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1. 发明授权

US07344549B2 Expandable cages for embolic filtering devices 有权
标题翻译：用于栓塞过滤装置的可膨胀笼
公开(公告)号：US07344549B2
公开(公告)日：2008-03-18
申请号：US10066314
申请日：2002-01-31
申请人： William J. Boyle , William J. Harrison , Benjamin C. Huter , Scott J. Huter , Paul F. Muller , John E. Papp
发明人： William J. Boyle , William J. Harrison , Benjamin C. Huter , Scott J. Huter , Paul F. Muller , John E. Papp
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A self-expanding cage for use in conjunction with an embolic filtering device includes a circumferential member adapted to expand from an unexpanded position to a expanded position within the patient's body vessel. A proximal strut and distal strut are attached to the circumferential member to form the cage. A plurality of proximal and distal struts may be attached the circumferential member. Additionally, a second circumferential member can be attached to the first circumferential member. Each circumferential member can be connected by a single or a plurality of connecting struts. One embodiment of the cage utilizes a single wire to form to the cage. A delivery system attached to the single wire cage moves the cage and its associated filter element between the expanded and unexpanded positions through relative movement of the distal delivery system. This can be accomplished by either torquing the guide wire onto which the expandable cage is mounted or by longitudinally moving a tubular member which forms part of the delivery system longitudinally in relation to the guide wire.
摘要翻译：用于与栓塞过滤装置结合使用的自膨胀笼包括适于从未膨胀位置膨胀到患者体内容器内的扩张位置的周向构件。近端支柱和远侧支柱附接到周向构件以形成保持架。多个近端和远侧支柱可以附接在周向构件上。此外，第二周向构件可以附接到第一圆周构件。每个周向构件可以通过单个或多个连接支柱连接。笼的一个实施例使用单个线来形成笼。附接到单线笼的输送系统通过远端输送系统的相对运动使笼及其相关联的过滤元件在膨胀位置和未膨胀位置之间移动。这可以通过扭转其上安装有可膨胀笼的引导线或通过纵向移动相对于导丝纵向移动形成输送系统的一部分的管状构件来实现。

2. 发明授权

US06702834B1 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US06702834B1
公开(公告)日：2004-03-09
申请号：US09727102
申请日：2000-11-28
申请人： John F. Boylan , William J. Boyle , Andy E. Denison , Debashis Dutta , Benjamin C. Huter , Scott J. Huter , Paul F. Muller , Samir Patel , Christopher J. Tarapata , Chicheng Wang , Francisco Sanchez , Kent C. B. Stalker
发明人： John F. Boylan , William J. Boyle , Andy E. Denison , Debashis Dutta , Benjamin C. Huter , Scott J. Huter , Paul F. Muller , Samir Patel , Christopher J. Tarapata , Chicheng Wang , Francisco Sanchez , Kent C. B. Stalker
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

3. 发明授权

US08591540B2 Embolic filtering devices 有权
标题翻译：栓塞过滤装置
公开(公告)号：US08591540B2
公开(公告)日：2013-11-26
申请号：US10675611
申请日：2003-09-29
申请人： William J. Boyle , John E. Papp , Charles R. Peterson , Paul F. Muller , Donald Schwarten , Kathern J. Lind
发明人： William J. Boyle , John E. Papp , Charles R. Peterson , Paul F. Muller , Donald Schwarten , Kathern J. Lind
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/97 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： An embolic filtering system includes a guide wire, a filter device disposed on the guide wire, a sheath adapted to maintain the filter device in an unexpanded position and a torque device having a lumen for receiving the guide wire and a locking mechanism for locking the torque device to the guide wire. The torque device may include a side port adapted to receive the proximal end of the sheath to allow a portion of the guide wire to shear the sheath from the guide wire through retraction of the sheath through the side port. The torque device may include an extension arm having a distal opening adapted to receive both the guide wire and the sheath. A second lumen may be used to allow a portion of the guide wire to shear the sheath away from the guide wire through retraction of the sheath through the second lumen.
摘要翻译：栓塞过滤系统包括引导线，设置在引导线上的过滤器装置，适于将过滤装置保持在未膨胀位置的护套和具有用于容纳引导线的内腔的扭矩装置和用于锁定扭矩的锁定机构设备到导丝。扭矩装置可以包括适于容纳护套的近端的侧端口，以允许导线的一部分通过护套通过侧端部缩回而从引导线剪切护套。扭矩装置可以包括延伸臂，其具有适于接纳导丝和护套的远端开口。可以使用第二内腔来允许引导线的一部分通过使护套通过第二内腔缩回而将护套从引导线上剪切。

