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1. 发明授权

US09045563B2 CXC chemokine receptor 4 (CXCR4) antagonistic polypeptide 有权
标题翻译： CXC趋化因子受体4（CXCR4）拮抗多肽
公开(公告)号：US09045563B2
公开(公告)日：2015-06-02
申请号：US12452480
申请日：2008-07-03
申请人： Wolf-Georg Forssmann , Frank Kirchhoff , Jan Münch , Ludger Ständker
发明人： Wolf-Georg Forssmann , Frank Kirchhoff , Jan Münch , Ludger Ständker
IPC分类号： C07K14/435 , C07K14/765 , A61K38/00
CPC分类号： C07K14/765 , A61K38/00 , G01N2333/715 , Y02A50/463 , Y02A50/465
摘要： A peptide having the following amino acid sequence: Z1-LVRYTKKVPQVSTPTL-Z2(ALB-408) and its biologically active fragments and/or variants and/or derivatives, especially amidated, acetylated, sulfated, phosphorylated and/or glycosylated derivatives, and peptides obtainable by multiple synthesis which have the biological activity of ALB408-423; wherein Z represents number of from 0 to 10 amino acid residues.
摘要翻译：具有以下氨基酸序列的肽：Z1-LVRYTKKVPQVSTPTL-Z2（ALB-408）及其生物活性片段和/或变体和/或衍生物，特别是酰胺化的，乙酰化的，硫酸化的，磷酸化的和/或糖基化的衍生物，以及可获得的肽通过具有ALB408-423生物活性的多重合成; 其中Z表示0至10个氨基酸残基的数目。

2. 发明申请

US20130029902A1 CXC CHEMOKINE RECEPTOR 4 (CXCR4) ANTAGONISTIC POLYPEPTIDE 有权
标题翻译： CXC CHEMOKINE RECEPTOR 4（CXCR4）ANTAGONISTIC POLYPEPTIDE
公开(公告)号：US20130029902A1
公开(公告)日：2013-01-31
申请号：US12452480
申请日：2008-07-03
申请人： Wolf-Georg Forssmann , Frank Kirchhoff , Jan Münch , Ludger Ständker
发明人： Wolf-Georg Forssmann , Frank Kirchhoff , Jan Münch , Ludger Ständker
IPC分类号： A61K38/10 , C07K7/08 , C12N15/12 , C12N15/63 , C07K16/18 , A61K38/08 , A61K31/7088 , C07K1/18 , C07K1/04 , C12P21/02 , A61P31/12 , A61P31/18 , A61P31/22 , A61P31/14 , A61P31/16 , A61P31/04 , A61P31/10 , A61P29/00 , A61P7/04 , A61P25/00 , A61P35/00 , A61P17/02 , A61P19/00 , C12N1/00 , H01J49/26 , C07K7/06
CPC分类号： C07K14/765 , A61K38/00 , G01N2333/715 , Y02A50/463 , Y02A50/465
摘要： A peptide having the following amino acid sequence: Z1-LVRYTKKVPQVSTPTL-Z2(ALB-408) and its biologically active fragments and/or variants and/or derivatives, especially amidated, acetylated, sulfated, phosphorylated and/or glycosylated derivatives, and peptides obtainable by multiple synthesis which have the biological activity of ALB408-423; wherein Z represents number of from 0 to 10 amino acid residues.
摘要翻译：具有以下氨基酸序列的肽：Z1-LVRYTKKVPQVSTPTL-Z2（ALB-408）及其生物活性片段和/或变体和/或衍生物，特别是酰胺化的，乙酰化的，硫酸化的，磷酸化的和/或糖基化的衍生物，以及可获得的肽通过具有ALB408-423生物活性的多重合成; 其中Z表示0至10个氨基酸残基的数目。

3. 发明授权

US08299031B2 Human semen enhancer of viral infection peptides (SEVI) and their use 失效
标题翻译：病毒感染肽（SEVI）的人类精液增强剂及其用途
公开(公告)号：US08299031B2
公开(公告)日：2012-10-30
申请号：US12162093
申请日：2007-01-25
申请人： Ludger Ständker , Wolf-Georg Forssmann , Knut Adermann , Jan Münch , Frank Kirchhoff , Elke Rücker
发明人： Ludger Ständker , Wolf-Georg Forssmann , Knut Adermann , Jan Münch , Frank Kirchhoff , Elke Rücker
IPC分类号： A61K38/16 , A61K39/00 , C12N7/01 , C12N15/867
CPC分类号： C12N9/16 , A61K38/00 , C07K14/47 , C12N2740/16011
摘要： Subject of the invention are peptides corresponding to a fragment of amino acids 240-290 of human prostatic acid phosphatase. The invention also relates to nucleic acids, antibodies, medicaments and diagnostics and their use and use of the peptides for the treatment and diagnosis of viral diseases, especially HIV disease.
摘要翻译：本发明的主题是对应于人前列腺酸性磷酸酶的氨基酸240-290的片段的肽。本发明还涉及核酸，抗体，药物和诊断及其用于治疗和诊断病毒性疾病，特别是HIV疾病的肽的用途和用途。

