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1. 发明申请

US20050130163A1 Serrs reactive particles 审中-公开
标题翻译： Serrs反应性颗粒
公开(公告)号：US20050130163A1
公开(公告)日：2005-06-16
申请号：US10507717
申请日：2003-07-11
申请人： William Smith , Duncan Graham , Peter Cormack , Ailie McCabe
发明人： William Smith , Duncan Graham , Peter Cormack , Ailie McCabe
IPC分类号： G01N21/65 , B01J13/14 , C07B61/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , C12Q1/6816 , G01N33/53 , G01N33/543 , G01N33/553 , G01N33/566 , G01N33/58
CPC分类号： G01N33/587 , B01J13/14 , B82Y15/00 , C07B2200/11 , C12Q1/6816 , C40B20/04 , G01N21/658 , C12Q2563/149 , C12Q2563/137
摘要： The present invention relates to the provision of SERRS active polymer beads and a method of their production for use in detecting targect molecules, as well as methods of detecting target molecules.
摘要翻译：本发明涉及提供SERRS活性聚合物珠粒及其制备用于检测分子量的方法，以及检测靶分子的方法。

2. 发明申请

US20060246460A1 Nucleic acid sequence identification 审中-公开
标题翻译：核酸序列鉴定
公开(公告)号：US20060246460A1
公开(公告)日：2006-11-02
申请号：US10569698
申请日：2004-08-26
申请人： Duncan Graham , William Smith , Ljiljana Fruk
发明人： Duncan Graham , William Smith , Ljiljana Fruk
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： G01N21/658 , G01J3/44 , G01N2021/653
摘要： The invention provides modified molecular beacons detectable by surface enhanced Raman spectroscopy (SERS) and related materials, processes, and methods of use. Examples methods provide for the determination of the presence or absence of a target nucleotide sequence in a sample nucleic acid by (a) providing a detection agent, which agent comprises: (i) a probe comprising a target complement sequence (TCS) being complementary to the target sequence and flanking the TCS, first and second oligonucleotide arms, said first and second oligonucleotide arms forming a stem duplex, and said first arm incorporating a first label moiety being detectable by SERS (e.g. a fluoroscein dye) and said second arm terminating in a second label moiety being detectable by SERS, which second arm further includes a surface seeking group (SSG—e.g. an azo-benzotriazole) capable of promoting association of the second label onto an enhancing surface ii) associated with said probe via said SSG, an enhancing surface, such that said first and second label moieties are in close proximity to each other and to the enhancing surface (b) exposing the sample to the detection agent, (c) detecting hybridisation of the TCS to any target sequence present in the sample by a change in the SERS spectra of said agent.
摘要翻译：本发明提供通过表面增强拉曼光谱（SERS）和相关材料，方法和使用方法可检测的修饰分子信标。实例方法通过（a）提供检测剂来确定样品核酸中靶核苷酸序列的存在或不存在，所述检测剂包括：（i）包含与SEQ ID NO：1的互补序列的靶互补序列（TCS）的探针所述靶序列和所述TCS第一和第二寡核苷酸臂的侧翼，所述第一和第二寡核苷酸臂形成茎双相，并且所述第一臂结合第一标记部分可被SERS（例如氟代染料染料）检测，所述第二臂终止于第二标记部分可由SERS检测，该第二臂还包括能够促进第二标记与经由所述SSG与所述探针相关联的增强表面ii）的表面寻找组（SSG，例如偶氮 - 苯并三唑），使得所述第一和第二标签部分彼此靠近并且与所述增强表面（b）将样品暴露于检测剂，（c）通过所述试剂的SERS光谱的变化来检测TCS与样品中存在的任何靶序列的杂交。