4. 发明授权

US06290656B1 Guide wire with damped force vibration mechanism 有权
标题翻译：导丝采用阻尼力振动机构
公开(公告)号：US06290656B1
公开(公告)日：2001-09-18
申请号：US09475381
申请日：1999-12-30
申请人： William J. Boyle , Paul F. Muller
发明人： William J. Boyle , Paul F. Muller
IPC分类号： A61B500
CPC分类号： A61M25/09
摘要： A guide wire having a damped force vibration mechanism which isolates vibrations or shockwaves which otherwise would be transmitted along the length of the guide wire to its distal end. The damped force vibration mechanism helps absorb some of the energy created during the exchange of a delivery catheter or an interventional device on the guide wire or any shock or force generated from an external source. The damped force vibration mechanism absorbs vibrations or shock which would otherwise act on medical devices attached near the distal end of a guide wire. The damped force vibration mechanism may consist of a reduced segment on the guide wire which can be made from a material such as superelastic or plastically deformable, biocompatible materials. The damped force vibration mechanism can have a relatively straight configuration or can have a wave-shaped form, or other shape which helps absorb vibratory motion.
摘要翻译：具有阻尼力振动机构的引导线，其隔离振动或冲击波，否则其将沿着导丝的长度传递到其远端。阻尼力振动机制有助于吸收在导丝或交流导管或介入装置交换导线时产生的一些能量，或从外部源产生的任何冲击或力。阻尼力振动机构吸收振动或冲击，否则这些振动或冲击将作用在附着在导丝末端附近的医疗装置上。阻尼力振动机构可以由导丝上的减少的部分组成，其可由诸如超弹性或塑性变形的生物相容性材料的材料制成。阻尼力振动机构可以具有相对直的构造或者可以具有波形形状或其它有助于吸收振动的形状。

5. 发明授权

US08262689B2 Embolic filtering devices 有权
标题翻译：栓塞过滤装置
公开(公告)号：US08262689B2
公开(公告)日：2012-09-11
申请号：US09967906
申请日：2001-09-28
申请人： Gary Schneiderman , Anuja H. Patel , Paul F. Muller , William J. Boyle , Thomas A. Hassing , Thomas H. Majcher
发明人： Gary Schneiderman , Anuja H. Patel , Paul F. Muller , William J. Boyle , Thomas A. Hassing , Thomas H. Majcher
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/005 , A61F2230/008
摘要： A self-expanding basket for use in conjunction with an embolic filtering device has a proximal set of struts which are connected to a distal set of struts by a bending region which provides enhanced bending characteristics to the basket. The bending region can be formed by intermediate links which are extremely flexible and bendable to allow the basket to be delivered through tortuous anatomy. The intermediate links are extremely flexible and create a mechanical hinge-like connection between the proximal and distal strut assemblies. The basket thus is capable of substantial bending when being delivered through the patient's vasculature and will bend and conform to the patient's anatomy once positioned for filtering purposes. The intermediate links can also lengthen, when needed, when positioned in a curved vessel in the patient's vasculature, when needed. As a result, the basket will easily conform to a curved body vessel to maintain proper wall apposition of the filtering element with the wall of the body vessel.
摘要翻译：与栓塞过滤装置结合使用的自膨胀篮具有近侧的支柱，其通过弯曲区域连接到远侧的一组支柱，该弯曲区域向篮提供增强的弯曲特性。弯曲区域可以通过中间链节形成，这些中间链接是非常柔软的并且是可弯曲的，以允许篮子通过曲折的解剖结构递送。中间环节是非常灵活的，并且在近端和远端支柱组件之间产生机械铰链式连接。因此，当通过患者的脉管系统递送时，篮子能够实质弯曲，并且一旦定位以便过滤，就会弯曲并符合患者的解剖结构。当需要时，当需要时，中间连杆还可以在患者的脉管系统中定位在弯曲的血管中时延长。结果，篮子将容易地符合弯曲的身体容器，以保持过滤元件与身体血管的壁的适当的壁连接。

