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1. 发明授权

US06602204B2 Intraoperative tissue treatment methods 有权
标题翻译：术中组织治疗方法
公开(公告)号：US06602204B2
公开(公告)日：2003-08-05
申请号：US09844661
申请日：2001-04-27
申请人： William R. Dubrul , Richard E. Fulton , Robert M. Curtis
发明人： William R. Dubrul , Richard E. Fulton , Robert M. Curtis
IPC分类号： A61B1000
CPC分类号： A61B10/0266 , A61B6/502 , A61B10/02 , A61B17/221 , A61B17/3421 , A61B18/14 , A61B90/39 , A61B2090/3904 , A61B2090/3908 , A61B2090/3962
摘要： Intraoperative tissue treatment methods are used following the removal of target tissue, e.g. diseased tissue, from a target site, e.g. within a patient's breast, leaving access to the target site. In one method an expandable element is introduced into and expanded within a void at the target site. If all of the target tissue was not removed, then a layer of tissue at least partially surrounding the expanded element is removed from the patient, preferably in a substantially intact form. In a second method the suction inlet of a suction device is in fluid communication with the void. If all of the target tissue has not been removed, at least a portion of the collapsed tissue is removed from the patient and analyzed. With a third method, a flexible implant is passed through the sheath and into the void to at least substantially fill the void.
摘要翻译：术后组织治疗方法是在去除靶组织后使用的。患病组织，来自靶位点，例如。在患者的乳房内，进入目标部位。在一种方法中，可扩张元件被引入到目标位置的空隙内并扩大。如果没有去除所有的目标组织，则至少部分地围绕扩张的元件的组织层从患者中移除，优选以基本上完整的形式。在第二种方法中，抽吸装置的吸入口与空隙流体连通。如果所有的目标组织都没有被去除，则从患者身上移除至少一部分塌陷的组织并进行分析。利用第三种方法，将柔性植入物穿过护套并进入空隙以至少基本上填充空隙。

2. 发明授权

US06530923B1 Tissue removal methods and apparatus 有权
公开(公告)号：US06530923B1
公开(公告)日：2003-03-11
申请号：US09588278
申请日：2000-06-05
申请人： William R. Dubrul , Richard E. Fulton , Robert M. Curtis
发明人： William R. Dubrul , Richard E. Fulton , Robert M. Curtis
IPC分类号： A61B1717
CPC分类号： A61B10/0266 , A61B6/502 , A61B10/02 , A61B17/221 , A61B17/3421 , A61B18/14 , A61B90/39 , A61B2090/3904 , A61B2090/3908 , A61B2090/3962
摘要： Target tissues are accessed and removed using various types of devices and methods.

3. 发明申请

US20100130965A1 Redundant Tissue Closure Methods and Apparatuses 有权
标题翻译：冗余组织封闭方法和装置
公开(公告)号：US20100130965A1
公开(公告)日：2010-05-27
申请号：US12559377
申请日：2009-09-14
申请人： Wilmer L. Sibbitt, JR. , Robert M. Curtis , Randy R. Sibbitt
发明人： Wilmer L. Sibbitt, JR. , Robert M. Curtis , Randy R. Sibbitt
IPC分类号： A61B18/20 , A61B17/10 , A61B17/08 , A61B18/00 , A61B18/04
CPC分类号： A61B17/10 , A61B17/0057 , A61B17/0643 , A61B17/083 , A61B2017/00663 , A61B2017/00668 , A61B2017/0641
摘要： A tissue closure device including a tissue eversion apparatus, and a first and a second, redundant closure element that are placed on the external surface of a tissue puncture wound to enhance the efficacy of closure. The first closure element and the second closure element closure are left resident on the external surface of or in proximity to the tissue puncture wound in order to provide redundancy of closure.
摘要翻译：一种组织封闭装置，包括组织外翻装置，以及第一和第二冗余封闭元件，其被放置在组织穿刺伤口的外表面上，以增强关闭的功效。第一闭合元件和第二闭合元件闭合件留在组织穿刺伤口的外表面上或附近，以提供闭合的冗余。

4. 发明授权

US4182739A Blood oxygenator 失效
标题翻译：血液充氧器
公开(公告)号：US4182739A
公开(公告)日：1980-01-08
申请号：US868168
申请日：1978-01-09
申请人： Robert M. Curtis
发明人： Robert M. Curtis
IPC分类号： A61M1/32 , A61M1/03
CPC分类号： A61M1/32 , Y10S128/03
摘要： A blood oxygenator wherein blood and oxygen are admixed by flowing blood, into which has been introduced bubbles of oxygen, through a three-dimensional, open cellular mixing material having a substantial void volume. The resulting arterialized blood and blood foam rise to the top of the admixing chamber and are contained in a channel located at the top of the chamber and directed through this channel to the input of a defoamer chamber. A defoamer filter of annular configuration is retained within the defoamer chamber such that the defoamer inlet is located at the top of the defoamer filter within the interior annular space thereof. The blood foam thus enters the interior of the defoamer filter and is distributed over a substantial portion of the defoamer surface and collapsed therein to remove substantially all entrapped gases. The oxygenated defoamed blood collects at the bottom of the defoamer chamber for return to the patient's body. In the preferred embodiment, the defoamer chamber is provided with an unobstructed annular defoamer filter inlet opening for enhanced contacting of the defoaming material by the blood and blood foam while minimizing blood hemolysis, and an integral vent which permits the entrapped gases to be exhausted from the oxygenator either by free flow or by a vacuum source.
摘要翻译：一种血液氧合器，其中血液和氧气通过流过已经引入气泡的血液通过具有实质空隙体积的三维开放细胞混合材料混合。所产生的动脉血和血液泡沫升高到混合室的顶部并且被容纳在位于室顶部的通道中，并且通过该通道引导到消泡器室的输入端。消泡剂室内保持环状构造的消泡剂过滤器，使得消泡剂入口位于消泡剂过滤器的内部环形空间的顶部。血液泡沫因此进入消泡剂过滤器的内部并且分布在消泡剂表面的大部分上并且在其中折叠以除去基本上所有的夹带的气体。含氧消泡的血液聚集在消泡室的底部，以返回到患者的身体。在优选实施例中，消泡器室设置有无障碍环形消泡剂过滤器入口，用于通过血液和血液泡沫增强接触消泡材料，同时使血液溶血最小化;以及整体通风口，其允许捕获的气体从充氧器通过自由流动或通过真空源。