3. 发明申请

US20050042615A1 Microfluidic ser(r)s detection 审中-公开
标题翻译：微流控ser（r）检测
公开(公告)号：US20050042615A1
公开(公告)日：2005-02-24
申请号：US10494168
申请日：2002-11-04
申请人： William Smith , Duncan Graham , Jonathan Cooper , Ruth Keir , Eishi Igata
发明人： William Smith , Duncan Graham , Jonathan Cooper , Ruth Keir , Eishi Igata
IPC分类号： B01F5/06 , B01F13/00 , B01J13/00 , B01L3/00 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N35/00 , G01N35/08
CPC分类号： G01N33/54373 , B01F5/061 , B01F13/0059 , B01F2005/0621 , B01F2005/0636 , B01J13/0043 , B01L3/502769 , B01L2300/0816 , B01L2300/0867 , B01L2300/1822 , B01L2400/0415 , B01L2400/0487 , C12Q1/6816 , G01N35/08 , G01N2035/00237 , C12Q2565/632 , C12Q2565/629
摘要： The present invention relates to a microfluidic method of generating in situ a colloid for use in detecting an an using for example SER(R)S, as well as a method of detecting an analyte using SER(R)S in a microfluidic system. The invention also relates to microfluidic devices for use in detecting analytes such as by way of SER(R)S signals.
摘要翻译：本发明涉及一种原位生成用于检测使用例如S S的胶体的微流体方法，以及在微流体系统中使用SER检测分析物的方法。本发明还涉及用于检测分析物例如通过SER（S）信号的微流体装置。

4. 外观设计

USD981581S1 Arched massage head 有权
公开(公告)号：USD981581S1
公开(公告)日：2023-03-21
申请号：US29772188
申请日：2021-02-26
申请人： William Smith , Cameron Smith , Dominic Rainville
设计人： William Smith , Cameron Smith , Dominic Rainville

5. 发明申请

US20220257018A1 Reclining Chair Assembly 有权
公开(公告)号：US20220257018A1
公开(公告)日：2022-08-18
申请号：US17178305
申请日：2021-02-18
申请人： William Smith
发明人： William Smith
IPC分类号： A47C1/024 , A47C7/50
摘要： A reclining chair assembly includes a reclining chair that has a backrest portion and a chair portion for having a user sit therein. A pair of footrests is each disposed on the chair portion of the reclining chair and each of the footrests is positionable in a lowered position or a raised position to raise the respective user's leg. Moreover, the pair of footrests is independently positionable in the raised position to facilitate one of the user's legs to be lifted while the other of the user's legs is not lifted. A pair of lifting units is each in mechanical communication with a respective one of the pair of footrests. Each of the lifting units independently urges the respective footrest into the raised position or the lowered position.

6. 发明申请

US20220008284A1 SELF-MASSAGE DEVICE HAVING INTERCHANGEABLE MASSAGE HEADS AND BOARD 有权
公开(公告)号：US20220008284A1
公开(公告)日：2022-01-13
申请号：US17180654
申请日：2021-02-19
申请人： William Smith , Cameron Smith , Dominic Rainville
发明人： William Smith , Cameron Smith , Dominic Rainville
IPC分类号： A61H23/02
摘要： Described is a self-massage device including a massage board with multiple connected indentations formed along the length of the massage board. The self-massage device also includes one or more massage heads having a top portion formed to contact a portion of a user's body, and a bottom portion having a protrusion formed to be removably inserted into one or more of the connected indentations in the massage board via a pressure mechanism.

7. 发明申请

US20170326427A1 GOLF SWING TEACHING DEVICE 审中-公开
公开(公告)号：US20170326427A1
公开(公告)日：2017-11-16
申请号：US15230802
申请日：2016-08-08
申请人： William Smith , Kelsey Baker
发明人： William Smith , Kelsey Baker
IPC分类号： A63B69/36 , A63B71/06 , A63B57/10 , G09B19/00 , A63B24/00 , A63B102/32
CPC分类号： A63B69/3661 , A63B24/0006 , A63B57/10 , A63B69/36 , A63B69/3614 , A63B71/0622 , A63B71/0686 , A63B2024/0015 , A63B2071/0625 , A63B2071/0694 , A63B2102/32 , A63B2207/02 , G09B19/0038
摘要： A golf swing teaching device to interpret a golf swing comprising a golf club, where the golf club includes a handle, a shaft and a head; a laser attached to the golf club, where the laser directs a beam parallel to the shaft of the golf club; a reflective indicator mat, where the reflective indicator mat extends between a first end and a second end; a rest toward the first end, where the rest positions a golf ball on the reflective indicator mat; an ideal swing line along a central portion of the reflective indicator mat, where the ideal swing line extends from the first end to the second end; and a plurality of sensors along the reflective indicator mat, where the plurality of sensors detect a path of the beam over the reflective indicator mat and deviation of the beam from the ideal swing line.