6. 发明授权

US06264671B1 Stent delivery catheter and method of use 有权
标题翻译：支架输送导管及使用方法
公开(公告)号：US06264671B1
公开(公告)日：2001-07-24
申请号：US09439692
申请日：1999-11-15
申请人： Richard S. Stack , Udayan Patel , William J. Boyle , Kent C. B. Stalker , Paul F. Muller
发明人： Richard S. Stack , Udayan Patel , William J. Boyle , Kent C. B. Stalker , Paul F. Muller
IPC分类号： A61M2900
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958
摘要： A deformable sheath is attached to a catheter and introduced intravascularly to be expanded against an arterial wall and entrap plaque therebetween. A stent is subsequently deployed within the expanded sheath and the sheath is then withdrawn from within the vasculature to leave the stent expanded against the arterial wall with the plaque entrapped therebetween.
摘要翻译：可变形护套附着在导管上，血管内引入以相对于动脉壁扩张并在其间夹带斑块。随后将支架部署在扩张的护套内，然后从脉管系统中撤出护套，以使支架膨胀抵靠动脉壁，其间夹有斑块。

7. 发明授权

US07048758B2 Vessel occlusion device for embolic protection system 有权
公开(公告)号：US07048758B2
公开(公告)日：2006-05-23
申请号：US10457073
申请日：2003-06-06
申请人： William J. Boyle , Andy E. Denison , Paul F. Muller
发明人： William J. Boyle , Andy E. Denison , Paul F. Muller
IPC分类号： A61M29/00
CPC分类号： A61B17/12172 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B2017/22067 , A61F2/013 , A61F2/95 , A61F2002/018 , A61F2230/0006 , A61F2230/008 , A61F2230/0093
摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region, which is capable of capturing embolic material which may be released into a blood vessel during a therapeutic interventional procedure at the site of a lesion in the blood vessel. The system is adapted to be utilized in a collateral blood supply system adapted to enable the flow of blood to bypass the blood vessel upon blocking thereof and to enable the reverse flow of blood through the blood vessel upon unblocking thereof. The system includes a guide wire, including a distal end, adapted to be positioned in a blood vessel relative to an interventional procedure site. A guide catheter, including a distal end, is adapted to enable the interventional procedure to be performed, and to be inserted over the guide wire and through a patient's vasculature to a position in the blood vessel relative to the interventional procedure site. An occluding device for occluding and blocking a blood vessel at a location relative to the interventional procedure site is adapted to be positionable at a location relative to he interventional procedure site, to be expandable so as to prevent and block the flow of blood past the occlusion, and to enable the capture of embolic material which may be released into the blood in the blood vessel during the therapeutic interventional procedure, and to be contracted to unblock the blood vessel and enable the recovery of captured embolic material.

8. 发明授权

US06833002B2 Stent delivery catheter assembly and method of use 有权
标题翻译：支架输送导管组装及使用方法
公开(公告)号：US06833002B2
公开(公告)日：2004-12-21
申请号：US09885468
申请日：2001-06-19
申请人： Richard S. Stack , Udayan Patel , William J. Boyle , Kent C. B. Stalker , Paul F. Muller
发明人： Richard S. Stack , Udayan Patel , William J. Boyle , Kent C. B. Stalker , Paul F. Muller
IPC分类号： A61F206
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958
摘要： A deformable sheath is attached to a catheter and introduced intravascularly to be expanded against an arterial wall and entrap plaque therebetween. A stent is subsequently deployed within the expanded sheath and the sheath is then withdrawn from within the vasculature to leave the stent expanded against the arterial wall with the plaque entrapped therebetween.
摘要翻译：可变形护套附着在导管上，血管内引入以相对于动脉壁扩张并在其间夹带斑块。随后将支架部署在扩张的护套内，然后从脉管系统中撤出护套，以使支架膨胀抵靠动脉壁，其间夹有斑块。

