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1. 发明授权

US07485249B2 Double-layer hollow membrane for bio-reactor applications 失效
标题翻译：用于生物反应器应用的双层中空膜
公开(公告)号：US07485249B2
公开(公告)日：2009-02-03
申请号：US10762225
申请日：2004-01-16
申请人： Wolfgang Albrecht , Dieter Paul , Roland Hilke , Barbara Seifert , Thomas Weigel , Thomas Groth
发明人： Wolfgang Albrecht , Dieter Paul , Roland Hilke , Barbara Seifert , Thomas Weigel , Thomas Groth
IPC分类号： B01D69/12
CPC分类号： D01F8/08 , A61M1/3489 , B01D69/02 , B01D69/08 , B01D69/12 , B01D71/42 , D01D5/24
摘要： In a method of manufacturing a double-layer membrane of different polymers or polymer mixtures with opposite blood-compatible and tissue-compatible surfaces, a first polymer solution of a blood-compatible polymer and a second solution of a tissue-compatible polymer are extruded concurrently in layered form through a nozzle into a coagulation bath so as to form a double layer membrane.
摘要翻译：在制备具有相反血液相容性和组织相容性表面的不同聚合物或聚合物混合物的双层膜的方法中，血液相容性聚合物的第一聚合物溶液和组织相容性聚合物的第二溶液同时挤出以分层形式通过喷嘴进入凝固浴，以形成双层膜。

2. 发明授权

US07273551B2 Functionalized polyimide molded body and functionalized polyimide membrane 失效
标题翻译：功能化聚酰亚胺成型体和功能化聚酰亚胺膜
公开(公告)号：US07273551B2
公开(公告)日：2007-09-25
申请号：US10662166
申请日：2003-09-08
申请人： Wolfgang Albrecht , Lars-Ingemar Dahms , Karola Lützow , Thomas Weigel , Roland Hilke , Dieter Paul
发明人： Wolfgang Albrecht , Lars-Ingemar Dahms , Karola Lützow , Thomas Weigel , Roland Hilke , Dieter Paul
IPC分类号： B01D39/00 , B01D67/00 , B01D29/00
CPC分类号： B01D67/0093 , B01D71/64 , B01J20/28033 , B01J20/3212 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3255 , C08J5/2256 , C08J2379/00 , C08L79/08
摘要： In a polyimide molded body, in particular a polyimide membrane which is functionalized with a chemical group and a method for production thereof, a molded body or membrane is obtained, whereby a pre-prepared polyimide body, as starting material, is brought into contact with an aqueous modifier solution for a period of 1 second to 1 hour. The modifier solution contains at least one modifier substance at least partially dissolved therein, which comprises a primary or secondary amino group, or a similar amino group and additionally at least one further functional group per molecule. The polyimide molded body is brought to an elevated temperature, either during the contact period with the modifier solution or thereafter and then purified and dried. The membrane obtained according to the invention may be functionalized in a targeted adjustable manner and has a high functionalization degree. The functionalization may be achieved simply and economically in an aqueous medium. The membranes obtained are suitable for use in the technical, biotechnological and medical fields and as starter membranes for the production of affinity membranes.
摘要翻译：在聚酰亚胺成型体中，特别是用化学基团官能化的聚酰亚胺膜及其制造方法，得到成型体或膜，由此将作为起始原料的预先制备的聚酰亚胺主体与水性改性剂溶液，持续1秒至1小时。改性剂溶液含有至少部分溶解于其中的至少一种改性物质，其包含伯或仲氨基或类似的氨基，另外每分子含有至少一个另外的官能团。在与改性剂溶液的接触期间或之后使聚酰亚胺成型体达到升高的温度，然后进行纯化和干燥。根据本发明获得的膜可以以目标可调节的方式进行官能化并具有高官能度。功能化可以在水性介质中简单且经济地实现。所获得的膜适用于技术，生物技术和医学领域以及用于生产亲和膜的起始膜。

