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1. 发明授权

US09066899B2 Vaccines 有权
标题翻译：疫苗
公开(公告)号：US09066899B2
公开(公告)日：2015-06-30
申请号：US12673272
申请日：2008-08-11
申请人： William Ripley Ballou , Joseph D Cohen
发明人： William Ripley Ballou , Joseph D Cohen
IPC分类号： A61K39/015 , A61K39/116 , A61K39/00
CPC分类号： A61K39/015 , A61K39/0017 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K2039/5258 , A61K2039/55 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6075 , A61K2039/70 , C12N2730/10134 , Y02A50/412
摘要： The invention relates to use of an antigen derived from the circumsporozoite protein (CS) protein of Plasmodium falciparum which is expressed at the pre-erythrocytic stage of malarial infection in combination with a pharmaceutically acceptable adjuvant, in the manufacture of a medicament for vaccinating infants against malaria.
摘要翻译：本发明涉及来自恶性疟原虫的环孢子蛋白（CS）蛋白的抗原，其在疟疾感染的红细胞前期与药学上可接受的佐剂组合在制备用于疫苗接种疫苗的药物中的用途疟疾。

2. 发明授权

US08137146B2 Closed loop fluid cooling system for marine outboard, inboard, and inboard-outboard motors 有权
标题翻译：船用舷外，内侧和内侧舷外电机的闭环流体冷却系统
公开(公告)号：US08137146B2
公开(公告)日：2012-03-20
申请号：US12410374
申请日：2009-03-24
申请人： Joseph D Cohen
发明人： Joseph D Cohen
IPC分类号： B63H21/14 , F01P3/20 , F02B61/04 , F28F9/02 , F28F9/04
CPC分类号： F01P7/16 , F01P2003/006 , F01P2050/06 , F01P2060/045 , F28D1/022
摘要： A closed loop fluid cooling system for marine motors is described. The system includes a motor cooling circuit in fluidic communication with fluid cooling jackets about a motor. The system includes a heat dissipation circuit. The motor cooling circuit is in closed fluidic communication with the heat dissipation circuit. A cooling fluid variably circulates between the motor cooling circuit and the heat dissipation circuit. A heat dissipation member is in fluidic communication with the heat dissipation circuit to receive the circulating cooling fluid, and the heat dissipation member is submerged in the body of water in which the boat is traveling to transfer heat from the cooling fluid to the body of water. A temperature control valve is in fluidic communication with the motor cooling circuit and the heat dissipation circuit. The temperature control valve variably connects the motor cooling circuit and the heat dissipation circuit in response to a temperature of the cooling fluid or the motor to provide for the circulation of the cooling fluid between the motor cooling circuit and the heat dissipation circuit.
摘要翻译：描述了用于船用电动机的闭环流体冷却系统。该系统包括与围绕电动机的流体冷却套流体连通的电动机冷却回路。该系统包括散热电路。电机冷却回路与散热回路封闭流体连通。冷却流体在电动机冷却回路和散热回路之间可变地循环。散热构件与散热回路流体连通以接收循环冷却流体，并且散热构件浸没在船运行的水体中，以将热量从冷却流体传递到水体。温度控制阀与电机冷却回路和散热回路流体连通。温度控制阀响应于冷却流体或电动机的温度可变地连接电动机冷却回路和散热回路，以提供冷却流体在电动机冷却回路和散热回路之间的循环。

3. 发明授权

US09279006B2 Anti-malaria vaccine 有权
标题翻译：抗疟疫苗
公开(公告)号：US09279006B2
公开(公告)日：2016-03-08
申请号：US11917788
申请日：2006-06-29
申请人： Joseph D Cohen
发明人： Joseph D Cohen
IPC分类号： A61K39/00 , A61K39/002 , A61P37/02 , C07K14/445 , A61K35/68 , A61K39/015 , A61K39/29
CPC分类号： C07K14/445 , A61K35/68 , A61K38/164 , A61K39/015 , A61K39/292 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/6075 , A61K2039/627 , C07K2319/00 , C12N2730/10122 , Y02A50/412 , A61K2300/00
摘要： There is provided, inter alia, a method for the prophylaxis of productive malaria infection in travelers to endemic regions comprising the administration of suitable amounts of a formulation comprising a Plasmodium antigen or an immunogenic fragment or derivative thereof and an adjuvant, comprising a lipid A derivative and a saponin in a liposome formulation.
摘要翻译：特别地，提供了一种预防在流行地区的旅行者中产生疟疾感染的方法，包括施用合适量的包含疟原虫抗原或其免疫原性片段或其衍生物和佐剂的制剂，其包含脂质A衍生物和脂质体制剂中的皂角苷。

4. 发明授权

US08999347B2 Vaccines for malaria 有权
标题翻译：疟疾疫苗
公开(公告)号：US08999347B2
公开(公告)日：2015-04-07
申请号：US12810364
申请日：2008-12-22
申请人： Joseph D Cohen , Martine Marchand
发明人： Joseph D Cohen , Martine Marchand
IPC分类号： A61K39/015 , C07K14/445 , C12N7/00 , A61K39/00
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/5258 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6075 , C07K2319/40 , C12N7/00 , C12N2730/10123 , Y02A50/412
摘要： The present invention relates to a novel lipoprotein particle, methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, compositions/vaccines containing the particle or antibodies against the protein particle such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. Furthermore, particles with the specific ratio can be prepared by employing yeast, Saccharomyces cerevisiae or Pichia pastoris. In particular it relates to an immunogenic protein particle comprising the following monomers: a. a fusion protein comprising sequences derived from a CS protein of P. vivax and the S antigen of Hepatitis B (CSV-S), and b. S antigen derived from Hepatitis B virus, and characterized in that the ratio of S to CSV-S is in the range 0.1 to 1. Suitably, the ratio of S to CSV-S is in the range 0.19 to 0.30 or 0.68 to 0.80.
摘要翻译：本发明涉及一种新的脂蛋白颗粒，其制备和纯化方法，其在医学中的用途，特别是在预防疟疾感染中，含有颗粒的组合物/疫苗或针对蛋白质颗粒的抗体如单克隆抗体或多克隆抗体，以及使用相同，特别是在治疗中。此外，具有特定比例的颗粒可以通过使用酵母，酿酒酵母或巴斯德毕赤酵母来制备。尤其涉及包含以下单体的免疫原性蛋白质颗粒：a。包含源自间日疟原虫的CS蛋白的序列和乙型肝炎的S抗原（CSV-S）的融合蛋白，以及b。 S抗原来自乙型肝炎病毒，其特征在于S与CSV-S的比例在0.1〜1范围内.S与CSV-S的比例在0.19〜0.30或0.68〜0.80的范围内。

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