9. 发明授权

US08257310B2 Digital syringe with compensation control 有权
标题翻译：带补偿控制的数字式注射器
公开(公告)号：US08257310B2
公开(公告)日：2012-09-04
申请号：US13196256
申请日：2011-08-02
申请人： Brian W. Donovan , Andrea Y. Leung , Lisanne A. Eng , David P. Thompson , Robert B. Hubler , Stephanie A. Barnes , Thomas C. Arends , Keith Schubert , Paul C. Leonard , Paul F. Muller
发明人： Brian W. Donovan , Andrea Y. Leung , Lisanne A. Eng , David P. Thompson , Robert B. Hubler , Stephanie A. Barnes , Thomas C. Arends , Keith Schubert , Paul C. Leonard , Paul F. Muller
IPC分类号： A61M37/00 , A61M31/00
CPC分类号： A61B17/8872 , A61B2017/0256 , A61M5/1452 , A61M5/16854 , A61M5/16877 , A61M2205/3317 , A61M2205/3389 , A61M2205/50 , A61M2205/502
摘要： A syringe for performing a medical procedure includes a pressure sensor, a volume sensor, and a compensation circuit. The volume sensor measures a volume of a flowable material that is dispensed from the syringe, the pressure sensor measures a pressure being applied to the flowable material, and the compensation circuit calculates a delivered volume of the flowable material by accounting for system compliance (expansion) as the pressure is increased. By compensating for system compliance in this manner, a syringe can be used in high pressure procedures while still providing accurately controllable material delivery.
摘要翻译：用于执行医疗程序的注射器包括压力传感器，体积传感器和补偿电路。体积传感器测量从注射器分配的可流动材料的体积，压力传感器测量施加到可流动材料的压力，并且补偿电路通过考虑系统顺应性（膨胀）来计算可流动材料的输送体积，随着压力的增加。通过以这种方式补偿系统顺应性，注射器可以在高压程序中使用，同时仍然提供准确可控的材料输送。

10. 发明申请

US20110288523A1 Digital Syringe With Compensation Control 有权
标题翻译：数字注射器补偿控制
公开(公告)号：US20110288523A1
公开(公告)日：2011-11-24
申请号：US13196256
申请日：2011-08-02
申请人： Brian W. Donovan , Andrea Y. Leung , Lisanne Eng , David P. Thompson , Robert B. Hubler , Stephanie Ann Barnes , Thomas C. Arends , Keith Schubert , Paul C. Leonard , Paul F. Muller
发明人： Brian W. Donovan , Andrea Y. Leung , Lisanne Eng , David P. Thompson , Robert B. Hubler , Stephanie Ann Barnes , Thomas C. Arends , Keith Schubert , Paul C. Leonard , Paul F. Muller
IPC分类号： A61M5/00
CPC分类号： A61B17/8872 , A61B2017/0256 , A61M5/1452 , A61M5/16854 , A61M5/16877 , A61M2205/3317 , A61M2205/3389 , A61M2205/50 , A61M2205/502
摘要： A syringe for performing a medical procedure includes a pressure sensor, a volume sensor, and a compensation circuit. The volume sensor measures a volume of a flowable material that is dispensed from the syringe, the pressure sensor measures a pressure being applied to the flowable material, and the compensation circuit calculates a delivered volume of the flowable material by accounting for system compliance (expansion) as the pressure is increased. By compensating for system compliance in this manner, a syringe can be used in high pressure procedures while still providing accurately controllable material delivery.
摘要翻译：用于执行医疗程序的注射器包括压力传感器，体积传感器和补偿电路。体积传感器测量从注射器分配的可流动材料的体积，压力传感器测量施加到可流动材料的压力，并且补偿电路通过考虑系统顺应性（膨胀）来计算可流动材料的输送体积，随着压力的增加。通过以这种方式补偿系统顺应性，注射器可以在高压程序中使用，同时仍然提供准确可控的材料输送。

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