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1. 发明申请

US20050106678A1 Human circulating cytokine CC-1 审中-公开
标题翻译：人循环细胞因子CC-1
公开(公告)号：US20050106678A1
公开(公告)日：2005-05-19
申请号：US10760557
申请日：2004-01-21
申请人： Wolf-Georg Forssmann , Peter Schulz-Knappe , Markus Meyer , Hans-Jurgen Magert
发明人： Wolf-Georg Forssmann , Peter Schulz-Knappe , Markus Meyer , Hans-Jurgen Magert
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07H21/04 , C07K1/18 , C07K1/20 , C07K1/30 , C07K14/52 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68
CPC分类号： C07K14/523 , A61K38/00
摘要： Cytokine CC-1 having the amino acid sequence according to SEQ ID No. 6 and its biologically active fragments and/or derivatives, in particular amidized, acetylized, phosphorylized and/or glycosylized derivatives.
摘要翻译：具有根据SEQ ID No.6的氨基酸序列的细胞因子CC-1及其生物活性片段和/或衍生物，特别是酰胺化的，乙酰化的，磷酸化的和/或糖基化的衍生物。

2. 发明申请

US20080234187A1 Human circulating cytokine CC-1 审中-公开
标题翻译：人循环细胞因子CC-1
公开(公告)号：US20080234187A1
公开(公告)日：2008-09-25
申请号：US11601848
申请日：2006-11-20
申请人： Wolf-Georg Forssmann , Peter Schulz-Knappe , Markus Meyer , Hans-Jurgen Magert
发明人： Wolf-Georg Forssmann , Peter Schulz-Knappe , Markus Meyer , Hans-Jurgen Magert
IPC分类号： A61K38/19 , C07K14/52 , A61K31/7088 , C07H21/04
CPC分类号： C07K14/523 , A61K38/00
摘要： Cytokine CC-1 having the amino acid sequence according to SEQ ID No. 6 and its biologically active fragments and/or derivatives, in particular amidized, acetylized, phosphorylized and/or glycosylized derivatives.
摘要翻译：具有根据SEQ ID No.6的氨基酸序列的细胞因子CC-1及其生物活性片段和/或衍生物，特别是酰胺化的，乙酰化的，磷酸化的和/或糖基化的衍生物。

3. 发明授权

US6083483A Inhibitors of phosphodiesterase IV for x-ray imaging 失效
标题翻译：磷酸二酯酶IV的抑制剂用于X射线成像
公开(公告)号：US6083483A
公开(公告)日：2000-07-04
申请号：US272759
申请日：1999-03-19
申请人： Christian Stief , Torsten Strohmeyer , Wolf-Georg Forssmann , Markus Meyer , Peter Schulz-Knappe , Akmal Taher
发明人： Christian Stief , Torsten Strohmeyer , Wolf-Georg Forssmann , Markus Meyer , Peter Schulz-Knappe , Akmal Taher
IPC分类号： C07D239/96 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/415 , A61K31/4166 , A61K31/44 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/52 , A61K31/522 , A61K31/54 , A61K31/541 , A61K45/00 , A61P1/00 , A61P13/00 , A61P13/02 , A61P15/00 , A61P43/00 , C07D207/273 , C07D241/18 , C07D333/70 , C07D473/06 , A61K49/04 , A61B5/055
CPC分类号： A61K31/522 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/415 , A61K31/4166 , A61K31/44 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/52 , A61K31/54 , A61K31/541
摘要： The invention relates to the use of inhibitors of phosphodiesterase IV for the modulation of the motility and peristalsis of the hollow organs of the urogenital and gastrointestinal tract.
摘要翻译：本发明涉及磷酸二酯酶IV抑制剂用于调节泌尿生殖道和胃肠道中空器官的运动和蠕动的用途。

4. 发明授权

US5891904A Use of inhibitors of phosphodiesterase IV 失效
标题翻译：磷酸二酯酶抑制剂的使用IV
公开(公告)号：US5891904A
公开(公告)日：1999-04-06
申请号：US937590
申请日：1997-09-29
申请人： Christian Stief , Torsten Strohmeyer , Wolf-Georg Forssmann , Markus Meyer , Peter Schulz-Knappe , Akmal Taher
发明人： Christian Stief , Torsten Strohmeyer , Wolf-Georg Forssmann , Markus Meyer , Peter Schulz-Knappe , Akmal Taher
IPC分类号： A61K31/381 , A61K31/4015 , A61K31/4166 , A61K31/517 , A61K31/541 , A61K31/40
CPC分类号： A61K31/4166 , A61K31/381 , A61K31/4015 , A61K31/517 , A61K31/541
摘要： The invention relates to the use of inhibitors of phosphodiesterase IV for the modulation of the motility and peristalsis of the hollow organs of the urogenital and gastrointestinal tract.
摘要翻译：本发明涉及磷酸二酯酶IV抑制剂用于调节泌尿生殖道和胃肠道中空器官的运动和蠕动的用途。

