing efficient collagen scaffolds with strengthen and stabilized microstructure, thus improving the physiochemical properties of the collagen scaffold. It improves the thermo stability, mechanical property and swelling ratio of newly formed scaffold. Photochemical cross-linked collagens shows antimicrobial effect, when irradiated with suitable wavelength it disinfects the treatment site and curbs microbial growth.
摘要翻译：提出了通过光活性剂在体内对胶原蛋白的光化学交联的方法和组合物。该方法包括具有胶原蛋白的组合物的无毒光活性制剂，其局部施用于治疗区域; 然后用合适的波长照射。在其中一个实施方案中，将脂质体配制的mTHPC加入到胶原中并用652nm激光照射，从而产生具有强化和稳定的微结构的有效的胶原支架，从而改善胶原支架的物理化学性质。提高新成型脚手架的热稳定性，机械性能和溶胀比。光化学交联胶原显示抗菌效果，当用合适的波长照射时，其消毒处理部位并抑制微生物生长。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式