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1. 发明授权

US07217356B2 Medical system, method and apparatus employing MEMS 有权
标题翻译：采用MEMS的医疗系统，方法和装置
公开(公告)号：US07217356B2
公开(公告)日：2007-05-15
申请号：US11198804
申请日：2005-08-05
申请人： William H. Cork , James J. Ulmes , Richard L. West , Ying-Cheng Lo , Mark C. Weber , Kyungyoon Min
发明人： William H. Cork , James J. Ulmes , Richard L. West , Ying-Cheng Lo , Mark C. Weber , Kyungyoon Min
IPC分类号： B01D61/32
CPC分类号： A61B5/14546 , A61B5/14557 , A61B5/417 , A61B50/13 , A61B2562/028 , A61M1/0209 , A61M1/3609 , A61M1/367 , A61M1/3696 , A61M1/38 , A61M2205/12 , A61M2205/33 , A61M2205/52 , A61M2230/20 , B01D61/22 , G01N33/491 , G01N33/5005 , G01N33/5094 , G01N35/08 , G01N2035/00237 , Y10T436/117497
摘要： A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least one microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selected characteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communicate with the interior for sensing a characteristic of the fluid contained therein. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.
摘要翻译：公开了一种生物悬浮处理系统，其可以包括用于处理生物悬浮液的一种或多种组分的悬浮处理装置，用于将悬浮液引入处理装置的第一流体流动路径和用于取出生物悬浮液的成分的第二流体流动路径从设备暂停。至少一个微机电（MEM）传感器与流体流动路径中的一个通信，用于感测流体的选定特性。 MEM传感器可以位于别处，例如在容器或袋上，并与内部连通，以便感测其中所含流体的特性。可以检测各种各样的特征，例如流速，pH，细胞类型，细胞抗原性，DNA，病毒或细菌存在，胆固醇，血细胞比容，细胞浓度，细胞计数，分压，病原体存在或粘度。

2. 发明授权

US06994781B2 Medical system, method and apparatus employing MEMS 有权
标题翻译：采用MEMS的医疗系统，方法和装置
公开(公告)号：US06994781B2
公开(公告)日：2006-02-07
申请号：US10031112
申请日：2001-07-03
申请人： William H. Cork , James J. Ulmes , Richard L. West , Ying-Cheng Lo , Mark C. Weber , Kyungyoon Min
发明人： William H. Cork , James J. Ulmes , Richard L. West , Ying-Cheng Lo , Mark C. Weber , Kyungyoon Min
IPC分类号： B01D61/32
CPC分类号： A61B5/14546 , A61B5/14557 , A61B5/417 , A61B50/13 , A61B2562/028 , A61M1/0209 , A61M1/3609 , A61M1/367 , A61M1/3696 , A61M1/38 , A61M2205/12 , A61M2205/33 , A61M2205/52 , A61M2230/20 , B01D61/22 , G01N33/491 , G01N33/5005 , G01N33/5094 , G01N35/08 , G01N2035/00237 , Y10T436/117497
摘要： A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least on microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selected characteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communicate with the interior for sensing a characteristic of the fluid contained therein. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.
摘要翻译：公开了一种生物悬浮处理系统，其可以包括用于处理生物悬浮液的一种或多种组分的悬浮处理装置，用于将悬浮液引入处理装置的第一流体流动路径和用于取出生物悬浮液的成分的第二流体流动路径从设备暂停。至少在微机电（MEM）传感器上与其中一个流体流路连通，以便感测流体的所选特征。 MEM传感器可以位于别处，例如在容器或袋上，并与内部连通，以便感测其中所含流体的特性。可以检测各种各样的特征，例如流速，pH，细胞类型，细胞抗原性，DNA，病毒或细菌存在，胆固醇，血细胞比容，细胞浓度，细胞计数，分压，病原体存在或粘度。

3. 发明授权

US09764075B2 Data management system and method for membrane separation systems 有权
公开(公告)号：US09764075B2
公开(公告)日：2017-09-19
申请号：US14003294
申请日：2012-03-09
申请人： Bryan Blickhan , Kyungyoon Min , William H. Cork
发明人： Bryan Blickhan , Kyungyoon Min , William H. Cork
IPC分类号： C02F1/44 , B01D11/00 , B01D61/00 , A61M1/34 , A61M1/36 , A61M1/02 , B01D61/18 , B01D63/06 , B01D63/16 , A61M1/38 , A61M1/26 , B01D35/00 , G06F19/00 , G09G5/00
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