5. 发明授权

US06875616B1 Process for determining the status of an organism by peptide measurement 失效
标题翻译：通过肽测量确定生物体状态的方法
公开(公告)号：US06875616B1
公开(公告)日：2005-04-05
申请号：US09242254
申请日：1997-08-13
申请人： Wolf-Georg Forssmann , Peter Schulz-Knappe , Michael Schrader , Hans-Georg Opitz
发明人： Wolf-Georg Forssmann , Peter Schulz-Knappe , Michael Schrader , Hans-Georg Opitz
IPC分类号： G01N27/62 , C07K2/00 , C12N15/09 , C12Q1/02 , G01N33/483 , G01N33/68 , G01N33/48 , B01D59/44 , C12Q1/68 , C12Q1/70
CPC分类号： G01N33/6848 , G01N33/68 , G01N33/6842 , G01N33/6893 , Y10T436/24 , Y10T436/25375 , Y10T436/255
摘要： A method for detecting the condition of an organism through the measurement of peptides from a sample of said organism containing high- and low-molecular weight peptides, as an indication of the condition of said organism, wherein low-molecular weight peptides are directly detected and characterized; and related to a reference.
摘要翻译：通过测量来自含有高分子量肽和低分子量肽的所述生物体的样品的肽来检测生物体的状况的方法，作为所述生物体的条件的指示，其中直接检测和表征低分子量肽 ; 并与参考有关。

6. 发明授权

US5744444A HPTH-fragment-(1-37), the preparation thereof, medicaments containing same and the use thereof 失效
标题翻译： HPTH片段 - （1-37），其制备方法，含有其的药物及其用途
公开(公告)号：US5744444A
公开(公告)日：1998-04-28
申请号：US440117
申请日：1995-05-12
申请人： Wolf-Georg Forssmann , Franz Herbst , Peter Schulz-Knappe , Knut Adermann , Michael Gagelmann
发明人： Wolf-Georg Forssmann , Franz Herbst , Peter Schulz-Knappe , Knut Adermann , Michael Gagelmann
IPC分类号： A61K38/00 , C07K14/635 , A61K38/17 , C07K4/635
CPC分类号： C07K14/635 , A61K38/00
摘要： The invention relates to a peptide from human blood, designated as hPTH-(1-37), the structure of which was elucidated for the purpose of the diagnostic, medical and commercial utilization thereof. The isolation of a fragment hPTH-(38-84) proves the existence of the hPTH-(1-37). A removal of amino-terminal amino acids from the hPTH fragment-(1-37) reduces its biological activity. The hPTH-(1-37) circulating in the blood is identical with the synthetic reference substance hPTH-(1-37), however not with fragments such as hPTH-(1-33), hPTH-(1-34) or hPTH-(1-38). The molecule form hPTH-(1-37) has been proven by mass spectrometry (plasma desorption method). A different biological activity and differences in the three-dimensional peptide structure of the hPTH fragment-(1-37) in comparison to other hPTH fragments furnish evidence of that this fragment is the preferential natural peptide of the parathormone family which should be used for the treatment of diseases of the parathyroid, circulatory system, respiratory system, male genital organ and kidneys.
摘要翻译：本发明涉及一种称为hPTH-（1-37）的人血液肽，其结构用于诊断，医学和商业应用的目的。片段hPTH-（38-84）的分离证明了hPTH-（1-37）的存在。从hPTH片段（1-37）去除氨基末端氨基酸降低其生物活性。在血液中循环的hPTH-（1-37）与合成参考物质hPTH-（1-37）相同，但不与hPTH-（1-33），hPTH-（1-34）或hPTH - （1-38）。分子形式的hPTH-（1-37）已经通过质谱法（血浆解吸法）证实。与其他hPTH片段相比，hPTH片段（1-37）的三维肽结构的不同生物活性和差异提供了证据，证明该片段是parathormone家族的优选天然肽，其应用于治疗甲状旁腺，循环系统，呼吸系统，男性生殖器官和肾脏的疾病。

