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1. 发明授权

US6117851A Treatment of osteoarthritis by administering poly-N-acetyl-D-glucosamine 失效
标题翻译：通过施用聚-N-乙酰基-D-葡糖胺来治疗骨关节炎
公开(公告)号：US6117851A
公开(公告)日：2000-09-12
申请号：US990161
申请日：1997-12-12
申请人： William T. Sherman , Robert W. Gracy
发明人： William T. Sherman , Robert W. Gracy
IPC分类号： A61K31/722 , A61K31/726 , A61K31/70
CPC分类号： A61K31/726 , A61K31/722
摘要： The methods of the present invention relate to administering to a mammal afflicted with osteoarthritis an effective amount of poly-N-acetyl-D-glucosamine (poly-NAG), partially depolimerized poly-NAG, pharmaceutically acceptable salts of poly-NAG, or mixtures thereof, to treat osteoarthritis and/or alleviate the symptoms of osteoarthritis such as pain, joint tenderness and swelling and impaired joint mobility. The present invention also comprises solid and liquid pharmaceutical dosage forms comprising poly-NAG, its pharmaceutically acceptable salts and mixtures thereof. These dosage forms may be administered orally and by-injection to treat osteoarthritis and/or alleviate the symptoms thereof.
摘要翻译：本发明的方法涉及向患有骨关节炎的哺乳动物施用有效量的聚-N-乙酰基-D-葡糖胺（poly-NAG），部分去分解多聚NAG，聚-NAG的药学上可接受的盐或混合物治疗骨关节炎和/或减轻骨关节炎的症状，例如疼痛，关节压痛和肿胀以及关节活动受损。本发明还包括固体和液体药物剂型，其包含聚-NAG，其药学上可接受的盐和混合物。这些剂型可以口服和副注射剂治疗骨关节炎和/或缓解其症状。

2. 发明授权

US06471958B2 Non-contracting tissue equivalent 失效
标题翻译：非收缩组织当量
公开(公告)号：US06471958B2
公开(公告)日：2002-10-29
申请号：US09775843
申请日：2001-02-01
申请人： S. Dan Dimitrijevich , Robert W. Gracy
发明人： S. Dan Dimitrijevich , Robert W. Gracy
IPC分类号： C12N508
CPC分类号： A61L27/3804 , A61L27/24 , A61L27/3895 , C12N5/0698 , C12N2502/091 , C12N2502/094 , C12N2502/1323 , C12N2503/06
摘要： The present invention provides a non-contracting tissue equivalent comprising at least one cellular component and at least one non-cellular component. The tissue equivalent closely resembles normal tissue in being substantially non-contracting. In addition, the non-contracting tissue equivalent is translucent, allowing direct visual observation of the different layers of cells in the tissue equivalent. The non-contracting tissue equivalent is useful for a variety of complete tissue replacements including skin and cornea. The non-contracting tissue equivalent is useful for in vitro testing, evaluation and screening of potential pharmaceuticals or consumer products, production of biocompatible clinical products for tissue replacement and augmentation, and research studies on fundamental aspects of tissue structure and function. The capability for direct visual observation of layers of cells permits manual or automated assessment of important biological parameters of the tissue, including cell viability, proliferation, motility, and differentiation.
摘要翻译：本发明提供了包含至少一种细胞组分和至少一种非细胞组分的非收缩组织当量。组织当量基本上不收缩时非常类似于正常组织。另外，非收缩组织当量是半透明的，允许对组织等效的细胞的不同层的直接目视观察。非收缩组织当量可用于各种完整的组织替代物，包括皮肤和角膜。非收缩组织等效物可用于潜在药物或消费品的体外测试，评估和筛选，用于组织置换和增殖的生物相容性临床产品的生产，以及关于组织结构和功能的基本方面的研究。直接观察细胞层的能力允许手动或自动评估组织的重要生物学参数，包括细胞活力，增殖，运动和分化。

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