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1. 发明授权

US4255433A (+)-(3-Methyl-4-oxo-5N-piperidinothiazolidin-2-ylidene)acetic acid esters, method of preparation and use 失效
标题翻译：（+） - （3-甲基-4-氧代-5N-哌啶子基异噻唑烷-2-亚基）乙酸酯，制备和使用方法
公开(公告)号：US4255433A
公开(公告)日：1981-03-10
申请号：US132577
申请日：1980-03-21
申请人： Wolfgang Herrmann , Gerhard Satzinger , Manfred Herrmann , Wolfgang Steinbrecher , Heinrich Bahrmann
发明人： Wolfgang Herrmann , Gerhard Satzinger , Manfred Herrmann , Wolfgang Steinbrecher , Heinrich Bahrmann
IPC分类号： C07D417/04 , A61K31/4453 , A61K31/4523 , A61P9/12 , C07D277/42 , A61K31/445
CPC分类号： C07D277/42
摘要： The invention discloses (+)-(3-methyl-4-oxo-5N-piperidinothiazolidin-2-ylidene)acetic acid esters and a process for their preparation. The process provides the dextrorotatory isomers substantially free from the corresponding levorotatory isomers. Antihypertensive pharmaceutical compositions comprising the dextrorotatory esters and methods for using said compositions are also disclosed.
摘要翻译：本发明公开了（+） - （3-甲基-4-氧代-5N-哌啶子基异噻唑烷-2-亚基）乙酸酯及其制备方法。该方法提供基本上不含相应左旋异构体的右旋异构体。还公开了包含右旋酯的抗高血压药物组合物和使用所述组合物的方法。

2. 发明授权

US4415495A 5,6;8,9-Tetrahydro-7H-dibenz(d,f)azonines 失效
标题翻译： 5,6; 8,9-四氢-7H-二苯并（d，f）吖嗪
公开(公告)号：US4415495A
公开(公告)日：1983-11-15
申请号：US238501
申请日：1981-02-24
申请人： Gerhard Satzinger , Manfred Herrmann , Edgar Fritschi , Heinrich Bahrmann , Volker Ganser , Bernd Wagner , Wolfgang Steinbrecher
发明人： Gerhard Satzinger , Manfred Herrmann , Edgar Fritschi , Heinrich Bahrmann , Volker Ganser , Bernd Wagner , Wolfgang Steinbrecher
IPC分类号： C07D225/06 , A61K31/395 , A61K31/485 , A61P9/06 , C07D225/08 , A61K31/355
CPC分类号： C07D225/08
摘要： The present invention provides 5,6;8,9-tetrahydro-7H-dibenz(d,f)azonine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, are hydrogen or halogen atoms or lower alkyl or alkoxy radicals, R.sup.3 is a hydrogen atom or a lower alkyl radical, R.sup.4 is a hydrogen atom or a lower alkyl or alkanoyl radical and n is 1 or 2; and the pharmaceutically acceptable salts thereof formed with inorganic and organic acids; but excluding 6-benzyl-2,12-dimethoxy-1-hydroxy-7-methyl-5,6;8,9-tetrahydro-7H-dibenz(d,f)azonine in which case R.sup.1, R.sup.2 and R.sup.4 are hydrogen, n is 1 and R.sup.3 is methyl. The lower alkyl, alkanoyl and alkoxy radicals are straight chained or branched radicals containing 1 to 5 carbon atoms.The present invention also provides a process for the preparation of these compounds, as well as pharmaceutical compositions containing them.
摘要翻译：本发明提供下式的5,6,8,9-四氢-7H-二苯并（d，f）吖嗪衍生物：其中R 1和R 2相同或不同，为氢或卤原子或更低级烷基或烷氧基，R3是氢原子或低级烷基，R4是氢原子或低级烷基或烷酰基，n是1或2; 和其与无机酸和有机酸形成的药学上可接受的盐; 但不包括6-苄基-2,12-二甲氧基-1-羟基-7-甲基-5,6; 8,9-四氢-7H-二苯并吖嗪（d，f）吖嗪，其中R1，R2和R4是氢，n为1，R 3为甲基。低级烷基，烷酰基和烷氧基是含有1至5个碳原子的直链或支链基团。本发明还提供了制备这些化合物的方法以及含有它们的药物组合物。