7. 发明授权

US06180773B2 Tandem cDNAs encoding chemokines CC-1, CC-2, and CC-3 失效
标题翻译：编码趋化因子CC-1，CC-2和CC-3的串联cDNA
公开(公告)号：US06180773B2
公开(公告)日：2001-01-30
申请号：US09180077
申请日：1998-12-30
申请人： Wolf-Georg Forssmann , Andreas Pardigol , Hans-J{umlaut over (u)}rgen M{umlaut over (a)}gert , Peter Schulz-Knappe
发明人： Wolf-Georg Forssmann , Andreas Pardigol , Hans-J{umlaut over (u)}rgen M{umlaut over (a)}gert , Peter Schulz-Knappe
IPC分类号： C12N1519
CPC分类号： C07K14/523 , A61K38/00
摘要： The CC type chemokines belong to a family of polypeptides which have proven to be mediators of immune reactions, and they have recently attracted attention due to their antiviral activity with respect to HIV. The cloning and molecular characterization of a human tandem gene is disclosed which contains the closely linked coding regions for two new CC type chemokines the sequences of which are highly homologous with that of MIP-1&agr;. The transcription of the tandem gene leads to a bicistronic mature transcript which contains the non-overlapping open reading frames for the recently described factor HCC-1 and an as yet unknown CC type chemokine, designated as CC-2. Moreover, alternative splicing of the primary transcript yields at least one additional CC type chemokine, cytokine CC-3. Two functional promoter regions were identified within the tandem gene. The disclosed data provide some basic knowledge about the structure and expression of the new human CC-2/HCC-1 tandem gene and describe a mechanism according to which the coexpression of closely linked genes could be regulated in higher eucaryotes.
摘要翻译： CC型趋化因子属于被证明是免疫反应介质的多肽家族，并且由于它们对于HIV的抗病毒活性，它们最近引起关注。公开了人串联基因的克隆和分子表征，其包含两个新的CC型趋化因子的紧密连锁的编码区，其序列与MIP-1α的序列高度同源。串联基因的转录导致二顺反子成熟转录物，其包含最近描述的因子HCC-1的非重叠开放阅读框和称为CC-2的尚未知的CC型趋化因子。此外，主要转录物的选择性剪接产生至少一种另外的CC型趋化因子，细胞因子CC-3。在串联基因内鉴定了两个功能启动子区域。所公开的数据提供了关于新型人CC-2 / HCC-1串联基因的结构和表达的一些基本知识，并描述了一种机制，根据该机制可以在较高的真核生物中调节紧密连锁的基因的共表达。

8. 发明申请

US20140309133A1 Novel Method for Diagnosis of High-Affinity Binders and Marker Sequences 审中-公开
标题翻译：用于诊断高亲和力和标记序列的新方法
公开(公告)号：US20140309133A1
公开(公告)日：2014-10-16
申请号：US14239224
申请日：2012-08-18
申请人： Stefan Müllner , Peter Schulz-Knappe , Angelika Lueking , Heike Göhler , Jessica Schwermann
发明人： Stefan Müllner , Peter Schulz-Knappe , Angelika Lueking , Heike Göhler , Jessica Schwermann
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , G01N33/564 , G01N33/6845 , G01N33/6854
摘要： The present invention relates to a novel method for diagnosing high-affinity binders, in particular antibodies or autoantibodies, and the identification, characterisation and selection of marker sequences and diagnostic use thereof, in particular in the form of a panel. The invention also relates to a singleplex assay in which the discovered selection of marker sequences is used in the form of a panel and high-affinity binders are detected using a single signal.
摘要翻译：本发明涉及用于诊断高亲和力结合剂，特别是抗体或自身抗体的新方法，以及特别是面板形式的标记序列的鉴定，表征和选择及其诊断用途。本发明还涉及单重检测，其中所发现的标记序列的选择以面板的形式使用，并且使用单个信号检测高亲和力结合物。

9. 发明申请

US20110111513A1 MASS SPECTROMETRIC ANALYSIS 有权
标题翻译：质谱分析
公开(公告)号：US20110111513A1
公开(公告)日：2011-05-12
申请号：US12994400
申请日：2009-05-18
申请人： Christian Baumann , Helen Byers , Peter Schulz-Knappe , Malcolm Ward
发明人： Christian Baumann , Helen Byers , Peter Schulz-Knappe , Malcolm Ward
IPC分类号： G01N33/00 , H01J49/00
CPC分类号： G01N33/6848 , Y10T436/143333
摘要： The disclosure provides a method for assaying for a target analyte, comprising providing a plurality of samples which may comprise the target analyte, wherein each sample is differentially labelled with a mass label or a combination of mass labels, wherein the mass labels are from a set of mass labels, wherein each mass label is an isobaric mass label comprising a mass spectrometrically distinct mass marker group, such that the samples can be distinguished by mass spectrometry and determining from the mass spectrum the quantity of the target analyte in each sample.
摘要翻译：本公开提供了一种用于分析目标分析物的方法，包括提供可包含目标分析物的多个样品，其中每个样品用质量标签或质量标签的组合差异标记，其中质量标签来自一组的质量标签，其中每个质量标签是包含质谱分辨率不同的质量标记物组的等压质量标签，使得可以通过质谱法区分样品，并从质谱确定每个样品中的目标分析物的量。

10. 发明授权

US10060911B2 Method for diagnosis of high-affinity binders and marker sequences 有权
公开(公告)号：US10060911B2
公开(公告)日：2018-08-28
申请号：US14239224
申请日：2012-08-18
申请人： Stefan Müllner , Peter Schulz-Knappe , Angelika Lueking , Heike Göhler , Jessica Schwermann
发明人： Stefan Müllner , Peter Schulz-Knappe , Angelika Lueking , Heike Göhler , Jessica Schwermann
IPC分类号： G01N33/53 , G01N33/543 , G01N33/68 , G01N33/564
CPC分类号： G01N33/54306 , G01N33/564 , G01N33/6845 , G01N33/6854
摘要： The present invention relates to a novel method for diagnosing high-affinity binders, in particular antibodies or autoantibodies, and the identification, characterization and selection of marker sequences and diagnostic use thereof, in particular in the form of a panel. The invention also relates to a singleplex assay in which the discovered selection of marker sequences is used in the form of a panel and high-affinity binders are detected using a single signal.

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