4. 发明授权

US07741287B2 Peptides for the treatment of herpes virus infections 有权
标题翻译：用于治疗疱疹病毒感染的肽
公开(公告)号：US07741287B2
公开(公告)日：2010-06-22
申请号：US11658269
申请日：2005-08-16
申请人： Wolf-Georg Forssmann , Frank Kirchhoff , Jan Münch , Ludger Ständker
发明人： Wolf-Georg Forssmann , Frank Kirchhoff , Jan Münch , Ludger Ständker
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K38/017
摘要： The present invention relates to the use of a peptide having the amino acid sequence NH2-VCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH-COOH (SEQ ID NO:1) as well as variants, derivatives and fragments of the peptide for the treatment of viral diseases.
摘要翻译：本发明涉及具有氨基酸序列NH2-VCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH-COOH（SEQ ID NO：1）的肽以及该肽的变体，衍生物和片段用于治疗病毒性疾病的用途。

5. 发明授权

US07037896B1 Peptide (VIRIP) which inhibits a circulating virus in humans and the use thereof 失效
标题翻译：抑制人类循环病毒的肽（VIRIP）及其用途
公开(公告)号：US07037896B1
公开(公告)日：2006-05-02
申请号：US10111427
申请日：2000-11-08
申请人： Frank Kirchhoff , Jan Münch , Ludger Ständker , Wolf-Georg Forssmann
发明人： Frank Kirchhoff , Jan Münch , Ludger Ständker , Wolf-Georg Forssmann
IPC分类号： A61K38/16 , C07K7/08 , C07K2/00 , A61K38/00 , A61K38/02
CPC分类号： C07K7/08 , A61K38/00
摘要： A peptide having the following amino acid sequence: Z1-LEAIPMSIPPEVKFNKPFVF-Z2 (VIRIP) and its biologically active fragments and/or variants and/or derivatives, especially amidated, acetylated, sulfated, polyethylene glycol (PEG) modified, phosphorylated and/or glycosylated derivatives, and peptides obtainable by multiple synthesis which have the biological activity of VIRIP; wherein Z1 and Z2 are independently a sequence of from 0 to 10 amino acid residues, and if Z1 or Z2=zero amino acid residues, then Z1=H and/or Z2=COOH.
摘要翻译：具有以下氨基酸序列的肽：<？in-line-formula description =“In-line Formulas”end =“lead”？> Z 1 -leAIPMSIPPEVKFNKPFVF-Z 2 （VIRIP）<？in-line-formula description =“In-line Formulas”end =“tail”？>及其生物活性片段和/或变体和/或衍生物，特别是酰胺化，乙酰化，硫酸化，聚乙二醇（PEG）修饰的，磷酸化和/或糖基化衍生物，以及可通过多重合成获得的具有VIRIP生物学活性的肽; 其中Z 1和Z 2独立地是0至10个氨基酸残基的序列，并且如果Z 1或Z 2 0个氨基酸残基，则Z 1 = H和/或Z 2 = COOH。

6. 发明申请

US20090191206A1 Human Semen Enhancer of Viral Infection Peptides (SEVI) and Their Use 失效
标题翻译：人类精液增强病毒感染肽（SEVI）及其应用
公开(公告)号：US20090191206A1
公开(公告)日：2009-07-30
申请号：US12162093
申请日：2007-01-25
申请人： Ludger Ständker , Wolf-Georg Forssmann , Knut Adermann , Jan Münch , Frank Kirchhoff , Elke Rücker
发明人： Ludger Ständker , Wolf-Georg Forssmann , Knut Adermann , Jan Münch , Frank Kirchhoff , Elke Rücker
IPC分类号： A61K39/395 , C12N9/16 , A61K38/46 , C12N7/00 , C12N15/87 , C40B30/00 , C12N15/11 , C12N15/00 , C12N5/06 , A61K31/7088 , A61K39/12 , C07K16/18 , C12Q1/70
CPC分类号： C12N9/16 , A61K38/00 , C07K14/47 , C12N2740/16011
摘要： Subject of the invention are peptides corresponding to a fragment of amino acids 240-290 of human prostatic acid phosphatase. The invention also relates to nucleic acids, antibodies, medicaments and diagnostics and their use and use of the peptides for the treatment and diagnosis of viral diseases, especially HIV disease.
摘要翻译：本发明的主题是对应于人前列腺酸性磷酸酶的氨基酸240-290的片段的肽。本发明还涉及核酸，抗体，药物和诊断及其用于治疗和诊断病毒性疾病，特别是HIV疾病的肽的用途和用途。