3. 发明授权

US08404278B2 Polyimide microparticles 有权
标题翻译：聚酰亚胺微粒
公开(公告)号：US08404278B2
公开(公告)日：2013-03-26
申请号：US11086714
申请日：2005-03-22
申请人： Wolfgang Albrecht , Roland Hilke , Karola Lützow , Mario Rettschlag , Filiana Santoso , Thomas Weigel
发明人： Wolfgang Albrecht , Roland Hilke , Karola Lützow , Mario Rettschlag , Filiana Santoso , Thomas Weigel
IPC分类号： A61K9/50
CPC分类号： C08J3/122 , C08J3/14 , C08J2379/08
摘要： The invention relates to a polyimide microparticles which can be obtained by means of the following steps: a) a polymer solution consisting of at least one polyimide polymer and a solvent or a solvent mixture is produced according to methods known per se, b) microparticles are formed from the polymer solution by spraying or by thermal phase inversion, c) the microparticles obtained in step b) are treated with an aqueous functionalization solution containing an amine-containing modifier at a high temperature, with or without stirring, and d) the modified obtained are washed and optionally dried, according to methods known per se.
摘要翻译：本发明涉及可以通过以下步骤获得的聚酰亚胺微粒：a）根据本身已知的方法制备由至少一种聚酰亚胺聚合物和溶剂或溶剂混合物组成的聚合物溶液，b）微粒为由聚合物溶液通过喷雾或通过热相转化形成，c）步骤b）中获得的微粒在含或不含搅拌下在高温下用含胺改性剂的水性官能化溶液处理，和d）经修饰的根据本身已知的方法将获得的物质洗涤并任选地干燥。

4. 发明申请

US20050163860A1 Polyimide microparticles 有权
标题翻译：聚酰亚胺微粒
公开(公告)号：US20050163860A1
公开(公告)日：2005-07-28
申请号：US11086714
申请日：2005-03-22
申请人： Wolfgang Albrecht , Roland Hilke , Karola Lutzow , Mario Rettschlag , Filiana Santoso , Thomas Weigel
发明人： Wolfgang Albrecht , Roland Hilke , Karola Lutzow , Mario Rettschlag , Filiana Santoso , Thomas Weigel
IPC分类号： C08J3/12 , C08J3/14 , A61K9/14 , A61K9/50
CPC分类号： C08J3/122 , C08J3/14 , C08J2379/08
摘要： The invention relates to a polyimide microparticles which can be obtained by means of the following steps: a) a polymer solution consisting of at least one polyimide polymer and a solvent or a solvent mixture is produced according to methods known per se, b) microparticles are formed from the polymer solution by spraying or by thermal phase inversion, c) the microparticles obtained in step b) are treated with an aqueous functionalization solution containing an amine-containing modifier at a high temperature, with or without stirring, and d) the modified obtained are washed and optionally dried, according to methods known per se.
摘要翻译：本发明涉及可以通过以下步骤获得的聚酰亚胺微粒：a）根据本身已知的方法制备由至少一种聚酰亚胺聚合物和溶剂或溶剂混合物组成的聚合物溶液，b）微粒为由聚合物溶液通过喷雾或通过热相转化形成，c）步骤b）中获得的微粒在含或不含搅拌下在高温下用含胺改性剂的水性官能化溶液处理，和d）经修饰的根据本身已知的方法将获得的物质洗涤并任选地干燥。

5. 发明申请

US20110305889A1 Item with at least one thermoprogrammable switching section for applications in contact with materials having high heat transfer coefficients 有权
标题翻译：具有至少一个可编程热切换部件的物品，用于与具有高传热系数的材料接触
公开(公告)号：US20110305889A1
公开(公告)日：2011-12-15
申请号：US13126822
申请日：2009-10-30
申请人： Thomas Weigel , Andreas Lendlein , Karola Lutzow , Frank Klein , Samy Madbouly
发明人： Thomas Weigel , Andreas Lendlein , Karola Lutzow , Frank Klein , Samy Madbouly
IPC分类号： B32B3/26 , C08J9/00 , B05D1/02 , B32B7/02 , B82Y30/00
CPC分类号： B29C61/0625 , A61B17/06166 , A61B2017/00871 , A61B2017/0619 , Y10T428/24942 , Y10T428/249953
摘要： The present invention provides an article with at least one switching segment. The switching segment comprises a shape-memory compound and an isolating region surrounding the shape memory compound. The present invention also provides a method of producing such an article.
摘要翻译：本发明提供一种具有至少一个切换段的物品。切换部分包括形状记忆化合物和围绕形状记忆化合物的隔离区域。本发明还提供了制造这种制品的方法。