4. 发明申请

US20120041777A1 MOBILE APPLICATIONS FOR BLOOD CENTERS 审中-公开
标题翻译：用于血液中心的移动应用程序
公开(公告)号：US20120041777A1
公开(公告)日：2012-02-16
申请号：US13209161
申请日：2011-08-12
申请人： Brian C. Case , Jonathan Prendergast , John W. Barry, JR. , Kyungyoon Min , William H. Cork , Daryl Richard Calhoun , Christine M. Larson
发明人： Brian C. Case , Jonathan Prendergast , John W. Barry, JR. , Kyungyoon Min , William H. Cork , Daryl Richard Calhoun , Christine M. Larson
IPC分类号： G06Q10/08 , G06Q50/22
CPC分类号： G16H40/63 , G06F19/3418 , G06Q10/087 , G06Q10/1093 , G06Q50/22 , G06T11/206 , G16H10/60
摘要： Certain examples provide systems, methods, and apparatus to provide information regarding blood collection instruments via a mobile device. An example method for blood collection instrument management includes providing a graphical representation of one or more blood collection instruments with a visual indication of a status for each instrument. The graphical representation is to visually convey information regarding each of the one or more blood collection instruments and is selectable by a user to provide additional information regarding each of the one or more blood collection instruments. The method includes facilitating access to troubleshoot and interact with the one or more blood collection instruments via the mobile device. The method includes dynamically updating the status for each instrument via communication between the mobile device and one or more blood collection facilities at which the one or more blood collection instruments are located.
摘要翻译：某些实例提供了通过移动设备提供关于采血仪器的信息的系统，方法和装置。用于采血仪器管理的示例性方法包括提供一个或多个采血器具的图形表示，其具有每个器械的状态的视觉指示。图形表示是视觉地传达关于一个或多个采血器具中的每一个的信息，并且可由用户选择以提供关于一个或多个采血器械中的每一个的附加信息。该方法包括便利访问以经由移动设备对一个或多个采血器具进行故障排除和交互。该方法包括通过移动设备与一个或多个采血设备所在的一个或多个血液采集设备之间的通信动态地更新每个仪器的状态。

5. 发明授权

US08448992B2 Sterile docking device, medical fluid flow system with sterile docking device and method of using same 有权
标题翻译：无菌对接装置，具有无菌对接装置的医用流体流动系统及其使用方法
公开(公告)号：US08448992B2
公开(公告)日：2013-05-28
申请号：US13028372
申请日：2011-02-16
申请人： Kyungyoon Min , William H. Cork
发明人： Kyungyoon Min , William H. Cork
IPC分类号： F16L35/00 , B32B38/04
CPC分类号： A61M39/143 , F04C2270/0421 , F16L29/005 , F16L47/02 , F16L2201/44
摘要： Method and apparatus are disclosed for forming a sealed communication between conduits or conduit subassemblies, each of which has a wall with an exterior surface, and at least one of the walls includes an electrically conductive portion. The exterior surfaces may be brought into a facing relationship, and each conductive portion is heated sufficiently to sterilize the exterior surfaces of the walls by generating electrical current in the conductive portion, such as by application of a voltage or by induction. An aperture is then provided, as by an aperture-forming member, through the facing walls to provide communication between the conduits or conduit subassemblies.
摘要翻译：公开了用于在导管或导管子组件之间形成密封连接的方法和装置，每个管子组件具有带有外表面的壁，并且至少一个壁包括导电部分。外表面可以处于面对的关系，并且每个导电部分被充分加热以通过在导电部分中产生电流来消除（例如通过施加电压或通过感应）的电流。然后，通过孔形成构件，通过面向壁提供孔，以在导管或导管组件之间提供连通。

6. 发明申请

US20140043930A1 PLATELET RESUSPENSION METHOD AND APPARATUS 审中-公开
公开(公告)号：US20140043930A1
公开(公告)日：2014-02-13
申请号：US14113077
申请日：2012-05-02
申请人： Fletcher C. Belt , Michael J. Kast , Kyungyoon Min , Katherine Radwanski , William H. Cork
发明人： Fletcher C. Belt , Michael J. Kast , Kyungyoon Min , Katherine Radwanski , William H. Cork
IPC分类号： A61M1/02
CPC分类号： A61M1/025 , A61M1/0281 , A61M1/3693 , A61M1/3696
摘要： A method is disclosed for resuspending a concentrated blood component collected in a single-use processing chamber that is mounted to a rotatable support of a centrifugal collection system. A resuspension solution is introduced to the single-use processing chamber constraining the concentrated blood component. The rotatable support with the single-use processing chamber mounted thereto is removed from the centrifugal collection system and mounted to a resuspension device. The device is then activated for a period of time sufficient to resuspend the concentrated blood component in the resuspension solution. In another aspect, the resuspension device is configured to impart a reciprocating arcuate motion to the support and its associated single-use processing chamber. A frequency of approximately 300 to 325 rpm over a period of time of approximately 1.5 to 2.5 minutes has been found effective for resuspending platelets. Reciprocation through an arc of less than 200° is provided.
摘要翻译：公开了一种用于将收集在一次性处理室中的浓缩血液成分重新悬浮的方法，所述一次性处理室安装在离心收集系统的可旋转支撑件上。将再悬浮溶液引入约束浓缩血液成分的一次性加工室中。安装在其上的一次性处理室的可旋转支撑件从离心收集系统中移除并安装到再悬挂装置。然后将该装置激活足以将浓缩血液成分重悬于再悬浮液中的一段时间。在另一方面，再悬浮装置被配置为向支撑件及其相关联的一次性使用处理室施加往复的弓形运动。发现在约1.5至2.5分钟的时间段内约300至325rpm的频率已经被有效用于重悬血小板。提供通过小于200°的弧的往复运动。

