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1. 发明授权

US07943728B2 Disintegrin variants and their use in treating osteoporosis-induced bone loss and angiogenesis-related diseases 有权
标题翻译： Disintegrin变体及其在治疗骨质疏松症引起的骨丢失和血管发生相关疾病中的应用
公开(公告)号：US07943728B2
公开(公告)日：2011-05-17
申请号：US12004045
申请日：2007-12-20
申请人： Woei-Jer Chuang , Wen-Mei Fu , Tur-Fu Huang , Wenya Huang , Chih-Hsin Tang , Chiu-Yueh Chen
发明人： Woei-Jer Chuang , Wen-Mei Fu , Tur-Fu Huang , Wenya Huang , Chih-Hsin Tang , Chiu-Yueh Chen
IPC分类号： A61K38/00 , A61K38/04 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C12P21/06 , C12P15/00 , C12N15/74 , A01N37/18
CPC分类号： C07K14/46 , A61K38/00 , C07K14/745
摘要： Disintegrin variants and pharmaceutical uses thereof are disclosed. The disintegrin variant includes an isolated polypeptide that has integrin αvβ3 receptor-antagonist activity and substantially reduced integrin αllbβ3 and/or α5β1 receptor-blocking activity as compared to a wild-type disintegrin. The variant is encoded by a modified disintegrin nucleotide sequence that encodes a modified amino acid sequence, resulting in a polypeptide having substantially reduced affinity to integrin αllbβ3 and/or α5β1 as compared to a wild-type disintegrin. The variant is useful for treatment and/or prevention of αvβ3 integrin-associated diseases in a mammal, which include osteoporosis, bone tumor or cancer growth, angiogenesis-related tumor growth and metastasis, tumor metastasis in bone, malignancy-induced hypercalcemia, angiogenesis-related eye diseases, Paget's disease, rheumatic arthritis, and osteoarthritis. The angiogenesis-related eye diseases include age-related macular degeneration, diabetic retinopathy, corneal neovascularizing diseases, ischaemia-induced neovascularizing retinopathy, high myopia, and retinopathy of prematurity.
摘要翻译：公开了解聚体变体及其药物用途。去整合素变体包含与野生型去整合素相比具有整联蛋白αv＆bgr 3受体 - 拮抗剂活性和显着降低的整合素α1b和bgr3和/或α5＆bgr1受体阻断活性的分离多肽。该变体由编码修饰的氨基酸序列的修饰的整合素核苷酸序列编码，导致与野生型去整合素相比，具有显着降低的对整联蛋白αbb和bgr3和/或α5和bgr的亲和力的多肽。该变体可用于治疗和/或预防哺乳动物中的αv＆bgr 3整联蛋白相关疾病，其包括骨质疏松症，骨肿瘤或癌症生长，血管生成相关的肿瘤生长和转移，骨中的肿瘤转移，恶性肿瘤性高钙血症，血管生成相关眼病，佩吉特氏病，风湿性关节炎和骨关节炎。血管生成相关的眼睛疾病包括年龄相关性黄斑变性，糖尿病性视网膜病变，角膜新生血管性疾病，缺血诱导的新生血管性视网膜病变，高度近视和早产儿视网膜病变。