3. 发明授权

US4626546A 3-aryl-3-pyrroline derivatives 失效
标题翻译： 3-芳基-3-吡咯啉衍生物
公开(公告)号：US4626546A
公开(公告)日：1986-12-02
申请号：US637351
申请日：1984-08-03
申请人： Gerhard Satzinger , Karl Mannhardt , Johannes Hartenstein , Manfred Herrmann , Edgar Fritschi , Wolfgang Steinbrecher
发明人： Gerhard Satzinger , Karl Mannhardt , Johannes Hartenstein , Manfred Herrmann , Edgar Fritschi , Wolfgang Steinbrecher
IPC分类号： A61K31/40 , A61P9/08 , A61P9/10 , C07D207/20
CPC分类号： C07D207/20
摘要： The invention is concerned with partially new compounds of the general formula ##STR1## wherein R.sup.1 is a hydrogen atom or an alkyl group with up to four carbon atoms and R.sup.2 a substituted phenyl radical and the pharmacologically acceptable salts thereof.The compounds can be prepared according to known procedures and show surprisingly a cardiovascular efficacy. They are capable of decompensating cardiac insufficiencies to a large extent. In addition to the new compounds, claim is also made for pharmaceutical compositions which contain compounds according to the general formula and their application for controlling cardiac and vascular diseases.
摘要翻译：本发明涉及通式“IMAGE”的部分新化合物，其中R 1为氢原子或具有至多4个碳原子的烷基，R 2为取代的苯基及其药理学上可接受的盐。这些化合物可以根据已知的方法制备并令人惊奇地显示出心血管功能。它们能够在很大程度上失代偿心脏功能不全。除了新化合物之外，还提出了含有根据通式的化合物及其用于控制心脏和血管疾病的应用的药物组合物。

4. 发明授权

US4751228A 1,6-naphthyridine derivatives 失效
标题翻译： 1,6-萘啶衍生物
公开(公告)号：US4751228A
公开(公告)日：1988-06-14
申请号：US7691
申请日：1987-01-28
申请人： Jorgen Kleinschroth , Karl Mannhardt , Johannes Hartenstein , Gerhard Satzinger , Dieter Muster , Wolfgang Steinbrecher , Bernd Wagner , Hartmut Osswald
发明人： Jorgen Kleinschroth , Karl Mannhardt , Johannes Hartenstein , Gerhard Satzinger , Dieter Muster , Wolfgang Steinbrecher , Bernd Wagner , Hartmut Osswald
IPC分类号： A61K31/435 , A61P3/00 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , C07D213/80 , C07D471/04
CPC分类号： C07D213/80 , C07D471/04
摘要： The present invention provides 1,6-naphthyridine derivatives of formula ##STR1## wherein R.sup.1 is an unsubstituted or substituted aromatic or heteroaromatic ring or an unsubstituted or substituted condensed aromatic or heterocyclic ring system, R.sup.2 is a straight-chained or branched alkyl radical containing up to 4 carbon atoms, a benzyl radical or a straight-chained or branched, substituted or unsubstituted aminoalkyl radical containing up to 8 carbon atoms, R.sup.3 is a hydrogen atom, a straight-chained or branched alkyl radical or an alkoxycarbonyl radical, in each case containing up to 4 carbon atoms, R.sup.4 is a straight-chained or branched hydrocarbon radical containing up to 21 carbon atoms, which can also contain oxygen, sulphur, nitrogen or halogen atoms and is optionally substituted by carbocyclic or heterocyclic ring systems, or is an amino, cyano, formyl, halogenomethyl or dihalomethyl radical and R.sup.5 is an alkoxycarbonyl radical or an unsubstituted or substituted carboxamide radical with, in each case, up to 21 carbon atoms which can also contain oxygen, sulphur or nitrogen atoms and is optionally substituted by carbocyclic or heterocyclic ring systems or is a carboxyl or cyano group as well as the pharmaceutically acceptable salts thereof.The compounds are useful for blood vessel diseases.The present invention also provides processes for the preparation of these 1,6-naphthyridine derivatives, pharmaceutical compositions containing them, and methods for using them.
摘要翻译：本发明提供了式（I）的1,6-萘啶衍生物，其中R 1是未取代或取代的芳族或杂芳环或未取代或取代的稠合芳族或杂环系，R2是直链或支链烷基含有至多4个碳原子的基团，含有至多8个碳原子的苄基或直链或支链，取代或未取代的氨基烷基，R3是氢原子，直链或支链烷基或烷氧基羰基，在每种情况下最多含有4个碳原子，R4是含有至多21个碳原子的直链或支链烃基，其也可以含有氧，硫，氮或卤素原子，并且任选地被碳环或杂环系统取代，或者是氨基，氰基，甲酰基，卤代甲基或二卤甲基，R5是烷氧基羰基或未取代或取代的酰胺基团w 在每种情况下，最多21个碳原子，其也可以含有氧，硫或氮原子，并且任选被碳环或杂环系统取代，或者是羧基或氰基以及其药学上可接受的盐。这些化合物可用于血管疾病。本发明还提供制备这些1,6-萘啶衍生物的方法，含有它们的药物组合物及其使用方法。

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