7. 发明申请

US20130345674A1 MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20130345674A1
公开(公告)日：2013-12-26
申请号：US14003284
申请日：2012-03-09
申请人： Benjamin E. Kusters , Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , William H. Cork , Daryl R. Calhoun , Bryan Blickhan , Daniel Lynn
发明人： Benjamin E. Kusters , Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , William H. Cork , Daryl R. Calhoun , Bryan Blickhan , Daniel Lynn
IPC分类号： A61M1/36 , A61M1/38
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

8. 发明授权

US11462321B2 Mobile applications for blood centers 有权
公开(公告)号：US11462321B2
公开(公告)日：2022-10-04
申请号：US13209161
申请日：2011-08-12
申请人： Brian C. Case , Jonathan Prendergast , John W. Barry, Jr. , Kyungyoon Min , William H. Cork , Daryl Richard Calhoun , Christie Larson , Robert Bronersky
发明人： Brian C. Case , Jonathan Prendergast , John W. Barry, Jr. , Kyungyoon Min , William H. Cork , Daryl Richard Calhoun , Christie Larson , Robert Bronersky
IPC分类号： G06Q10/08 , G16H40/63 , G06T11/20 , G16H10/60 , G16H40/67 , G06Q10/10
摘要： Certain examples provide systems, methods, and apparatus to provide information regarding blood collection instruments via a mobile device. An example method for blood collection instrument management includes providing a graphical representation of one or more blood collection instruments with a visual indication of a status for each instrument. The graphical representation is to visually convey information regarding each of the one or more blood collection instruments and is selectable by a user to provide additional information regarding each of the one or more blood collection instruments. The method includes facilitating access to troubleshoot and interact with the one or more blood collection instruments via the mobile device. The method includes dynamically updating the status for each instrument via communication between the mobile device and one or more blood collection facilities at which the one or more blood collection instruments are located.

9. 发明申请

US20140034230A1 FLUID FLOW CONDUITS AND APPARATUS AND METHODS FOR MAKING AND JOINING FLUID CONDUITS 有权
标题翻译：流体流量和流体流量的制作和接合方法
公开(公告)号：US20140034230A1
公开(公告)日：2014-02-06
申请号：US14110010
申请日：2012-12-12
申请人： Christopher Wegener , Kyungyoon Min , Mark Brierton , Benjamin Kusters , James Madsen , William H. Cork
发明人： Christopher Wegener , Kyungyoon Min , Mark Brierton , Benjamin Kusters , James Madsen , William H. Cork
IPC分类号： B29C65/36
CPC分类号： A61M39/143 , A61M39/14 , B29C65/022 , B29C65/2015 , B29C65/203 , B29C65/30 , B29C65/32 , B29C65/3444 , B29C65/3456 , B29C65/36 , B29C65/3644 , B29C65/3656 , B29C65/4855 , B29C65/5021 , B29C65/5057 , B29C65/7841 , B29C66/0342 , B29C66/1142 , B29C66/3494 , B29C66/5221 , B29C66/5223 , B29C66/52298 , B29C66/5346 , B29C66/5414 , B29C66/543 , B29C66/71 , B29C66/72321 , B29C66/73115 , B29C66/73141 , B29C66/857 , B29C66/91231 , B29C66/91421 , B29C66/91651 , B29C66/919 , B29C66/91933 , B29C66/949 , B29C66/954 , B29K2027/06 , B29K2023/12 , B29K2067/003
摘要： Fluid flow conduits (14a, 14b) and apparatus (40) and methods for joining the conduits (14a, 14b), preferably in a sterile manner, are disclosed. Each conduit (14, 14b) has a polymeric open end that is sealed by a sealing member (26a, 26b) that may include a heating element (28). The polymeric end material is melted, the sealing members (26a, 26b) are moved to expose the melted open ends of the conduits (14a, 14b) and the ends are brought together to form a fused or welded connection (12) between the conduits (14a, 14b).
摘要翻译：公开了优选以无菌方式连接导管（14a，14b）的流体流动导管（14a，14b）和装置（40）和方法。每个导管（14,14b）具有由可包括加热元件（28）的密封构件（26a，26b）密封的聚合物开口端。聚合物端部材料被熔化，密封件（26a，26b）被移动以露出导管（14a，14b）的熔化的开口端，并且端部被接合在一起，以在导管之间形成熔接或焊接的连接（12）（14a，14b）。

10. 发明申请

US20130334139A1 MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS 有权
公开(公告)号：US20130334139A1
公开(公告)日：2013-12-19
申请号：US14003294
申请日：2012-03-09
申请人： Bryan Blickhan , Kyungyoon Min , William H. Cork
发明人： Bryan Blickhan , Kyungyoon Min , William H. Cork
IPC分类号： A61M1/38
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

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