7. 发明申请

US20140328900A1 PROCESS FOR PREPARING HUMAN RELAXIN-2 有权
标题翻译：制备人类赖氨酸-2的方法
公开(公告)号：US20140328900A1
公开(公告)日：2014-11-06
申请号：US14234919
申请日：2012-08-03
申请人： Wolf-Georg Forssmann , Thomas Dschietzig , Ludger Ständker , Andreas Zgraja , Jochen Hirsch
发明人： Wolf-Georg Forssmann , Thomas Dschietzig , Ludger Ständker , Andreas Zgraja , Jochen Hirsch
IPC分类号： C07K14/64
CPC分类号： C07K14/64 , Y02P20/55
摘要： A process for preparing human relaxin-2 having the following amino acid sequence:A chain: (SEQ ID NO: 1) pGlu-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His- Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys B chain: (SEQ ID NO: 2) Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly- Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly- Met-Ser-Thr-Trp-Ser; comprising the following steps:providing the amino acids necessary for the synthesis of the A and B chains with usual protective groups, wherein the cysteines are employed as trityl-protected amino acids (L-Cys(Trt)-OH);effecting a chromatographic purification of the individual chains A and B after the solid state synthesis;followed by the simultaneous folding and combination of the individual chains A and B in ammonium hydrogencarbonate buffer at pH 7.9 to 8.4; andsubsequent purification of the relaxin-2 formed.
摘要翻译：具有以下氨基酸序列的人松弛素-2的制备方法：A链：（SEQ ID NO：1）pGlu-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val -Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys B链：（SEQ ID NO：2）Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys- Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser; 包括以下步骤：用通常的保护基提供合成A和B链所必需的氨基酸，其中半胱氨酸用作三苯甲基保护的氨基酸（L-Cys（Trt）-OH））; 在固态合成后进行单链A和B的色谱纯化; 然后在pH 7.9至8.4的同时折叠和组合各个链A和B在碳酸氢铵缓冲液中; 并随后纯化形成的松弛素-2。

8. 发明授权

US07232796B2 Medicament containing a tissue inhibitor of metalloproteinases-2 (TIMP-2) as an osteoanabolically active substance 失效
标题翻译：含有金属蛋白酶-2（TIMP-2）的组织抑制剂作为骨代谢活性物质的药物
公开(公告)号：US07232796B2
公开(公告)日：2007-06-19
申请号：US10239870
申请日：2001-04-04
申请人： Franz-Josef Kramer , Silke Mark , Ludger Ständker , Wolf-Georg Forssmann
发明人： Franz-Josef Kramer , Silke Mark , Ludger Ständker , Wolf-Georg Forssmann
IPC分类号： A61K38/00 , A61K49/00
CPC分类号： A61K38/57 , A61K38/1777
摘要： The invention relates to tissue inhibitor of metalloproteinase-2 (TIMP-2) as an osteoanabolically active peptide for use as a medicament for treating bone defects, bone diseases and for improving bone regeneration.
摘要翻译：本发明涉及金属蛋白酶-2（TIMP-2）作为骨代谢活性肽的组织抑制剂，用作治疗骨缺损，骨疾病和改善骨再生的药物。

9. 发明授权

US09434780B2 Process for preparing human relaxin-2 有权
标题翻译：人松弛素-2的制备方法
公开(公告)号：US09434780B2
公开(公告)日：2016-09-06
申请号：US14234919
申请日：2012-08-03
申请人： Wolf-Georg Forssmann , Thomas Dschietzig , Ludger Ständker , Andreas Zgraja , Jochen Hirsch
发明人： Wolf-Georg Forssmann , Thomas Dschietzig , Ludger Ständker , Andreas Zgraja , Jochen Hirsch
IPC分类号： C07K14/64
CPC分类号： C07K14/64 , Y02P20/55
摘要： A process for preparing human relaxin-2 having the following amino acid sequence: A chain: (SEQ ID NO: 1) pGlu-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His- Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys B chain: (SEQ ID NO: 2) Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly- Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly- Met-Ser-Thr-Trp-Ser; comprising the following steps: providing the amino acids necessary for the synthesis of the A and B chains with usual protective groups, wherein the cysteines are employed as trityl-protected amino acids (L-Cys(Trt)-OH); effecting a chromatographic purification of the individual chains A and B after the solid state synthesis; followed by the simultaneous folding and combination of the individual chains A and B in ammonium hydrogencarbonate buffer at pH 7.9 to 8.4; and subsequent purification of the relaxin-2 formed.

10. 发明授权

US07045594B1 Serine proteinase inhibitors 失效
标题翻译：丝氨酸蛋白酶抑制剂
公开(公告)号：US07045594B1
公开(公告)日：2006-05-16
申请号：US09582328
申请日：1998-12-23
申请人： Wolf-Georg Forssmann , Hans-Jürgen Magert , Ludger Ständker , Peter Kreuztmann
发明人： Wolf-Georg Forssmann , Hans-Jürgen Magert , Ludger Ständker , Peter Kreuztmann
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： C07K14/8135 , A61K38/00 , A61K48/00
摘要： A serine protease inhibitor, characterized by having a domain with four cysteines, and a sequence of 0 to 20 amino acids is present between the first and second cysteines, or the serine protease inhibitor has a domain with six cysteines, and a sequence of 7 to 20 amino acids is present between the first and second cysteines.
摘要翻译：特征在于具有四个半胱氨酸的结构域和0至20个氨基酸的序列的丝氨酸蛋白酶抑制剂存在于第一个和第二个半胱氨酸之间，或者丝氨酸蛋白酶抑制剂具有六个半胱氨酸的结构域，在第一和第二半胱氨酸之间存在20个氨基酸。

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