8. 发明申请

US20140362485A1 Transient Protection Filter Circuit that Minimizes the Effects of Thermal Runaway 审中-公开
标题翻译：瞬态保护滤波电路，尽可能减少热失控的影响
公开(公告)号：US20140362485A1
公开(公告)日：2014-12-11
申请号：US13911305
申请日：2013-06-06
申请人： William Smith
发明人： William Smith
IPC分类号： H02H9/04
CPC分类号： H02H9/04 , H02H9/001 , H02H9/041 , H02H9/042
摘要： Commonly, a transient protection filter circuit is integrated between power sources and the circuits that follow to suppress voltage transients. Pre-existing transient protection filters are implemented such that when a transient is detected, transistors in the path become linear regulators. Instead, this invention uses bridge resistors to form a voltage divider to dissipate the extra power. The novelty of this invention is that it protects the load not by dissipating the extra power in front of the load as other transient protection filter circuits do, but by providing energy from the transient to the load through a resistor. This implementation solves the problem of thermal runaway that is commonly caused when transient voltages are filtered by dissipating power within the transistors in the path of the transient and the electric circuits after the transistors.
摘要翻译：通常，瞬态保护滤波器电路集成在电源和随后的电路之间以抑制电压瞬变。实现了现有的瞬态保护滤波器，使得当检测到瞬态时，路径中的晶体管变为线性稳压器。相反，本发明使用桥式电阻器来形成分压器以耗散额外功率。本发明的新颖之处在于，其它瞬态保护滤波器电路不是通过消耗负载前面的额外功率来保护负载，而是通过电阻将瞬态能量提供给负载。该实现解决了当瞬态电压通过在晶体管之后的瞬态路径和电路中的晶体管内消耗功率而被滤波时通常引起的热失控的问题。

9. 外观设计

USD629364S1 Grounding clamp 有权
标题翻译：接地夹
公开(公告)号：USD629364S1
公开(公告)日：2010-12-21
申请号：US29359187
申请日：2010-04-07
申请人： William Smith , Daniel Cardin
设计人： William Smith , Daniel Cardin
CPC分类号： H01R4/36 , H01R4/646

10. 发明申请

US20090193742A1 PREFABRICATED WALL PANEL WITH TONGUE AND GROOVE CONSTRUCTION 有权
标题翻译：具有连接和沟槽结构的预制墙板
公开(公告)号：US20090193742A1
公开(公告)日：2009-08-06
申请号：US12026876
申请日：2008-02-06
申请人： David H. Wolf , James S. Belt , William Smith , Donn R. Vermilion , Wayne Buoni , Joy Stickel
发明人： David H. Wolf , James S. Belt , William Smith , Donn R. Vermilion , Wayne Buoni , Joy Stickel
IPC分类号： E04F13/14 , B28B7/20 , E04B2/94
CPC分类号： E04F13/0894 , B29C39/18 , B29C39/36 , B29D99/001 , B29L2031/10 , E04F13/0873 , E04F13/147 , E04F15/02038
摘要： A prefabricated wall panel has a precast body including at least one decorative design element. In addition, the wall panel includes a mounting element having a first end embedded in the precast body and a second end projecting from the precast body. A groove is formed between the precast body and the second end of the mounting element along a first edge of the precast body. A tongue is formed along a second edge of the precast body opposite the first edge. The tongue and groove cooperate to allow prefabricated wall panels to be more easily installed on a support substrate.
摘要翻译：预制墙板具有包括至少一个装饰设计元件的预制体。此外，壁板包括安装元件，其具有嵌入预制体的第一端和从预制体突出的第二端。沿着预制体的第一边缘在预制体和安装元件的第二端之间形成凹槽。沿着与第一边缘相对的预制体的第二边缘形成舌部。舌和槽配合使得预制的墙板更容易地安装在支撑基板上。

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