5. 发明授权

US08932324B2 Redundant tissue closure methods and apparatuses 有权
标题翻译：冗余组织封闭方法和装置
公开(公告)号：US08932324B2
公开(公告)日：2015-01-13
申请号：US12559377
申请日：2009-09-14
申请人： Wilmer L. Sibbitt, Jr. , Robert M. Curtis , Randy R. Sibbitt
发明人： Wilmer L. Sibbitt, Jr. , Robert M. Curtis , Randy R. Sibbitt
IPC分类号： A61B17/08 , A61D1/00 , A61B17/064 , A61B17/00
CPC分类号： A61B17/10 , A61B17/0057 , A61B17/0643 , A61B17/083 , A61B2017/00663 , A61B2017/00668 , A61B2017/0641
摘要： A tissue closure device including a tissue eversion apparatus, and a first and a second, redundant closure element that are placed on the external surface of a tissue puncture wound to enhance the efficacy of closure. The first closure element and the second closure element are left resident on the external surface of or in proximity to the tissue puncture wound in order to provide redundancy of closure.
摘要翻译：一种组织封闭装置，包括组织外翻装置，以及第一和第二冗余封闭元件，其被放置在组织穿刺伤口的外表面上，以增强关闭的功效。第一闭合元件和第二闭合元件留在组织穿刺伤口的外表面上或附近，以提供闭合的冗余。

6. 发明申请

US20120089211A1 METHODS AND APPARATUS FOR CRYOGENICALLY TREATING MULTIPLE TISSUE SITES WITH A SINGLE PUNCTURE 审中-公开
标题翻译：用单节治疗多发性组织细胞的方法和装置
公开(公告)号：US20120089211A1
公开(公告)日：2012-04-12
申请号：US13083029
申请日：2011-04-08
申请人： Robert M. Curtis , Phillip Olsen
发明人： Robert M. Curtis , Phillip Olsen
IPC分类号： A61F7/12
CPC分类号： A61N7/00 , A61B5/150129 , A61B18/02 , A61B18/0206 , A61B18/1477 , A61B18/1815 , A61B18/20 , A61B2018/00011 , A61N2007/0008 , A61N2007/0034
摘要： A method for cryogenically treating tissue comprises piercing the skin, inserting a sheath into tissue, and passing a cryoprobe through the sheath into the tissue. The cryoprobe cools a first region of the tissue, is repositioned in the sheath, and then cools a second region of the tissue.
摘要翻译：用于低温处理组织的方法包括刺穿皮肤，将鞘插入组织中，并将冷冻探针穿过鞘进入组织。冷冻探针冷却组织的第一区域，重新定位在鞘中，然后冷却组织的第二区域。

7. 发明授权

US4183961A Method of oxygenating blood 失效
标题翻译：血液充氧的方法
公开(公告)号：US4183961A
公开(公告)日：1980-01-15
申请号：US817643
申请日：1977-07-21
申请人： Robert M. Curtis
发明人： Robert M. Curtis
IPC分类号： A61M1/32 , A61K45/00 , A61K35/14
CPC分类号： A61M1/32 , Y10S261/28 , Y10S514/959
摘要： A method of oxygenating venous blood in a blood oxygenator wherein blood and oxygen are admixed by flowing blood, into which has been introduced bubbles of oxygen, through a three dimensional, open cellular mixing material having a substantial void volume. In one embodiment, the admixing chamber is provided by an upright cylinder having an open interior. In a second embodiment, the chamber has an annular interior configuration. In both embodiments, the open cellular mixing material completely fills the cross-sectional interior of the chamber. The resulting arterialized blood and blood foam rise to the top of the admixing chamber and are contained in a channel located at the top of the chamber and directed through this channel to the input of a defoamer chamber. A defoamer filter of annular configuration is retained within the defoamer chamber such that the defoamer inlet is located at the top of the defoamer filter within the interior annular space thereof. The blood foam thus enters the interior of the defoamer filter and is distributed over a substantial portion of the defoamer surface and collapsed therein to remove all entrapped gases. The oxygenated defoamed blood collects at the bottom of the defoamer chamber for return to the patient's body.
摘要翻译：一种在血液氧合器中给予静脉血的方法，其中通过使已经引入气泡的血液通过具有基本空隙体积的三维开孔细胞混合材料流动而将血液和氧气混合。在一个实施例中，混合室由具有开放内部的直立圆柱体提供。在第二实施例中，腔室具有环形内部构造。在两个实施方案中，开孔混合材料完全填充室的横截面内部。所产生的动脉血和血液泡沫升高到混合室的顶部并且被容纳在位于室顶部的通道中，并且通过该通道引导到消泡器室的输入端。消泡剂室内保持环状构造的消泡剂过滤器，使得消泡剂入口位于消泡剂过滤器的内部环形空间的顶部。因此，血液泡沫进入消泡剂过滤器的内部并且分散在消泡剂表面的大部分上并且在其中折叠以除去所有被夹带的气体。含氧消泡的血液聚集在消泡室的底部，以返回到患者的身体。

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