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    • 1. 发明申请
    • Compositions and Methods for Improving Heart Function
    • 改善心脏功能的组合和方法
    • US20080313753A1
    • 2008-12-18
    • US11574232
    • 2005-08-25
    • Wolfgang DillmannDarrell H. BelkeYing HuRaymond Clark
    • Wolfgang DillmannDarrell H. BelkeYing HuRaymond Clark
    • A01K67/00A61K31/7088A61K38/00A61K35/12C12N5/00
    • C12Y204/0115A61K38/45C12N9/1051
    • The present invention relates to treating or ameliorating heart disease associated with poor myocardial performance, e.g., diabetic cardiomyopathy and associated disorders, particularly to treating, preventing or ameliorating such disorders through inhibition of O-GlcNAcylation and/or increased activity of O-GlnNAcase. The invention provides vectors for gene transfer of O-GlnNAcase. In one aspect, the invention provides cells, vectors, formulations comprising them and methods of using them, for the gene transfer of the human O-GlnNAcase gene, e.g., to treat conditions and diseases associated with impaired cardiac contractility, such as that, found associated with diabetic cardiomyopathy. In another aspect, the invention provides non-human transgenic animals and host cells comprising genetically engineered cells having increased activity of O-GlnNAcase.
    • 本发明涉及治疗或改善与心肌不良相关的心脏疾病,例如糖尿病性心肌病和相关疾病,特别是通过抑制O-GlcNAc化和/或增加O-Gln​​NAcase活性来治疗,预防或改善此类疾病。 本发明提供了用于O-Gln​​NAcase基因转移的载体。 一方面,本发明提供了包含它们的细胞,载体,包含它们的制剂和使用它们的方法,用于人类O-Gln​​NAcase基因的基因转移,例如治疗与受损的心脏收缩力相关的病症和疾病,例如发现的 与糖尿病性心肌病有关。 另一方面,本发明提供非人转基因动物和宿主细胞,其包含具有增加的O-Gln​​NAcase活性的基因工程细胞。
    • 2. 发明授权
    • Method and system of circuit switched domain page realization, method of service realization
    • 电路交换域页面实现方法与系统,服务实现方法
    • US09380561B2
    • 2016-06-28
    • US12865952
    • 2009-01-24
    • Ying HuZhiming YuJinguo ZhuLei YuLiping Geng
    • Ying HuZhiming YuJinguo ZhuLei YuLiping Geng
    • H04L12/66H04W68/12H04W8/06H04W60/00
    • H04W68/12H04W8/06H04W60/005
    • A method and a system for implementing CS domain paging are disclosed, applied in scenarios of performing CS domain paging for a called UE after ISR function is introduced in PS domain, and comprising: MSC/VLR only storing one Gs association; during CS domain paging, MSC/VLR sending a CS domain paging request message to the PS domain network element recorded in the Gs association in the MSC/VLR; after receiving the message, the PS domain network element initiating one or two CS domain paging procedures in the PS domain to transmit the CS domain paging to the called UE; or sending a paging response to the MSC/VLR directly without initiating CS domain paging. A method for transferring service information is also disclosed, applied in the scenarios that ISR function is activated in PS domain, and comprising: transmitting service message(s) between the ISR-associated PS domain network elements serving the UE to implement transfer of service information.
    • 公开了一种用于实现CS域寻呼的方法和系统,其应用于在PS域中引入ISR功能之后为被叫UE执行CS域寻呼的场景,并且包括:MSC / VLR仅存储一个Gs关联; 在CS域寻呼期间,MSC / VLR向MSC / VLR中的Gs关联中记录的PS域网元发送CS域寻呼请求消息; 接收到该消息后,PS域网单元在PS域中发起一个或两个CS域寻呼过程,将CS域寻呼发送给被叫UE; 或直接向MSC / VLR发送寻呼响应而不发起CS域寻呼。 还公开了一种用于传送服务信息的方法,其应用于在PS域中激活ISR功能的场景,包括:在服务于UE的ISR相关联的PS域网元之间传送业务消息,实现业务信息的传输 。
    • 4. 发明申请
    • CONSTRUCTING MULTIDIMENSIONAL HISTOGRAMS FOR COMPLEX SPATIAL GEOMETRY OBJECTS
    • 构造复杂空间几何对象的多维组态
    • US20140052711A1
    • 2014-02-20
    • US13587897
    • 2012-08-16
    • Bhuvan BambaRichard J. AndersonYing HuSiva Ravada
    • Bhuvan BambaRichard J. AndersonYing HuSiva Ravada
    • G06F17/30
    • G06F17/30241
    • Techniques are described for generating histograms for a multidimensional space. In the presence of large spatial objects, fuzzy splitting techniques are utilized to recursively divide the multidimensional space into partitions, where a single spatial object may belong to multiple partitions. Large spatial objects are essentially broken down into smaller objects that may allow for more efficient partitioning of the multidimensional space. A count of spatial objects in each partition yields a spatial histogram. A spatial object that belongs to multiple partitions may have a weighted count for each of the multiple partitions, based on the extent to which the spatial object overlaps with each partition. Thus, an object that is split among a handful of partitions will only contribute a fraction of a count to each partition. Small partitions having relatively few objects are avoided by refusing to subdivide a partition whose members drop below a threshold number.
    • 描述了用于生成多维空间的直方图的技术。 在存在大空间物体的情况下,使用模糊分割技术将多维空间递归地划分成分区,其中单个空间对象可能属于多个分区。 大的空间对象基本上被分解成更小的对象,这可以允许对多维空间进行更有效的划分。 每个分区中的空间对象的计数产生空间直方图。 基于空间对象与每个分区重叠的程度,属于多个分区的空间对象可以具有针对每个多个分区的加权计数。 因此,在少数分区之间分割的对象只会为每个分区贡献一部分计数。 通过拒绝细分成员下降到阈值以下的分区来避免具有相对较少对象的小分区。
    • 6. 发明授权
    • Queries with hard time constraints
    • 具有困难时间限制的查询
    • US08015180B2
    • 2011-09-06
    • US11804508
    • 2007-05-18
    • Ying HuSeema SundaraJagannathan Srinivasan
    • Ying HuSeema SundaraJagannathan Srinivasan
    • G06F17/30
    • G06F17/30522G06F17/30533
    • Systems, methodologies, media, and other embodiments associated with supporting queries with hard time constraints are described. One exemplary system embodiment includes logic for accepting a query having a hard time constraint. The example system may also include logic for selectively rewriting the query having the hard time constraint into a query having a row limitation or a sample percentage limitation. In one example, the row limitation or sample percentage limitation are computed by repetitively comparing an estimated query execution time to the hard time constraint. The example system may also include logic for establishing a timer(s) associated with the rewritten query.
    • 描述了与支持具有硬时间约束的查询相关联的系统,方法,媒体和其他实施例。 一个示例性系统实施例包括用于接受具有硬时间约束的查询的逻辑。 示例系统还可以包括用于选择性地将具有硬时间约束的查询重写到具有行限制或样本百分比限制的查询中的逻辑。 在一个示例中,通过将估计的查询执行时间与硬时间约束重复比较来计算行限制或抽样百分比限制。 示例系统还可以包括用于建立与重写查询相关联的定时器的逻辑。