6. 发明授权

US08652621B2 Item with at least one thermoprogrammable switching section for applications in contact with materials having high heat transfer coefficients 有权
标题翻译：具有至少一个可编程热切换部件的物品，用于与具有高传热系数的材料接触
公开(公告)号：US08652621B2
公开(公告)日：2014-02-18
申请号：US13126822
申请日：2009-10-30
申请人： Thomas Weigel , Andreas Lendlein , Karola Lützow , Frank Klein , Samy Madbouly
发明人： Thomas Weigel , Andreas Lendlein , Karola Lützow , Frank Klein , Samy Madbouly
IPC分类号： B32B7/02 , B32B3/26 , B05D1/02
CPC分类号： B29C61/0625 , A61B17/06166 , A61B2017/00871 , A61B2017/0619 , Y10T428/24942 , Y10T428/249953
摘要： The present invention provides an article with at least one switching segment. The switching segment comprises a shape-memory compound and an isolating region surrounding the shape memory compound. The present invention also provides a method of producing such an article.
摘要翻译：本发明提供一种具有至少一个切换段的物品。切换部分包括形状记忆化合物和围绕形状记忆化合物的隔离区域。本发明还提供了制造这种制品的方法。

7. 发明申请

US20130053276A1 Method and kit for testing various selected materials and/or surface structures for culturing cells 有权
标题翻译：用于测试培养细胞的各种选择的材料和/或表面结构的方法和试剂盒
公开(公告)号：US20130053276A1
公开(公告)日：2013-02-28
申请号：US13508540
申请日：2010-09-24
申请人： Frank Klein , Thomas Weigel , Karl Kratz , Friedrich Jung , Bernhard Hiebl , Andreas Lendlein , Karola Lützow , Andreas Kurtz , Petra Reinke , Andy Römhild
发明人： Frank Klein , Thomas Weigel , Karl Kratz , Friedrich Jung , Bernhard Hiebl , Andreas Lendlein , Karola Lützow , Andreas Kurtz , Petra Reinke , Andy Römhild
IPC分类号： C40B30/06 , C40B40/00
CPC分类号： G01N33/5008
摘要： The present invention relates to a method for testing different selected materials and/or surface structures for the culture of cells and/or microorganisms, said method comprising the following steps: i) providing a plurality of different selected materials and/or surface structures to be tested in the form of beaker-shaped inserts, wherein the beaker-shaped inserts are dimensioned in such a way that a beaker-shaped insert can be inserted in a substantially accurately fitting manner into a well of a multiwell plate suitable for cell culture, wherein each beaker-shaped insert has walls, a base, and an opening in the side facing away from the base, wherein the walls and base of the beaker-shaped inserts are liquid-tight, and wherein each beaker-shaped insert has a selected material and/or a selected surface structure, at least on the inner face of the base; ii) inserting the beaker-shaped inserts into wells of multiwell plates of appropriate dimensioning so that the outer face of the beaker base points towards the inner face of the base of a well of the multiwell plate; iii) culturing the cells in the lumen of the beaker-shaped inserts, and to a kit for carrying out this method.
摘要翻译：本发明涉及一种用于测试用于培养细胞和/或微生物的不同选择的材料和/或表面结构的方法，所述方法包括以下步骤：i）提供多种不同的选择的材料和/或表面结构为以烧杯形插入物的形式进行测试，其中烧杯形插入件的尺寸设计使得可将烧杯形插入件以基本上精确适合的方式插入适合于细胞培养的多孔板的孔中，其中每个烧杯形插件具有壁，基部和在背离基部的一侧的开口，其中烧杯形插入件的壁和底部是液密的，并且其中每个烧杯形插入件具有选定的材料和/或选定的表面结构，至少在基底的内表面上; ii）将所述烧杯形插入物插入适合尺寸的多孔板的孔中，使得所述烧杯基底的外表面指向所述多孔板的孔的底部的内表面; iii）在烧杯形插入物的内腔中培养细胞，以及用于实施该方法的试剂盒。

8. 发明授权

US09726660B2 Method and kit for testing various selected materials and/or surface structures for culturing cells 有权
公开(公告)号：US09726660B2
公开(公告)日：2017-08-08
申请号：US13508540
申请日：2010-09-24
申请人： Frank Klein , Thomas Weigel , Karl Kratz , Friedrich Jung , Bernhard Hiebl , Andreas Lendlein , Karola Lützow , Andreas Kurtz , Petra Reinke , Andy R•mhild
发明人： Frank Klein , Thomas Weigel , Karl Kratz , Friedrich Jung , Bernhard Hiebl , Andreas Lendlein , Karola Lützow , Andreas Kurtz , Petra Reinke , Andy R•mhild
IPC分类号： C40B30/06 , C40B40/00 , G01N33/50
CPC分类号： G01N33/5008
摘要： The present invention relates to a method for testing different selected materials and/or surface structures for the culture of cells and/or microorganisms.

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