2. 发明申请

US20080188413A1 Disintegrin variants and pharmaceutical uses thereof 有权
标题翻译：消融素变体及其药物用途
公开(公告)号：US20080188413A1
公开(公告)日：2008-08-07
申请号：US12004045
申请日：2007-12-20
申请人： Woei-Jer Chuang , Wen-Mei Fu , Tur-Fu Huang , Wenya Huang , Chih-Hsin Tang , Chiu-Yueh Chen
发明人： Woei-Jer Chuang , Wen-Mei Fu , Tur-Fu Huang , Wenya Huang , Chih-Hsin Tang , Chiu-Yueh Chen
IPC分类号： A61K38/16 , A61K38/02 , A61K38/08 , C07K2/00 , C07K14/00 , C07K7/06 , C12P21/00 , C07H21/00 , A61P35/00 , A61P19/10 , A61P19/02
CPC分类号： C07K14/46 , A61K38/00 , C07K14/745
摘要： Disintegrin variants and pharmaceutical uses thereof are disclosed. The disintegrin variant includes an isolated polypeptide that has integrin αvβ3 receptor-antagonist activity and substantially reduced integrin αllbβ3 and/or α5β1 receptor-blocking activity as compared to a wild-type disintegrin. The variant is encoded by a modified disintegrin nucleotide sequence that encodes a modified amino acid sequence, resulting in a polypeptide having substantially reduced affinity to integrin αllbβ3 and/or α5β1 as compared to a wild-type disintegrin. The variant is useful for treatment and/or prevention of αvβ3 integrin-associated diseases in a mammal, which include osteoporosis, bone tumor or cancer growth, angiogenesis-related tumor growth and metastasis, tumor metastasis in bone, malignancy-induced hypercalcemia, angiogenesis-related eye diseases, Paget's disease, rheumatic arthritis, and osteoarthritis. The angiogenesis-related eye diseases include age-related macular degeneration, diabetic retinopathy, corneal neovascularizing diseases, ischaemia-induced neovascularizing retinopathy, high myopia, and retinopathy of prematurity.
摘要翻译：公开了解聚体变体及其药物用途。去整合素变体包含与野生型去整合素相比具有整合素α1受体 - 拮抗剂活性的分离的多肽和显着降低的整联蛋白α1bβ3和/或α5β1受体阻断活性。该变体由编码修饰的氨基酸序列的修饰的整合素核苷酸序列编码，导致与野生型去整合素相比，具有显着降低的对整联蛋白αββ和/或α5β1的整合素的多肽的多肽。该变体可用于治疗和/或预防哺乳动物中的α2β1整联蛋白相关疾病，其包括骨质疏松症，骨肿瘤或癌症生长，血管生成相关的肿瘤生长和转移，骨中的肿瘤转移，恶性肿瘤性高钙血症，血管生成 - 相关的眼睛疾病，佩吉特氏病，风湿性关节炎和骨关节炎。血管生成相关的眼睛疾病包括年龄相关性黄斑变性，糖尿病性视网膜病变，角膜新生血管性疾病，缺血诱导的新生血管性视网膜病变，高度近视和早产儿视网膜病变。

3. 发明申请

US20100003668A1 Oligonucleotides and Use Thereof for Determining Deletion in HBV Pre-S Region 有权
标题翻译：寡核苷酸及其用途，用于确定HBV Pre-S区域的缺失
公开(公告)号：US20100003668A1
公开(公告)日：2010-01-07
申请号：US12481091
申请日：2009-06-09
申请人： Wenya Huang , Ih-Jen Su , Fang-Ching Shen
发明人： Wenya Huang , Ih-Jen Su , Fang-Ching Shen
IPC分类号： C12Q1/70 , C07H21/04
CPC分类号： C12Q1/706
摘要： This invention provides combinations of novel oligonucleotides and their use in detecting a deletion(s) in the Pre-S region of HBV. Such a deletion(s) is associated with an increased risk of developing cirrhosis or hepatocellular carcinoma.
摘要翻译：本发明提供新型寡核苷酸的组合及其在检测HBV前S区缺失中的用途。这种缺失与发生肝硬化或肝细胞癌的风险增加相关。

4. 发明授权

US08293474B2 Oligonucleotides and use thereof for determining deletion in HBV Pre-S region 有权
标题翻译：寡核苷酸及其用于确定HBV Pre-S区域缺失的用途
公开(公告)号：US08293474B2
公开(公告)日：2012-10-23
申请号：US12481091
申请日：2009-06-09
申请人： Wenya Huang , Ih-Jen Su , Fang-Ching Shen
发明人： Wenya Huang , Ih-Jen Su , Fang-Ching Shen
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/706
摘要： This invention provides combinations of novel oligonucleotides and their use in detecting a deletion(s) in the Pre-S region of HBV. Such a deletion(s) is associated with an increased risk of developing cirrhosis or hepatocellular carcinoma.
摘要翻译：本发明提供新型寡核苷酸的组合及其在检测HBV前S区缺失中的用途。这种缺失与发生肝硬化或肝细胞癌的风险增加相关。

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